NLRC3 Delays the Progression of AD in APP/PS1 Mice via Inhibiting PI3K Activation

NLRC3 inhibits PDGF‐induced PASMCs proliferation via PI3K‐mTOR pathway

(2020) Li‐huang Zha et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Magnolol Ameliorates Behavioral Impairments and Neuropathology in a Transgenic Mouse Model of Alzheimer’s Disease

(2020) Yan-Fang Xian et al.   Oxidative Medicine and Cellular Longevity

Inhibition of Stat3‐mediated astrogliosis ameliorates pathology in an Alzheimer's disease model

(2019) Nicole Reichenbach et al.   EMBO Molecular Medicine

NLRC3 inhibits MCT-induced pulmonary hypertension in rats via attenuating PI3K activation

(2019) Li-Huang Zha et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Exploiting microglial and peripheral immune cell crosstalk to treat Alzheimer’s disease

(2019) Dawling A. Dionisio-Santos et al.   Journal of Neuroinflammation

A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease

(2019) Sung Hoon Baik et al.   Cell Metabolism

Upregulation of the lncRNA MEG3 improves cognitive impairment, alleviates neuronal damage, and inhibits activation of astrocytes in hippocampus tissues in Alzheimer's disease through inactivating the PI3K/Akt signaling pathway

(2019) Jiping Yi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Nlrc3-like is required for microglia maintenance in zebrafish

(2019) Tienan Wang et al.   Journal of Genetics and Genomics

Classic Prescription, Kai-Xin-San, Ameliorates Alzheimer’s Disease as an Effective Multitarget Treatment: From Neurotransmitter to Protein Signaling Pathway

(2019) Sirui Guo et al.   Oxidative Medicine and Cellular Longevity

P2Y1 receptor blockade normalizes network dysfunction and cognition in an Alzheimer’s disease model

(2018) Nicole Reichenbach et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer’s disease

(2018) Joseph Park et al.   NATURE NEUROSCIENCE

Eriodictyol Attenuates LPS-Induced Neuroinflammation, Amyloidogenesis, and Cognitive Impairments via the Inhibition of NF-κB in Male C57BL/6J Mice and BV2 Microglial Cells

(2018) Pandi He et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Blood-derived plasminogen drives brain inflammation and plaque deposition in a mouse model of Alzheimer’s disease

(2018) Sarah K. Baker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Influence of microglia and astrocyte activation in the neuroinflammatory pathogenesis of Alzheimer’s disease: Rational insights for the therapeutic approaches

(2018) Mir Hilal Ahmad et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Astrocyte-derived lipocalin-2 mediates hippocampal damage and cognitive deficits in experimental models of vascular dementia

(2017) Jae-Hong Kim et al.   GLIA

NLRC3 protein inhibits inflammation by disrupting NALP3 inflammasome assembly via competition with the adaptor protein ASC for pro-caspase-1 binding

(2017) Elif Eren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of inflammatory molecules in the Alzheimer's disease progression and diagnosis

(2017) Eva Bagyinszky et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Caspase-3-dependent cleavage of Akt modulates tau phosphorylation via GSK3β kinase: implications for Alzheimer’s disease

(2017) J Chu et al.   MOLECULAR PSYCHIATRY

Immune responses against protozoan parasites: a focus on the emerging role of Nod-like receptors

(2016) Prajwal Gurung et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Effects of CX3CR1 and Fractalkine Chemokines in Amyloid Beta Clearance and p-Tau Accumulation in Alzheimer,s Disease (AD) Rodent Models: Is Fractalkine a Systemic Biomarker for AD?

(2016) José Joaquín Merino et al.   Current Alzheimer Research

Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease

(2016) H. Lian et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's disease

(2016) Philip Scheltens et al.   LANCET

Early onset Alzheimer's disease: many mountains to climb

(2016) Jules Morgan   LANCET NEUROLOGY

Neuroprotection Through Rapamycin-Induced Activation of Autophagy and PI3K/Akt1/mTOR/CREB Signaling Against Amyloid-β-Induced Oxidative Stress, Synaptic/Neurotransmission Dysfunction, and Neurodegeneration in Adult Rats

(2016) Abhishek Kumar Singh et al.   MOLECULAR NEUROBIOLOGY

NLRC3 is an inhibitory sensor of PI3K–mTOR pathways in cancer

(2016) Rajendra Karki et al.   NATURE

Network abnormalities and interneuron dysfunction in Alzheimer disease

(2016) Jorge J. Palop et al.   NATURE REVIEWS NEUROSCIENCE

Melatonin ameliorates amyloid beta-induced memory deficits, tau hyperphosphorylation and neurodegeneration via PI3/Akt/GSk3β pathway in the mouse hippocampus

(2015) Tahir Ali et al.   JOURNAL OF PINEAL RESEARCH

Overexpressed NLRC3 Acts as an Anti-Inflammatory Cytosolic Protein

(2014) Yetiş Gültekin et al.   Journal of Innate Immunity

The neglected co-star in the dementia drama: the putative roles of astrocytes in the pathogeneses of major neurocognitive disorders

(2014) W K Jo et al.   MOLECULAR PSYCHIATRY

An Anti-inflammatory NOD-like Receptor Is Required for Microglia Development

(2013) Celia E. Shiau et al.   Cell Reports

Microglial activation in Alzheimer's disease: an (R)-[11C]PK11195 positron emission tomography study

(2012) Alie Schuitemaker et al.   NEUROBIOLOGY OF AGING

Whether, when and how chronic inflammation increases the risk of developing late-onset Alzheimer's disease

(2012) Piet Eikelenboom et al.   Alzheimers Research & Therapy

Neuroprotective and neurotoxic properties of glial cells in the pathogenesis of Alzheimer's disease

(2008) D. Farfara et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE