Oral Delivery of Glutamic Acid Decarboxylase (GAD)-65 and IL10 by Lactococcus lactis Reverses Diabetes in Recent-Onset NOD Mice

The clinical and immunological significance of GAD-specific autoantibody and T-cell responses in type 1 diabetes

(2013) Tobias Boettler et al.   JOURNAL OF AUTOIMMUNITY

Reversal of autoimmune diabetes by restoration of antigen-specific tolerance using genetically modified Lactococcus lactis in mice

(2012) Tatiana Takiishi et al.   JOURNAL OF CLINICAL INVESTIGATION

GAD65 Antigen Therapy in Recently Diagnosed Type 1 Diabetes Mellitus

(2012) Johnny Ludvigsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Long-Term Outcome of Individuals Treated With Oral Insulin: Diabetes Prevention Trial-Type 1 (DPT-1) oral insulin trial

(2011) K. Vehik et al.   DIABETES CARE

Delta-cell-specific expression of hedgehog pathway Ptch1 receptor in murine and human endocrine pancreas

(2011) F. A. Grieco et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Intestinal Tolerance Requires Gut Homing and Expansion of FoxP3+ Regulatory T Cells in the Lamina Propria

(2011) Usriansyah Hadis et al.   IMMUNITY

Antigen-based therapy with glutamic acid decarboxylase (GAD) vaccine in patients with recent-onset type 1 diabetes: a randomised double-blind trial

(2011) Diane K Wherrett et al.   LANCET

Control of TH17 cells occurs in the small intestine

(2011) Enric Esplugues et al.   NATURE

Type 1 Diabetes: Etiology, Immunology, and Therapeutic Strategies

(2011) Tom L. Van Belle et al.   PHYSIOLOGICAL REVIEWS

Gut CD103+ dendritic cells express indoleamine 2,3-dioxygenase which influences T regulatory/T effector cell balance and oral tolerance induction

(2010) G. Matteoli et al.   GUT

Modulation of Gut-Associated Lymphoid Tissue Functions with Genetically ModifiedLactococcus lactis

(2010) Pieter Rottiers et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Treatment of patients with new onset Type 1 diabetes with a single course of anti-CD3 mAb teplizumab preserves insulin production for up to 5 years

(2009) Kevan C. Herold et al.   CLINICAL IMMUNOLOGY

Genetic-induced Variations in the GAD65 T-cell Repertoire Governs Efficacy of Anti-CD3/GAD65 Combination Therapy in New-onset Type 1 Diabetes

(2009) Damien Bresson et al.   MOLECULAR THERAPY

Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis

(2009) Masako Murai et al.   NATURE IMMUNOLOGY

Innocuous IFNγ induced by adjuvant-free antigen restores normoglycemia in NOD mice through inhibition of IL-17 production

(2008) Renu Jain et al.   JOURNAL OF EXPERIMENTAL MEDICINE

GAD Treatment and Insulin Secretion in Recent-Onset Type 1 Diabetes

(2008) Johnny Ludvigsson et al.   NEW ENGLAND JOURNAL OF MEDICINE