Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome

ATF6 safeguards organelle homeostasis and cellular aging in human mesenchymal stem cells

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The Potential of iPSCs for the Treatment of Premature Aging Disorders

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The endothelial border to health: Mechanistic evidence of the hyperglycemic culprit of inflammatory disease acceleration

(2017) Nina Waerling Hansen et al.   IUBMB LIFE

Nucleolar expansion and elevated protein translation in premature aging

(2017) Abigail Buchwalter et al.   Nature Communications

Progerin impairs vascular smooth muscle cell growth via the DNA damage response pathway

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A Tissue Engineered Blood Vessel Model of Hutchinson-Gilford Progeria Syndrome Using Human iPSC-derived Smooth Muscle Cells

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CRISPR/Cas9-mediated targeted gene correction in amyotrophic lateral sclerosis patient iPSCs

(2017) Lixia Wang et al.   Protein & Cell

Identification of novel RNA isoforms of LMNA

(2017) Emily DeBoy et al.   Nucleus

Identification of novel RNA isoforms of LMNA

(2017) Emily DeBoy et al.   Nucleus

Mesenchymal Stromal/Stem Cells: A New Era in the Cell-Based Targeted Gene Therapy of Cancer

(2017) Faroogh Marofi et al.   Frontiers in Immunology

Repression of the Antioxidant NRF2 Pathway in Premature Aging

(2016) Nard Kubben et al.   CELL

SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2

(2016) Huize Pan et al.   CELL RESEARCH

Adventitial MSC-like Cells Are Progenitors of Vascular Smooth Muscle Cells and Drive Vascular Calcification in Chronic Kidney Disease

(2016) Rafael Kramann et al.   Cell Stem Cell

Molecular insights into the premature aging disease progeria

(2016) Sandra Vidak et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Endothelial cell senescence and thrombosis: Ageing clots

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Small nucleoli are a cellular hallmark of longevity

(2016) Varnesh Tiku et al.   Nature Communications

Modeling xeroderma pigmentosum associated neurological pathologies with patients-derived iPSCs

(2016) Lina Fu et al.   Protein & Cell

Vitamin C alleviates aging defects in a stem cell model for Werner syndrome

(2016) Ying Li et al.   Protein & Cell

Accelerated aging syndromes, are they relevant to normal human aging?

(2016) Oliver Dreesen et al.   Aging-US

Model of human aging: Recent findings on Werner’s and Hutchinson-Gilford progeria syndromes

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Pluripotent stem cells to model Hutchinson-Gilford progeria syndrome (HGPS): Current trends and future perspectives for drug discovery

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DNA repair defects and genome instability in Hutchinson–Gilford Progeria Syndrome

(2015) Susana Gonzalo et al.   CURRENT OPINION IN CELL BIOLOGY

Progeria accelerates adult stem cell aging

(2015) R. Brunauer et al.   SCIENCE

A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging

(2015) W. Zhang et al.   SCIENCE

PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype

(2015) Shunlei Duan et al.   Nature Communications

Nuclear lamina remodelling and its implications for human disease

(2014) Alexandre Chojnowski et al.   CELL AND TISSUE RESEARCH

Normal and aberrant splicing ofLMNA

(2014) Yue-Bei Luo et al.   JOURNAL OF MEDICAL GENETICS

An Upregulation in the Expression of Vanilloid Transient Potential Channels 2 Enhances Hypotonicity-Induced Cytosolic Ca2+ Rise in Human Induced Pluripotent Stem Cell Model of Hutchinson Gillford Progeria

(2014) Chun-Yin Lo et al.   PLoS One

Telomerase Protects Werner Syndrome Lineage-Specific Stem Cells from Premature Aging

(2014) Hoi-Hung Cheung et al.   Stem Cell Reports

Rapamycin decreases DNA damage accumulation and enhances cell growth of WRN-deficient human fibroblasts

(2013) Bidisha Saha et al.   AGING CELL

The Hallmarks of Aging

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Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging

(2013) Justine D. Miller et al.   Cell Stem Cell

Concealing cellular defects in pluripotent stem cells

(2013) Weiqi Zhang et al.   TRENDS IN CELL BIOLOGY

Perturbed replication induced genome wide or at common fragile sites is differently managed in the absence of WRN

(2012) I. Murfuni et al.   CARCINOGENESIS

iPSC technology to study human aging and aging-related disorders

(2012) Guang-Hui Liu et al.   CURRENT OPINION IN CELL BIOLOGY

Computational image analysis of nuclear morphology associated with various nuclear-specific aging disorders

(2012) Siwon Choi et al.   Nucleus

DNA-damage accumulation and replicative arrest in Hutchinson–Gilford progeria syndrome

(2011) Phillip R. Musich et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Targeted Gene Correction of Laminopathy-Associated LMNA Mutations in Patient-Specific iPSCs

(2011) Guang-Hui Liu et al.   Cell Stem Cell

Inflammation and mesenchymal stem cell aging

(2011) Günter Lepperdinger   CURRENT OPINION IN IMMUNOLOGY

Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts

(2011) Kan Cao et al.   JOURNAL OF CLINICAL INVESTIGATION

Recapitulation of premature ageing with iPSCs from Hutchinson–Gilford progeria syndrome

(2011) Guang-Hui Liu et al.   NATURE

Comparison of Proliferation and Genomic Instability Responses to WRN Silencing in Hematopoietic HL60 and TK6 Cells

(2011) Xuefeng Ren et al.   PLoS One

Cardiovascular Pathology in Hutchinson-Gilford Progeria: Correlation With the Vascular Pathology of Aging

(2010) Michelle Olive et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

RecQ family helicases in genome stability: Lessons from gene disruption studies in DT40 cells

(2010) Masayuki Seki et al.   CELL CYCLE

A Human iPSC Model of Hutchinson Gilford Progeria Reveals Vascular Smooth Muscle and Mesenchymal Stem Cell Defects

(2010) Jinqiu Zhang et al.   Cell Stem Cell

Prelamin A Acts to Accelerate Smooth Muscle Cell Senescence and Is a Novel Biomarker of Human Vascular Aging

(2010) Cassandra D. Ragnauth et al.   CIRCULATION

Isolation and characterization of multipotent progenitor cells from the human fetal aorta wall

(2010) Baijun Fang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Progeria syndromes and ageing: what is the connection?

(2010) Christopher R. Burtner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DNA damage response and cellular senescence in tissues of aging mice

(2009) Chunfang Wang et al.   AGING CELL

Increased mechanosensitivity and nuclear stiffness in Hutchinson–Gilford progeria cells: effects of farnesyltransferase inhibitors

(2008) Valerie L. R. M. Verstraeten et al.   AGING CELL

Human vascular adventitial fibroblasts contain mesenchymal stem/progenitor cells

(2008) Ayuko Hoshino et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The clinical characteristics of Werner syndrome: molecular and biochemical diagnosis

(2008) Meltem Muftuoglu et al.   HUMAN GENETICS