The effects of pdr1, djr1.1 and pink1 loss in manganese-induced toxicity and the role of α-synuclein in C. elegans

Manganese-exposed developing rats display motor deficits and striatal oxidative stress that are reversed by Trolox

(2013) Fabiano M. Cordova et al.   ARCHIVES OF TOXICOLOGY

Parkinson Disease Protein DJ-1 Binds Metals and Protects against Metal-induced Cytotoxicity

(2013) Benny Björkblom et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ER-stress-associated functional link between Parkin and DJ-1 via a transcriptional cascade involving the tumor suppressor p53 and the spliced X-box binding protein XBP-1

(2013) E. Duplan et al.   JOURNAL OF CELL SCIENCE

Dopaminergic neurotoxicity ofS-ethylN,N-dipropylthiocarbamate (EPTC), molinate, andS-methyl-N,N-diethylthiocarbamate (MeDETC) inCaenorhabditis elegans

(2013) Samuel W. Caito et al.   JOURNAL OF NEUROCHEMISTRY

Deregulation of calcium homeostasis mediates secreted α–synuclein-induced neurotoxicity

(2013) Katerina Melachroinou et al.   NEUROBIOLOGY OF AGING

Early-Life Exposure to Methylmercury in Wildtype and pdr-1/parkin Knockout C. elegans

(2013) Ebany J. Martinez-Finley et al.   NEUROCHEMICAL RESEARCH

Manganism in the 21st century: The Hanninen lecture

(2013) Brad A. Racette   NEUROTOXICOLOGY

Site-Specific Perturbations of Alpha-Synuclein Fibril Structure by the Parkinson's Disease Associated Mutations A53T and E46K

(2013) Luisel R. Lemkau et al.   PLoS One

PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria

(2013) Y. Chen et al.   SCIENCE

Complex II of the Mitochondrial Respiratory Chain Is the Key Mediator of Divalent Manganese-Induced Hydrogen Peroxide Production in Microglia

(2013) Yue Liu et al.   TOXICOLOGICAL SCIENCES

Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2

(2013) Jiajie Diao et al.   eLife

Nigrostriatal overabundance of α-synuclein leads to decreased vesicle density and deficits in dopamine release that correlate with reduced motor activity

(2012) Meret Nora Gaugler et al.   ACTA NEUROPATHOLOGICA

Involvement and interplay of Parkin, PINK1, and DJ1 in neurodegenerative and neuroinflammatory disorders

(2012) Micha M.M. Wilhelmus et al.   FREE RADICAL BIOLOGY AND MEDICINE

Human DJ-1 and its homologs are novel glyoxalases

(2012) Ju-young Lee et al.   HUMAN MOLECULAR GENETICS

Inactivation ofPink1Genein VivoSensitizes Dopamine-producing Neurons to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and Can Be Rescued by Autosomal Recessive Parkinson Disease Genes,ParkinorDJ-1

(2012) M. Emdadul Haque et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Voltage-dependent Anion Channels (VDACs) Recruit Parkin to Defective Mitochondria to Promote Mitochondrial Autophagy

(2012) Yu Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peculiarities of Copper Binding to α-Synuclein

(2012) Atta Ahmad et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Parkinson’s disease-associated DJ-1 mutations impair mitochondrial dynamics and cause mitochondrial dysfunction

(2012) Xinglong Wang et al.   JOURNAL OF NEUROCHEMISTRY

Dopamine Induced Neurodegeneration in a PINK1 Model of Parkinson's Disease

(2012) Sonia Gandhi et al.   PLoS One

Manganese exposure induces α-synuclein aggregation in the frontal cortex of non-human primates

(2012) Tatyana Verina et al.   TOXICOLOGY LETTERS

PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria

(2012) Kei Okatsu et al.   Nature Communications

Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice

(2012) Francisco Pan-Montojo et al.   Scientific Reports

Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue

(2012) Yoichi Imaizumi et al.   Molecular Brain

α-Synuclein Stimulates a Dopamine Transporter-dependent Chloride Current and Modulates the Activity of the Transporter

(2011) Jarod Swant et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The parkin Mutant Phenotype in the Fly Is Largely Rescued by Metal-Responsive Transcription Factor (MTF-1)

(2011) N. Saini et al.   MOLECULAR AND CELLULAR BIOLOGY

Neuroprotection of α-synuclein under acute and chronic rotenone and maneb treatment is abolished by its familial Parkinson's disease mutations A30P, A53T and E46K

(2011) Chi-Jing Choong et al.   NEUROTOXICOLOGY

Alpha-Synuclein Is a Cellular Ferrireductase

(2011) Paul Davies et al.   PLoS One

Oxidation of DJ-1 Induced by 6-Hydroxydopamine Decreasing Intracellular Glutathione

(2011) Akiko Miyama et al.   PLoS One

Manganese and Parkinson’s Disease: A Critical Review and New Findings

(2010) Tomás R. Guilarte   ENVIRONMENTAL HEALTH PERSPECTIVES

Mitochondrial dysfunction and loss of Parkinson's disease-linked proteins contribute to neurotoxicity of manganese-containing welding fumes

(2010) Krishnan Sriram et al.   FASEB JOURNAL

Parkin regulates metal transport via proteasomal degradation of the 1B isoforms of divalent metal transporter 1

(2010) Jerome A. Roth et al.   JOURNAL OF NEUROCHEMISTRY

Metalloproteomics and metal toxicology of α-synuclein

(2010) Aaron Santner et al.   Metallomics

Extended lifespan of Drosophila parkin mutants through sequestration of redox-active metals and enhancement of anti-oxidative pathways

(2010) Nidhi Saini et al.   NEUROBIOLOGY OF DISEASE

Genetic Animal Models of Parkinson's Disease

(2010) Ted M. Dawson et al.   NEURON

Changes in Dietary Iron Exacerbate Regional Brain Manganese Accumulation as Determined by Magnetic Resonance Imaging

(2010) Vanessa A. Fitsanakis et al.   TOXICOLOGICAL SCIENCES

Extracellular Dopamine Potentiates Mn-Induced Oxidative Stress, Lifespan Reduction, and Dopaminergic Neurodegeneration in a BLI-3–Dependent Manner in Caenorhabditis elegans

(2010) Alexandre Benedetto et al.   PLoS Genetics

Condition-adapted stress and longevity gene regulation byCaenorhabditis elegansSKN-1/Nrf

(2009) Riva P. Oliveira et al.   AGING CELL

The mitochondrial kinase PINK1, stress response and Parkinson’s disease

(2009) Marina Jendrach et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation

(2009) Hui Xiong et al.   JOURNAL OF CLINICAL INVESTIGATION

Parkin deficiency increases the resistance of midbrain neurons and glia to mild proteasome inhibition: the role of autophagy and glutathione homeostasis

(2009) Maria J. Casarejos et al.   JOURNAL OF NEUROCHEMISTRY

Parkinson's disease

(2009) Andrew J Lees et al.   LANCET

Interaction Between α-Synuclein and Metal Ions, Still Looking for a Role in the Pathogenesis of Parkinson’s Disease

(2009) Marco Bisaglia et al.   NEUROMOLECULAR MEDICINE

Manganese and its Role in Parkinson’s Disease: From Transport to Neuropathology

(2009) Michael Aschner et al.   NEUROMOLECULAR MEDICINE

SMF-1, SMF-2 and SMF-3 DMT1 Orthologues Regulate and Are Regulated Differentially by Manganese Levels in C. elegans

(2009) Catherine Au et al.   PLoS One

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

(2009) C. Vives-Bauza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidative damage and neurodegeneration in manganese-induced neurotoxicity

(2009) Dejan Milatovic et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

PINK1 controls mitochondrial localization of Parkin through direct phosphorylation

(2008) Yongsung Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Manganese Neurotoxicity: Lessons Learned from Longitudinal Studies in Nonhuman Primates

(2008) Neal C. Burton et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Cell-produced α-synuclein oligomers are targeted to, and impair, the 26S proteasome

(2008) Evangelia Emmanouilidou et al.   NEUROBIOLOGY OF AGING

α-Synuclein aggregation alters tyrosine hydroxylase phosphorylation and immunoreactivity: Lessons from viral transduction of knockout mice

(2008) Tshianda N.M. Alerte et al.   NEUROSCIENCE LETTERS

Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease

(2008) J. Salazar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA