Immune responses against protozoan parasites: a focus on the emerging role of Nod-like receptors

The Nlrp3 inflammasome, IL-1β, and neutrophil recruitment are required for susceptibility to a nonhealing strain of Leishmania major in C57BL/6 mice

(2016) Melanie Charmoy et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Contribution of inflammasome genetics in Plasmodium vivax malaria

(2016) Marina L.S. Santos et al.   INFECTION GENETICS AND EVOLUTION

Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling

(2015) Maayan Levy et al.   CELL

Innate immunity againstLeishmaniainfections

(2015) Prajwal Gurung et al.   CELLULAR MICROBIOLOGY

The NLRP12 Sensor Negatively Regulates Autoinflammatory Disease by Modulating Interleukin-4 Production in T Cells

(2015) John R. Lukens et al.   IMMUNITY

An NLRP3 inflammasome–triggered Th2-biased adaptive immune response promotes leishmaniasis

(2015) Prajwal Gurung et al.   JOURNAL OF CLINICAL INVESTIGATION

The receptor NLRP3 is a transcriptional regulator of TH2 differentiation

(2015) Mélanie Bruchard et al.   NATURE IMMUNOLOGY

CD8+ T cells in Trypanosoma cruzi infection

(2015) Rick L. Tarleton   Seminars in Immunopathology

PKC/ROS-Mediated NLRP3 Inflammasome Activation Is Attenuated by Leishmania Zinc-Metalloprotease during Infection

(2015) Marina Tiemi Shio et al.   PLoS Neglected Tropical Diseases

The NLRP3 Inflammasome Is a Pathogen Sensor for Invasive Entamoeba histolytica via Activation of α5β1 Integrin at the Macrophage-Amebae Intercellular Junction

(2015) Leanne Mortimer et al.   PLoS Pathogens

CD4 T-Cell Subsets in Malaria: TH1/TH2 Revisited

(2015) Damian Perez-Mazliah et al.   Frontiers in Immunology

Eosinophils and mast cells in leishmaniasis

(2014) Nilda E. Rodríguez et al.   IMMUNOLOGIC RESEARCH

Local Immune Response to Injection of Plasmodium Sporozoites into the Skin

(2014) L. Mac-Daniel et al.   JOURNAL OF IMMUNOLOGY

Nucleotide Oligomerization and Binding Domain 2-Dependent Dendritic Cell Activation Is Necessary for Innate Immunity and Optimal CD8+ T Cell Responses to Influenza A Virus Infection

(2014) C. Lupfer et al.   JOURNAL OF VIROLOGY

Toxoplasmosis – A Global Threat. Correlation of Latent Toxoplasmosis with Specific Disease Burden in a Set of 88 Countries

(2014) Jaroslav Flegr et al.   PLoS One

Dual Role for Inflammasome Sensors NLRP1 and NLRP3 in Murine Resistance to Toxoplasma gondii

(2014) G. Gorfu et al.   mBio

Malaria-Induced NLRP12/NLRP3-Dependent Caspase-1 Activation Mediates Inflammation and Hypersensitivity to Bacterial Superinfection

(2014) Marco A. Ataide et al.   PLoS Pathogens

NLRP1 Is an Inflammasome Sensor for Toxoplasma gondii

(2013) Sarah E. Ewald et al.   INFECTION AND IMMUNITY

Apoptosis-Associated Speck-like Protein Containing a Caspase Recruitment Domain Inflammasomes Mediate IL-1  Response and Host Resistance to Trypanosoma cruzi Infection

(2013) G. K. Silva et al.   JOURNAL OF IMMUNOLOGY

Gal-lectin-dependent contact activates the inflammasome by invasive Entamoeba histolytica

(2013) L Mortimer et al.   Mucosal Immunology

Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection

(2013) Gilad Doitsh et al.   NATURE

Malaria biology and disease pathogenesis: insights for new treatments

(2013) Louis H Miller et al.   NATURE MEDICINE

Inflammasome-derived IL-1β production induces nitric oxide–mediated resistance to Leishmania

(2013) Djalma S Lima-Junior et al.   NATURE MEDICINE

Human Innate Immunity to Toxoplasma gondii Is Mediated by Host Caspase-1 and ASC and Parasite GRA15

(2013) L. Gov et al.   mBio

NLRP3 Controls Trypanosoma cruzi Infection through a Caspase-1-Dependent IL-1R-Independent NO Production

(2013) Virginia M. Gonçalves et al.   PLoS Neglected Tropical Diseases

Different peripheral neuroendocrine responses to Trypanosoma cruzi infection in mice lacking adaptive immunity

(2012) Eduardo Roggero et al.   Annals of the New York Academy of Sciences

Epidemiology of and Diagnostic Strategies for Toxoplasmosis

(2012) F. Robert-Gangneux et al.   CLINICAL MICROBIOLOGY REVIEWS

TLR-mediated distinct IFN-γ/IL-10 pattern induces protective immunity against murine visceral leishmaniasis

(2012) Joydeep Paul et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The NLRP12 Inflammasome Recognizes Yersinia pestis

(2012) Gregory I. Vladimer et al.   IMMUNITY

NLRP12 Suppresses Colon Inflammation and Tumorigenesis through the Negative Regulation of Noncanonical NF-κB Signaling

(2012) Irving C. Allen et al.   IMMUNITY

Dendritic cells in Leishmania major infections: mechanisms of parasite uptake, cell activation and evidence for physiological relevance

(2012) Kordula Kautz-Neu et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens

(2012) Paras K. Anand et al.   NATURE

The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB

(2012) Monika Schneider et al.   NATURE IMMUNOLOGY

Leishmaniasis Worldwide and Global Estimates of Its Incidence

(2012) Jorge Alvar et al.   PLoS One

The dynamic interdependence of amebiasis, innate immunity, and undernutrition

(2012) Hans P. Verkerke et al.   Seminars in Immunopathology

TLR4 and NKT Cell Synergy in Immunotherapy against Visceral Leishmaniasis

(2012) Subir Karmakar et al.   PLoS Pathogens

The NOD-Like Receptor NLRP12 Attenuates Colon Inflammation and Tumorigenesis

(2011) Md. Hasan Zaki et al.   CANCER CELL

Intrinsic expression of Nod2 in CD4+ T lymphocytes is not necessary for the development of cell-mediated immunity and host resistance to Toxoplasma gondii

(2011) Braulia C. Caetano et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cell Death in the Maintenance and Abrogation of Tolerance: The Five Ws of Dying Cells

(2011) Thomas S. Griffith et al.   IMMUNITY

NLRX1 Negatively Regulates TLR-Induced NF-κB Signaling by Targeting TRAF6 and IKK

(2011) Xiaojun Xia et al.   IMMUNITY

NLRX1 Protein Attenuates Inflammatory Responses to Infection by Interfering with the RIG-I-MAVS and TRAF6-NF-κB Signaling Pathways

(2011) Irving C. Allen et al.   IMMUNITY

Caspase-1 Activation of Interleukin-1β (IL-1β) and IL-18 Is Dispensable for Induction of Experimental Cerebral Malaria

(2011) Maximilian Kordes et al.   INFECTION AND IMMUNITY

A Role for Leukocyte-Derived IL-1RA in DC Homeostasis Revealed by Increased Susceptibility of IL-1RA-Deficient Mice to Cutaneous Leishmaniasis

(2011) Kordula Kautz-Neu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Therapeutic blockade of PD-L1 and LAG-3 rapidly clears established blood-stage Plasmodium infection

(2011) Noah S Butler et al.   NATURE IMMUNOLOGY

The expression of REG 1A and REG 1B is increased during acute amebic colitis

(2011) Kristine M. Peterson et al.   PARASITOLOGY INTERNATIONAL

Epithelial Cell Apoptosis Facilitates Entamoeba histolytica Infection in the Gut

(2010) Stephen M. Becker et al.   AMERICAN JOURNAL OF PATHOLOGY

NLRC5 Negatively Regulates the NF-κB and Type I Interferon Signaling Pathways

(2010) Jun Cui et al.   CELL

IL-1 signalling is dispensable for protective immunity in Leishmania-resistant mice

(2010) Kordula Kautz-Neu et al.   EXPERIMENTAL DERMATOLOGY

The immunopathogenesis of Entamoeba histolytica

(2010) Leanne Mortimer et al.   EXPERIMENTAL PARASITOLOGY

NALP1 Influences Susceptibility to Human Congenital Toxoplasmosis, Proinflammatory Cytokine Response, and Fate ofToxoplasma gondii-Infected Monocytic Cells

(2010) William H. Witola et al.   INFECTION AND IMMUNITY

IL-1-induced inflammation promotes development of leishmaniasis in susceptible BALB/c mice

(2010) E. Voronov et al.   INTERNATIONAL IMMUNOLOGY

Chagas disease: changes in knowledge and management

(2010) François-Xavier Lescure et al.   LANCET INFECTIOUS DISEASES

NLR family member NLRC5 is a transcriptional regulator of MHC class I genes

(2010) T. B. Meissner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD4+ and CD8+ T cell- and IL-17-mediated protection against Entamoeba histolytica induced by a recombinant vaccine

(2010) Xiaoti Guo et al.   VACCINE

Muc2 Protects against Lethal Infectious Colitis by Disassociating Pathogenic and Commensal Bacteria from the Colonic Mucosa

(2010) Kirk S. B. Bergstrom et al.   PLoS Pathogens

Experimental cerebral malaria progresses independently of the Nlrp3 inflammasome

(2009) Thornik Reimer et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A retrospective evaluation of the role of T cells in the development of malaria vaccine

(2009) Moriya Tsuji   EXPERIMENTAL PARASITOLOGY

Protection against Intestinal Amebiasis by a Recombinant Vaccine Is Transferable by T Cells and Mediated by Gamma Interferon

(2009) X. Guo et al.   INFECTION AND IMMUNITY

Toxoplasmosis: A history of clinical observations

(2009) Louis M. Weiss et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Pure Hemozoin Is Inflammatory In Vivo and Activates the NALP3 Inflammasome via Release of Uric Acid

(2009) J. W. Griffith et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Nucleotide-Binding Oligomerization Domain 1-Dependent Responses Account for Murine Resistance against Trypanosoma cruzi Infection

(2009) G. K. Silva et al.   JOURNAL OF IMMUNOLOGY

Neutrophils and Macrophages Cooperate in Host Resistance against Leishmania braziliensis Infection

(2009) F. O. Novais et al.   JOURNAL OF IMMUNOLOGY

T cell–intrinsic role of Nod2 in promoting type 1 immunity to Toxoplasma gondii

(2009) Michael H Shaw et al.   NATURE IMMUNOLOGY

Malarial Hemozoin Is a Nalp3 Inflammasome Activating Danger Signal

(2009) Catherine Dostert et al.   PLoS One

Leishmania amazonensis promastigotes induce and are killed by neutrophil extracellular traps

(2009) A. B. Guimaraes-Costa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Perspectives on Trypanosoma cruzi–Induced Heart Disease (Chagas Disease)

(2009) Herbert B. Tanowitz et al.   PROGRESS IN CARDIOVASCULAR DISEASES

Natural Killer T Cells Activated by a Lipopeptidophosphoglycan from Entamoeba histolytica Are Critically Important To Control Amebic Liver Abscess

(2009) Hannelore Lotter et al.   PLoS Pathogens

Malarial Hemozoin Activates the NLRP3 Inflammasome through Lyn and Syk Kinases

(2009) Marina Tiemi Shio et al.   PLoS Pathogens

Host Cell Traversal Is Important for Progression of the Malaria Parasite through the Dermis to the Liver

(2008) Rogerio Amino et al.   Cell Host & Microbe

Interactions with apoptotic but not with necrotic neutrophils increase parasite burden in human macrophages infected with Leishmania amazonensis

(2008) Lilian Afonso et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Interleukin-18 enhances a Th2 biased response and susceptibility to Leishmania mexicana in BALB/c mice

(2008) Karen Jane Bryson et al.   MICROBES AND INFECTION

Persistence of Entamoeba histolytica infection in CBA mice owes to intestinal IL-4 production and inhibition of protective IFN-γ

(2008) X Guo et al.   Mucosal Immunology

In Vivo Imaging Reveals an Essential Role for Neutrophils in Leishmaniasis Transmitted by Sand Flies

(2008) N. C. Peters et al.   SCIENCE

The Neglected Tropical Diseases of Latin America and the Caribbean: A Review of Disease Burden and Distribution and a Roadmap for Control and Elimination

(2008) Peter J. Hotez et al.   PLoS Neglected Tropical Diseases

Haemozoin formation

(2007) Timothy J. Egan   MOLECULAR AND BIOCHEMICAL PARASITOLOGY