The Endothelium: An Active Regulator of Lipid and Glucose Homeostasis

Single-Cell Transcriptome Atlas of Murine Endothelial Cells

(2020) Joanna Kalucka et al.   CELL

Role of the GLUT1 Glucose Transporter in Postnatal CNS Angiogenesis and Blood-Brain Barrier Integrity

(2020) Koen Veys et al.   CIRCULATION RESEARCH

Endothelial Notch signaling controls insulin transport in muscle

(2020) Sana S Hasan et al.   EMBO Molecular Medicine

VEGF‐B signaling impairs endothelial glucose transcytosis by decreasing membrane cholesterol content

(2020) Christine Moessinger et al.   EMBO REPORTS

Local Mitochondrial ATP Production Regulates Endothelial Fatty Acid Uptake and Transport

(2020) Ayon Ibrahim et al.   Cell Metabolism

Physiological blood–brain transport is impaired with age by a shift in transcytosis

(2020) Andrew C. Yang et al.   NATURE

Angiopoietin-2–integrin α5β1 signaling enhances vascular fatty acid transport and prevents ectopic lipid-induced insulin resistance

(2020) Hosung Bae et al.   Nature Communications

Triggering of a Dll4–Notch1 loop impairs wound healing in diabetes

(2019) Xiaowei Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endothelial cell barriers: Transport of molecules between blood and tissues

(2019) Samaneh Yazdani et al.   TRAFFIC

GPIHBP1 and Lipoprotein Lipase, Partners in Plasma Triglyceride Metabolism

(2019) Stephen G. Young et al.   Cell Metabolism

Inhibition of Endothelial Notch Signaling Impairs Fatty Acid Transport and Leads to Metabolic and Vascular Remodeling of the Adult Heart

(2018) Markus Jabs et al.   CIRCULATION

The Vasculature in Prediabetes

(2018) David H. Wasserman et al.   CIRCULATION RESEARCH

Vascular endothelial growth factor signaling in development and disease

(2018) Sinem Karaman et al.   DEVELOPMENT

Insulin exits skeletal muscle capillaries by fluid-phase transport

(2018) Ian M. Williams et al.   JOURNAL OF CLINICAL INVESTIGATION

Ablation of endothelial VEGFR1 improves metabolic dysfunction by inducing adipose tissue browning

(2018) Takahiro Seki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Endothelial Cell Metabolism

(2018) Guy Eelen et al.   PHYSIOLOGICAL REVIEWS

A disordered acidic domain in GPIHBP1 harboring a sulfated tyrosine regulates lipoprotein lipase

(2018) Kristian K. Kristensen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metastatic Brain Tumors Disrupt the Blood-Brain Barrier and Alter Lipid Metabolism by Inhibiting Expression of the Endothelial Cell Fatty Acid Transporter Mfsd2a

(2018) Shweta Tiwary et al.   Scientific Reports

The Role of Apelin in Cardiovascular Diseases, Obesity and Cancer

(2018) Marta B. Wysocka et al.   Frontiers in Physiology

Emerging Roles of Vascular Endothelium in Metabolic Homeostasis

(2018) Xinchun Pi et al.   CIRCULATION RESEARCH

Endothelial cell CD36 optimizes tissue fatty acid uptake

(2018) Ni-Huiping Son et al.   JOURNAL OF CLINICAL INVESTIGATION

Insulin transport across the blood-brain barrier can occur independently of the insulin receptor

(2018) Elizabeth M. Rhea et al.   JOURNAL OF PHYSIOLOGY-LONDON

Endothelial Cells: New Players in Obesity and Related Metabolic Disorders

(2018) Mariona Graupera et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

An Endothelial-to-Adipocyte Extracellular Vesicle Axis Governed by Metabolic State

(2018) Clair Crewe et al.   CELL

Endothelial-specific FoxO1 depletion prevents obesity-related disorders by increasing vascular metabolism and growth

(2018) Martina Rudnicki et al.   eLife

Use of LDL receptor–targeting peptide vectors for in vitro and in vivo cargo transport across the blood-brain barrier

(2017) Yves Molino et al.   FASEB JOURNAL

The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis

(2017) Clair Crewe et al.   JOURNAL OF CLINICAL INVESTIGATION

Autoantibodies against GPIHBP1 as a Cause of Hypertriglyceridemia

(2017) Anne P. Beigneux et al.   NEW ENGLAND JOURNAL OF MEDICINE

Endothelial insulin receptors differentially control insulin signaling kinetics in peripheral tissues and brain of mice

(2017) Masahiro Konishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Organotypic vasculature: From descriptive heterogeneity to functional pathophysiology

(2017) Hellmut G. Augustin et al.   SCIENCE

Endothelial APLNR regulates tissue fatty acid uptake and is essential for apelin’s glucose-lowering effects

(2017) Cheol Hwangbo et al.   Science Translational Medicine

Endothelial LRP1 regulates metabolic responses by acting as a co-activator of PPARγ

(2017) Hua Mao et al.   Nature Communications

Angiopoietin-2 in white adipose tissue improves metabolic homeostasis through enhanced angiogenesis

(2017) Yu A An et al.   eLife

Myeloid-Cell-Derived VEGF Maintains Brain Glucose Uptake and Limits Cognitive Impairment in Obesity

(2016) Alexander Jais et al.   CELL

VEGFB/VEGFR1-Induced Expansion of Adipose Vasculature Counteracts Obesity and Related Metabolic Complications

(2016) Marius R. Robciuc et al.   Cell Metabolism

Regulation of lipid metabolism by angiopoietin-like proteins

(2016) Wieneke Dijk et al.   CURRENT OPINION IN LIPIDOLOGY

Selective Insulin Resistance and the Development of Cardiovascular Diseases in Diabetes: The 2015 Edwin Bierman Award Lecture

(2016) George L. King et al.   DIABETES

PGC-1α Coordinates Mitochondrial Respiratory Capacity and Muscular Fatty Acid Uptake via Regulation of VEGF-B

(2016) Annika Mehlem et al.   DIABETES

Epigenetic regulation of the glucose transporter geneSlc2a1by β-hydroxybutyrate underlies preferential glucose supply to the brain of fasted mice

(2016) Kosuke Tanegashima et al.   GENES TO CELLS

Angiocrine functions of organ-specific endothelial cells

(2016) Shahin Rafii et al.   NATURE

A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance

(2016) Cholsoon Jang et al.   NATURE MEDICINE

Meox2/Tcf15 Heterodimers Program the Heart Capillary Endothelium for Cardiac Fatty Acid Uptake

(2015) G. Coppiello et al.   CIRCULATION

Clathrin-dependent entry and vesicle-mediated exocytosis define insulin transcytosis across microvascular endothelial cells

(2015) Paymon M. Azizi et al.   MOLECULAR BIOLOGY OF THE CELL

Inactivating mutations in MFSD2A, required for omega-3 fatty acid transport in brain, cause a lethal microcephaly syndrome

(2015) Alicia Guemez-Gamboa et al.   NATURE GENETICS

GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration

(2015) Ethan A Winkler et al.   NATURE NEUROSCIENCE

Regulation of tissue morphogenesis by endothelial cell-derived signals

(2015) Saravana K. Ramasamy et al.   TRENDS IN CELL BIOLOGY

Notch signaling as a novel regulator of metabolism

(2015) Pengpeng Bi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Endothelial cells respond to hyperglycemia by increasing the LPL transporter GPIHBP1

(2014) Amy Pei-Ling Chiu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

VEGF-B-induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart

(2014) Riikka Kivelä et al.   EMBO Molecular Medicine

The many roles of PGC-1α in muscle — recent developments

(2014) Mun Chun Chan et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Mfsd2a is critical for the formation and function of the blood–brain barrier

(2014) Ayal Ben-Zvi et al.   NATURE

Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid

(2014) Long N. Nguyen et al.   NATURE

Endothelial Notch activity promotes angiogenesis and osteogenesis in bone

(2014) Saravana K. Ramasamy et al.   NATURE

Modulation of age-related insulin sensitivity by VEGF-dependent vascular plasticity in adipose tissues

(2014) J. Honek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lack of cardiac and high-fat diet induced metabolic phenotypes in two independent strains of Vegf-b knockout mice

(2014) M. H. Dijkstra et al.   Scientific Reports

Capillary Endothelial Fatty Acid Binding Proteins 4 and 5 Play a Critical Role in Fatty Acid Uptake in Heart and Skeletal Muscle

(2013) Tatsuya Iso et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Interleukin 6 Stimulates Endothelial Binding and Transport of High-Density Lipoprotein Through Induction of Endothelial Lipase

(2013) Jérôme Robert et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Adipose Vascular Endothelial Growth Factor Regulates Metabolic Homeostasis through Angiogenesis

(2013) Hoon-Ki Sung et al.   Cell Metabolism

Endothelium as a gatekeeper of fatty acid transport

(2013) Devi Mehrotra et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Peroxisome Proliferator‐Activated Receptor‐γ in Capillary Endothelia Promotes Fatty Acid Uptake by Heart During Long‐Term Fasting

(2013) Kosaku Goto et al.   Journal of the American Heart Association

Adipose Tissue Overexpression of Vascular Endothelial Growth Factor Protects Against Diet-Induced Obesity and Insulin Resistance

(2012) I. Elias et al.   DIABETES

Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes

(2012) Carolina E. Hagberg et al.   NATURE

Normal glucose uptake in the brain and heart requires an endothelial cell-specific HIF-1 -dependent function

(2012) Y. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dichotomous effects of VEGF-A on adipose tissue dysfunction

(2012) K. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired Insulin Signaling in Endothelial Cells Reduces Insulin-Induced Glucose Uptake by Skeletal Muscle

(2011) Tetsuya Kubota et al.   Cell Metabolism

Caveolin-1 is required for vascular endothelial insulin uptake

(2010) Hong Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Vascular endothelial growth factor B controls endothelial fatty acid uptake

(2010) Carolina E. Hagberg et al.   NATURE

A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

(2009) Christopher B. Newgard et al.   Cell Metabolism