Manganese Accumulation in the Brain via Various Transporters and Its Neurotoxicity Mechanisms

The transcription factor REST up-regulates tyrosine hydroxylase and antiapoptotic genes and protects dopaminergic neurons against manganese toxicity

(2020) Edward Pajarillo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Localization of ZIP14 and ZIP8 in HIBCPP Cells

(2020) Shannon E. Morgan et al.   Brain Sciences

Manganese increases Aβ and Tau protein levels through proteasome 20S and heat shock proteins 90 and 70 alteration, leading to SN56 cholinergic cell death following single and repeated treatment

(2020) Paula Moyano et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Astrocyte-specific deletion of the transcription factor Yin Yang 1 in murine substantia nigra mitigates manganese-induced dopaminergic neurotoxicity

(2020) Edward Pajarillo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alpha-synuclein is involved in manganese-induced spatial memory and synaptic plasticity impairments via TrkB/Akt/Fyn-mediated phosphorylation of NMDA receptors

(2020) Zhuo Ma et al.   Cell Death & Disease

Mitochondrial Dysfunction, Oxidative Stress and Neuroinflammation in Neurodegeneration with Brain Iron Accumulation (NBIA)

(2020) Isabel Hinarejos et al.   Antioxidants

LRRK2 kinase plays a critical role in manganese-induced inflammation and apoptosis in microglia

(2019) Judong Kim et al.   PLoS One

Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein

(2019) Dilshan S. Harischandra et al.   Science Signaling

Mn-Induced Neurocytes Injury and Autophagy Dysfunction in Alpha-Synuclein Wild-Type and Knock-Out Mice: Highlighting the Role of Alpha-Synuclein

(2019) Dong-Ying Yan et al.   NEUROTOXICITY RESEARCH

Loss of nuclear REST/NRSF in aged-dopaminergic neurons in Parkinson’s disease patients

(2019) Miwako Kawamura et al.   NEUROSCIENCE LETTERS

Manganese Uptake by A549 Cells is Mediated by Both ZIP8 and ZIP14

(2019) Ivo F. Scheiber et al.   Nutrients

Manganese-Induced Neurotoxicity: New Insights Into the Triad of Protein Misfolding, Mitochondrial Impairment, and Neuroinflammation

(2019) Dilshan S. Harischandra et al.   Frontiers in Neuroscience

The solute carriers ZIP8 and ZIP14 regulate manganese accumulation in brain microvascular endothelial cells and control brain manganese levels

(2019) Brittany L. Steimle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Manganese metabolism in humans

(2018) Pan Chen   Frontiers in Bioscience-Landmark

17β-estradiol and tamoxifen protect mice from manganese-induced dopaminergic neurotoxicity

(2018) Edward Pajarillo et al.   NEUROTOXICOLOGY

Environmental neurotoxicant manganese regulates exosome-mediated extracellular miRNAs in cell culture model of Parkinson's disease: Relevance to α-synuclein misfolding in metal neurotoxicity

(2018) Dilshan S. Harischandra et al.   NEUROTOXICOLOGY

Valproic acid attenuates manganese-induced reduction in expression of GLT-1 and GLAST with concomitant changes in murine dopaminergic neurotoxicity

(2018) James Johnson et al.   NEUROTOXICOLOGY

Hypermanganesemia due to mutations in SLC39A14: further insights into Mn deposition in the central nervous system

(2018) L. Marti-Sanchez et al.   Orphanet Journal of Rare Diseases

SLC39A14 deficiency alters manganese homeostasis and excretion resulting in brain manganese accumulation and motor deficits in mice

(2018) Supak Jenkitkasemwong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A role for divalent metal transporter (DMT1) in mitochondrial uptake of iron and manganese

(2018) Natascha A. Wolff  et al.   Scientific Reports

Ferroportin disease mutations influence manganese accumulation and cytotoxicity

(2018) Eun-Kyung Choi et al.   FASEB JOURNAL

High Manganese, A Risk for Alzheimer's Disease: High Manganese Induces Amyloid-β Related Cognitive Impairment

(2018) Yawei Tong et al.   JOURNAL OF ALZHEIMERS DISEASE

SLC30A10 transporter in the digestive system regulates brain manganese under basal conditions while brain SLC30A10 protects against neurotoxicity

(2018) Cherish A. Taylor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The effect of postnatal manganese exposure on the NMDA receptor signaling pathway in rat hippocampus

(2017) Lei Wang et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Direct Comparison of Manganese Detoxification/Efflux Proteins and Molecular Characterization of ZnT10 Protein as a Manganese Transporter

(2016) Yukina Nishito et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Melatonin Attenuates Manganese and Lipopolysaccharide-Induced Inflammatory Activation of BV2 Microglia

(2016) Euteum Park et al.   NEUROCHEMICAL RESEARCH

Developmental manganese exposure in combination with developmental stress and iron deficiency: Effects on behavior and monoamines

(2016) Robyn M. Amos-Kroohs et al.   NEUROTOXICOLOGY AND TERATOLOGY

Mutations in SLC39A14 disrupt manganese homeostasis and cause childhood-onset parkinsonism–dystonia

(2016) Karin Tuschl et al.   Nature Communications

“Manganese-induced neurotoxicity: a review of its behavioral consequences and neuroprotective strategies”

(2016) Tanara V. Peres et al.   BMC Pharmacology & Toxicology

SLC39A8 Deficiency: A Disorder of Manganese Transport and Glycosylation

(2015) Julien H. Park et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Influence of ZIP14 (slc39A14) on intestinal zinc processing and barrier function

(2015) Gregory J. Guthrie et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Targeted mutagenesis of aryl hydrocarbon receptor 2a and 2b genes in Atlantic killifish (Fundulus heteroclitus)

(2015) Neelakanteswar Aluru et al.   AQUATIC TOXICOLOGY

N-acetylcysteineamide protects against manganese-induced toxicity in SHSY5Y cell line

(2015) Yasaswi Maddirala et al.   BRAIN RESEARCH

Genome-wide association study of toxic metals and trace elements reveals novel associations

(2015) Esther Ng et al.   HUMAN MOLECULAR GENETICS

Transcriptional Regulation of the Astrocytic Excitatory Amino Acid Transporter 1 (EAAT1) via NF-κB and Yin Yang 1 (YY1)

(2015) Pratap Karki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Manganese homeostasis in the nervous system

(2015) Pan Chen et al.   JOURNAL OF NEUROCHEMISTRY

Identification of dopaminergic neurons of the substantia nigra pars compacta as a target of manganese accumulation

(2015) Gregory Robison et al.   Metallomics

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Elevated Adult Neurogenesis in Brain Subventricular Zone Following In vivo Manganese Exposure: Roles of Copper and DMT1

(2015) Sherleen Fu et al.   TOXICOLOGICAL SCIENCES

Mitochondria represent another locale for the divalent metal transporter 1 (DMT1)

(2014) Natascha A Wolff et al.   Channels

Evidence for mitochondrial localization of divalent metal transporter 1 (DMT1)

(2014) Natascha A. Wolff et al.   FASEB JOURNAL

SLC30A10 Is a Cell Surface-Localized Manganese Efflux Transporter, and Parkinsonism-Causing Mutations Block Its Intracellular Trafficking and Efflux Activity

(2014) D. Leyva-Illades et al.   JOURNAL OF NEUROSCIENCE

Environmental manganese compounds accumulate as Mn(ii) within the Golgi apparatus of dopamine cells: relationship between speciation, subcellular distribution, and cytotoxicity

(2014) Asuncion Carmona et al.   Metallomics

Yin Yang 1 Is a Repressor of Glutamate Transporter EAAT2, and It Mediates Manganese-Induced Decrease of EAAT2 Expression in Astrocytes

(2014) P. Karki et al.   MOLECULAR AND CELLULAR BIOLOGY

REST and stress resistance in ageing and Alzheimer’s disease

(2014) Tao Lu et al.   NATURE

Vulnerability of welders to manganese exposure – A neuroimaging study

(2014) Zaiyang Long et al.   NEUROTOXICOLOGY

α-Synuclein Protects Against Manganese Neurotoxic Insult During the Early Stages of Exposure in a Dopaminergic Cell Model of Parkinson’s Disease

(2014) Dilshan S. Harischandra et al.   TOXICOLOGICAL SCIENCES

Cellular manganese content is developmentally regulated in human dopaminergic neurons

(2014) Kevin K. Kumar et al.   Scientific Reports

Manganese-exposed developing rats display motor deficits and striatal oxidative stress that are reversed by Trolox

(2013) Fabiano M. Cordova et al.   ARCHIVES OF TOXICOLOGY

The effects of pdr1, djr1.1 and pink1 loss in manganese-induced toxicity and the role of α-synuclein in C. elegans

(2013) Julia Bornhorst et al.   Metallomics

The effect of manganese on dopamine toxicity and dopamine transporter (DAT) in control and DAT transfected HEK cells

(2013) Jerome A. Roth et al.   NEUROTOXICOLOGY

Oxidative stress involvement in manganese-induced alpha-synuclein oligomerization in organotypic brain slice cultures

(2013) Bin Xu et al.   TOXICOLOGY

Manganese-induced oxidative DNA damage in neuronal SH-SY5Y cells: Attenuation of thymine base lesions by glutathione and N-acetylcysteine

(2013) Adrienne P. Stephenson et al.   TOXICOLOGY LETTERS

Role of astrocytes in manganese mediated neurotoxicity

(2013) Marta Sidoryk-Wegrzynowicz et al.   BMC Pharmacology & Toxicology

Mutations in SLC30A10 Cause Parkinsonism and Dystonia with Hypermanganesemia, Polycythemia, and Chronic Liver Disease

(2012) Marialuisa Quadri et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Syndrome of Hepatic Cirrhosis, Dystonia, Polycythemia, and Hypermanganesemia Caused by Mutations in SLC30A10 , a Manganese Transporter in Man

(2012) Karin Tuschl et al.   AMERICAN JOURNAL OF HUMAN GENETICS

ZIP8 Is an Iron and Zinc Transporter Whose Cell-surface Expression Is Up-regulated by Cellular Iron Loading

(2012) Chia-Yu Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

X-ray fluorescence analysis of iron and manganese distribution in primary dopaminergic neurons

(2012) Tanja Dučić et al.   JOURNAL OF NEUROCHEMISTRY

Characterization of cellular protective effects of ATP13A2/PARK9 expression and alterations resulting from pathogenic mutants

(2012) Jason P. Covy et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Manganese transport via the transferrin mechanism

(2012) Thomas E. Gunter et al.   NEUROTOXICOLOGY

Manganese exposure induces α-synuclein aggregation in the frontal cortex of non-human primates

(2012) Tatyana Verina et al.   TOXICOLOGY LETTERS

Role of glial cells in manganese neurotoxicity

(2011) Nikolay M. Filipov et al.   JOURNAL OF APPLIED TOXICOLOGY

Regulation of Intracellular Manganese Homeostasis by Kufor-Rakeb Syndrome-associated ATP13A2 Protein

(2011) Jieqiong Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Altered striatal dopamine release following a sub-acute exposure to manganese

(2011) Madiha Khalid et al.   JOURNAL OF NEUROSCIENCE METHODS

Role of manganese in neurodegenerative diseases

(2011) Aaron B. Bowman et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

High sensitivity of RBL-2H3 cells to cadmium and manganese: an implication of the role of ZIP8

(2011) Hitomi Fujishiro et al.   Metallomics

DMT1 polymorphism and risk of Parkinson’s disease

(2011) Qing He et al.   NEUROSCIENCE LETTERS

Manganese potentiates LPS-induced heme-oxygenase 1 in microglia but not dopaminergic cells: Role in controlling microglial hydrogen peroxide and inflammatory cytokine output

(2011) Celia A. Dodd et al.   NEUROTOXICOLOGY

Gene Deletion of nos2 Protects Against Manganese-Induced Neurological Dysfunction in Juvenile Mice

(2011) Karin M. Streifel et al.   TOXICOLOGICAL SCIENCES

Manganese-Induced NF-κB Activation and Nitrosative Stress Is Decreased by Estrogen in Juvenile Mice

(2011) Julie A. Moreno et al.   TOXICOLOGICAL SCIENCES

The inhibitory effect of manganese on acetylcholinesterase activity enhances oxidative stress and neuroinflammation in the rat brain

(2011) Dinamene Santos et al.   TOXICOLOGY

Protective effects of antioxidants and anti-inflammatory agents against manganese-induced oxidative damage and neuronal injury

(2011) Dejan Milatovic et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Effects of manganese on tyrosine hydroxylase (TH) activity and TH-phosphorylation in a dopaminergic neural cell line

(2011) Danhui Zhang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

α-Synuclein overexpression enhances manganese-induced neurotoxicity through the NF-κB-mediated pathway

(2011) Krishnan Prabhakaran et al.   TOXICOLOGY MECHANISMS AND METHODS

Manganese induces the overexpression of α-synuclein in PC12 cells via ERK activation

(2010) Tongjian Cai et al.   BRAIN RESEARCH

In Vivo Measurement of Brain GABA Concentrations by Magnetic Resonance Spectroscopy in Smelters Occupationally Exposed to Manganese

(2010) Ulrike Dydak et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Manganese modulation of MAPK pathways: effects on upstream mitogen activated protein kinase kinases and mitogen activated kinase phosphatase-1 in microglial cells

(2010) Patrick L. Crittenden et al.   JOURNAL OF APPLIED TOXICOLOGY

APLP1, Alzheimer's-like pathology and neurodegeneration in the frontal cortex of manganese-exposed non-human primates

(2010) Tomás R. Guilarte   NEUROTOXICOLOGY

Manganese Induces Tau Hyperphosphorylation through the Activation of ERK MAPK Pathway in PC12 Cells

(2010) Tongjian Cai et al.   TOXICOLOGICAL SCIENCES

Extracellular Dopamine Potentiates Mn-Induced Oxidative Stress, Lifespan Reduction, and Dopaminergic Neurodegeneration in a BLI-3–Dependent Manner in Caenorhabditis elegans

(2010) Alexandre Benedetto et al.   PLoS Genetics

α-Synuclein overexpression during manganese-induced apoptosis in SH-SY5Y neuroblastoma cells

(2009) Yan Li et al.   BRAIN RESEARCH BULLETIN

Manganese induces sustained Ser40 phosphorylation and activation of tyrosine hydroxylase in PC12 cells

(2009) Thaís Posser et al.   JOURNAL OF NEUROCHEMISTRY

Ferroportin is a manganese-responsive protein that decreases manganese cytotoxicity and accumulation

(2009) Zhaobao Yin et al.   JOURNAL OF NEUROCHEMISTRY

Synergistic dopaminergic neurotoxicity of manganese and lipopolysaccharide: differential involvement of microglia and astroglia

(2009) Ping Zhang et al.   JOURNAL OF NEUROCHEMISTRY

Silencing the SPCA1 (Secretory Pathway Ca2+-ATPase Isoform 1) Impairs Ca2+ Homeostasis in the Golgi and Disturbs Neural Polarity

(2009) M. R. Sepulveda et al.   JOURNAL OF NEUROSCIENCE

Parkinson's disease

(2009) Andrew J Lees et al.   LANCET

Two Rabs for exosome release

(2009) Suzanne R. Pfeffer   NATURE CELL BIOLOGY

α-Synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity

(2009) Aaron D Gitler et al.   NATURE GENETICS

Manganese Flux Across the Blood–Brain Barrier

(2009) Robert A. Yokel   NEUROMOLECULAR MEDICINE

Levels of reduced and oxidized coenzymeQ-10 and 8-hydroxy-2′-deoxyguanosine in the cerebrospinal fluid of patients with living Parkinson's disease demonstrate that mitochondrial oxidative damage and/or oxidative DNA damage contributes to the neurodegenerative process

(2009) Chiaki Isobe et al.   NEUROSCIENCE LETTERS

Developmental Exposure to Manganese Increases Adult Susceptibility to Inflammatory Activation of Glia and Neuronal Protein Nitration

(2009) Julie A. Moreno et al.   TOXICOLOGICAL SCIENCES

Oxidative damage and neurodegeneration in manganese-induced neurotoxicity

(2009) Dejan Milatovic et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Speciation analysis of selected metals and determination of their total contents in paired serum and cerebrospinal fluid samples: An approach to investigate the permeability of the human blood-cerebrospinal fluid-barrier

(2008) Volker Nischwitz et al.   ANALYTICA CHIMICA ACTA

Manganese Neurotoxicity: Lessons Learned from Longitudinal Studies in Nonhuman Primates

(2008) Neal C. Burton et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

The overlapping roles of manganese and Cu/Zn SOD in oxidative stress protection

(2008) Amit R. Reddi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hepatic cirrhosis, dystonia, polycythaemia and hypermanganesaemia—A new metabolic disorder

(2008) Karin Tuschl et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Increased APLP1 expression and neurodegeneration in the frontal cortex of manganese-exposed non-human primates

(2008) Tomás R. Guilarte et al.   JOURNAL OF NEUROCHEMISTRY

Manganese potentiates nuclear factor‐κB‐dependent expression of nitric oxide synthase 2 in astrocytes by activating soluble guanylate cyclase and extracellular responsive kinase signaling pathways

(2008) Julie A. Moreno et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Slc39a14 Gene Encodes ZIP14, A Metal/Bicarbonate Symporter: Similarities to the ZIP8 Transporter

(2008) K. Girijashanker et al.   MOLECULAR PHARMACOLOGY

Manganese exposure alters extracellular GABA, GABA receptor and transporter protein and mRNA levels in the developing rat brain

(2008) Joel G. Anderson et al.   NEUROTOXICOLOGY

Manganese accumulates primarily in nuclei of cultured brain cells

(2008) Kiran Kalia et al.   NEUROTOXICOLOGY

Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease

(2008) J. Salazar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA