Article
Nutrition & Dietetics
Ningdong Pang, Chao Zhao, Jinyu Li, Lei Li, Xiaofei Yang, Minling Yang, Zhifeng Wu, Duiping Feng
Summary: This study showed that TIPS treatment can improve weight, BMI, and other parameters in individuals with cirrhotic portal hypertension, with no significant differences in the long term. Additionally, there is a dose-response association between pre-TIPS blood ammonia levels and increased post-TIPS BMI in men.
Review
Medicine, General & Internal
Ziyao Cheng, Jiayu Ju, Qingliang Zhu, Mingming Deng, Hailong Zhang
Summary: This case report discusses a patient with cirrhosis who developed intrahepatic hematoma and hepatic pseudoaneurysm due to hepatic artery injury after TIPSS. The report highlights the importance of paying attention to these complications and implementing early-stage prevention measures.
Review
Gastroenterology & Hepatology
Adelina Horhat, Christophe Bureau, Dominique Thabut, Marika Rudler
Summary: Transjugular intrahepatic portosystemic shunt is an effective treatment for liver cirrhosis and portal hypertension, but careful patient selection is crucial to prevent complications.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2021)
Article
Surgery
Pietro Addeo, Caroline Schaaf, Francois Faitot, Alfonso Terrone, Olivier Julliard, Camille Besch, Lawrence Serfaty, Philippe Bachellier
Summary: This systematic review examined the outcomes of liver transplantation with misplaced transjugular intrahepatic portosystemic shunt. It was found that in most cases, the misplaced shunt could be successfully removed with low mortality and good postoperative outcomes. However, some patients required additional surgical interventions postoperatively and certain complications were observed.
Article
Biophysics
Keli Yin, Xiaoze Wang, Tinghui Zheng
Summary: This study investigated the impact of stent position on post-TIPS hemodynamic performance using computational fluid dynamics. The results showed that placing the stent entry site closer to the portal vein bifurcation resulted in greater and more stable shunting blood flow. However, TIPS on the right branch of the portal vein may be associated with a higher risk of post-TIPS hepatic encephalopathy.
JOURNAL OF BIOMECHANICS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jiacheng Liu, Jinqiang Ma, Chongtu Yang, Manman Chen, Qin Shi, Chen Zhou, Songjiang Huang, Yang Chen, Yingliang Wang, Tongqiang Li, Bin Xiong
Summary: In this study, changes in skeletal muscle and fat mass in patients with cirrhosis after TIPS were evaluated, and it was found that muscle mass reduction was an important factor associated with mortality.
Review
Medicine, General & Internal
Ilaria de Felice, Lorenzo Ridola, Oliviero Riggio, Jessica Faccioli, Silvia Nardelli, Stefania Gioia
Summary: Malnutrition is a common complication of cirrhosis with portal hypertension, affecting muscle and adipose tissue, leading to the main complications of liver disease and increased mortality. Transjugular intrahepatic portosystemic shunt (TIPS) can improve nutritional status, especially in sarcopenic patients, improving cognitive impairment and increasing survival rate.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Huzheng Yan, Zhanwang Xiang, Chenghao Zhao, Shuyang Luo, Huan Liu, Mingan Li, Mingsheng Huang
Summary: This study proposed a strategy for creating a 6-mm TIPS and assessed its effectiveness compared to a conventional 8-mm shunt for TIPS-induced hepatic encephalopathy. The results showed that the 6-mm shunt significantly reduced the incidence of overt HE, protected perioperative liver function, and did not affect stent patency or rebleeding rate.
EUROPEAN RADIOLOGY
(2023)
Review
Medicine, General & Internal
Dario Saltini, Federica Indulti, Tomas Guasconi, Marcello Bianchini, Biagio Cuffari, Cristian Caporali, Federico Casari, Francesco Prampolini, Marco Senzolo, Antonio Colecchia, Filippo Schepis
Summary: This review outlines the progression of transjugular intrahepatic portosystemic shunt (TIPS) procedure and emphasizes the significant influence of advancements in stent technology on its effectiveness. The use of expanding polytetrafluoroethylene-covered stent grafts (ePTFE-SGs) has greatly improved patency rates and decreased complications compared to bare metal stents (BMSs). However, technical improvements alone are insufficient for optimizing patient outcomes, and a comprehensive understanding of hemodynamic, cardiac, and systemic factors is crucial.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Gastroenterology & Hepatology
Faisal Khan, Dhiraj Tripathi
Summary: Variceal bleeding is a serious complication of cirrhosis and portal hypertension, with the main treatment goal being the reduction of portal pressure. TIPSS is highly effective in this regard, but its use in refractory bleeding still carries high mortality rates.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Gastroenterology & Hepatology
Yong Lv, Daiming Fan, Guohong Han
Summary: Liver diseases, especially viral hepatitis, have a major impact in China and globally. Portal hypertension is the most severe complication of chronic liver diseases, and TIPS is an effective treatment for these complications. This review focuses on the history, current application, and management of TIPS complications in China.
LIVER INTERNATIONAL
(2023)
Article
Biology
Lingyu Jiang, Hao Han, Jian Yang, Runxin Fang, Ying Xin, Qiang Chen, Jing Yao, Zhiyong Li
Summary: This study investigated the effects of different stent insertion positions and diameters on the outcomes of TIPS surgery. The results showed that the stent insertion position had minimal impact on hemodynamic indexes and shunt effect. However, a larger diameter stent was found to improve the shunt effect compared to a smaller diameter one. Nevertheless, the higher risk of hepatic encephalopathy associated with the larger stent diameter suggested the use of a 6mm diameter stent.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Shi-Hua Luo, Mi-Mi Zhou, Ming-Jin Cai, Shao-Lei Han, Xue-Qiang Zhang, Jian-Guo Chu
Summary: This study compared the clinical outcomes and incidence of HE after one-third PSG reduction during TIPS. The results showed that reducing PSG by one third can lower the risk of HE, protect liver function, and achieve good clinical results.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Luisa Fuerschuss, Florian Rainer, Maria Effenberger, Markus Niederreiter, Rupert H. Portugaller, Angela Horvath, Peter Fickert, Vanessa Stadlbauer
Summary: This study aimed to develop a simple and reliable tool to accurately predict early post-TIPS mortality. A scoring system integrating urea, international normalized ratio (INR) and bilirubin was developed based on the retrospective analysis of 144 cases of TIPS implantation. The Modified TIPS-Score (MOTS) showed significant prognostic discrimination and accurate predictive performance in different patient subgroups.
LIVER INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Simone Anna Keimburg, Jens Theysohn, Matthias Buechter, Jassin Rashidi-Alavijeh, Katharina Willuweit, Hannah Schneider, Axel Wetter, Benjamin Maasoumy, Christian Lange, Heiner Wedemeyer, Antoaneta Angelova Markova
Summary: The study investigated the survival outcomes of liver cirrhosis patients after TIPS treatment, finding that the FIB-4 score can predict liver-related events, and that APRI and FIB-4 scores are associated with survival.
Article
Nutrition & Dietetics
Katherine L. Ford, Claire F. Trottier, Wendy V. Wismer, Michael B. Sawyer, Mario Siervo, Nicolaas E. P. Deutz, Carla M. Prado, Helen Vallianatos
Summary: This qualitative study explored the dietary decisions made by patients with colorectal cancer (CRC) starting chemotherapy. The results showed that patients' dietary choices were influenced by medical factors, health beliefs, fixed diets, and external influences. Understanding these factors can guide healthcare providers in providing tailored dietary support for CRC patients.
JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS
(2023)
Article
Geriatrics & Gerontology
Wayne W. Campbell, Nicolaas E. P. Deutz, Elena Volpi, Caroline M. Apovian
Summary: This narrative review discusses the impact of dietary protein intake on muscle-related attributes of older adults. Insufficient protein intake exacerbates age-related reductions in muscle size, quality, and function. Adequate protein intake promotes muscle size and function, with observational studies suggesting higher protein intake may enhance muscle strength and function. Higher protein intake benefits lean body mass changes under stress conditions. Specialized protein supplements can help attenuate muscle loss in older adults with medical conditions or acute illness. Animal protein sources are preferred for sarcopenia-related parameters. The quantity, quality, and patterning of dietary protein intake are important for supporting muscle size and function in older adults.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Immunology
Min Deng, Merel R. Aberle, Annemarie A. J. H. M. van Bijnen, Gregory van der Kroft, Kaatje Lenaerts, Ulf P. Neumann, Georg Wiltberger, Frank G. Schaap, Steven W. M. Olde Damink, Sander S. Rensen
Summary: This study found that high levels of lipocalin-2 are associated with neutrophil activation in patients with pancreatic cancer cachexia and may contribute to their poor nutritional status.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Health Care Sciences & Services
Nicole Hildebrand, Allard G. Wijma, Bart C. Bongers, Sander S. Rensen, Marcel den Dulk, Joost M. Klaase, Steven W. M. Olde Damink
Summary: The study aims to assess the feasibility of a home-based exercise prehabilitation program in unfit patients scheduled for pancreatic surgery. The program includes high-intensity interval training and functional task exercises to improve patients' aerobic capacity and muscle function, leading to better treatment outcomes and quality of life. The results of this study may have important implications for implementing prehabilitation programs in complex abdominal surgeries such as pancreatic surgery.
JMIR RESEARCH PROTOCOLS
(2023)
Editorial Material
Nutrition & Dietetics
Nathalie Delzenne, Nicolaas E. Deutz, Dileep N. Lobo, George Grimble
Summary: In this education paper, advice is given on successful scientific grant writing. The paper emphasizes the importance of defining research hypothesis, fulfilling technical aspects, and understanding the requirements before writing the proposal. It also highlights the need to develop a timeline, create an attractive summary, and set SMART research objectives. Additionally, the paper emphasizes the importance of making the proposal understandable to non-experts while providing sufficient details for experts.
CLINICAL NUTRITION ESPEN
(2023)
Article
Oncology
Roos G. F. M. van der Ven, Daan N. Westra, Felice H. van Erning, Ignace de Hingh, Steven W. M. Olde Damink, Agnes Paulus, Wouter K. G. Leclercq, Marcel den Dulk, OncoZON Consortium
Summary: This study examines whether inequalities in the utilization of resection and/or ablation for synchronous colorectal liver metastases (SCLM) between expert and non-expert hospitals changed since the implementation of a multi-hospital network. The findings show that despite the establishment of the network, patients diagnosed in expert hospitals were more likely to receive specialized treatment than those diagnosed in non-expert hospitals, and this disparity increased over time.
Article
Critical Care Medicine
Michelle R. Baggerman, Ingeborg M. Dekker, Bjorn Winkens, Steven W. M. Olde Damink, Sandra N. Stapel, Peter J. M. Weijs, Marcel C. G. van de Poll
Summary: This study investigated the association between visceral obesity, BMI and 90-day mortality in critically ill patients. The results showed no significant association between visceral obesity and BMI with 90-day mortality, although obesity and visceral obesity tended to be associated with improved 90-day mortality.
JOURNAL OF CRITICAL CARE
(2023)
Article
Nutrition & Dietetics
Soumia Majait, Emma C. E. Meessen, Frederic Maxime Vaz, E. Marleen Kemper, Samuel van Nierop, Steven W. Olde Damink, Frank G. Schaap, Johannes A. Romijn, Max Nieuwdorp, Aad Verrips, Filip Krag Knop, Maarten R. Soeters
Summary: This study examined the plasma profiles of bile acids, glucose, insulin, GLP-1, and FGF19 in CTX patients and healthy controls. The results showed that CTX patients had lower levels of bile acids and FGF19, abnormal postprandial glucose and insulin profiles, and elevated postprandial GLP-1 responses.
Article
Medicine, General & Internal
Annet A. M. Duivenvoorden, Mathias Clarysse, Laurens J. Ceulemans, Robert H. Geelkerken, Joep P. M. Derikx, Jean-Paul P. M. de Vries, Hessel C. J. L. Buscher, Steven W. M. Olde Damink, Frederik Jan van Schooten, Tim Lubbers, Kaatje Lenaerts
Summary: This study aims to validate a panel of plasma biomarkers and investigate volatile organic compound (VOC) profiles in exhaled air as a tool to timely and accurately diagnose Acute Mesenteric Ischaemia (AMI). 120 patients with clinical suspicion of AMI will be recruited, and their plasma levels and VOCs in exhaled air will be assessed. The diagnosis of AMI will be based on CT, endovascular and surgical reports, clinical findings, and verified by histopathological examination if applicable.
Article
Immunology
Nicky A. Beelen, Merel R. Aberle, Virginia Bruno, Steven W. M. Olde Damink, Gerard M. J. Bos, Sander S. Rensen, Lotte Wieten
Summary: This study evaluated the cytotoxic potential of adoptive NK cells against pancreatic cancer organoids and found that ADCC-inducing antibodies can enhance NK cell anti-tumor responses.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Nutrition & Dietetics
Nicolaas E. Deutz, Nathalie Delzenne, George Grimble, Dileep N. Lobo
Summary: Publishing a scientific paper is a challenging process that depends on the quality of study design, research questions, clear primary endpoints, and data from a large population. Before submission, it is important to meet ethical requirements, register in public databases, and declare any conflicts of interest. The structure of the manuscript includes sections for introduction, materials and methods, results, discussion, and an abstract that summarizes all aspects concisely. The publication process involves editors, reviewers, and publishers, with the initial impression being crucial for review. Thoughtful responses to reviewers' feedback are necessary for revisions. The goal is acceptance and publication of the paper.
CLINICAL NUTRITION ESPEN
(2023)
Article
Nutrition & Dietetics
George Grimble, Dileep N. Lobo, Nathalie Delzenne, Nicolaas E. Deutz
Summary: When presenting a paper, it is important to tailor your presentation to the audience's knowledge level and the title and abstract you submitted. Keep the talk simple and avoid complexity. Stick to the scheduled time and present the information in a concise manner. Make sure your slides are clear and informative, readable from a distance. Practice the talk beforehand, preferably with colleagues, and be prepared to make any necessary changes. Familiarize yourself with the content so you can relax and enjoy the experience.
CLINICAL NUTRITION ESPEN
(2023)
Article
Surgery
Iakovos Amygdalos, Lea Hitpass, Felix Schmidt, Gerrit Josephs, Jan Bednarsch, Marie-Luise Berres, Tom Luedde, Steven W. M. Olde Damink, Tom Florian Ulmer, Ulf P. Neumann, Philipp Bruners, Sven Arke Lang
Summary: This study examines the efficacy of liver resection combined with local ablative therapy compared to liver resection only, in the treatment of patients with = 4 colorectal liver metastases (CRLM). The results show that combined resection-ablation is a viable option for patients with = 4 CRLM in terms of overall survival (OS) and recurrence-free survival (RFS).
LANGENBECKS ARCHIVES OF SURGERY
(2023)
Article
Surgery
Xinwei Chang, Remon Korenblik, Bram Olij, Robrecht R. M. M. Knapen, Christiaan van der Leij, Daniel Heise, Marcel den Dulk, Ulf P. Neumann, Frank G. Schaap, Ronald M. van Dam, Steven W. M. Olde Damink
Summary: The study aimed to investigate the impact of cholestasis on portal vein embolization-induced hypertrophy of the future liver remnant (FLR). In a pre-clinical setting, it was found that hepatocellular bile salt accumulation did not affect FLR hypertrophy induced by PVE.
LANGENBECKS ARCHIVES OF SURGERY
(2023)
Article
Oncology
Pierre-Maxence Vaysse, Mari F. C. M. van den Hout, Sanne M. E. Engelen, Kristien B. M. I. Keymeulen, Marc H. A. Bemelmans, Ron M. A. Heeren, Steven W. M. Olde Damink, Tiffany Porta Siegel
Summary: Lipid profiling by REIMS can accurately discriminate and identify different soft tissue sarcomas from normal tissues, providing a potential asset to improve surgical resection of soft tissue sarcomas in the future.
JOURNAL OF SURGICAL ONCOLOGY
(2023)