Article
Oncology
Sushant Kumar, Soumitra Marathe, Bhavuk Dhamija, Uddhao Zambare, Richa Bilala, Sanyogita Warang, Chitra Nayak, Rahul Purwar
Summary: The presence of Th9 cells in vitiligo patients and their role in reducing oxidative stress in melanocytes have been identified. However, there was no significant difference in Th9 cell frequency between early and chronic disease stages in vitiligo patients.
PIGMENT CELL & MELANOMA RESEARCH
(2021)
Article
Immunology
Karine Garcez Schuster Franco, Fabio Jorge Ramalho de Amorim, Mario Adriano Santos, Carla Virginia Vieira Rollemberg, Fabricia Alvisi de Oliveira, Alex Vianey Callado Franca, Camilla Natalia Oliveira Santos, Lucas Sousa Magalhaes, Rodrigo Anselmo Cazzaniga, Frederico Santana de Lima, Luciana Benevides, Vanessa Carregaro, Joao Santana Silva, Hugo Leite de Farias Brito, Daniel Alvarenga Fernandes, Angela Maria da Silva, Roque Pacheco de Almeida, Marcio Bezerra-Santos, Amelia Ribeiro de Jesus
Summary: The study found higher levels of IL-9, IL-10, and IL-17 in PBMC supernatants of patients with advanced hepatic fibrosis, with direct correlations to spleen sizes and portal vein diameters. Patients with the CD209 rs2287886 AG polymorphism produced higher levels of IL-17, suggesting a role of these cytokines in the immunopathogenesis of advanced fibrosis in human schistosomiasis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Su Jung Hwang, Bum Ju Ahn, Min-Wook Shin, Ye-Seul Song, Youngbin Choi, Goo Taeg Oh, Kyu-Won Kim, Hyo-Jong Lee
Summary: Ninj1 plays a critical role in maintaining vascular integrity, while miR-125a-5p acts as a novel regulator in inflammatory diseases and diabetic retinopathy.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Cell Biology
Purvi Purohit, Dipayan Roy, Shailendra Dwivedi, Naresh Nebhinani, Praveen Sharma
Summary: The study found that individuals with chronic opioid use disorder had elevated levels of inflammatory cytokines TNF-alpha and IL-10, while IL-6 was reduced. There was a dose-dependent upregulation of miR-155-5p and miR-187-5p at opium doses greater than 1500 g/month, along with an increase in TNF-alpha and IL-10.
Article
Biochemistry & Molecular Biology
Tsung-Ju Wu, Sunny Li-Yun Chang, Chih-Yang Lin, Chao-Yang Lai, Xiu-Yuan He, Chun-Hao Tsai, Chih-Yuan Ko, Yi-Chin Fong, Chen-Ming Su, Chih-Hsin Tang
Summary: IL-17 increases monocyte adhesion in OA synovium by reducing miR-5701 expression and enhancing VCAM-1 production. These findings improve our understanding of IL-17's impact on OA progression and provide insights for the design of more effective OA treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Yuze Ma, Yu Fu, Xiaoli Fan, Qiang Ji, XiaoJiao Duan, Yanfeng Wang, Yongmin Zhang, Zhigang Wang, Huifang Hao
Summary: Gastric cancer is common in China and has a high mortality rate. The development of gastric cancer is influenced by genetic and environmental factors. FAK, a protein kinase, is highly expressed in cancer and plays a role in promoting cancer cell proliferation, migration, and angiogenesis. IL-8, which is upregulated in many types of malignant tumors, also affects the proliferation, migration, invasion, angiogenesis, and EMT of cancer cells. This study found that FAK is essential for the proliferation, migration, and peritoneal metastasis of gastric cancer cells, and that IL-8 activates FAK activity. The IL-8-FAK-IL-8 positive feedback loop plays a role in the proliferation and migration of gastric cancer cells.
Article
Medicine, Research & Experimental
Fengqi Zhou, Binbin Wang, Hong Wang, Lang Hu, Junxia Zhang, Tianfu Yu, Xiupeng Xu, Wei Tian, Chunsheng Zhao, Haifeng Zhu, Ning Liu
Summary: This study demonstrates that circMELK acts as an oncogene in GBM, regulating mesenchymal transition and GSC maintenance by sponging miR-593. EphB2 is involved in the circMELK/miR-593 axis induced GBM tumorigenesis. This finding suggests a potential novel therapeutic target for gliomas.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Cell Biology
Libing Wang, Mingxin Cui, Daming Cheng, Fengzhi Qu, Jingkun Yu, Yanbin Wei, Ling Cheng, Xiaotang Wu, Xiaogang Liu
Summary: The study revealed that miR-9-5p is highly expressed in HCC cells while ESR1 is poorly expressed; overexpression of miR-9-5p can enhance cell proliferation, invasion, and migration; ESR1 is identified as a downstream target of miR-9-5p in HCC.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Dharma Pally, Mallar Banerjee, Shahid Hussain, Rekha Kumar, Alexandra Petersson, Ebba Rosendal, Ludvig Gunnarsson, Kristoffer Peterson, Hakon Leffler, Ulf J. Nilsson, Ramray Bhat
Summary: Aberrations in glycan and lectin expression and function contribute to the development of cancer. This study focused on Galectin-9, a member of the beta-galactoside-binding lectin family, and investigated its role in breast cancer cell invasiveness. The results showed a correlation between Galectin-9 expression and the ability of invasive cancer cells to adhere and invade extracellular matrix microenvironments. Further experiments revealed that Galectin-9 induced Focal Adhesion Kinase activity and S100A4 expression, which are associated with cancer cell invasion. The findings provide crucial insights into the mechanisms by which elevated Galectin-9 expression enhances breast cancer cell invasiveness during the early stages of invasion.
ACS CHEMICAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hongxin Xu, Ying Cui, Xianwei Liu, Xiao Zheng, Jiaqing Liu, Xinxin Hu, Fuhua Gao, Xiaoyan Hu, Mei Li, Xiaoqing Wei, Ying Gao, Ying Zhao
Summary: MicroRNA-1290 (miR-1290) is highly expressed in hyperlipidemia patients and can promote cell adhesion, regulate cell proliferation, and inhibit inflammatory response in HUVECs mediated by IL-8. Mechanistically, miR-1290 directly targets GSK-3 beta, which may provide a potential target for atherosclerosis treatment.
MOLECULAR BIOLOGY REPORTS
(2022)
Review
Oncology
Samuel S. Widodo, Marija Dinevska, Liam M. Furst, Stanley S. Stylli, Theo Mantamadiotis
Summary: The prognosis for patients with GBM is very poor despite current standard treatments. The immunosuppressive tumour microenvironment hinders the development of effective immunotherapies for GBM, and understanding the role of IL-10 in GBM is crucial for improving immunotherapy.
BRITISH JOURNAL OF CANCER
(2021)
Article
Physiology
Yijiang Huang, Daosen Chen, Zijian Yan, Jingdi Zhan, Xinghe Xue, Xiaoyun Pan, Huachen Yu
Summary: The study demonstrates that MEG3 promotes chondrocyte proliferation and migration, while inhibiting apoptosis and inflammation by sponging miR-9-5p to induce KLF4 expression. This provides a potential therapy target for osteoarthritis treatment.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Bo Wang, Long Zhao, Changjiang Yang, Yilin Lin, Shan Wang, Yingjiang Ye, Jianyuan Luo, Zhanlong Shen
Summary: This study investigates the effect of IDH1 hyperacetylation on the acidic microenvironment in colorectal cancer (CRC). The results show that increased alpha-KG affects the hydroxylation of Ago2 and mediates miR-9-5p targeting NHE1 protein. Knockdown of NHE1 inhibits CRC cell proliferation and migration by restricting intracellular H+ transport. This study reveals a novel mechanism through which IDH1 deacetylation regulates the cellular acidic microenvironment and inhibits CRC metastasis.
Article
Pharmacology & Pharmacy
Bin Yang, Huijun Yang, Xiaomei Lu, Laiyuan Wang, Hongfan Li, Shufeng Chen, Xianqiang Wang, Chenyang Shen, Jianfeng Huang, Xiangfeng Lu, Dongfeng Gu
Summary: The study demonstrated that miR-520b is expressed in human atherosclerotic plaques and suppresses EC inflammation by down-regulating the NF-KB p65-ICAM1/VCAM1 axis, regulating the interaction between monocytes and ECs, and potentially serving as a therapeutic target for EC dysfunction and atherosclerosis.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Chemistry, Analytical
Shurong Wang, Ying He, Tongtong Tian, Jiayin Lu, Yanwei Lu, Xuedong Huang, Yan Zou, Lei Zhang, Xiaoni Fang, Baohong Liu
Summary: This study introduces anodic aluminum oxide films with different pore sizes (AAO nanoarray) for size-based isolation and proteomics profiling of small extracellular vesicle (sEV) subpopulations. The AAO nanoarray allows for size-dependent isolation of sEV subpopulations and comprehensive proteomic analysis, providing a new avenue for liquid biopsy.
ANALYTICAL CHEMISTRY
(2023)
Article
Materials Science, Multidisciplinary
Xu-dong Yang, Ying Cheng, Xiao-lei He, Kun-ming Yang, Rong-rong Zong
Summary: The research demonstrates that solution treatment significantly enhances the compressive strength of Al-Mg-Si alloy foams, with the compressive strength increasing with temperature in a certain range, and the alloy foams exhibit good performance at high temperatures after solution treatment.
ADVANCED ENGINEERING MATERIALS
(2021)
Article
Computer Science, Information Systems
Ante Su, Xiaolei He, Xianfeng Zhao
Summary: The latest research in image steganalysis shows that convolutional neural networks (CNNs) greatly enhance the field. A novel CNN architecture was proposed to address JPEG steganalysis, integrating Gauss partial derivative (GPD) filters and two blocks based on ResNeXt. Experimental results demonstrated the remarkable performance in image classification and feature extraction of the proposed network.
MULTIMEDIA TOOLS AND APPLICATIONS
(2021)
Article
Computer Science, Interdisciplinary Applications
Xue Deng, Xiaolei He, Cuirong Huang
Summary: This paper presents a fuzzy random multi-objective portfolio model with different entropy measures and a hybrid algorithm to solve it. By considering the effects of various entropy measures and designing the algorithm, the optimal solution for the portfolio optimization problem is efficiently found.
ENGINEERING COMPUTATIONS
(2022)
Article
Engineering, Electrical & Electronic
Jimin Zhang, Xianfeng Zhao, Xiaolei He, Hong Zhang
Summary: This letter proposes an improved robust steganography method by introducing a robustness cost function to enhance the ability against JPEG recompression. Experimental results demonstrate that the proposed method achieves significant improvement in robustness performance while maintaining satisfying security performance.
IEEE SIGNAL PROCESSING LETTERS
(2022)
Article
Chemistry, Physical
Fang Wang, Xiongwei Qi, Jiahong Geng, Xiaoyan Liu, Dong Li, Hui Zhang, Peng Zhang, Xiaolei He, Baowei Li, Zhijia Li, Ruitao Yu, Xiaoying Yang, Guangshuo Wang
Summary: Monodisperse hollow mesoporous Fe3O4 nanospheres were successfully synthesized via a template-free one-pot solvothermal method with the presence of iron chloride hexahydrate, polyvinylpyrrolidone, and urea. The nanospheres exhibited narrow particle size distribution, superparamagnetic characteristics, and typical mesoporous structures. When loaded with the anti-cancer drug DOX, they showed significant cytotoxic effects towards HeLa cells and had high drug loading capacity and pH-responsive feature.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Cell Biology
Ling Gao, Xian Shao, Qingqing Yue, Weifei Wu, Xuejuan Yang, Xiaolei He, Limin Li, Fujun Hou, Ruonan Zhang
Summary: This study revealed that circAMOTL1L has an antioncogenic role in RCC growth by modulating the miR-92a-2-5p-KLLN pathway. Downregulation of circAMOTL1L was associated with tumor progression and poor prognosis in RCC. Functional experiments demonstrated that circAMOTL1L can inhibit cell proliferation and enhance apoptosis in RCC cells.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Computer Science, Information Systems
Haocheng Fu, Xianfeng Zhao, Xiaolei He
Summary: With the rise of social network platforms as the most common channel for image sharing, transmitting secret messages through steganography has become a popular method. This study proposes a robust JPEG steganographic scheme that uses a deep learning model and cover block selection strategy to enhance security and robustness in image transmission.
SECURITY AND COMMUNICATION NETWORKS
(2021)
Article
Chemistry, Physical
Yanju Wang, Wei Wei, Xiaolei He, Xiang Lan, Aixue Sha, Wenfeng Hao
Summary: This paper considers the strength and geometric discrete distribution characteristics of composite reinforcement, introduces the discrete distribution function of reinforcement, and realizes the secondary development of ABAQUS using Python language. The parametric automatic generation method of representative volume elements of particle-reinforced composites is established, and the tensile properties of silicon carbide particle-reinforced aluminum matrix composites are analyzed. The effects of particle strength, particle volume fraction, and particle random distribution on the mechanical properties of SiCp/Al composites are studied.
Article
Agronomy
Ji Xianglong, Wang Peng, He Xiaolei, Jiang Yuzhou
Summary: The study investigated the dynamics of nitrogen accumulation in mung bean under different nitrogen levels and different nitrogen forms. It found that appropriate application of chemical nitrogen fertilizer can increase the yield of mung bean, while the use of organic nitrogen fertilizer can alleviate the inhibition effect of chemical nitrogen fertilizer on Rhizobia, reduce the loss of soil nitrogen, and further improve the yield of mung bean.
COMMUNICATIONS IN SOIL SCIENCE AND PLANT ANALYSIS
(2022)
Article
Chemistry, Applied
Xiaolei He, Jingyu Zhang, Huaiyu Long, Peng Wang
Summary: This research investigates the impact of negative pressure irrigation on dry matter accumulation and nutrient absorption in eggplants. The findings suggest that lower water supply pressure (-3 kPa) can enhance dry matter accumulation, nitrogen, phosphorus, and potassium absorption in eggplant organs, thereby improving yield and irrigation efficiency.
JOURNAL OF BIOBASED MATERIALS AND BIOENERGY
(2022)
Article
Chemistry, Physical
Yanju Wang, Pengfei Wu, Xiaolei He, Wei Zhao, Xiang Lan, Yanshan Lou
Summary: This study investigated the effects of temperature and strain rate on the mechanical behavior of SiC/Al 2009 composites and used an artificial neural network model to accurately model the strain hardening behavior. The results showed that the plastic deformation behavior of the composites was influenced by a coupling effect of strain, strain rate, and temperature.
Article
Computer Science, Information Systems
Xiaolei He
Summary: This paper proposes a speech scoring mechanism based on multimodal fusion, which achieves good error detection effects under different conditions, providing new ideas for oral English teaching.
MOBILE INFORMATION SYSTEMS
(2022)
Article
Meteorology & Atmospheric Sciences
Nan Xue-jing, Lin Wei-li, He Xiao-lei, Lei Yong, Andrea Merlone
Summary: Inhalable particles (PM10) are a growing health concern, particularly in northern China. This study recorded and analyzed PM10 concentrations at an observation station in Beijing from 2006 to 2017. The results show a significant downward trend in PM10 concentrations, indicating the effectiveness of recent reduction actions. However, further efforts are still needed to reduce PM10 in Beijing.
JOURNAL OF TROPICAL METEOROLOGY
(2022)
Article
Computer Science, Interdisciplinary Applications
Weiguo Zhang, Xiaolei He
Summary: This article proposes a mixed integer linear programming model based on moment information to improve the accuracy of traditional scenario reduction methods, and designs an improved algorithm to solve the model. Empirical and comparative studies demonstrate the superiority of this method in international portfolio selection.
INFORMS JOURNAL ON COMPUTING
(2022)
Proceedings Paper
Computer Science, Interdisciplinary Applications
Ante Su, Xianfeng Zhao, Xiaolei He
Summary: In this paper, a novel end-to-end steganalyzer based on fully convolutional network is proposed, which is capable of training and testing arbitrary-sized images and provides state-of-the-art detection accuracy for both fixed and arbitrary size.
DIGITAL FORENSICS AND WATERMARKING, IWDW 2021
(2022)
