Review
Immunology
Erica L. Katz, John E. Harris
Summary: Vitiligo is a skin disease characterized by white spots, and significant progress has been made in understanding its pathogenesis over the past 30 years through perseverance, collaboration, and open-minded discussion. Researchers have explored various possible mechanisms through innervation, microvascular anomalies, oxidative stress, defects in melanocyte adhesion, autoimmunity, somatic mosaicism, and genetics, with animal models and improved patient sample collection methods playing important roles in translational studies.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Chemistry, Medicinal
Jianru Chen, Shuli Li, Chunying Li
Summary: Vitiligo is an autoimmune depigment disease caused by the destruction of melanocytes due to various factors, including genetic susceptibility, oxidative stress, and immune dysfunction. Research suggests that most melanocyte deaths are a result of abnormal immune responses, including heightened innate immunity, skewed T helper cells, and cytotoxic T lymphocytes.
MEDICINAL RESEARCH REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Asako Yamamoto, Lingli Yang, Yasutaka Kuroda, Jiao Guo, Lanting Teng, Daisuke Tsuruta, Ichiro Katayama
Summary: The skin, as the outermost barrier of the body, is a major target of oxidative stress. Local synthesis of estrogen in the skin to protect from oxidative stress has been explored, with abnormal local estrogen synthesis potentially involved in skin disorders. The findings suggest potential new intervention targets for combination therapy for conditions such as vitiligo.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Nan-Hyung Kim, Ha Jung Kim, Ai-Young Lee
Summary: AQP3 downregulation in vitiligo leads to oxidative stress and subsequent melanocyte death.
BIOMOLECULES & THERAPEUTICS
(2023)
Article
Oncology
Xiuyi Wu, Shanglin Jin, Yiwen Yang, Xiaoli Lu, Xiaoxi Dai, Zhongyi Xu, Chengfeng Zhang, Leihong Flora Xiang
Summary: The expression of ferroptosis markers is altered in the epidermis of vitiligo patients and iron deficiency is revealed in their blood. Erastin induces ferroptosis in human epidermal MCs in vitro, while NAC protects MCs from ferroptosis.
PIGMENT CELL & MELANOMA RESEARCH
(2022)
Review
Dermatology
Shintaro Inoue, Ichiro Katayama, Tamio Suzuki, Atsushi Tanemura, Shosuke Ito, Yuko Abe, Yasuyuki Sumikawa, Momoko Yoshikawa, Kayoko Suzuki, Akiko Yagami, Yukiko Masui, Akiko Ito, Kayoko Matsunaga
Summary: This review examines the major considerations for developing rhododendrol-induced leukoderma, providing a wide range of information on pathophysiology, mechanisms, risk evaluation, and potential treatments. The review discusses cytotoxicity of rhododendrol, cytoprotective functions, involvement of the immune system, and potential novel treatments, addressing individual differences and the mechanisms underlying the condition. Understanding rhododendrol-induced leukoderma not only sheds light on the mechanisms of non-segmental vitiligo, but also suggests possible prevention and treatment strategies.
JOURNAL OF DERMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Nonhlakanipho F. Sangweni, Phiwayinkosi V. Dludla, Nireshni Chellan, Lawrence Mabasa, Jyoti R. Sharma, Rabia Johnson
Summary: The study found that DMSO concentrations lower than 0.5% can enhance respiratory control ratio and cellular viability in cardiomyoblasts, while exposure to 3.7% DMSO increases apoptosis in cardiomyoblasts due to mitochondrial dysfunction and oxidative stress. In cancer cells, DMSO at concentrations equal to or higher than 0.009 reduces maximal respiratory capacity and ATP-linked respiration, leading to increased ROS production and apoptosis. Surprisingly, 0.001% DMSO exposure resulted in increased proliferative activity in cancer cells. These findings suggest caution when using DMSO in cancer cells, while demonstrating no cytotoxic effects or therapeutic benefits at concentrations equal to or lower than 0.5% in cardiomyoblasts.
Article
Agriculture, Dairy & Animal Science
Xinghui Wang, Mengyao Zhu, Juan J. Loor, Qianming Jiang, Yiwei Zhu, Wei Li, Xiliang Du, Yuxiang Song, Wenwen Gao, Lin Lei, Jianguo Wang, Guowen Liu, Xinwei Li
Summary: The study aimed to investigate the impact of propionate supply on mitochondrial dysfunction, oxidative stress, and apoptosis in calf hepatocytes under high FFA load. The results demonstrated that propionate supply could alleviate mitochondrial dysfunction, oxidative stress, and apoptosis by upregulating PGC-1 alpha in FFA-treated calf hepatocytes.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Ozgur Ocal, Mustafa Naziroglu
Summary: This study investigates the combined treatment of CiSP and EPA in DBTRG cells and finds that the activation of TRPM2 channel can enhance the anticancer, apoptotic, and oxidant actions of CiSP. Therefore, stimulating TRPM2 via EPA could be an effective approach in the treatment of glioblastoma tumors.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Neurosciences
Yener Yazgan, Mustafa Naziroglu
Summary: The activation and maintenance of TRPM2 channel play critical roles in regulating pain, oxidative stress, apoptosis, inflammation, and other processes involved in migraine. Activation of TRPM2 can further increase pain and cell damage induced by glyceryl trinitrate, while restoring the balance of TRPM2 channels helps alleviate these discomforts.
MOLECULAR NEUROBIOLOGY
(2021)
Review
Dermatology
Yi Lin, Yuecen Ding, Yue Wu, Yiwen Yang, Ziqi Liu, Leihong Xiang, Chengfeng Zhang
Summary: Vitiligo is a depigmentary disorder caused by mitochondrial alterations and downregulation of Nrf2. The abnormal mitochondria lead to melanocyte loss, while Nrf2 plays a critical role in maintaining mitochondrial homeostasis.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Junjie Du, Dongmin Yu, Jinghang Li, Linjie Si, Dawei Zhu, Ben Li, Yizhou Gao, Lifu Sun, Xufeng Wang, Xiaowei Wang
Summary: Through mouse experiments and in vitro cell experiments, it was found that Asiatic acid (AA) enhances the survival of cardiomyocytes and alleviates cardiac dysfunction by protecting mitochondrial structure, reducing oxidative stress, inhibiting mitochondrial-dependent apoptosis pathway, and inhibiting the activation of the JNK pathway, which highlights its potential therapeutic value in chronic pressure overload-induced heart failure and oxidative stress-induced cardiomyocyte apoptosis.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Cell Biology
Wojciech Trybus, Teodora Krol, Ewa Trybus, Anna Stachurska
Summary: Physcion exerts antitumor effects by inducing oxidative stress, autophagy, and apoptosis in HeLa cells, resulting in decreased cell viability, G0/G1 phase cell cycle arrest, and activation of the lysosomal system.
Article
Immunology
Jun Ding, Jian Jin, Yan Na Lei, Sheng Cui, Hui Ying Li, Hai Lan Zheng, Shang Guo Piao, Yu Ji Jiang, Mei Ying Xuan, Ji Zhe Jin, Ying Shun Jin, Jung Pyo Lee, Byung Ha Chung, Bum Soon Choi, Chul Woo Yang, Can Li
Summary: The study demonstrated that PK treatment protects against chronic TAC-induced renal injury by inhibiting PI3K/AKT signaling. PK improved renal function and histopathology, while also downregulating proinflammatory and profibrotic cytokine expression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Michela Peruch, Emiliana Giacomello, Davide Radaelli, Monica Concato, Riccardo Addobbati, Alessandra Lucia Fluca, Aneta Aleksova, Stefano D'Errico
Summary: Cocaine abuse leads to complex cardiotoxicity, involving multiple mechanisms such as sodium channel blockade, increased oxygen demand, mitochondrial dysfunction, and promotion of apoptosis. Research on mitochondrial mechanisms has mainly been conducted in animal models, with limited studies in humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Zhenpeng Dai, Eddy Hsi Chun Wang, Lynn Petukhova, Yuqian Chang, Eunice Yoojin Lee, Angela M. Christiano
Summary: The IL-7 signaling pathway is crucial in regulating T cell function and survival. Overexpression of IL-7 in AA patients and mice accelerates disease progression, while blocking IL-7 shows potential for enhancing therapeutic effects.
Article
Dermatology
Bowei Li, Xiuli Yi, Tongtian Zhuang, Shaolong Zhang, Shuli Li, Yuqi Yang, Tingting Cui, Jiaxi Chen, Yuqian Chang, Tianwen Gao, Chunying Li, Ling Liu
Summary: This study found evidence of necroptosis in melanocytes from vitiligo perilesional skin, and oxidative stress was shown to trigger melanocyte death. The RIP1 signaling pathway plays a crucial role in this process.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Dermatology
Sijia Wang, Xiuli Yi, Zhenjie Wu, Sen Guo, Wei Dai, Huina Wang, Qiong Shi, Kang Zeng, Weinan Guo, Chunying Li
Summary: CAMKK2 regulates the sensitivity of melanoma cells to ferroptosis by modulating the AMPK.NRF2 pathway, potentially playing a crucial role in melanoma treatment.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Dermatology
Tingting Cui, Yinghan Wang, Pu Song, Xiuli Yi, Jiaxi Chen, Yuqi Yang, Huina Wang, Pan Kang, Sen Guo, Ling Liu, Kai Li, Zhe Jian, Shuli Li, Chunying Li
Summary: This study found that autophagy plays a protective role in oxidative stress-induced melanocyte death, and dysregulated autophagy increases the sensitivity of melanocytes to oxidative damage. HSF1 was identified as the key transcription factor for autophagosome formation, and deficiency of HSF1 led to melanocyte apoptosis under oxidative stress. Overexpression of HSF1 could ameliorate oxidative stress-induced melanocyte death through upregulation of ATG5 and ATG12. These findings suggest that targeting the HSF1-ATG5/12 axis could be a potential therapeutic strategy for vitiligo treatment.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Dermatology
Huina Wang, Xiuli Yi, Sen Guo, Sijia Wang, Jinyuan Ma, Tao Zhao, Qiong Shi, Yangzi Tian, Hao Wang, Lintao Jia, Tianwen Gao, Chunying Li, Weinan Guo
Summary: The XBP1-MARCH5-MFN2 axis in melanoma cells coordinates mitochondrial fission and mitophagy, promoting resistance to ER stress. Targeting mitochondrial quality control machinery could enhance the efficacy of ER stress inducing agents against cancer.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Cell Biology
Jun Tian, Yaojun Wang, Ming Ding, Yue Zhang, Jiaoni Chi, Tao Wang, Bin Jiao, Zhe Jian, Xiuli Yi, Ye Huang, Ling Liu, Kai Li, Jiaxi Chen, Gang Wang, Tianwen Gao, Chunying Li, Qiang Li
Summary: This study revealed that vitiligo autoantigens translocate into apoptotic bodies during apoptosis induced by oxidative stress. The activation of cytoskeletal protein pathway and JNK-related apoptosis pathway are involved in the transport of autoantigens and the formation of apoptotic bodies. Apoptotic bodies may serve as a crucial link between melanocyte cell apoptosis and cellular immunity in vitiligo.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Immunology
Zhubiao Ye, Jianru Chen, Pengran Du, Qingrong Ni, Baizhang Li, Zhe Zhang, Qi Wang, Tingting Cui, Xiuli Yi, Chunying Li, Shuli Li
Summary: This study aimed to determine the differences in specific fatty acids between vitiligo patients and healthy individuals and to investigate their association with clinical features. The results showed that the serological level of alpha-linolenic acid (ALA) was increased in vitiligo patients, while the levels of arachidonic acid (ARA), arachidic acid (AA), and behenic acid were decreased. ALA levels were positively associated with the vitiligo area scoring index (VASI). Supplementation with ARA or nordihydroguaiaretic acid (NDGA) could suppress the function of CD8(+) T cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Jingjing Ma, Qiong Shi, Sen Guo, Peng Xu, Xiuli Yi, Yuqi Yang, Weigang Zhang, Yu Liu, Lin Liu, Qiao Yue, Tao Zhao, Tianwen Gao, Weinan Guo, Chunying Li
Summary: This study explored the expression profile and role of long non-coding RNAs (lncRNAs) in melanoma progression. Through microarray analysis, differentially-expressed lncRNAs in primary melanomas compared with nevus were identified. Bioinformatics analysis revealed the involvement of dysregulated lncRNAs in melanoma biology and immune response. CD27-AS1-208, a novel nuclear-localized lncRNA, was found to facilitate melanoma cell proliferation, invasion, and migration by interacting with STAT3. The up-regulation of CD27-AS1-208 was shown to contribute to melanoma progression by activating the STAT3 pathway.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Pan Kang, Jianru Chen, Weigang Zhang, Ningning Guo, Xiuli Yi, Tingting Cui, Jiaxi Chen, Yuqi Yang, Yinghan Wang, Pengran Du, Zhubiao Ye, Baizhang Li, Chunying Li, Shuli Li
Summary: This study found that in addition to apoptosis and necroptosis, other cell death modalities may exist in melanocytes under oxidative stress. Furthermore, it was demonstrated that Oxeiptosis occurs in oxidative stress-induced melanocyte death and contributes to the pathogenesis of vitiligo.
CELL DEATH DISCOVERY
(2022)
Review
Immunology
Yuhan Chen, Xiuli Yi, Ningyue Sun, Weinan Guo, Chunying Li
Summary: This review introduces the epidemiology, clinical characteristics, and therapeutic innovations of melanoma, discusses the tumor microenvironment and functions of different types of infiltrating immune cells in melanoma, systematically summarizes the linkage between epigenetics and antitumor immunity in melanoma, and introduces the progress of clinical trials regarding epigenetics-based melanoma immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Weinan Guo, Zhenjie Wu, Jianru Chen, Sen Guo, Weiming You, Sijia Wang, Jinyuan Ma, Huina Wang, Xiangxu Wang, Hao Wang, Jingjing Ma, Yuqi Yang, Yangzi Tian, Qiong Shi, Tianwen Gao, Xiuli Yi, Chunying Li
Summary: The upregulation of miR-21-3p contributes to IFN-gamma-driven ferroptosis and synergizes with anti-PD-1 antibody. Nanoparticle delivery of miR-21-3p is a promising therapeutic approach to increase immunotherapy efficacy without obvious systemic side effects.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Immunology
Sen Guo, Jianru Chen, Xiuli Yi, Zifan Lu, Weinan Guo
Summary: The risk prediction model based on ferroptosis-related lncRNAs can independently predict the prognosis of melanoma patients and provide a basis for evaluating the response of clinical treatment in melanoma.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Hao Wang, Hengxiang Zhang, Yuhan Chen, Huina Wang, Yangzi Tian, Xiuli Yi, Qiong Shi, Tao Zhao, Baolu Zhang, Tianwen Gao, Sen Guo, Chunying Li, Weinan Guo
Summary: This study found that Wnt/β-catenin signaling regulates ferroptosis in melanoma cells via the regulation of MITF, thus affecting the efficacy of immunotherapy. Targeting the Wnt/β-catenin-MITF pathway could be a promising strategy to enhance ferroptosis and increase the efficacy of anti-PD-1 immunotherapy.
Article
Biochemistry & Molecular Biology
Xiuli Yi, Huina Wang, Yuqi Yang, Hao Wang, Hengxiang Zhang, Sen Guo, Jianru Chen, Juan Du, Yangzi Tian, Jingjing Ma, Baolu Zhang, Lili Wu, Qiong Shi, Tianwen Gao, Weinan Guo, Chunying Li
Summary: Melanoma is a deadly type of skin cancer originating from the transformation of melanocyte. The SIRT7 protein plays a crucial role in regulating tumor cell biology and tumor immunology in melanoma, promoting tumor cell survival and immune evasion. Targeting SIRT7 could restrain tumor growth and enhance the effect of melanoma immunotherapy.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)