Covalent Strategies for Targeting Messenger and Non-Coding RNAs: An Updated Review on siRNA, miRNA and antimiR Conjugates

Tracking and protection of transplanted stem cells using a ferrocenecarboxylic acid-conjugated peptide that mimics hTERT

(2018) Hyun-Hee Park et al.   BIOMATERIALS

Immune phenotype and function of natural killer and T cells in chronic hepatitis C patients who received a single dose of anti-MicroRNA-122, RG-101

(2017) Femke Stelma et al.   HEPATOLOGY

Aptamer delivery of siRNA, radiopharmaceutics and chemotherapy agents in cancer

(2017) Carlos E.B. de Almeida et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Current Status and Perspectives Regarding LNA-Anti-miR Oligonucleotides and microRNA miR-21 Inhibitors as a Potential Therapeutic Option in Treatment of Colorectal Cancer

(2017) Reza Nedaeinia et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Targeting nanocarriers containing antisense oligonucleotides to cancer cell

(2017) Parth Patel et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Clinical Proof of Concept for a Novel Hepatocyte-Targeting GalNAc-siRNA Conjugate

(2017) Tracy S. Zimmermann et al.   MOLECULAR THERAPY

Functional Delivery of Lipid-Conjugated siRNA by Extracellular Vesicles

(2017) Aisling J. O’Loughlin et al.   MOLECULAR THERAPY

FDA-Approved Oligonucleotide Therapies in 2017

(2017) Cy A. Stein et al.   MOLECULAR THERAPY

The chemical evolution of oligonucleotide therapies of clinical utility

(2017) Anastasia Khvorova et al.   NATURE BIOTECHNOLOGY

5΄-Vinylphosphonate improves tissue accumulation and efficacy of conjugated siRNAs in vivo

(2017) Reka A. Haraszti et al.   NUCLEIC ACIDS RESEARCH

High-Yield Synthesis of Monomeric LMWP(CPP)-siRNA Covalent Conjugate for Effective Cytosolic Delivery of siRNA

(2017) Junxiao Ye et al.   Theranostics

Advances in the delivery of RNA therapeutics: from concept to clinical reality

(2017) James C. Kaczmarek et al.   Genome Medicine

Targeting MicroRNAs in Cancer Gene Therapy

(2017) Weidan Ji et al.   Genes

The Formation of Nanoparticles between Small Interfering RNA and Amphipathic Cell-Penetrating Peptides

(2017) Ly Pärnaste et al.   Molecular Therapy-Nucleic Acids

Preclinical and Clinical Advances of GalNAc-Decorated Nucleic Acid Therapeutics

(2017) Yuanyu Huang   Molecular Therapy-Nucleic Acids

Therapeutic miRNA and siRNA: Moving from Bench to Clinic as Next Generation Medicine

(2017) Chiranjib Chakraborty et al.   Molecular Therapy-Nucleic Acids

Chemical and structural modifications of RNAi therapeutics

(2016) Sook Hee Ku et al.   ADVANCED DRUG DELIVERY REVIEWS

Peptides for nucleic acid delivery

(2016) Taavi Lehto et al.   ADVANCED DRUG DELIVERY REVIEWS

Biological Properties of a 3′,3″-Bis-Peptide-siRNA Conjugate in Vitro and in Vivo

(2016) Xinmeng Fan et al.   BIOCONJUGATE CHEMISTRY

Multifunctional aptamer-based nanoparticles for targeted drug delivery to circumvent cancer resistance

(2016) Juan Liu et al.   BIOMATERIALS

Tumor suppressor microRNAs: Targeted molecules and signaling pathways in breast cancer

(2016) F. Asghari et al.   BIOMEDICINE & PHARMACOTHERAPY

Synergistic effect of phosphorothioate, 5′-vinylphosphonate and GalNAc modifications for enhancing activity of synthetic siRNA

(2016) Thazha P. Prakash et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Locked nucleic acid anti-miR-21 inhibits cell growth and invasive behaviors of a colorectal adenocarcinoma cell line: LNA-anti-miR as a novel approach

(2016) R Nedaeinia et al.   CANCER GENE THERAPY

A Rapid and Versatile Assay for Ago2-Mediated Cleavage by Using Branched Rolling Circle Amplification

(2016) Marlen Hesse et al.   CHEMBIOCHEM

5′-(E)-Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA-GalNAc Conjugates

(2016) Rubina Parmar et al.   CHEMBIOCHEM

Utility of the 2-Nitrobenzenesulfonamide Group as a Chemical Linker for Enhanced Extracellular Stability and Cytosolic Cleavage in siRNA-Conjugated Polymer Systems

(2016) Chih Hao Huang et al.   ChemMedChem

Thermal and magnetic dual-responsive liposomes with a cell-penetrating peptide-siRNA conjugate for enhanced and targeted cancer therapy

(2016) Yanfang Yang et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Oligonucleotide conjugates – Candidates for gene silencing therapeutics

(2016) Matt Gooding et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Mir-221/222 are promising targets for innovative anticancer therapy

(2016) Maria Teresa Di Martino et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Small-molecule approaches toward the targeting of oncogenic miRNAs: roadmap for the discovery of RNA modulators

(2016) Audrey Di Giorgio et al.   Future Medicinal Chemistry

Targeting oncomiRNAs and mimicking tumor suppressor miRNAs: New trends in the development of miRNA therapeutic strategies in oncology (Review)

(2016) ROBERTO GAMBARI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Dual stimulus of hyperthermia and intracellular redox environment triggered release of siRNA for tumor-specific therapy

(2016) Yanfang Yang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Multivalent Aptamer-RNA Conjugates for Simple and Efficient Delivery of Doxorubicin/siRNA into Multidrug-Resistant Cells

(2016) Hyosook Jeong et al.   MACROMOLECULAR BIOSCIENCE

Acid Sensitive Polymeric Micelles Combining Folate and Bioreducible Conjugate for Specific Intracellular siRNA Delivery

(2016) Yanfang Yang et al.   MACROMOLECULAR BIOSCIENCE

Non-coding RNAs as drug targets

(2016) Masayuki Matsui et al.   NATURE REVIEWS DRUG DISCOVERY

Neural stem cells injured by oxidative stress can be rejuvenated by GV1001, a novel peptide, through scavenging free radicals and enhancing survival signals

(2016) Hyun-Hee Park et al.   NEUROTOXICOLOGY

Phosphorylation-specific status of RNAi triggers in pharmacokinetic and biodistribution analyses

(2016) Vladimir S. Trubetskoy et al.   NUCLEIC ACIDS RESEARCH

Building a chimera of aptamer–antisense oligonucleotide for silencing galectin-1 gene

(2016) Shanni Hong et al.   RSC Advances

Co-targeting EGFR and survivin with a bivalent aptamer-dual siRNA chimera effectively suppresses prostate cancer

(2016) Hong Yan Liu et al.   Scientific Reports

Utilization of G-Quadruplex-Forming Aptamers for the Construction of Luminescence Sensing Platforms

(2016) Dik-Lung Ma et al.   ChemPlusChem

siRNA and RNAi optimization

(2016) Adele Alagia et al.   Wiley Interdisciplinary Reviews-RNA

Nanoparticle delivery systems for siRNA-based therapeutics

(2016) Jinming Li et al.   Journal of Materials Chemistry B

Docosahexaenoic Acid Conjugation Enhances Distribution and Safety of siRNA upon Local Administration in Mouse Brain

(2016) Mehran Nikan et al.   Molecular Therapy-Nucleic Acids

Targeted Delivery of Anti-miR-712 by VCAM1-Binding Au Nanospheres for Atherosclerosis Therapy

(2016) Tianmeng Sun et al.   ChemNanoMat

Inhibition of HIV-1 reactivation by a telomerase-derived peptide in a HSP90-dependent manner

(2016) Hong Kim et al.   Scientific Reports

siRNA Conjugates Carrying Sequentially Assembled Trivalent N-Acetylgalactosamine Linked Through Nucleosides Elicit Robust Gene Silencing In Vivo in Hepatocytes

(2015) Shigeo Matsuda et al.   ACS Chemical Biology

Synthetic RNAi triggers and their use in chronic hepatitis B therapies with curative intent

(2015) Robert G. Gish et al.   ANTIVIRAL RESEARCH

Incorporation of Naked Peptide Nucleic Acids into Liposomes Leads to Fast and Efficient Delivery

(2015) Concetta Avitabile et al.   BIOCONJUGATE CHEMISTRY

Hepatocyte-Specific Delivery of siRNAs Conjugated to Novel Non-nucleosidic TrivalentN-Acetylgalactosamine Elicits Robust Gene Silencing in Vivo

(2015) Kallanthottathil G. Rajeev et al.   CHEMBIOCHEM

High levels of apoptosis are induced in human glioma cell lines by co-administration of peptide nucleic acids targeting miR-221 and miR-222

(2015) ELEONORA BROGNARA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The Anti-Inflammatory Effect of Human Telomerase-Derived Peptide onP. gingivalisLipopolysaccharide-Induced Inflammatory Cytokine Production and Its Mechanism in Human Dental Pulp Cells

(2015) Yoo-Jin Ko et al.   MEDIATORS OF INFLAMMATION

Systemic Administration and Targeted Radiosensitization via Chemically Synthetic Aptamer-siRNA Chimeras in Human Tumor Xenografts

(2015) X. Ni et al.   MOLECULAR CANCER THERAPEUTICS

Differential fates of biomolecules delivered to target cells via extracellular vesicles

(2015) Masamitsu Kanada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enteral siRNA delivery technique for therapeutic gene silencing in the liver via the lymphatic route

(2015) Masahiro Murakami et al.   Scientific Reports

Hydrophobically Modified siRNAs Silence Huntingtin mRNA in Primary Neurons and Mouse Brain

(2015) Julia F Alterman et al.   Molecular Therapy-Nucleic Acids

MiR-20a Promotes Cervical Cancer Proliferation and Metastasis In Vitro and In Vivo

(2015) Shan Zhao et al.   PLoS One

In VitroAntiviral Activity and Preclinical and Clinical Resistance Profile of Miravirsen, a Novel Anti-Hepatitis C Virus Therapeutic Targeting the Human Factor miR-122

(2014) Søren Ottosen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Long-term safety and efficacy of microRNA-targeted therapy in chronic hepatitis C patients

(2014) Meike H. van der Ree et al.   ANTIVIRAL RESEARCH

High-Throughput Platform Assay Technology for the Discovery of pre-microRNA-Selective Small Molecule Probes

(2014) Daniel A. Lorenz et al.   BIOCONJUGATE CHEMISTRY

Improving the In Vivo Therapeutic Index of siRNA Polymer Conjugates through Increasing pH Responsiveness

(2014) Erin N. Guidry et al.   BIOCONJUGATE CHEMISTRY

Novel Endosomolytic Poly(amido amine) Polymer Conjugates for Systemic Delivery of siRNA to Hepatocytes in Rodents and Nonhuman Primates

(2014) Rubina Giare Parmar et al.   BIOCONJUGATE CHEMISTRY

Ligand-Directed Active Tumor-Targeting Polymeric Nanoparticles for Cancer Chemotherapy

(2014) Yinan Zhong et al.   BIOMACROMOLECULES

Synergistic inhibition of lung cancer cell invasion, tumor growth and angiogenesis using aptamer-siRNA chimeras

(2014) Wei-Yun Lai et al.   BIOMATERIALS

Comparison of pH-sensitive degradability of maleic acid amide derivatives

(2014) Sunyoung Kang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Multivalent comb-type aptamer–siRNA conjugates for efficient and selective intracellular delivery

(2014) Hyundong Yoo et al.   CHEMICAL COMMUNICATIONS

Oral Druggable Space beyond the Rule of 5: Insights from Drugs and Clinical Candidates

(2014) Bradley Croy Doak et al.   CHEMISTRY & BIOLOGY

Development of microRNA therapeutics is coming of age

(2014) E. van Rooij et al.   EMBO Molecular Medicine

MicroRNAs as therapeutic targets in atherosclerosis

(2014) Xavier Loyer et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

An in vivo evaluation of amphiphilic, biodegradable peptide copolymers as siRNA delivery agents

(2014) Stephanie E. Barrett et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Uptake by human glioma cell lines and biological effects of a peptide-nucleic acids targeting miR-221

(2014) Eleonora Brognara et al.   JOURNAL OF NEURO-ONCOLOGY

Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing

(2014) Jayaprakash K. Nair et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Therapeutic targeting of microRNAs: current status and future challenges

(2014) Zhonghan Li et al.   NATURE REVIEWS DRUG DISCOVERY

Protective Effect of Peptide GV1001 Against Renal Ischemia-Reperfusion Injury in Mice

(2014) T.Y. Koo et al.   TRANSPLANTATION PROCEEDINGS

Prodrug-based nanoparticulate drug delivery strategies for cancer therapy

(2014) Cong Luo et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Nucleic acid therapeutics: basic concepts and recent developments

(2014) Vivek K. Sharma et al.   RSC Advances

Cell-type-specific, Aptamer-functionalized Agents for Targeted Disease Therapy

(2014) Jiehua Zhou et al.   Molecular Therapy-Nucleic Acids

Electrochemical genosensors for the detection of cancer-related miRNAs

(2013) Susana Campuzano et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Acidic pH-Responsive siRNA Conjugate for Reversible Carrier Stability and Accelerated Endosomal Escape with Reduced IFNα-Associated Immune Response

(2013) Hiroyasu Takemoto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Double-tailed lipid modification as a promising candidate for oligonucleotide delivery in mammalian cells

(2013) Begoña Ugarte-Uribe et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Endosomolytic Bioreducible Poly(amido amine disulfide) Polymer Conjugates for the in Vivo Systemic Delivery of siRNA Therapeutics

(2013) Rubina Giare Parmar et al.   BIOCONJUGATE CHEMISTRY

Heat shock protein-mediated cell penetration and cytosolic delivery of macromolecules by a telomerase-derived peptide vaccine

(2013) Seoung-Ae Lee et al.   BIOMATERIALS

Synthesis, RNAi activity and nuclease-resistant properties of apolar carbohydrates siRNA conjugates

(2013) Empar Vengut-Climent et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Chemistry and formulations for siRNA therapeutics

(2013) Andrzej Gallas et al.   CHEMICAL SOCIETY REVIEWS

Therapeutic targeting of non-coding RNAs

(2013) Thomas C. Roberts et al.   Essays in Biochemistry

Is there a future for cell-penetrating peptides in oligonucleotide delivery?

(2013) Soo Hyeon Lee et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Nanoparticle-mediated delivery of therapeutic genes: focus on miRNA therapeutics

(2013) Muthunarayanan Muthiah et al.   Expert Opinion on Drug Delivery

Design of Nanodrugs for miRNA Targeting in Tumor Cells

(2013) Byunghee Yoo et al.   Journal of Biomedical Nanotechnology

Hepatocyte-targeted RNAi Therapeutics for the Treatment of Chronic Hepatitis B Virus Infection

(2013) Christine I Wooddell et al.   MOLECULAR THERAPY

Delivery materials for siRNA therapeutics

(2013) Rosemary Kanasty et al.   NATURE MATERIALS

The atypical mechanosensitive microRNA-712 derived from pre-ribosomal RNA induces endothelial inflammation and atherosclerosis

(2013) Dong Ju Son et al.   Nature Communications

A biomimetic nanovector-mediated targeted cholesterol-conjugated siRNA delivery for tumor gene therapy

(2012) Yang Ding et al.   BIOMATERIALS

Cellular Uptakes, Biostabilities and Anti-miR-210 Activities of Chiral Arginine-PNAs in Leukaemic K562 Cells

(2012) Alex Manicardi et al.   CHEMBIOCHEM

Designing Chemically Modified Oligonucleotides for Targeted Gene Silencing

(2012) Glen F. Deleavey et al.   CHEMISTRY & BIOLOGY

MicroRNA Profiling Identifies MicroRNA-155 as an Adverse Mediator of Cardiac Injury and Dysfunction During Acute Viral Myocarditis

(2012) Maarten F. Corsten et al.   CIRCULATION RESEARCH

Delivering the promise of miRNA cancer therapeutics

(2012) Diane M. Pereira et al.   DRUG DISCOVERY TODAY

Stabilization of polyplexes via polymer crosslinking for efficient siRNA delivery

(2012) Thomas Fröhlich et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Characterization of polyplexes involving small RNA

(2012) Patrícia Pereira et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Glycomimetic Ligands for the Human Asialoglycoprotein Receptor

(2012) Sreeman K. Mamidyala et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Context-dependent differences in miR-10b breast oncogenesis can be targeted for the prevention and arrest of lymph node metastasis

(2012) M V Yigit et al.   ONCOGENE

The Silencing of Pokemon Attenuates the Proliferation of Hepatocellular Carcinoma Cells In Vitro and In Vivo by Inhibiting the PI3K/Akt Pathway

(2012) Chan-Chan Lin et al.   PLoS One

MiR-122 in hepatic function and liver diseases

(2012) Jun Hu et al.   Protein & Cell

Thermal Stability of siRNA Modulates Aptamer- conjugated siRNA Inhibition

(2012) Alexey Berezhnoy et al.   Molecular Therapy-Nucleic Acids

siRNA-Aptamer Chimeras on Nanoparticles: Preserving Targeting Functionality for Effective Gene Silencing

(2011) Vaishali Bagalkot et al.   ACS Nano

Non-viral vectors for the mediation of RNAi

(2011) Shubiao Zhang et al.   BIOORGANIC CHEMISTRY

Synthesis of Lipid-Oligonucleotide Conjugates for RNA Interference Studies

(2011) Santiago Grijalvo et al.   CHEMISTRY & BIODIVERSITY

Modulation of the Biological Activity of microRNA-210 with Peptide Nucleic Acids (PNAs)

(2011) Enrica Fabbri et al.   ChemMedChem

Nucleic Acid Aptamers: Clinical Applications and Promising New Horizons

(2011) X. Ni et al.   CURRENT MEDICINAL CHEMISTRY

miR221/222 in Cancer: Their Role in Tumor Progression and Response to Therapy

(2011) M. Garofalo et al.   CURRENT MOLECULAR MEDICINE

Chemical modification and design of anti-miRNA oligonucleotides

(2011) K A Lennox et al.   GENE THERAPY

Effective delivery of anti-miRNA DNA oligonucleotides by functionalized gold nanoparticles

(2011) Jae-Hong Kim et al.   JOURNAL OF BIOTECHNOLOGY

Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery

(2011) Ru Cheng et al.   JOURNAL OF CONTROLLED RELEASE

Synthesis, Characterization, and in Vivo Delivery of siRNA-Squalene Nanoparticles Targeting Fusion Oncogene in Papillary Thyroid Carcinoma

(2011) Mouna Raouane et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and in vitro inhibition properties of siRNA conjugates carrying glucose and galactose with different presentations

(2011) Anna Aviñó et al.   MOLECULAR DIVERSITY

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Chemical structure requirements and cellular targeting of microRNA-122 by peptide nucleic acids anti-miRs

(2011) Adrian G. Torres et al.   NUCLEIC ACIDS RESEARCH

Downregulation of miR-221/222 sensitizes glioma cells to temozolomide by regulating apoptosis independently of p53 status

(2011) Chuanlu Jiang   ONCOLOGY REPORTS

MicroRNA-122 antagonism against hepatitis C virus genotypes 1-6 and reduced efficacy by host RNA insertion or mutations in the HCV 5' UTR

(2011) Y.-P. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nucleic Acid-Gold Nanoparticle Conjugates as Mimics of microRNA

(2011) Liangliang Hao et al.   Small

miRNA therapeutics: delivery and biological activity of peptide nucleic acids targeting miRNAs

(2011) Enrica Fabbri et al.   Epigenomics

Imaging and drug delivery using theranostic nanoparticles

(2010) Siti M. Janib et al.   ADVANCED DRUG DELIVERY REVIEWS

Gold Nanoparticles for Biology and Medicine

(2010) David A. Giljohann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform

(2010) C. Frank Bennett et al.   Annual Review of Pharmacology and Toxicology

Simple Solid-Phase Synthesis and Biological Properties of Carbohydrate−Oligonucleotide Conjugates Modified at the 3′-Terminus

(2010) Yutaka Ikeda et al.   BIOCONJUGATE CHEMISTRY

miR-210 is overexpressed in late stages of lung cancer and mediates mitochondrial alterations associated with modulation of HIF-1 activity

(2010) M-P Puisségur et al.   CELL DEATH AND DIFFERENTIATION

A functionalized gold nanoparticles-assisted universal carrier for antisense DNA

(2010) Jae-Hong Kim et al.   CHEMICAL COMMUNICATIONS

Cu-free click cycloaddition reactions in chemical biology

(2010) John C. Jewett et al.   CHEMICAL SOCIETY REVIEWS

MicroRNA-210 as a Novel Therapy for Treatment of Ischemic Heart Disease

(2010) S. Hu et al.   CIRCULATION

Microrna let-7: an emerging next-generation cancer therapeutic

(2010) D. Barh et al.   Current Oncology

Gene Targeting and Expression Modulation by Peptide Nucleic Acids (PNA)

(2010) Peter E. Nielsen   CURRENT PHARMACEUTICAL DESIGN

Current status of GV1001 and other telomerase vaccination strategies in the treatment of cancer

(2010) VE Shaw et al.   Expert Review of Vaccines

High-Density Lipoprotein Facilitates In Vivo Delivery of α-Tocopherol–Conjugated Short-Interfering RNA to the Brain

(2010) Yoshitaka Uno et al.   HUMAN GENE THERAPY

Self-assembled siRNA–PLGA conjugate micelles for gene silencing

(2010) Soo Hyeon Lee et al.   JOURNAL OF CONTROLLED RELEASE

Synthesis of Oligonucleotides Carrying Amino Lipid Groups at the 3′-End for RNA Interference Studies

(2010) Santiago Grijalvo et al.   JOURNAL OF ORGANIC CHEMISTRY

Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model

(2010) Li Ma et al.   NATURE BIOTECHNOLOGY

Efficient inhibition of miR-155 function in vivo by peptide nucleic acids

(2010) Martin M. Fabani et al.   NUCLEIC ACIDS RESEARCH

PNA-Based Antisense Oligonucleotides for MicroRNAs Inhibition in the Absence of a Transfection Reagent

(2010) Su Young Oh et al.   OLIGONUCLEOTIDES

MicroRNA sponges: Progress and possibilities

(2010) M. S. Ebert et al.   RNA

MiR-210 – micromanager of the hypoxia pathway

(2010) Xin Huang et al.   TRENDS IN MOLECULAR MEDICINE

Recent advances in the use of cell-penetrating peptides for medical and biological applications☆

(2009) Sonali B. Fonseca et al.   ADVANCED DRUG DELIVERY REVIEWS

miR-21as a key regulator of oncogenic processes

(2009) S. Duygu Selcuklu et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

miR-155 gene: A typical multifunctional microRNA

(2009) Isabella Faraoni et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Hydrophobically Modified Oligoethylenimines as Highly Efficient Transfection Agents for siRNA Delivery

(2009) Alexander Philipp et al.   BIOCONJUGATE CHEMISTRY

MicroRNA-Based Therapeutics for Cancer

(2009) Vivien Wang et al.   BIODRUGS

miR-205 Exerts Tumor-Suppressive Functions in Human Prostate through Down-regulation of Protein Kinase C 

(2009) P. Gandellini et al.   CANCER RESEARCH

Proteolytic Cleavage of Protein Tyrosine Phosphatase   Regulates Glioblastoma Cell Migration

(2009) A. M. Burgoyne et al.   CANCER RESEARCH

Intracellular delivery of siRNA by cell-penetrating peptides modified with cationic oligopeptides

(2009) Tsutomu Ishihara et al.   DRUG DELIVERY

miR-155: On the Crosstalk Between Inflammation and Cancer

(2009) Esmerina Tili et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Synthesis and Biological Evaluation of a Bioresponsive and Endosomolytic siRNA−Polymer Conjugate

(2009) Martin Meyer et al.   MOLECULAR PHARMACEUTICS

Endocytosis and signalling: intertwining molecular networks

(2009) Alexander Sorkin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Polyelectrolyte compaction by pH-responsive agents

(2009) A. F. Jorge et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Therapeutic Silencing of MicroRNA-122 in Primates with Chronic Hepatitis C Virus Infection

(2009) R. E. Lanford et al.   SCIENCE

Bioconjugated quantum dots for in vivo molecular and cellular imaging☆

(2008) A SMITH et al.   ADVANCED DRUG DELIVERY REVIEWS

Gold nanoparticles in delivery applications☆

(2008) P GHOSH et al.   ADVANCED DRUG DELIVERY REVIEWS

Targeting of microRNAs for therapeutics

(2008) Jan Stenvang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

microRNAs: small molecules with big roles -C. elegans to human cancer

(2008) Masaomi Kato et al.   BIOLOGY OF THE CELL

Progress in developing cationic vectors for non-viral systemic gene therapy against cancer

(2008) Marie Morille et al.   BIOMATERIALS

Modulation of miRNA activity in human cancer: a new paradigm for cancer gene therapy?

(2008) A W Tong et al.   CANCER GENE THERAPY

Survivin: Key Regulator of Mitosis and Apoptosis and Novel Target for Cancer Therapeutics

(2008) A. C. Mita et al.   CLINICAL CANCER RESEARCH

Polyplexes from Poly(aspartamide) Bearing 1,2-Diaminoethane Side Chains Induce pH-Selective, Endosomal Membrane Destabilization with Amplified Transfection and Negligible Cytotoxicity

(2008) Kanjiro Miyata et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Efficient In Vivo Delivery of siRNA to the Liver by Conjugation of α-Tocopherol

(2008) Kazutaka Nishina et al.   MOLECULAR THERAPY

LNA-mediated microRNA silencing in non-human primates

(2008) Joacim Elmén et al.   NATURE

Cell-penetrating peptides as delivery vehicles for biology and medicine

(2008) Kelly M. Stewart et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Aptamer-based endocytosis of a lysosomal enzyme

(2008) C.-h. B. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosis

(2008) L.-X. Yan et al.   RNA