Article
Biochemistry & Molecular Biology
Derrick R. Samuelson, Deandra R. Smith, Kelly C. Cunningham, Todd A. Wyatt, Sannette C. Hall, Daryl J. Murry, Yashpal S. Chhonker, Daren L. Knoell
Summary: Pneumococcal pneumonia is a major cause of disease and death worldwide, with compromised immune function and an insufficient dietary intake of zinc increasing the risk. This study reveals the critical role of the zinc transporter ZIP8 in host defense and the adverse impact of a common defective ZIP8 allele on the gut microbiota essential for lung immunity. Loss of ZIP8 function leads to intestinal dysbiosis and impaired host defense in the lung, highlighting the need for further investigation and improved surveillance and treatment strategies given the high incidence of dietary zinc deficiency and the ZIP8 variant allele in the human population.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Hezhongrong Nie, Qingquan Xiong, Guanghui Lan, Chunli Song, Xiaohong Yu, Lei Chen, Daming Wang, Tingyu Ren, Zeyan Chen, Xintong Liu, Yiwen Zhou
Summary: Emerging evidence suggests that atherosclerosis is a chronic inflammatory disease and immune cells play critical roles in vascular inflammation and plaque formation. Gastrointestinal disorder is considered a risk factor in mediating the atherosclerotic process. This study demonstrates the pharmacological benefits of sivelestat in protecting against atherosclerosis and the important role of intestinal homeostasis in atherosclerotic development.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Microbiology
Derrick R. Samuelson, Deandra R. Smith, Kelly C. Cunningham, Sabah Haq, Daniel N. Villageliu, Christi M. Ellis, Niaz Bahar Chowdhury, Amanda E. Ramer-Tait, Jeffrey D. Price, Daren L. Knoell
Summary: Intestinal dysbiosis increases susceptibility to infection due to metabolic profile changes, resulting in increased morbidity. The study found that ZIP8, a type of zinc transporter, is important for myeloid cells in maintaining host defense against bacterial pneumonia. Furthermore, a common variant of ZIP8 is closely associated with inflammation-based disorders and bacterial infection. The researchers developed a new model to study the effects of ZIP8-mediated intestinal dysbiosis on pulmonary host defense, independent of genetic factors. The results showed that the intestinal microbiota, regardless of host genetics, play a crucial role in regulating host defense in the lung against infection. These findings support future microbiome-based intervention studies, considering the high prevalence of zinc deficiency and the rs13107325 allele in humans.
Article
Nutrition & Dietetics
Samuel Blake Mitchell, Yu-Han Hung, Trista Lee Thorn, Jiaqi Zou, Filiz Baser, Sukru Gulec, Celeste Cheung, Tolunay Beker Aydemir
Summary: This study aims to investigate the impact of high sucrose consumption on zinc homeostasis and intestinal permeability, and its correlation with the development of chronic diseases.
FRONTIERS IN NUTRITION
(2023)
Article
Multidisciplinary Sciences
Zhongwei Zhao, Manqing Sun, Xinmu Cui, Jiaxin Chen, Chunhong Liu, Xuewu Zhang
Summary: Bacillus coagulans MZY531 has a protective effect on intestinal mucosal injury in immunosuppressed mice induced by cyclophosphamide. It promotes the expression of immune proteins, regulates intestinal inflammation and cellular repair. Furthermore, it can modulate the gut microbiota by increasing the abundance of beneficial bacteria. In conclusion, B. coagulans MZY531 has potential immunomodulatory activity.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Yan Wan, Bingkun Zhang
Summary: Zinc plays a crucial role in maintaining the normal functions of cells and organisms, as well as the structure and function of the intestinal mucosal barrier. Zinc excess or deficiency, and zinc homeostatic imbalance are associated with intestinal diseases.
Review
Cell Biology
Derrick R. Samuelson, Sabah Haq, Daren L. Knoell
Summary: Manganese and zinc are essential micronutrients that play a crucial role in regulating host immune response against infections. The metal transporter ZIP8 plays a key role in metal uptake and affects host defense mechanisms. Perturbations in metal homeostasis may impact the composition of bacterial communities in the host. Therefore, understanding the importance of zinc and manganese uptake is important for the development of intervention strategies against infectious diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Endocrinology & Metabolism
Lucas Massier, Matthias Blueher, Peter Kovacs, Rima M. Chakaroun
Summary: The intact intestinal barrier is crucial for maintaining health, and bacteria along with their products are shown to contribute to its impairment. Alterations in tight junction integrity can lead to increased influx of bacteria into the host circulation, potentially contributing to metabolic diseases like obesity and insulin resistance.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Nutrition & Dietetics
Noah Joseph Murr, Tyler B. Olender, Margaret R. Smith, Amari S. Smith, Jennifer Pilotos, Lyndsay B. Richard, Chishimba Nathan Mowa, Michael Makokha Opata
Summary: The study revealed that moderately malnourished mice infected with malaria had lower parasite burden at the peak of infection, but showed damaged mucosal epithelial cells, increased intestinal permeability, shortened small intestine, and decreased number of innate immune cells in the large intestine. Despite lower numbers, macrophages in the moderately malnourished mice were highly activated in the small intestine, indicating exacerbation of some abnormalities in the gut induced by the moderate malnutrition.
Article
Biochemistry & Molecular Biology
Evy Goossens, Jianhui Li, Chana Callens, Nathalie Van Rysselberghe, Hannele Kettunen, Juhani Vuorenmaa, Natalia Garcia Gonzalez, Claude Libert, Richard Ducatelle, Filip Van Immerseel
Summary: The acute stage of SIRS induces dysbiosis of the small intestinal and respiratory microbiome, which are associated with systemic inflammation and organ failure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Physical
Wenshuai Hao, Ruitao Cha, Mingzheng Wang, Pai Zhang, Xingyu Jiang
Summary: This review comprehensively discusses the impact of typical nanomaterials on the intestinal mucosal barrier (IMB) and summarizes the treatment of intestinal diseases by using nanomaterials. Factors such as dosage, size, morphology, and surface functional groups of nanomaterials influence the effects on the IMB. There is huge potential for nanomaterials to regulate the IMB and achieve optimal therapeutic effects for antibiotics, oral vaccines, and drug carriers.
NANOSCALE HORIZONS
(2022)
Article
Chemistry, Multidisciplinary
Kedong Liu, Yun Chen, Dutao Yang, Yanfei Cai, Zhaoqi Yang, Jian Jin
Summary: Glu-derived zwitterionic micelles have promising potential for oral delivery, with the ability to overcome the mucosal barrier, excellent mucus permeability, and enhanced cellular internalization capacity. The endocytosis was mediated by multiple amino acid transporters and the retrograde pathway played an important role in intracellular transport and transcytosis. The excellent villi absorption observed in situ provides convincing evidence for the potential of oral delivery.
Article
Food Science & Technology
Cintia Tomaz Sant'Ana, Ariane Dias de Amorim, Ana Paula Gava, Carla Mora Aguilar, Nayana Garcia Silva, Lillian Duarte Machado, Mirelle Lomar Viana, Daniela da Silva Oliveira, Pollyanna Ibrahim Silva, Neuza Maria Brunoro Costa, Andre Gustavo Vasconcelos Costa
Summary: This clinical trial investigated the effects of brown and golden flaxseeds on various health indicators in perimenopausal overweight women. The results showed that flaxseed consumption reduced intestinal permeability and improved lipid profiles, demonstrating positive effects on metabolic changes caused by menopausal transition.
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
(2022)
Article
Nutrition & Dietetics
Mohamad Hizami Mohamad Nor, Nurainina Ayob, Norfilza M. Mokhtar, Raja Affendi Raja Ali, Geok Chin Tan, Zhiqin Wong, Nor Hamizah Shafiee, Yin Ping Wong, Muaatamarulain Mustangin, Khairul Najmi Muhammad Nawawi
Summary: The use of probiotics did not lead to significant clinical improvement in NAFLD patients in terms of hepatic steatosis and fibrosis levels, but at the microenvironment level, probiotics seemed to stabilize mucosal immune function and protect patients against increased intestinal permeability. Further studies with larger sample sizes and different probiotic strains are needed to evaluate the true benefit of probiotics in NAFLD.
Article
Immunology
Yanmei Ma, Zhihua Yin, Li Li, Bingni Chen, Hanying Dai, Dandan Wu, Junxiao Cong, Liang Ye, Chenghui Liao, Lingyun Li, Zhizhong Ye, Zhong Huang
Summary: Food antigens and mucosal barrier injury act synergistically to cause intestinal inflammation; the study suggests that CII-induced enteritis is associated with higher levels of Th1, TLR2 and TLR4, and lower levels of Th2.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Ting Luo, Sarah M. Snyder, Bingxin Zhao, Debra K. Sullivan, Jill Hamilton-Reeves, Gregory Guthrie, Marie-Louise Ricketts, Kathleen T. Shiverick, Neil Shay
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2016)
Article
Nutrition & Dietetics
Gregory Guthrie, Bryan Tackett, Barbara Stoll, Camilia Martin, Oluyinka Olutoye, Douglas G. Burrin
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2018)
Review
Nutrition & Dietetics
Gregory Guthrie, Muralidhar Premkumar, Douglas G. Burrin
NUTRITION IN CLINICAL PRACTICE
(2017)
Article
Immunology
Tiffany L. Molina, Barbara Stoll, Mahmoud Mohammad, Carrie A. Mohila, Lee Call, Liwei Cui, Gregory Guthrie, Dennis Kunichoff, Sen Lin, Rebecca Welch-Jernigan, Jon Nielsen, Muralidhar Premkumar, Jason Robinson, Victoria Smith, Haley Teets, Karina Obelitz-Ryom, Joseph Hagan, Stephanie Cruz, Patricio Lau, Maurice Puyau, Roman Shypailo, Rodrigo Manjarin, Nancy Butte, Zhengfeng Fang, Oluyinka Olutoye, Thomas Thymann, Per Sangild, Douglas Burrin
BRAIN BEHAVIOR AND IMMUNITY
(2020)
Review
Biochemistry & Molecular Biology
J. Plat, S. Baumgartner, T. Vanmierlo, D. Luetjohann, K. L. Calkins, D. G. Burrin, G. Guthrie, C. Thijs, A. A. Te Velde, A. C. E. Vreugdenhil, R. Sverdlov, J. Garssen, K. Wouters, E. A. Trautwein, T. G. Wolfs, C. van Gorp, M. T. Mulder, N. P. Riksen, A. K. Groen, R. P. Mensink
PROGRESS IN LIPID RESEARCH
(2019)
Article
Gastroenterology & Hepatology
Gregory Guthrie, Barbara Stoll, Shaji Chacko, Charlotte Lauridsen, Jogchum Plat, Douglas Burrin
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2020)
Review
Nutrition & Dietetics
Gregory Guthrie, Douglas Burrin
Summary: Total parenteral nutrition (TPN) is a critical intervention for infants unable to feed orally, but prolonged reliance on TPN poses a risk of liver injury, particularly through parenteral nutrition associated cholestasis (PNAC) driven by lipid emulsions. Studies suggest that new emulsions containing fish oil and medium chain triglycerides show promise in reducing the incidence of PNAC.
Article
Cell Biology
Greg Guthrie, Caitlin Vonderohe, Douglas Burrin
Summary: This review summarizes the current literature on the protein FGF19, its target receptors, and the biological pathways they target through unique signaling cascades.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Editorial Material
Gastroenterology & Hepatology
Gregory Guthrie
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Nutrition & Dietetics
Valeria Melendez Hebib, Diana H. Taft, Barbara Stoll, Jinxin Liu, Lee Call, Gregory Guthrie, Nick Jensen, Amy B. Hair, David A. Mills, Douglas G. Burrin
Summary: Necrotizing enterocolitis (NEC) is the leading cause of death caused by gastrointestinal disease in preterm infants. Major risk factors include prematurity, formula feeding, and gut microbial colonization. Probiotics have been shown to reduce NEC incidence in infants, but their effectiveness depends on the specific species used.
Article
Nutrition & Dietetics
Nancy E. Moran, Joshua Wade, Rachel Stroh, Barbara Stoll, Gregory Guthrie, Amy B. Hair, Douglas G. Burrin
Summary: The study found that preterm pigs fed with donor human milk had higher concentrations of liver beta-carotene compared to those fed with premature infant formula. However, liver vitamin A stores were higher in pigs fed with infant formula. Additionally, plasma, liver, and jejunum concentrations of lutein, zeaxanthin, and lycopene were higher in pigs fed with donor human milk. The study suggests that further research should be conducted to investigate the bioactivity and bioavailability of carotenoids in infants.
JOURNAL OF NUTRITION
(2023)
Article
Endocrinology & Metabolism
Caitlin Vonderohe, Gregory Guthrie, Barbara Stoll, Valeria Melendez Hebib, Harry Dawson, Douglas Burrin
Summary: The impact of birth modality and gestational age on hormone levels, gene expression, and plasma levels of FGF19 in neonatal pigs was investigated. Vaginally born piglets had significantly higher plasma FGF19 levels at birth compared to cesarean and preterm piglets. However, FGF19 gene expression in the distal ileum was similar among all groups. Plasma FGF19 was positively correlated with plasma cortisol, and dexamethasone treatment increased FGF19 expression in pig tissue and human enteroids.
Meeting Abstract
Gastroenterology & Hepatology
Gregory Guthrie, Barbara Stoll, Sanjiv Harpavat, Douglas Burrin
Meeting Abstract
Gastroenterology & Hepatology
Lee Call, Tiffany Molina, Barbara Stoll, Gregory Guthrie, Jason Robinson, Jon Nielson, Stephanie Cruz, Patricio Lao, Murali Premkumar, Thomas Thymann, Oluyinka Olutoye, Robert Britton, Per Sangild, Douglas Burrin
Meeting Abstract
Biochemistry & Molecular Biology
Gregory Guthrie, Bryan Tackett, Barbara Stoll, Camilia Martin, Doug Burrin
