Role of the gut microbiota in type 2 diabetes and related diseases

Trimethylamine-N-Oxide Promotes Vascular Calcification Through Activation of NLRP3 (Nucleotide-Binding Domain, Leucine-Rich-Containing Family, Pyrin Domain-Containing-3) Inflammasome and NF-κB (Nuclear Factor κB) Signals

(2020) Xiuli Zhang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Enteric Nervous System-Derived IL-18 Orchestrates Mucosal Barrier Immunity

(2020) Abigail Jarret et al.   CELL

Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment

(2020) Zhigang Liu et al.   Nature Communications

Role of gut microbiota in type 2 diabetes pathophysiology

(2020) Manoj Gurung et al.   EBioMedicine

A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors

(2020) Ina Nemet et al.   CELL

Deficiency of Prebiotic Fiber and Insufficient Signaling Through Gut Metabolite-Sensing Receptors Leads to Cardiovascular Disease

(2020) David M. Kaye et al.   CIRCULATION

Faecal virome transplantation decreases symptoms of type 2 diabetes and obesity in a murine model

(2020) Torben Sølbeck Rasmussen et al.   GUT

Dietary cholesterol drives fatty liver-associated liver cancer by modulating gut microbiota and metabolites

(2020) Xiang Zhang et al.   GUT

Short-Chain Fatty Acids Ameliorate Diabetic Nephropathy via GPR43-Mediated Inhibition of Oxidative Stress and NF-κB Signaling

(2020) Wei Huang et al.   Oxidative Medicine and Cellular Longevity

The gut microbiome stability is altered by probiotic ingestion and improved by the continuous supplementation of galactooligosaccharide

(2020) Chenchen Ma et al.   Gut Microbes

Fecal Microbiota Transplant is Highly Effective in Real-World Practice: Initial Results from the FMT National Registry

(2020) Colleen R. Kelly et al.   GASTROENTEROLOGY

Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway

(2019) Rajbir Singh et al.   Nature Communications

Hydroxytyrosol Improves Obesity and Insulin Resistance by Modulating Gut Microbiota in High-Fat Diet-Induced Obese Mice

(2019) Zhuoqun Liu et al.   Frontiers in Microbiology

Indoles: metabolites produced by intestinal bacteria capable of controlling liver disease manifestation

(2019) T. Hendrikx et al.   JOURNAL OF INTERNAL MEDICINE

Microbiota Sensing by Mincle-Syk Axis in Dendritic Cells Regulates Interleukin-17 and -22 Production and Promotes Intestinal Barrier Integrity

(2019) María Martínez-López et al.   IMMUNITY

The Mediterranean Diet and Cardiovascular Health

(2019) Miguel A. Martínez-González et al.   CIRCULATION RESEARCH

Trimethylamine N ‐Oxide Aggravates Liver Steatosis through Modulation of Bile Acid Metabolism and Inhibition of Farnesoid X Receptor Signaling in Nonalcoholic Fatty Liver Disease

(2019) Xuying Tan et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases

(2019) Jason Lloyd-Price et al.   NATURE

The vaginal microbiome and preterm birth

(2019) Jennifer M. Fettweis et al.   NATURE MEDICINE

The short-chain fatty acid propionate increases glucagon and FABP4 production, impairing insulin action in mice and humans

(2019) Amir Tirosh et al.   Science Translational Medicine

Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease

(2019) Koichi Kikuchi et al.   Nature Communications

Synbiotic-driven improvement of metabolic disturbances is associated with changes in the gut microbiome in diet-induced obese mice

(2019) Xinxin Ke et al.   Molecular Metabolism

Dynamic Modulation of the Gut Microbiota and Metabolome by Bacteriophages in a Mouse Model

(2019) Bryan B. Hsu et al.   Cell Host & Microbe

Intestinal lysozyme liberates Nod1 ligands from microbes to direct insulin trafficking in pancreatic beta cells

(2019) Qin Zhang et al.   CELL RESEARCH

Modulating the gut microbiota and inflammation is involved in the effect of Bupleurum polysaccharides against diabetic nephropathy in mice

(2019) Yuchen Feng et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Intestinal microbiome and fitness in kidney disease

(2019) Björn Meijers et al.   Nature Reviews Nephrology

Host–Microbe Interplay in the Cardiometabolic Benefits of Dietary Polyphenols

(2019) F.F. Anhê et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

A Crucial Role for Diet in the Relationship Between Gut Microbiota and Cardiometabolic Disease

(2019) Ilias Attaye et al.   Annual Review of Medicine

Obese Individuals with and without Type 2 Diabetes Show Different Gut Microbial Functional Capacity and Composition

(2019) Louise B. Thingholm et al.   Cell Host & Microbe

Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction

(2019) Sifan Chen et al.   Cell Metabolism

Microbiota-driven gut vascular barrier disruption is a prerequisite for non-alcoholic steatohepatitis development

(2019) Juliette Mouries et al.   JOURNAL OF HEPATOLOGY

Fatty Liver Disease Caused by High-Alcohol-Producing Klebsiella pneumoniae

(2019) Jing Yuan et al.   Cell Metabolism

Drug-Resistant E. coli Bacteremia Transmitted by Fecal Microbiota Transplant

(2019) Zachariah DeFilipp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Characterization of antimicrobial resistance in lactobacilli and bifidobacteria used as probiotics or starter cultures based on integration of phenotypic and in silico data

(2019) Vita Rozman et al.   INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY

Magnesium lithospermate B improves the gut microbiome and bile acid metabolic profiles in a mouse model of diabetic nephropathy

(2018) Jing Zhao et al.   ACTA PHARMACOLOGICA SINICA

Dysbiosis of gut microbiota and microbial metabolites in Parkinson’s Disease

(2018) Meng-Fei Sun et al.   AGEING RESEARCH REVIEWS

Secretory autophagy of lysozyme in Paneth cells

(2018) Shai Bel et al.   Autophagy

Fiber-Mediated Nourishment of Gut Microbiota Protects against Diet-Induced Obesity by Restoring IL-22-Mediated Colonic Health

(2018) Jun Zou et al.   Cell Host & Microbe

Bifidobacteria or Fiber Protects against Diet-Induced Microbiota-Mediated Colonic Mucus Deterioration

(2018) Bjoern O. Schroeder et al.   Cell Host & Microbe

Restructuring of the Gut Microbiome by Intermittent Fasting Prevents Retinopathy and Prolongs Survival in db/db Mice

(2018) Eleni Beli et al.   DIABETES

IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045

(2018) N.H. Cho et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Aberrant intestinal microbiota in individuals with prediabetes

(2018) Kristine H. Allin et al.   DIABETOLOGIA

Effect of high amylose resistant starch (HAM-RS2) supplementation on biomarkers of inflammation and oxidative stress in hemodialysis patients: a randomized clinical trial

(2018) Hamid Tayebi Khosroshahi et al.   Hemodialysis International

Oncologists tap the microbiome in bid to improve immunotherapy outcomes

(2018) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Microbial modulation of cardiovascular disease

(2018) J. Mark Brown et al.   NATURE REVIEWS MICROBIOLOGY

Fecal Microbiota Transplantation for Primary Clostridium difficile Infection

(2018) Frederik E. Juul et al.   NEW ENGLAND JOURNAL OF MEDICINE

Intestinal Intraepithelial Lymphocytes: Sentinels of the Mucosal Barrier

(2018) Danyvid Olivares-Villagómez et al.   TRENDS IN IMMUNOLOGY

Reshaped fecal gut microbiota composition by the intake of high molecular weight persimmon tannin in normal and high-cholesterol diet-fed rats

(2018) Wei Zhu et al.   Food & Function

Gut Microbiota-Derived Tryptophan Metabolites Modulate Inflammatory Response in Hepatocytes and Macrophages

(2018) Smitha Krishnan et al.   Cell Reports

β Cell-Specific Deletion of the IL-1 Receptor Antagonist Impairs β Cell Proliferation and Insulin Secretion

(2018) Marianne Böni-Schnetzler et al.   Cell Reports

Branched Chain Amino Acids in Metabolic Disease

(2018) Zoltan Arany et al.   Current Diabetes Reports

Effects of daily consumption of the probiotic Bifidobacterium animalis subsp. lactis CECT 8145 on anthropometric adiposity biomarkers in abdominally obese subjects: a randomized controlled trial

(2018) Anna Pedret et al.   INTERNATIONAL JOURNAL OF OBESITY

Microbiome–Metabolomics Analysis of the Impacts of Long-Term Dietary Advanced-Glycation-End-Product Consumption on C57BL/6 Mouse Fecal Microbiota and Metabolites

(2018) Wanting Qu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Development of a gut microbe–targeted nonlethal therapeutic to inhibit thrombosis potential

(2018) Adam B. Roberts et al.   NATURE MEDICINE

Diabetic gut microbiota dysbiosis as an inflammaging and immunosenescence condition that fosters progression of retinopathy and nephropathy

(2018) Rosa Fernandes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Vascular complications in patients with type 2 diabetes: prevalence and associated factors in 38 countries (the DISCOVER study program)

(2018) Mikhail Kosiborod et al.   Cardiovascular Diabetology

Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1

(2018) Ara Koh et al.   CELL

Bacteria engineered to produce IL-22 in intestine induce expression of REG3G to reduce ethanol-induced liver disease in mice

(2018) Tim Hendrikx et al.   GUT

Interleukin-17/interleukin-17 receptor axis elicits intestinal neutrophil migration, restrains gut dysbiosis and lipopolysaccharide translocation in high-fat diet-induced metabolic syndrome model

(2018) Malena M. Pérez et al.   IMMUNOLOGY

Microbial impact on cholesterol and bile acid metabolism: current status and future prospects

(2018) Aicha Kriaa et al.   JOURNAL OF LIPID RESEARCH

Trimethylamine-N-oxide (TMAO) as Novel Potential Biomarker of Early Predictors of Metabolic Syndrome

(2018) Luigi Barrea et al.   Nutrients

The beneficial effects of Lactobacillus reuteri ADR-1 or ADR-3 consumption on type 2 diabetes mellitus: a randomized, double-blinded, placebo-controlled trial

(2018) Ming-Chia Hsieh et al.   Scientific Reports

Short-Chain Fatty Acids Inhibit Oxidative Stress and Inflammation in Mesangial Cells Induced by High Glucose and Lipopolysaccharide

(2017) Wei Huang et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Modifications in bacterial groups and short chain fatty acid production in the gut of healthy adult rats after long-term consumption of dietary Maillard reaction products

(2017) Cristina Delgado-Andrade et al.   FOOD RESEARCH INTERNATIONAL

Efficacy of Sterile Fecal Filtrate Transfer for Treating Patients With Clostridium difficile Infection

(2017) Stephan J. Ott et al.   GASTROENTEROLOGY

Recovery of ethanol-inducedAkkermansia muciniphiladepletion ameliorates alcoholic liver disease

(2017) Christoph Grander et al.   GUT

Gut microbiota dysbiosis in patients with non-alcoholic fatty liver disease

(2017) Feng Shen et al.   Hepatobiliary & Pancreatic Diseases International

Lipopolysaccharide, a possible molecular mediator between periodontitis and coronary artery disease

(2017) John M. Liljestrand et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Primary Prevention of Cardiovascular Disease in Diabetes Mellitus

(2017) Jonathan D. Newman et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Multidonor intensive faecal microbiota transplantation for active ulcerative colitis: a randomised placebo-controlled trial

(2017) Sudarshan Paramsothy et al.   LANCET

Interactions between gut bacteria and bile in health and disease

(2017) Sarah L. Long et al.   MOLECULAR ASPECTS OF MEDICINE

The Antidiabetic Mechanisms of Polyphenols Related to Increased Glucagon-Like Peptide-1 (GLP1) and Insulin Signaling

(2017) J. Domínguez Avila et al.   MOLECULES

Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice

(2017) Kerstin Berer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sodium butyrate attenuates high-fat diet-induced steatohepatitis in mice by improving gut microbiota and gastrointestinal barrier

(2017) Da Zhou et al.   WORLD JOURNAL OF GASTROENTEROLOGY

The gut microbiome in atherosclerotic cardiovascular disease

(2017) Zhuye Jie et al.   Nature Communications

Lactobacillus rhamnosus NCDC17 ameliorates type-2 diabetes by improving gut function, oxidative stress and inflammation in high-fat-diet fed and streptozotocintreated rats

(2017) S. Singh et al.   Beneficial Microbes

Gut microbiota dysbiosis associated with glucose metabolism disorders and the metabolic syndrome in older adults

(2017) K. Lippert et al.   Beneficial Microbes

Next-Generation Beneficial Microbes: The Case of Akkermansia muciniphila

(2017) Patrice D. Cani et al.   Frontiers in Microbiology

Gut microbiota dysbiosis contributes to the development of hypertension

(2017) Jing Li et al.   Microbiome

Effects of antidiabetic drugs on the incidence of macrovascular complications and mortality in type 2 diabetes mellitus: a new perspective on sodium–glucose co-transporter 2 inhibitors

(2016) Dario Rahelić et al.   ANNALS OF MEDICINE

Interaction of gut microbiota with bile acid metabolism and its influence on disease states

(2016) Christopher Staley et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility

(2016) Mahesh S. Desai et al.   CELL

Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk

(2016) Weifei Zhu et al.   CELL

Gut Microbial Metabolites Fuel Host Antibody Responses

(2016) Myunghoo Kim et al.   Cell Host & Microbe

Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism

(2016) Annika Wahlström et al.   Cell Metabolism

Periodontitis induced by Porphyromonas gingivalis drives periodontal microbiota dysbiosis and insulin resistance via an impaired adaptive immune response

(2016) Vincent Blasco-Baque et al.   GUT

Human gut microbes impact host serum metabolome and insulin sensitivity

(2016) Helle Krogh Pedersen et al.   NATURE

Diet, microorganisms and their metabolites and colon cancer

(2016) Stephen J. D. O'Keefe   Nature Reviews Gastroenterology & Hepatology

Impact of the gut microbiota on inflammation, obesity, and metabolic disease

(2016) Claire L. Boulangé et al.   Genome Medicine

Postoperative Changes in Fecal Bacterial Communities and Fermentation Products in Obese Patients Undergoing Bilio-Intestinal Bypass

(2016) Vania Patrone et al.   Frontiers in Microbiology

More Is Better: Selecting for Broad Host Range Bacteriophages

(2016) Alexa Ross et al.   Frontiers in Microbiology

Trimethylamine N‐Oxide Promotes Vascular Inflammation Through Signaling of Mitogen‐Activated Protein Kinase and Nuclear Factor‐κB

(2016) Marcus M. Seldin et al.   Journal of the American Heart Association

Chemical communication in the gut: Effects of microbiota-generated metabolites on gastrointestinal bacterial pathogens

(2015) Stefanie L. Vogt et al.   ANAEROBE

Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling

(2015) Maayan Levy et al.   CELL

Peroxisomal Lipid Synthesis Regulates Inflammation by Sustaining Neutrophil Membrane Phospholipid Composition and Viability

(2015) Irfan J. Lodhi et al.   Cell Metabolism

The Gut Microbiome Contributes to a Substantial Proportion of the Variation in Blood LipidsNovelty and Significance

(2015) Jingyuan Fu et al.   CIRCULATION RESEARCH

Engineered Commensal Bacteria Reprogram Intestinal Cells Into Glucose-Responsive Insulin-Secreting Cells for the Treatment of Diabetes

(2015) Franklin F. Duan et al.   DIABETES

IL-1β in eosinophil-mediated small intestinal homeostasis and IgA production

(2015) Y Jung et al.   Mucosal Immunology

Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome

(2015) Benoit Chassaing et al.   NATURE

Intestinal Microbiota Composition Modulates Choline Bioavailability from Diet and Accumulation of the Proatherogenic Metabolite Trimethylamine- N -Oxide

(2015) Kymberleigh A. Romano et al.   mBio

Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis

(2015) Ji Miao et al.   Nature Communications

Dysbiosis of Gut Microbiota With Reduced Trimethylamine‐N‐Oxide Level in Patients With Large‐Artery Atherosclerotic Stroke or Transient Ischemic Attack

(2015) Jia Yin et al.   Journal of the American Heart Association

Expansion of Urease- and Uricase-Containing, Indole- and p-Cresol-Forming and Contraction of Short-Chain Fatty Acid-Producing Intestinal Microbiota in ESRD

(2014) Jakk Wong et al.   AMERICAN JOURNAL OF NEPHROLOGY

Oral Delivery of Glutamic Acid Decarboxylase (GAD)-65 and IL10 by Lactococcus lactis Reverses Diabetes in Recent-Onset NOD Mice

(2014) S. Robert et al.   DIABETES

Incorporation of therapeutically modified bacteria into gut microbiota inhibits obesity

(2014) Zhongyi Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Combining sitagliptin/metformin with a functional fiber delays diabetes progression in Zucker rats

(2014) Raylene A Reimer et al.   JOURNAL OF ENDOCRINOLOGY

Maillard reaction products modulate gut microbiota composition in adolescents

(2014) Isabel Seiquer et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Retinoic acid primes human dendritic cells to induce gut-homing, IL-10-producing regulatory T cells

(2014) G Bakdash et al.   Mucosal Immunology

Alterations of the human gut microbiome in liver cirrhosis

(2014) Nan Qin et al.   NATURE

The gut microbiota, bacterial metabolites and colorectal cancer

(2014) Petra Louis et al.   NATURE REVIEWS MICROBIOLOGY

The SCFA Receptor GPR43 and Energy Metabolism

(2014) Ikuo Kimura et al.   Frontiers in Endocrinology

Bacteroides thetaiotaomicron and Faecalibacterium prausnitzii influence the production of mucus glycans and the development of goblet cells in the colonic epithelium of a gnotobiotic model rodent

(2013) Laura Wrzosek et al.   BMC BIOLOGY

Fecal Microbiome and Volatile Organic Compound Metabolome in Obese Humans With Nonalcoholic Fatty Liver Disease

(2013) Maitreyi Raman et al.   Clinical Gastroenterology and Hepatology

Gut metagenome in European women with normal, impaired and diabetic glucose control

(2013) Fredrik H. Karlsson et al.   NATURE

Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis

(2013) Robert A Koeth et al.   NATURE MEDICINE

Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk

(2013) W.H. Wilson Tang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Fatty Acid Synthase Modulates Intestinal Barrier Function through Palmitoylation of Mucin 2

(2012) Xiaochao Wei et al.   Cell Host & Microbe

Transfer of Intestinal Microbiota From Lean Donors Increases Insulin Sensitivity in Individuals With Metabolic Syndrome

(2012) Anne Vrieze et al.   GASTROENTEROLOGY

Reversal of autoimmune diabetes by restoration of antigen-specific tolerance using genetically modified Lactococcus lactis in mice

(2012) Tatiana Takiishi et al.   JOURNAL OF CLINICAL INVESTIGATION

The role of neutrophils during intestinal inflammation

(2012) B M Fournier et al.   Mucosal Immunology

A framework for human microbiome research

(2012)   NATURE

A metagenome-wide association study of gut microbiota in type 2 diabetes

(2012) Junjie Qin et al.   NATURE

Structure, function and diversity of the healthy human microbiome

(2012)   NATURE

Symptomatic atherosclerosis is associated with an altered gut metagenome

(2012) Fredrik H. Karlsson et al.   Nature Communications

Energy-balance studies reveal associations between gut microbes, caloric load, and nutrient absorption in humans

(2011) Reiner Jumpertz et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

Dissecting thein VivoMetabolic Potential of Two Human Gut Acetogens

(2010) Federico E. Rey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human oral, gut, and plaque microbiota in patients with atherosclerosis

(2010) O. Koren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coenzyme Q10 supplementation lowers hepatic oxidative stress and inflammation associated with diet-induced obesity in mice

(2009) Florence M. Sohet et al.   BIOCHEMICAL PHARMACOLOGY

Epigenetics: A Molecular Link Between Environmental Factors and Type 2 Diabetes

(2009) Charlotte Ling et al.   DIABETES

Secretion of Insulinotropic Proteins by Commensal Bacteria: Rewiring the Gut To Treat Diabetes

(2008) F. Duan et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Abdominal Obesity and the Metabolic Syndrome: Contribution to Global Cardiometabolic Risk

(2008) Jean-Pierre Després et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice

(2008) P. D. Cani et al.   DIABETES

Human colonic microbiota associated with diet, obesity and weight loss

(2008) S H Duncan et al.   INTERNATIONAL JOURNAL OF OBESITY