Addiction and the kynurenine pathway: A new dancing couple?

Indoleamine-2,3-Dioxygenase Mediates Emotional Deficits by the Kynurenine/Tryptophan Pathway in the Ethanol Addiction/Withdrawal Mouse Model

(2020) Xi Jiang et al.   Frontiers in Cellular Neuroscience

Neuroprotective and Neuromodulatory Effects Induced by Cannabidiol and Cannabigerol in Rat Hypo-E22 cells and Isolated Hypothalamus

(2020) Viviana di Giacomo et al.   Antioxidants

Antioxidant and Neuroprotective Effects Induced by Cannabidiol and Cannabigerol in Rat CTX-TNA2 Astrocytes and Isolated Cortexes

(2020) Viviana di Giacomo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Antidepressant-like effects of kynurenic acid in a modified forced swim test

(2020) Masaru Tanaka et al.   Pharmacological Reports

Activation of alpha7 nicotinic and NMDA receptors is necessary for performance in a working memory task

(2020) David Phenis et al.   PSYCHOPHARMACOLOGY

Aryl hydrocarbon receptor (AHR) functions: Balancing opposing processes including inflammatory reactions

(2020) Karl Walter Bock   BIOCHEMICAL PHARMACOLOGY

Prenatal THC exposure raises kynurenic acid levels in the prefrontal cortex of adult rats

(2020) Sarah Beggiato et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Early and late behavioral consequences of ethanol withdrawal: focus on brain indoleamine 2,3 dioxygenase activity

(2020) Luana Carla dos Santos et al.   ALCOHOL

Environmental pollutants and the immune response

(2020) Takafumi Suzuki et al.   NATURE IMMUNOLOGY

Drug Mimicry: Promiscuous Receptors PXR and AhR, and Microbial Metabolite Interactions in the Intestine

(2020) Zdeněk Dvořák et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Kynurenine Pathway of Tryptophan Metabolism in Neuropsychiatric Disorders: Pathophysiologic and Therapeutic Considerations

(2020) Ather Muneer   Clinical Psychopharmacology and Neuroscience

Oleoylethanolamide, Neuroinflammation, and Alcohol Abuse

(2019) Laura Orio et al.   Frontiers in Molecular Neuroscience

NMDA receptor antagonists and pain relief

(2019) Trevor Thompson et al.   NEUROLOGY

Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond

(2019) Michael Platten et al.   NATURE REVIEWS DRUG DISCOVERY

Changes in brain kynurenine levels via gut microbiota and gut-barrier disruption induced by chronic ethanol exposure in mice

(2019) Pablo Giménez-Gómez et al.   FASEB JOURNAL

Does kynurenic acid act on nicotinic receptors? An assessment of the evidence

(2019) Trevor W. Stone   JOURNAL OF NEUROCHEMISTRY

Serotonin is the main tryptophan metabolite associated with psychiatric comorbidity in abstinent cocaine-addicted patients

(2019) Pedro Araos et al.   Scientific Reports

VTA GABA Neurons at the Interface of Stress and Reward

(2019) Chloé Bouarab et al.   Frontiers in Neural Circuits

Ischemic stroke and kynurenines: medicinal chemistry aspects

(2018) Peter Hertelendy et al.   CURRENT MEDICINAL CHEMISTRY

Synaptic function and plasticity in identified inhibitory inputs onto VTA dopamine neurons

(2018) Abigail M. Polter et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Discovery and development of varenicline for smoking cessation

(2018) Chloe J. Jordan et al.   Expert Opinion on Drug Discovery

Increasing kynurenine brain levels reduces ethanol consumption in mice by inhibiting dopamine release in nucleus accumbens

(2018) Pablo Giménez-Gómez et al.   NEUROPHARMACOLOGY

Pharmacological activation of mGlu4 and mGlu7 receptors, by LSP2-9166, reduces ethanol consumption and relapse in rat

(2018) Sophie Lebourgeois et al.   NEUROPHARMACOLOGY

Repeated Administration of D-Amphetamine Induces Distinct Alterations in Behavior and Metabolite Levels in 129Sv and Bl6 Mouse Strains

(2018) Taavi Vanaveski et al.   Frontiers in Neuroscience

Pharmacological Inhibition of Indoleamine 2,3-Dioxygenase-2 and Kynurenine 3-Monooxygenase, Enzymes of the Kynurenine Pathway, Significantly Diminishes Neuropathic Pain in a Rat Model

(2018) Ewelina Rojewska et al.   Frontiers in Pharmacology

Kynurenine 3-Monooxygenase Gene Associated With Nicotine Initiation and Addiction: Analysis of Novel Regulatory Features at 5′ and 3′-Regions

(2018) Hassan A. Aziz et al.   Frontiers in Genetics

Diagnosis and Pharmacotherapy of Alcohol Use Disorder

(2018) Henry R. Kranzler et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The role of orphan G protein-coupled receptors in the modulation of pain: A review

(2018) Fahimeh Nourbakhsh et al.   LIFE SCIENCES

Astrocytic Mechanisms Involving Kynurenic Acid Control Δ9-Tetrahydrocannabinol-Induced Increases in Glutamate Release in Brain Reward-Processing Areas

(2018) Maria E. Secci et al.   MOLECULAR NEUROBIOLOGY

Ketamine reduces aversion in rodent pain models by suppressing hyperactivity of the anterior cingulate cortex

(2018) Haocheng Zhou et al.   Nature Communications

Gene expression and neurochemical characterization of the rostromedial tegmental nucleus (RMTg) in rats and mice

(2018) Rachel J. Smith et al.   Brain Structure & Function

Overexpression of kynurenic acid and 3-hydroxyanthranilic acid after rat traumatic brain injury

(2018) Arturo Mangas et al.   EUROPEAN JOURNAL OF HISTOCHEMISTRY

Role of CYP2B6 pharmacogenomics in bupropion-mediated smoking cessation

(2018) Andrew X. Tran et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

Presence of kynurenic acid in alcoholic beverages – Is this good news, or bad news?

(2018) Monika Turska et al.   MEDICAL HYPOTHESES

Metabolism and metabolomics of opiates: A long way of forensic implications to unravel

(2018) Ricardo Jorge Dinis-Oliveira   Journal of Forensic and Legal Medicine

Kynurenic acid and zaprinast diminished CXCL17-evoked pain-related behaviour and enhanced morphine analgesia in a mouse neuropathic pain model

(2018) Ewelina Rojewska et al.   Pharmacological Reports

Differential expression of long-term potentiation among identified inhibitory inputs to dopamine neurons

(2017) DeNard V. Simmons et al.   JOURNAL OF NEUROPHYSIOLOGY

First Time View on Human Metabolome Changes after a Single Intake of 3,4-Methylenedioxymethamphetamine in Healthy Placebo-Controlled Subjects

(2017) Martina I. Boxler et al.   JOURNAL OF PROTEOME RESEARCH

Kynurenic acid and its analogue can alter the opioid receptor G-protein signaling after acute treatment via NMDA receptor in rat cortex and striatum

(2017) Reza Samavati et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Kynurenine pathway metabolism and the microbiota-gut-brain axis

(2017) P.J. Kennedy et al.   NEUROPHARMACOLOGY

Attenuating Nicotine Reinforcement and Relapse by Enhancing Endogenous Brain Levels of Kynurenic Acid in Rats and Squirrel Monkeys

(2017) Maria E Secci et al.   NEUROPSYCHOPHARMACOLOGY

Microbiota-gut-brain axis and the central nervous system

(2017) Xiqun Zhu et al.   Oncotarget

Tryptophan 2,3-dioxygenase and indoleamine 2,3-dioxygenase 1 make separate, tissue-specific contributions to basal and inflammation-induced kynurenine pathway metabolism in mice

(2016) Paul B. Larkin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The Emerging Role of Metabotropic Glutamate Receptors in the Pathophysiology of Chronic Stress-Related Disorders

(2016) Daniel Peterlik et al.   Current Neuropharmacology

Pharmacological kynurenine 3-monooxygenase enzyme inhibition significantly reduces neuropathic pain in a rat model

(2016) Ewelina Rojewska et al.   NEUROPHARMACOLOGY

Kynurenic acid and zaprinast induce analgesia by modulating HCN channels through GPR35 activation

(2016) Francesco Resta et al.   NEUROPHARMACOLOGY

Diversity of Dopaminergic Neural Circuits in Response to Drug Exposure

(2016) Barbara Juarez et al.   NEUROPSYCHOPHARMACOLOGY

Relationship between Nonmedical Prescription-Opioid Use and Heroin Use

(2016) Wilson M. Compton et al.   NEW ENGLAND JOURNAL OF MEDICINE

Current Findings and Mechanisms of Action of Disulfiram in the Treatment of Alcohol Dependence

(2016) J. Mutschler et al.   PHARMACOPSYCHIATRY

Coca: The History and Medical Significance of an Ancient Andean Tradition

(2016) Amy Sue Biondich et al.   Emergency Medicine International

The Relationship of Alcohol Use Disorders and Depressive Symptoms to Tryptophan Metabolism: Cross-Sectional Data from a Nepalese Alcohol Treatment Sample

(2015) Sudan Prasad Neupane et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Reduction of kynurenic acid to quinolinic acid ratio in both the depressed and remitted phases of major depressive disorder

(2015) Jonathan Savitz et al.   BRAIN BEHAVIOR AND IMMUNITY

Differentiation and molecular heterogeneity of inhibitory and excitatory neurons associated with midbrain dopaminergic nuclei

(2015) Laura Lahti et al.   DEVELOPMENT

Psychostimulants affect dopamine transmission through both dopamine transporter-dependent and independent mechanisms

(2015) Ike dela Peña et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Amphetamines, new psychoactive drugs and the monoamine transporter cycle

(2015) Harald H. Sitte et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Tryptophan Metabolism in Post-Withdrawal Alcohol-Dependent Patients

(2014) Gabriele v. Gleissenthall et al.   ALCOHOL AND ALCOHOLISM

Inhibition of Opioid Receptor Mediated G-Protein Activity After Chronic Administration of Kynurenic Acid and its Derivative without Direct Binding to Opioid Receptors

(2014) Ferenc Zador et al.   CNS & Neurological Disorders-Drug Targets

IDO2 is critical for IDO1-mediated T-cell regulation and exerts a non-redundant function in inflammation

(2014) Richard Metz et al.   INTERNATIONAL IMMUNOLOGY

A systemically-available kynurenine aminotransferase II (KAT II) inhibitor restores nicotine-evoked glutamatergic activity in the cortex of rats

(2014) Ajeesh Koshy Cherian et al.   NEUROPHARMACOLOGY

Alcohol, stress hormones, and the prefrontal cortex: A proposed pathway to the dark side of addiction

(2014) Y.-L. Lu et al.   NEUROSCIENCE

Identification of Cinnabarinic Acid as a Novel Endogenous Aryl Hydrocarbon Receptor Ligand That Drives IL-22 Production

(2014) Margaret M. Lowe et al.   PLoS One

Continuous kynurenine administration during the prenatal period, but not during adolescence, causes learning and memory deficits in adult rats

(2014) Ana Pocivavsek et al.   PSYCHOPHARMACOLOGY

Nicotinic α7 receptor activation selectively potentiates the function of NMDA receptors in glutamatergic terminals of the nucleus accumbens

(2014) Stefania Zappettini et al.   Frontiers in Cellular Neuroscience

Metabolic profiling of urine and blood plasma in rat models of drug addiction on the basis of morphine, methamphetamine, and cocaine-induced conditioned place preference

(2013) Kei Zaitsu et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Thel-kynurenine-probenecid combination reduces neuropathic pain in rats

(2013) J.B. Pineda-Farias et al.   EUROPEAN JOURNAL OF PAIN

Amphetamine, past and present – a pharmacological and clinical perspective

(2013) David J Heal et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Reducing cannabinoid abuse and preventing relapse by enhancing endogenous brain levels of kynurenic acid

(2013) Zuzana Justinova et al.   NATURE NEUROSCIENCE

The brain reward circuitry in mood disorders

(2013) Scott J. Russo et al.   NATURE REVIEWS NEUROSCIENCE

Early developmental elevations of brain kynurenic acid impair cognitive flexibility in adults: Reversal with galantamine

(2013) K.S. Alexander et al.   NEUROSCIENCE

A Brain on Cannabinoids: The Role of Dopamine Release in Reward Seeking

(2013) E. B. Oleson et al.   Cold Spring Harbor Perspectives in Medicine

Metabolic Biomarkers of Prenatal Alcohol Exposure in Human Embryonic Stem Cell-Derived Neural Lineages

(2012) Jessica A. Palmer et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Kynurenic acid as an antagonist of α7 nicotinic acetylcholine receptors in the brain: Facts and challenges

(2012) Edson X. Albuquerque et al.   BIOCHEMICAL PHARMACOLOGY

Metabolic phenotype of rats exposed to heroin and potential markers of heroin abuse

(2012) Tian Zheng et al.   DRUG AND ALCOHOL DEPENDENCE

Pre- and postnatal exposure to kynurenine causes cognitive deficits in adulthood

(2012) Ana Pocivavsek et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Quinolinic acid: neurotoxicity

(2012) Gilles J. Guillemin   FEBS Journal

A selective aryl hydrocarbon receptor modulator 3,3'-Diindolylmethane inhibits gastric cancer cell growth

(2012) Xiao-Fei Yin et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Kynurenic acid: a metabolite with multiple actions and multiple targets in brain and periphery

(2012) Flavio Moroni et al.   JOURNAL OF NEURAL TRANSMISSION

Neuroanatomy of Dopamine: Reward and Addiction

(2012) Katherine H. Taber et al.   JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES

Kynurenines in the mammalian brain: when physiology meets pathology

(2012) Robert Schwarcz et al.   NATURE REVIEWS NEUROSCIENCE

Lack of Modulation of Nicotinic Acetylcholine Alpha-7 Receptor Currents by Kynurenic Acid in Adult Hippocampal Interneurons

(2012) Peter Dobelis et al.   PLoS One

An expanding range of targets for kynurenine metabolites of tryptophan

(2012) Trevor W. Stone et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Alcohol and depression

(2011) Joseph M. Boden et al.   ADDICTION

Tryptophan in Alcoholism Treatment I:  Kynurenine Metabolites Inhibit the Rat Liver Mitochondrial Low Km Aldehyde Dehydrogenase Activity, Elevate Blood Acetaldehyde Concentration and Induce Aversion to Alcohol

(2011) Abdulla A.-B. Badawy et al.   ALCOHOL AND ALCOHOLISM

Treating the Periphery to Ameliorate Neurodegenerative Diseases

(2011) Peter H. Reinhart et al.   CELL

Kynurenine 3-Monooxygenase Inhibition in Blood Ameliorates Neurodegeneration

(2011) Daniel Zwilling et al.   CELL

Subchronic elevation of brain kynurenic acid augments amphetamine-induced locomotor response in mice

(2011) Sara K. Olsson et al.   JOURNAL OF NEURAL TRANSMISSION

Behavioural studies with a newly developed neuroprotective KYNA-amide

(2011) Levente Gellért et al.   JOURNAL OF NEURAL TRANSMISSION

Age Dependency of Inhibition of  7 Nicotinic Receptors and Tonically Active N-Methyl-D-aspartate Receptors by Endogenously Produced Kynurenic Acid in the Brain

(2011) M. Alkondon et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

(2011) Christiane A. Opitz et al.   NATURE

Drug-Evoked Synaptic Plasticity in Addiction: From Molecular Changes to Circuit Remodeling

(2011) Christian Lüscher et al.   NEURON

Prefrontal  2 Subunit-Containing and  7 Nicotinic Acetylcholine Receptors Differentially Control Glutamatergic and Cholinergic Signaling

(2010) V. Parikh et al.   JOURNAL OF NEUROSCIENCE

G-protein coupled receptor 35 (GPR35) activation and inflammatory pain: Studies on the antinociceptive effects of kynurenic acid and zaprinast

(2010) Cristina Cosi et al.   NEUROPHARMACOLOGY

Metabotropic glutamate receptors: From the workbench to the bedside

(2010) F. Nicoletti et al.   NEUROPHARMACOLOGY

Exposure to Kynurenic Acid During Adolescence Produces Memory Deficits in Adulthood

(2010) C. O. Akagbosu et al.   SCHIZOPHRENIA BULLETIN

Increased Levels of Kynurenine and Kynurenic Acid in the CSF of Patients With Schizophrenia

(2010) K. R. Linderholm et al.   SCHIZOPHRENIA BULLETIN

Kynurenic Acid Is a Potent Endogenous Aryl Hydrocarbon Receptor Ligand that Synergistically Induces Interleukin-6 in the Presence of Inflammatory Signaling

(2010) Brett C. DiNatale et al.   TOXICOLOGICAL SCIENCES

Activation of Liver Tryptophan Pyrrolase Mediates the Decrease in Tryptophan Availability to the Brain after Acute Alcohol Consumption by Normal Subjects

(2009) A. A-B Badawy et al.   ALCOHOL AND ALCOHOLISM

Glutamate and reinstatement

(2009) Lori A Knackstedt et al.   CURRENT OPINION IN PHARMACOLOGY

Δ9-Tetrahydrocannabinol and cannabidiol modulate mitogen-induced tryptophan degradation and neopterin formation in peripheral blood mononuclear cells in vitro

(2009) Marcel Jenny et al.   JOURNAL OF NEUROIMMUNOLOGY

Electrophysiological characterisation of the actions of kynurenic acid at ligand-gated ion channels

(2009) M.H. Selina Mok et al.   NEUROPHARMACOLOGY

Neurocircuitry of Addiction

(2009) George F Koob et al.   NEUROPSYCHOPHARMACOLOGY

Alterations in tryptophan and purine metabolism in cocaine addiction: a metabolomic study

(2009) Ashwin A. Patkar et al.   PSYCHOPHARMACOLOGY

Long-term exposure to nicotine markedly reduces kynurenic acid in rat brain — In vitro and ex vivo evidence

(2009) Elżbieta Zielińska et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Allosteric modulation of α7 nicotinic receptors selectively depolarizes hippocampal interneurons, enhancing spontaneous GABAergic transmission

(2008) J. J. Arnaiz-Cot et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Elevated levels of kynurenic acid change the dopaminergic response to amphetamine: implications for schizophrenia

(2008) Sara K. Olsson et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

A Role for Brain Stress Systems in Addiction

(2008) George F. Koob   NEURON

Role of NMDA Receptors in Dopamine Neurons for Plasticity and Addictive Behaviors

(2008) Larry S. Zweifel et al.   NEURON

Glutamate transmission in addiction

(2008) Peter W. Kalivas et al.   NEUROPHARMACOLOGY

MDMA-induced neurotoxicity: long-term effects on 5-HT biosynthesis and the influence of ambient temperature

(2006) Esther O'shea et al.   BRITISH JOURNAL OF PHARMACOLOGY