Inhibition of signaling between human CXCR4 and zebrafish ligands by the small molecule IT1t impairs the formation of triple-negative breast cancer early metastases in a zebrafish xenograft model

miR-25 Modulates Invasiveness and Dissemination of Human Prostate Cancer Cells via Regulation of αv- and α6-Integrin Expression

(2015) E. Zoni et al.   CANCER RESEARCH

Molecular Pathways: Targeting the CXCR4-CXCL12 Axis--Untapped Potential in the Tumor Microenvironment

(2015) S. Scala   CLINICAL CANCER RESEARCH

Zebrafish: A New Companion for Translational Research in Oncology

(2015) J. Barriuso et al.   CLINICAL CANCER RESEARCH

The CXCR3-CXCL11 signaling axis mediates macrophage recruitment and dissemination of mycobacterial infection

(2015) V. Torraca et al.   Disease Models & Mechanisms

Chemokine-guided cell migration and motility in zebrafish development

(2015) J. Bussmann et al.   EMBO JOURNAL

Triple negative breast cancer: looking for the missing link between biology and treatments

(2015) Giuseppe Palma et al.   Oncotarget

Chemokine Receptor-Specific Antibodies in Cancer Immunotherapy: Achievements and Challenges

(2015) Maria Vela et al.   Frontiers in Immunology

Diversity and Inter-Connections in the CXCR4 Chemokine Receptor/Ligand Family: Molecular Perspectives

(2015) Lukas Pawig et al.   Frontiers in Immunology

SYK Is a Candidate Kinase Target for the Treatment of Advanced Prostate Cancer

(2014) V. P. S. Ghotra et al.   CANCER RESEARCH

The DNA Damage-Regulated Autophagy Modulator DRAM1 Links Mycobacterial Recognition via TLR-MYD88 to Autophagic Defense

(2014) Michiel van der Vaart et al.   Cell Host & Microbe

Hooking the big one: the potential of zebrafish xenotransplantation to reform cancer drug screening in the genomic era

(2014) C. J. Veinotte et al.   Disease Models & Mechanisms

CXCL12–CXCR4 contributes to the implication of bone marrow in cancer metastasis

(2014) Jingsheng Shi et al.   Future Oncology

Ewing sarcoma inhibition by disruption of EWSR1-FLI1 transcriptional activity and reactivation of p53

(2014) Wietske van der Ent et al.   JOURNAL OF PATHOLOGY

The chemokine receptor CXCR7 interacts with EGFR to promote breast cancer cell proliferation

(2014) Nicole Salazar et al.   Molecular Cancer

UniProt: a hub for protein information

(2014)   NUCLEIC ACIDS RESEARCH

Mycobacterium abscessus cording prevents phagocytosis and promotes abscess formation

(2014) A. Bernut et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Comprehensive Analysis of CXCL12 Isoforms in Breast Cancer1,2

(2014) Shuang Zhao et al.   Translational Oncology

Generation and Dynamics of an Endogenous, Self-Generated Signaling Gradient across a Migrating Tissue

(2013) Gayatri Venkiteswaran et al.   CELL

Gene expression signature of human HepG2 cell line

(2013) S. Costantini et al.   GENE

Optimized Method of G-Protein-Coupled Receptor Homology Modeling: Its Application to the Discovery of Novel CXCR7 Ligands

(2013) Yasushi Yoshikawa et al.   JOURNAL OF MEDICINAL CHEMISTRY

Directional tissue migration through a self-generated chemokine gradient

(2013) Erika Donà et al.   NATURE

Enrichment of human prostate cancer cells with tumor initiating properties in mouse and zebrafish xenografts by differential adhesion

(2013) Nitu Bansal et al.   PROSTATE

The Puzzling Role of CXCR4 in Human Immunodeficiency Virus Infection

(2013) Elisa Vicenzi et al.   Theranostics

Zebrafish xenografts as a tool for in vivo studies on human cancer

(2012) Martina Konantz et al.   Annals of the New York Academy of Sciences

Halting metastasis through CXCR4 inhibition

(2012) Deborah M. Ramsey et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

BMS-936564/MDX-1338: A Fully Human Anti-CXCR4 Antibody Induces Apoptosis In Vitro and Shows Antitumor Activity In Vivo in Hematologic Malignancies

(2012) M. R. Kuhne et al.   CLINICAL CANCER RESEARCH

Chemokine Signaling Directs Trunk Lymphatic Network Formation along the Preexisting Blood Vasculature

(2012) Young Ryun Cha et al.   DEVELOPMENTAL CELL

Intravital Imaging of Thymopoiesis Reveals Dynamic Lympho-Epithelial Interactions

(2012) Isabell Hess et al.   IMMUNITY

Neutrophil-mediated experimental metastasis is enhanced by VEGFR inhibition in a zebrafish xenograft model

(2012) Shuning He et al.   JOURNAL OF PATHOLOGY

Automated Whole Animal Bio-Imaging Assay for Human Cancer Dissemination

(2012) Veerander P. S. Ghotra et al.   PLoS One

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Regulation of neutrophil trafficking from the bone marrow

(2011) Ryan B. Day et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Assembly and patterning of the vascular network of the vertebrate hindbrain

(2011) M. Fujita et al.   DEVELOPMENT

Arterial-venous network formation during brain vascularization involves hemodynamic regulation of chemokine signaling

(2011) J. Bussmann et al.   DEVELOPMENT

Cxcl12 evolution - subfunctionalization of a ligand through altered interaction with the chemokine receptor

(2011) B. Boldajipour et al.   DEVELOPMENT

The CXC Chemokine Receptor 4 Ligands Ubiquitin and Stromal Cell-derived Factor-1α Function through Distinct Receptor Interactions

(2011) Vikas Saini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling

(2011) Arun K. Shukla et al.   TRENDS IN BIOCHEMICAL SCIENCES

mpeg1 promoter transgenes direct macrophage-lineage expression in zebrafish

(2010) F. Ellett et al.   BLOOD

Live imaging of neutrophil motility in a zebrafish model of WHIM syndrome

(2010) K. B. Walters et al.   BLOOD

CXCL12 (SDF-1)/CXCR4 Pathway in Cancer

(2010) B. A. Teicher et al.   CLINICAL CANCER RESEARCH

CXC Chemokine Receptor 4 Is a Cell Surface Receptor for Extracellular Ubiquitin

(2010) Vikas Saini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Visualizing extravasation dynamics of metastatic tumor cells

(2010) K. Stoletov et al.   JOURNAL OF CELL SCIENCE

Triple-negative breast cancer: Present challenges and new perspectives

(2010) Franca Podo et al.   Molecular Oncology

A new bioinformatics analysis tools framework at EMBL-EBI

(2010) M. Goujon et al.   NUCLEIC ACIDS RESEARCH

Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists

(2010) B. Wu et al.   SCIENCE

Functional diversity of SDF-1 splicing variants

(2010) Miroslaw Janowski   Cell Adhesion & Migration

Biology, Metastatic Patterns, and Treatment of Patients with Triple-Negative Breast Cancer

(2009) Carey K. Anders et al.   Clinical Breast Cancer

Pivotal Advance: Pharmacological manipulation of inflammation resolution during spontaneously resolving tissue neutrophilia in the zebrafish

(2009) Catherine A. Loynes et al.   JOURNAL OF LEUKOCYTE BIOLOGY

AMD3100 Is a CXCR7 Ligand with Allosteric Agonist Properties

(2009) I. Kalatskaya et al.   MOLECULAR PHARMACOLOGY

 -arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7

(2009) S. Rajagopal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of Chemokine-Guided Cell Migration by Ligand Sequestration

(2008) Bijan Boldajipour et al.   CELL

Orally Bioavailable Isothioureas Block Function of the Chemokine Receptor CXCR4 In Vitro and In Vivo

(2008) Gebhard Thoma et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chemokines and leukocyte traffic

(2008) Federica Sallusto et al.   NATURE IMMUNOLOGY