Kynurenines in the mammalian brain: when physiology meets pathology

Indoleamine 2,3-dioxygenase as a Modifier of Pathogenic Inflammation in Cancer and other Inflammation-Associated Diseases

(2012) G. C. Prendergast et al.   CURRENT MEDICINAL CHEMISTRY

Pre- and postnatal exposure to kynurenine causes cognitive deficits in adulthood

(2012) Ana Pocivavsek et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Kynurenic acid: a metabolite with multiple actions and multiple targets in brain and periphery

(2012) Flavio Moroni et al.   JOURNAL OF NEURAL TRANSMISSION

Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase

(2012) L. Pilotte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Downregulated Kynurenine 3-Monooxygenase Gene Expression and Enzyme Activity in Schizophrenia and Genetic Association With Schizophrenia Endophenotypes

(2011) Ikwunga Wonodi   ARCHIVES OF GENERAL PSYCHIATRY

α-methyl-L-tryptophan: mechanisms for tracer localization of epileptogenic brain regions

(2011) Diane C Chugani   Biomarkers in Medicine

Kynurenine 3-Monooxygenase Inhibition in Blood Ameliorates Neurodegeneration

(2011) Daniel Zwilling et al.   CELL

The Kynurenine Pathway Modulates Neurodegeneration in a Drosophila Model of Huntington's Disease

(2011) Susanna Campesan et al.   CURRENT BIOLOGY

Effect of some naturally occurring iron ion chelators on the formation of radicals in the reaction mixtures of rat liver microsomes with ADP, Fe3+ and NADPH

(2011) Katsuyuki Minakata et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Regulation of quinolinic acid neosynthesis in mouse, rat and human brain by iron and iron chelators in vitro

(2011) Erin K. Stachowski et al.   JOURNAL OF NEURAL TRANSMISSION

Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: Evidence for an immune-modulated glutamatergic neurotransmission?

(2011) Johann Steiner et al.   Journal of Neuroinflammation

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

(2011) Christiane A. Opitz et al.   NATURE

Cognitive dysfunction in depression: Neurocircuitry and new therapeutic strategies

(2011) James W. Murrough et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Fluctuations in Endogenous Kynurenic Acid Control Hippocampal Glutamate and Memory

(2011) Ana Pocivavsek et al.   NEUROPSYCHOPHARMACOLOGY

Depression, Antidepressants and Neurogenesis: A Critical Reappraisal

(2011) Nicola D Hanson et al.   NEUROPSYCHOPHARMACOLOGY

Interleukin-1β: A New Regulator of the Kynurenine Pathway Affecting Human Hippocampal Neurogenesis

(2011) Patricia A Zunszain et al.   NEUROPSYCHOPHARMACOLOGY

On the antioxidant properties of kynurenic acid: Free radical scavenging activity and inhibition of oxidative stress

(2011) R. Lugo-Huitrón et al.   NEUROTOXICOLOGY AND TERATOLOGY

Interaction and transport of kynurenic acid via human organic anion transporters hOAT1 and hOAT3

(2011) Yuichi Uwai et al.   PHARMACOLOGICAL RESEARCH

Acute elevations of brain kynurenic acid impair cognitive flexibility: normalization by the alpha7 positive modulator galantamine

(2011) Kathleen S. Alexander et al.   PSYCHOPHARMACOLOGY

Administration of kynurenine during adolescence, but not during adulthood, impairs social behavior in rats

(2011) Katelyn V. Trecartin et al.   SCHIZOPHRENIA RESEARCH

Peripheral and cerebral metabolic abnormalities of the tryptophan–kynurenine pathway in a murine model of major depression

(2010) Anthony Laugeray et al.   BEHAVIOURAL BRAIN RESEARCH

Chronic stress alters the density and morphology of microglia in a subset of stress-responsive brain regions

(2010) Ross J. Tynan et al.   BRAIN BEHAVIOR AND IMMUNITY

Glial activation precedes seizures and hippocampal neurodegeneration in measles virus-infected mice

(2010) Elin Lehrmann et al.   EPILEPSIA

Dendritic Cells, Indoleamine 2,3 Dioxygenase and Acquired Immune Privilege

(2010) Lei Huang et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Interferon-gamma-inducible kynurenines/pteridines inflammation cascade: implications for aging and aging-associated psychiatric and medical disorders

(2010) Gregory F. Oxenkrug   JOURNAL OF NEURAL TRANSMISSION

Inhibition of the Kynurenine-NAD+Pathway Leads to Energy Failure and Exacerbates Apoptosis in Pneumococcal Meningitis

(2010) Caroline L. Bellac et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Elevated levels of kynurenic acid in the cerebrospinal fluid of patients with bipolar disorder

(2010) Sara Olsson   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Kynurenine is an endothelium-derived relaxing factor produced during inflammation

(2010) Yutang Wang et al.   NATURE MEDICINE

Microglia in neurodegenerative disease

(2010) V. Hugh Perry et al.   Nature Reviews Neurology

Indoleamine 2,3-dioxygenase and 3-hydroxykynurenine modifications are found in the neuropathology of Alzheimer's disease

(2010) David J. Bonda et al.   REDOX REPORT

Impaired Kynurenine Pathway Metabolism in The Prefrontal Cortex of Individuals With Schizophrenia

(2010) K. V. Sathyasaikumar et al.   SCHIZOPHRENIA BULLETIN

Increased Levels of Kynurenine and Kynurenic Acid in the CSF of Patients With Schizophrenia

(2010) K. R. Linderholm et al.   SCHIZOPHRENIA BULLETIN

Kynurenic Acid Is a Potent Endogenous Aryl Hydrocarbon Receptor Ligand that Synergistically Induces Interleukin-6 in the Presence of Inflammatory Signaling

(2010) Brett C. DiNatale et al.   TOXICOLOGICAL SCIENCES

L-kynurenine treatment alters contextual fear conditioning and context discrimination but not cue-specific fear conditioning

(2009) Amy C. Chess et al.   BEHAVIOURAL BRAIN RESEARCH

Functional and Dysfunctional Synaptic Plasticity in Prefrontal Cortex: Roles in Psychiatric Disorders

(2009) Yukiori Goto et al.   BIOLOGICAL PSYCHIATRY

Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis

(2009) J. Rodgers et al.   BRAIN

Structure, expression, and function of kynurenine aminotransferases in human and rodent brains

(2009) Qian Han et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Astrocyte-derived kynurenic acid modulates basal and evoked cortical acetylcholine release

(2009) A. Zmarowski et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Induction of IDO by Bacille Calmette-Guerin Is Responsible for Development of Murine Depressive-Like Behavior

(2009) J. C. O'Connor et al.   JOURNAL OF IMMUNOLOGY

The Astrocyte-Derived α7 Nicotinic Receptor Antagonist Kynurenic Acid Controls Extracellular Glutamate Levels in the Prefrontal Cortex

(2009) Hui-Qiu Wu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

On the relationship between the two branches of the kynurenine pathway in the rat brainin vivo

(2009) Laura Amori et al.   JOURNAL OF NEUROCHEMISTRY

Interferon-  and Tumor Necrosis Factor-  Mediate the Upregulation of Indoleamine 2,3-Dioxygenase and the Induction of Depressive-Like Behavior in Mice in Response to Bacillus Calmette-Guerin

(2009) J. C. O'Connor et al.   JOURNAL OF NEUROSCIENCE

CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-α: relationship to CNS immune responses and depression

(2009) C L Raison et al.   MOLECULAR PSYCHIATRY

Electrophysiological characterisation of the actions of kynurenic acid at ligand-gated ion channels

(2009) M.H. Selina Mok et al.   NEUROPHARMACOLOGY

Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function

(2009) Edson X. Albuquerque et al.   PHYSIOLOGICAL REVIEWS

The Excitotoxin Quinolinic Acid Induces Tau Phosphorylation in Human Neurons

(2009) Abdur Rahman et al.   PLoS One

Glutamate-based antidepressants: 20 years on

(2009) Phil Skolnick et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Tryptophan 2,3-dioxygenase is a key modulator of physiological neurogenesis and anxiety-related behavior in mice

(2009) Masaaki Kanai et al.   Molecular Brain

Effect of indoleamine dioxygenase-1 deficiency and kynurenine pathway inhibition on murine cerebral malaria

(2008) Jenny Miu et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Indoleamine 2,3-dioxygenase-2; a new enzyme in the kynurenine pathway

(2008) Helen J. Ball et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Kynurenine pathway metabolism in human blood–brain–barrier cells: implications for immune tolerance & neurotoxicity

(2008) Robert Owe-Young et al.   JOURNAL OF NEUROCHEMISTRY

Xanthurenic acid distribution, transport, accumulation and release in the rat brain

(2008) Serge Gobaille et al.   JOURNAL OF NEUROCHEMISTRY

Specific inhibition of kynurenate synthesis enhances extracellular dopamine levels in the rodent striatum

(2008) L. Amori et al.   NEUROSCIENCE

Induction of indolamine 2,3-dioxygenase and kynurenine 3-monooxygenase in rat brain following a systemic inflammatory challenge: A role for IFN-γ?

(2008) Thomas J. Connor et al.   NEUROSCIENCE LETTERS

Prolonged kynurenine 3-hydroxylase inhibition reduces development of levodopa-induced dyskinesias in parkinsonian monkeys

(2007) L GREGOIRE et al.   BEHAVIOURAL BRAIN RESEARCH

Inflammatory Cytokine Alterations in Schizophrenia: A Systematic Quantitative Review

(2007) Stéphane Potvin et al.   BIOLOGICAL PSYCHIATRY

Autism-like behavioral phenotypes in BTBR T+tf/J mice

(2007) H. G. McFarlane et al.   GENES BRAIN AND BEHAVIOR