Structural Basis for High-Affinity Trapping of the NaV1.7 Channel in Its Resting State by Tarantula Toxin
出版年份 2020 全文链接
标题
Structural Basis for High-Affinity Trapping of the NaV1.7 Channel in Its Resting State by Tarantula Toxin
作者
关键词
analgesics, cryo-EM, electrophysiology, huwentoxin, gating-modifier toxins, NaV1.7, pain, protein structure, tarantula, voltage-gated sodium channel
出版物
MOLECULAR CELL
Volume 81, Issue 1, Pages 38-48.e4
出版商
Elsevier BV
发表日期
2020-11-23
DOI
10.1016/j.molcel.2020.10.039
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Employing NaChBac for cryo-EM analysis of toxin action on voltage-gated Na+channels in nanodisc
- (2020) Shuai Gao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin
- (2019) Hui Xu et al. CELL
- Molecular basis for pore blockade of human Na+ channel Nav1.2 by the μ-conotoxin KIIIA
- (2019) Xiaojing Pan et al. SCIENCE
- Structures of human Nav1.7 channel in complex with auxiliary subunits and animal toxins
- (2019) Huaizong Shen et al. SCIENCE
- Structural insight into TRPV5 channel function and modulation
- (2019) Shangyu Dang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Resting-State Structure and Gating Mechanism of a Voltage-Gated Sodium Channel
- (2019) Goragot Wisedchaisri et al. CELL
- Structure of the Cardiac Sodium Channel
- (2019) Daohua Jiang et al. CELL
- cisTEM, user-friendly software for single-particle image processing
- (2018) Timothy Grant et al. eLife
- Structure of the human voltage-gated sodium channel Nav1.4 in complex with β1
- (2018) Xiaojing Pan et al. SCIENCE
- Mechanism of calmodulin inactivation of the calcium-selective TRP channel TRPV6
- (2018) Appu K. Singh et al. Science Advances
- A Functional Na V 1.7-Na V Ab Chimera with a Reconstituted High-Affinity ProTx-II Binding Site
- (2017) Ramkumar Rajamani et al. MOLECULAR PHARMACOLOGY
- The chemical basis for electrical signaling
- (2017) William A Catterall et al. Nature Chemical Biology
- MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy
- (2017) Shawn Q Zheng et al. NATURE METHODS
- The complete structure of an activated open sodium channel
- (2017) Altin Sula et al. Nature Communications
- The structure, dynamics and selectivity profile of a NaV1.7 potency-optimised huwentoxin-IV variant
- (2017) Sassan Rahnama et al. PLoS One
- Gctf: Real-time CTF determination and correction
- (2016) Kai Zhang JOURNAL OF STRUCTURAL BIOLOGY
- Crystal structures of MBP fusion proteins
- (2016) David S. Waugh PROTEIN SCIENCE
- The hitchhiker’s guide to the voltage-gated sodium channel galaxy
- (2015) Christopher A. Ahern et al. JOURNAL OF GENERAL PHYSIOLOGY
- Mapping the interaction site for the tarantula toxin hainantoxin-IV (β-TRTX-Hn2a) in the voltage sensor module of domain II of voltage-gated sodium channels
- (2015) Tianfu Cai et al. PEPTIDES
- Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist
- (2015) S. Ahuja et al. SCIENCE
- A gating charge interaction required for late slow inactivation of the bacterial sodium channel NavAb
- (2013) Tamer M. Gamal El-Din et al. JOURNAL OF GENERAL PHYSIOLOGY
- Structure of a Prokaryotic Sodium Channel Pore Reveals Essential Gating Elements and an Outer Ion Binding Site Common to Eukaryotic Channels
- (2013) David Shaya et al. JOURNAL OF MOLECULAR BIOLOGY
- Quantifying the local resolution of cryo-EM density maps
- (2013) Alp Kucukelbir et al. NATURE METHODS
- Potency optimization of Huwentoxin-IV on hNav1.7: A neurotoxin TTX-S sodium-channel antagonist from the venom of the Chinese bird-eating spider Selenocosmia huwena
- (2013) Jefferson D. Revell et al. PEPTIDES
- Mapping the Interaction Site for a β-Scorpion Toxin in the Pore Module of Domain III of Voltage-gated Na+Channels
- (2012) Joel Z. Zhang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- RELION: Implementation of a Bayesian approach to cryo-EM structure determination
- (2012) Sjors H.W. Scheres JOURNAL OF STRUCTURAL BIOLOGY
- Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel
- (2012) Xu Zhang et al. NATURE
- Crystal structure of a voltage-gated sodium channel in two potentially inactivated states
- (2012) Jian Payandeh et al. NATURE
- The NaV1.7 sodium channel: from molecule to man
- (2012) Sulayman D. Dib-Hajj et al. NATURE REVIEWS NEUROSCIENCE
- Outcome of the First Electron Microscopy Validation Task Force Meeting
- (2012) Richard Henderson et al. STRUCTURE
- Spider-venom peptides that target voltage-gated sodium channels: Pharmacological tools and potential therapeutic leads
- (2012) Julie K. Klint et al. TOXICON
- Common Molecular Determinants of Tarantula Huwentoxin-IV Inhibition of Na+Channel Voltage Sensors in Domains II and IV
- (2011) Yucheng Xiao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structure-Function Map of the Receptor Site for β-Scorpion Toxins in Domain II of Voltage-gated Sodium Channels
- (2011) Joel Z. Zhang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The crystal structure of a voltage-gated sodium channel
- (2011) Jian Payandeh et al. NATURE
- Structural basis for gating charge movement in the voltage sensor of a sodium channel
- (2011) V. Yarov-Yarovoy et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Features and development ofCoot
- (2010) P. Emsley et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- PHENIX: a comprehensive Python-based system for macromolecular structure solution
- (2010) Paul D. Adams et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- The Tarantula Toxins ProTx-II and Huwentoxin-IV Differentially Interact with Human Nav1.7 Voltage Sensors to Inhibit Channel Activation and Inactivation
- (2010) Y. Xiao et al. MOLECULAR PHARMACOLOGY
- Tarantula Huwentoxin-IV Inhibits Neuronal Sodium Channels by Binding to Receptor Site 4 and Trapping the Domain II Voltage Sensor in the Closed Configuration
- (2008) Yucheng Xiao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- ProTx-II, a Selective Inhibitor of NaV1.7 Sodium Channels, Blocks Action Potential Propagation in Nociceptors
- (2008) W. A. Schmalhofer et al. MOLECULAR PHARMACOLOGY
- Synthesis and characterization of huwentoxin-IV, a neurotoxin inhibiting central neuronal sodium channels
- (2007) Yucheng Xiao et al. TOXICON
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