Safety and fate of nanomaterials in food: The role of in vitro tests

Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips

(2020) Anna Herland et al.   Nature Biomedical Engineering

β-lactoglobulin micro- and nanostructures as bioactive compounds vehicle: In vitro studies

(2020) Lívia S. Simões et al.   FOOD RESEARCH INTERNATIONAL

Gut-Liver Physiomimetics Reveal Paradoxical Modulation of IBD-Related Inflammation by Short-Chain Fatty Acids

(2020) Martin Trapecar et al.   Cell Systems

Design of nanoemulsion-based delivery systems to enhance intestinal lymphatic transport of lipophilic food bioactives: Influence of oil type

(2020) Mingfei Yao et al.   FOOD CHEMISTRY

Human Microphysiological Models of Intestinal Tissue and Gut Microbiome

(2020) Steven N. Steinway et al.   Frontiers in Bioengineering and Biotechnology

Investigation of absorption, metabolism and toxicity of ginsenosides compound K based on human organ chips

(2020) Dongdong Liu et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Homeostatic mini-intestines through scaffold-guided organoid morphogenesis

(2020) Mikhail Nikolaev et al.   NATURE

Nanoparticle translocation and multi-organ toxicity: A particularly small problem

(2019) Jennifer B. Raftis et al.   Nano Today

Microfluidic-based platform for the evaluation of nanomaterial-mediated drug delivery: From high-throughput screening to dynamic monitoring

(2019) Yamin Yang et al.   CURRENT PHARMACEUTICAL DESIGN

Ultra-processed food consumption and exposure to phthalates and bisphenols in the US National Health and Nutrition Examination Survey, 2013–2014

(2019) Jessie P. Buckley et al.   ENVIRONMENT INTERNATIONAL

Gastrointestinal digestion of food-use silver nanoparticles in the dynamic SIMulator of the GastroIntestinal tract (simgi®). Impact on human gut microbiota

(2019) Carolina Cueva et al.   FOOD AND CHEMICAL TOXICOLOGY

Development of a Gut-on-a-Chip Model for High Throughput Disease Modeling and Drug Discovery

(2019) Claudia Beaurivage et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Impact of in vitro digestion on gastrointestinal fate and uptake of silver nanoparticles with different surface modifications

(2019) Ashraf Abdelkhaliq et al.   Nanotoxicology

Bioavailability and cytotoxicity of Cerium- (IV), Copper- (II), and Zinc oxide nanoparticles to human intestinal and liver cells through food

(2019) Jinxing Li et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Physiologically Based Pharmacokinetic and Pharmacodynamic Analysis Enabled by Microfluidically Linked Organs-on-Chips

(2018) Rachelle Prantil-Baun et al.   Annual Review of Pharmacology and Toxicology

Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in Drug Development

(2018) Kacey Ronaldson-Bouchard et al.   Cell Stem Cell

Can dynamic in vitro digestion systems mimic the physiological reality?

(2018) D. Dupont et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Study of the presence of micro- and nanoparticles in drinks and foods by multiple analytical techniques

(2018) Inmaculada de la Calle et al.   FOOD CHEMISTRY

In vitro digestion of lactoferrin-glycomacropeptide nanohydrogels incorporating bioactive compounds: Effect of a chitosan coating

(2018) Ana I. Bourbon et al.   FOOD HYDROCOLLOIDS

A pumpless body-on-a-chip model using a primary culture of human intestinal cells and a 3D culture of liver cells

(2018) Huanhuan Joyce Chen et al.   LAB ON A CHIP

Silver nanoparticles induce lysosomal-autophagic defects and decreased expression of transcription factor EB in A549 human lung adenocarcinoma cells

(2018) Takamitsu Miyayama et al.   TOXICOLOGY IN VITRO

Modeling radiation injury-induced cell death and countermeasure drug responses in a human Gut-on-a-Chip

(2018) Sasan Jalili-Firoozinezhad et al.   Cell Death & Disease

Evaluating the behaviour of curcumin nanoemulsions and multilayer nanoemulsions during dynamic in vitro digestion

(2018) Hélder D. Silva et al.   Journal of Functional Foods

Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids

(2018) Magdalena Kasendra et al.   Scientific Reports

Fate of lutein-containing zein nanoparticles following simulated gastric and intestinal digestion

(2018) Christopher J. Cheng et al.   FOOD HYDROCOLLOIDS

Mucus interactions with liposomes encapsulating bioactives: Interfacial tensiometry and cellular uptake on Caco-2 and cocultures of Caco-2/HT29-MTX

(2017) Yang Li et al.   FOOD RESEARCH INTERNATIONAL

Usefulness of Caco-2/HT29-MTX and Caco-2/HT29-MTX/Raji B Coculture Models To Predict Intestinal and Colonic Permeability Compared to Caco-2 Monoculture

(2017) Isabel Lozoya-Agullo et al.   MOLECULAR PHARMACEUTICS

Preparation, characterization, and in vitro dosimetry of dispersed, engineered nanomaterials

(2017) Glen M DeLoid et al.   Nature Protocols

An integrated methodology for assessing the impact of food matrix and gastrointestinal effects on the biokinetics and cellular toxicity of ingested engineered nanomaterials

(2017) Glen M. DeLoid et al.   Particle and Fibre Toxicology

Screening of TiO 2 and Au nanoparticles in cosmetics and determination of elemental impurities by multiple techniques (DLS, SP-ICP-MS, ICP-MS and ICP-OES)

(2017) Inmaculada de la Calle et al.   TALANTA

Membrane-free culture and real-time barrier integrity assessment of perfused intestinal epithelium tubes

(2017) Sebastiaan J. Trietsch et al.   Nature Communications

Biological fate of food nanoemulsions and the nutrients they carry – internalisation, transport and cytotoxicity of edible nanoemulsions in Caco-2 intestinal cells

(2017) Tim J. Wooster et al.   RSC Advances

A microfluidic chip based model for the study of full thickness human intestinal tissue using dual flow

(2016) A. Dawson et al.   Biomicrofluidics

In vitro behaviour of curcumin nanoemulsions stabilized by biopolymer emulsifiers – Effect of interfacial composition

(2016) Ana C. Pinheiro et al.   FOOD HYDROCOLLOIDS

Lysosomal Dysfunction Caused by Cellular Accumulation of Silica Nanoparticles

(2016) Irene Schütz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How reliably can a material be classified as a nanomaterial? Available particle-sizing techniques at work

(2016) Frank Babick et al.   JOURNAL OF NANOPARTICLE RESEARCH

A microfluidics-based in vitro model of the gastrointestinal human–microbe interface

(2016) Pranjul Shah et al.   Nature Communications

Revised Estimates for the Number of Human and Bacteria Cells in the Body

(2016) Ron Sender et al.   PLOS BIOLOGY

Naturally occurring nanoparticles in food

(2016) Michael Armin Rogers   Current Opinion in Food Science

Dissecting stromal-epithelial interactions in a 3D in vitro cellularized intestinal model for permeability studies

(2015) Carla Pereira et al.   BIOMATERIALS

Degradation of magnetic nanoparticles mimicking lysosomal conditions followed by AC susceptibility

(2015) Lucía Gutiérrez et al.   Biomedical Engineering-Biomedizinische Technik

In vitroM-like cells genesis through a tissue-engineered triple-culture intestinal model

(2015) Francisca Araújo et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents

(2015) Ilka Maschmeyer et al.   LAB ON A CHIP

Nanotoxicology: advances and pitfalls in research methodology

(2015) Morteza Azhdarzadeh et al.   Nanomedicine

Effects of silver nanoparticles and ions on a co-culture model for the gastrointestinal epithelium

(2015) Anastasia Georgantzopoulou et al.   Particle and Fibre Toxicology

Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip

(2015) Hyun Jung Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Degradation of magnetic nanoparticles mimicking lysosomal conditions followed by AC susceptibility

(2015) Lucía Gutiérrez et al.   Biomedical Engineering-Biomedizinische Technik

Measurement of Nanomaterials in Foods: Integrative Consideration of Challenges and Future Prospects

(2014) Christopher Szakal et al.   ACS Nano

Measurement Methods to Detect, Characterize, and Quantify Engineered Nanomaterials in Foods

(2014) Gurmit Singh et al.   COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY

Engineered Nanoscale Food Ingredients: Evaluation of Current Knowledge on Material Characteristics Relevant to Uptake from the Gastrointestinal Tract

(2014) Rickey Y. Yada et al.   COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY

Characterization of Titanium Dioxide Nanoparticles in Food Products: Analytical Methods To Define Nanoparticles

(2014) Ruud J. B. Peters et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Body-on-a-chip simulation with gastrointestinal tract and liver tissues suggests that ingested nanoparticles have the potential to cause liver injury

(2014) Mandy B. Esch et al.   LAB ON A CHIP

Genotoxic evaluation of titanium dioxide nanoparticles in vivo and in vitro

(2014) Zhangjian Chen et al.   TOXICOLOGY LETTERS

A standardised static in vitro digestion method suitable for food – an international consensus

(2014) M. Minekus et al.   Food & Function

Models to Predict Intestinal Absorption of Therapeutic Peptides and Proteins

(2013) Filipa Antunes et al.   CURRENT DRUG METABOLISM

Investigation of the cytotoxicity of food-grade nanoemulsions in Caco-2 cell monolayers and HepG2 cells

(2013) Hailong Yu et al.   FOOD CHEMISTRY

Zinc oxide nanoparticles induce oxidative DNA damage and ROS-triggered mitochondria mediated apoptosis in human liver cells (HepG2)

(2012) Vyom Sharma et al.   APOPTOSIS

Cell-basedin vitromodels for predicting drug permeability

(2012) Bruno Sarmento et al.   Expert Opinion on Drug Metabolism & Toxicology

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

NutriChip: nutrition analysis meets microfluidics

(2012) Qasem Ramadan et al.   LAB ON A CHIP

Characterization and Preliminary Toxicity Assay of Nano-Titanium Dioxide Additive in Sugar-Coated Chewing Gum

(2012) Xin-Xin Chen et al.   Small

In vitro genotoxicity testing strategy for nanomaterials and the adaptation of current OECD guidelines

(2011) S.H. Doak et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Evaluation of the Genotoxicity of Chitosan Nanoparticles for Use in Food Packaging Films

(2010) Renata De Lima et al.   JOURNAL OF FOOD SCIENCE

Characterization of a gastrointestinal tract microscale cell culture analog used to predict drug toxicity

(2009) Gretchen J. Mahler et al.   BIOTECHNOLOGY AND BIOENGINEERING