Attenuating Nicotine Reinforcement and Relapse by Enhancing Endogenous Brain Levels of Kynurenic Acid in Rats and Squirrel Monkeys

Kynurenine-3-monooxygenase: a review of structure, mechanism, and inhibitors

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A systemically-available kynurenine aminotransferase II (KAT II) inhibitor restores nicotine-evoked glutamatergic activity in the cortex of rats

(2014) Ajeesh Koshy Cherian et al.   NEUROPHARMACOLOGY

The kynurenine pathway as a therapeutic target in cognitive and neurodegenerative disorders

(2013) Trevor W Stone et al.   BRITISH JOURNAL OF PHARMACOLOGY

Kynurenic acid, by targeting α7 nicotinic acetylcholine receptors, modulates extracellular GABA levels in the rat striatumin vivo

(2013) Sarah Beggiato et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Effects of blockade of α4β2 and α7 nicotinic acetylcholine receptors on cue-induced reinstatement of nicotine-seeking behaviour in rats

(2013) Xiu Liu   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

The causative role and therapeutic potential of the kynurenine pathway in neurodegenerative disease

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Reducing cannabinoid abuse and preventing relapse by enhancing endogenous brain levels of kynurenic acid

(2013) Zuzana Justinova et al.   NATURE NEUROSCIENCE

The reinstatement model of drug relapse: recent neurobiological findings, emerging research topics, and translational research

(2013) Jennifer M. Bossert et al.   PSYCHOPHARMACOLOGY

The co-occurring use and misuse of cannabis and tobacco: a review

(2012) Arpana Agrawal et al.   ADDICTION

Kynurenic acid: a metabolite with multiple actions and multiple targets in brain and periphery

(2012) Flavio Moroni et al.   JOURNAL OF NEURAL TRANSMISSION

Selective re-expression of β2 nicotinic acetylcholine receptor subunits in the ventral tegmental area of the mouse restores intravenous nicotine self-administration

(2012) María Juliana Orejarena et al.   NEUROPHARMACOLOGY

Alpha7 Nicotinic Acetylcholine Receptors Modulate Motivation to Self-Administer Nicotine: Implications for Smoking and Schizophrenia

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Blockade of Nicotine Reward and Reinstatement by Activation of Alpha-Type Peroxisome Proliferator-Activated Receptors

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Astrocyte-derived kynurenic acid modulates basal and evoked cortical acetylcholine release

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The Astrocyte-Derived α7 Nicotinic Receptor Antagonist Kynurenic Acid Controls Extracellular Glutamate Levels in the Prefrontal Cortex

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Second-by-second analysis of alpha 7 nicotine receptor regulation of glutamate release in the prefrontal cortex of awake rats

(2009) Åsa Konradsson-Geuken et al.   SYNAPSE

Long-term exposure to nicotine markedly reduces kynurenic acid in rat brain — In vitro and ex vivo evidence

(2009) Elżbieta Zielińska et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Pharmacology of Nicotine: Addiction, Smoking-Induced Disease, and Therapeutics

(2008) Neal L. Benowitz   Annual Review of Pharmacology and Toxicology

Nicotinic α7- or β2-containing receptor knockout: Effects on radial-arm maze learning and long-term nicotine consumption in mice

(2008) Edward D. Levin et al.   BEHAVIOURAL BRAIN RESEARCH

Differential Role of Nicotinic Acetylcholine Receptor Subunits in Physical and Affective Nicotine Withdrawal Signs

(2008) K. J. Jackson et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Inhibition of Anandamide Hydrolysis by Cyclohexyl Carbamic Acid 3'-Carbamoyl-3-yl Ester (URB597) Reverses Abuse-Related Behavioral and Neurochemical Effects of Nicotine in Rats

(2008) M. Scherma et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Specific inhibition of kynurenate synthesis enhances extracellular dopamine levels in the rodent striatum

(2008) L. Amori et al.   NEUROSCIENCE

Cocaine Serves as a Peripheral Interoceptive Conditioned Stimulus for Central Glutamate and Dopamine Release

(2008) Roy A. Wise et al.   PLoS One