Hyaluronan synthesis inhibition impairs antigen presentation and delays transplantation rejection

Autophagic degradation of HAS2 in endothelial cells: A novel mechanism to regulate angiogenesis

(2020) Carolyn G. Chen et al.   MATRIX BIOLOGY

Human Regulatory Dendritic Cells Develop From Monocytes in Response to Signals From Regulatory and Helper T Cells

(2020) Xiangyue Zhang et al.   Frontiers in Immunology

An integrated assay to probe endothelial glycocalyx-blood cell interactions under flow in mechanically and biochemically well-defined environments

(2019) Heather S. Davies et al.   MATRIX BIOLOGY

Bacteriophage trigger antiviral immunity and prevent clearance of bacterial infection

(2019) Johanna M. Sweere et al.   SCIENCE

Hyaluronan biology: A complex balancing act of structure, function, location and context

(2019) Stavros Garantziotis et al.   MATRIX BIOLOGY

4-Methylumbelliferyl glucuronide contributes to hyaluronan synthesis inhibition

(2019) Nadine Nagy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hyaluronan synthase 2–mediated hyaluronan production mediates Notch1 activation and liver fibrosis

(2019) Yoon Mee Yang et al.   Science Translational Medicine

Dynamic cell–cell adhesion mediated by pericellular matrix interaction – a hypothesis

(2019) Rudolf Winklbauer   JOURNAL OF CELL SCIENCE

Hyaluronic Acid Synthesis Contributes to Tissue Damage in Systemic Lupus Erythematosus

(2019) Abel Suarez-Fueyo et al.   Frontiers in Immunology

Tumor-suppressive functions of 4-MU on breast cancer cells of different ER status: Regulation of hyaluronan/HAS2/CD44 and specific matrix effectors

(2018) Theodoros T. Karalis et al.   MATRIX BIOLOGY

Role of hyaluronan in atherosclerosis: Current knowledge and open questions

(2018) Jens W. Fischer   MATRIX BIOLOGY

Hyaluronan in immune dysregulation and autoimmune diseases

(2018) Nadine Nagy et al.   MATRIX BIOLOGY

Activated hyaluronan metabolism in the tumor matrix — Causes and consequences

(2018) Markku I. Tammi et al.   MATRIX BIOLOGY

TSG-6: A multifunctional protein with anti-inflammatory and tissue-protective properties

(2018) Anthony J. Day et al.   MATRIX BIOLOGY

Regulation of hyaluronan biosynthesis and clinical impact of excessive hyaluronan production

(2018) Paraskevi Heldin et al.   MATRIX BIOLOGY

Cancer Cell Glycocalyx and Its Significance in Cancer Progression

(2018) Hongyan Kang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hyaluronan levels are increased systemically in human type 2 but not type 1 diabetes independently of glycemic control

(2018) Nadine Nagy et al.   MATRIX BIOLOGY

Regeneration of glycocalyx by heparan sulfate and sphingosine 1-phosphate restores inter-endothelial communication

(2017) Solomon A. Mensah et al.   PLoS One

Cell Surface Access Is Modulated by Tethered Bottlebrush Proteoglycans

(2016) Patrick S. Chang et al.   BIOPHYSICAL JOURNAL

Hepatitis C virus infection propagates through interactions between Syndecan-1 and CD81 and impacts the hepatocyte glycocalyx

(2016) Boyan Grigorov et al.   CELLULAR MICROBIOLOGY

The pharmacokinetics and dosing of oral 4-methylumbelliferone for inhibition of hyaluronan synthesis in mice

(2016) H. F. Kuipers et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Endothelial and Microcirculatory Function and Dysfunction in Sepsis

(2016) James F. Colbert et al.   CLINICS IN CHEST MEDICINE

Binding of Hyaluronan to the Native Lymphatic Vessel Endothelial Receptor LYVE-1 Is Critically Dependent on Receptor Clustering and Hyaluronan Organization

(2016) William Lawrance et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hyaluronan synthesis is necessary for autoreactive T-cell trafficking, activation, and Th1 polarization

(2016) Hedwich F. Kuipers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TCR Signal Strength Alters T–DC Activation and Interaction Times and Directs the Outcome of Differentiation

(2016) Nicholas van Panhuys   Frontiers in Immunology

Immunosuppressive Medications

(2015) A. C. Wiseman   Clinical Journal of the American Society of Nephrology

Inhibition of hyaluronan synthesis restores immune tolerance during autoimmune insulitis

(2015) Nadine Nagy et al.   JOURNAL OF CLINICAL INVESTIGATION

4-Methylumbelliferone Treatment and Hyaluronan Inhibition as a Therapeutic Strategy in Inflammation, Autoimmunity, and Cancer

(2015) Nadine Nagy et al.   Frontiers in Immunology

The endothelial glycocalyx: a review of the vascular barrier

(2014) C. S. Alphonsus et al.   ANAESTHESIA

Hyaluronan and Hyaluronan-Binding Proteins Accumulate in Both Human Type 1 Diabetic Islets and Lymphoid Tissues and Associate With Inflammatory Cells in Insulitis

(2014) M. Bogdani et al.   DIABETES

Treatment with the Hyaluronic Acid Synthesis Inhibitor 4-Methylumbelliferone Suppresses LPS-Induced Lung Inflammation

(2014) Robert J. McKallip et al.   INFLAMMATION

Inhibition of Hyaluronan Synthesis Protects against Central Nervous System (CNS) Autoimmunity and Increases CXCL12 Expression in the Inflamed CNS

(2014) Andre Michael Mueller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The structure and function of the pericellular matrix of articular cartilage

(2014) Rebecca E. Wilusz et al.   MATRIX BIOLOGY

Suppression of Hyaluronan Synthesis Alleviates Inflammatory Responses in Murine Arthritis and in Human Rheumatoid Synovial Fibroblasts

(2013) Yutaka Yoshioka et al.   ARTHRITIS AND RHEUMATISM

Differential Expression of MicroRNAs During Allograft Rejection

(2012) L. Wei et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Strong CD28 costimulation suppresses induction of regulatory T cells from naive precursors through Lck signaling

(2011) K. Semple et al.   BLOOD

Low-Dose Antigen Promotes Induction of FOXP3 in Human CD4+ T Cells

(2011) S. A. Long et al.   JOURNAL OF IMMUNOLOGY

Strength of TCR-Peptide/MHC Interactions and In Vivo T Cell Responses

(2011) E. Corse et al.   JOURNAL OF IMMUNOLOGY

Hyaluronan and versican in the control of human T-lymphocyte adhesion and migration

(2011) Stephen P. Evanko et al.   MATRIX BIOLOGY

Hyaluronan as an Immune Regulator in Human Diseases

(2011) Dianhua Jiang et al.   PHYSIOLOGICAL REVIEWS

ECM components guide IL-10 producing regulatory T-cell (TR1) induction from effector memory T-cell precursors

(2011) P. L. Bollyky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse

(2010) Paul L Bollyky et al.   Cellular & Molecular Immunology

Cellular Requirements for Diabetes Induction in DO11.10xRIPmOVA Mice

(2010) J. D. Wesley et al.   JOURNAL OF IMMUNOLOGY

4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3

(2009) Anne Kultti et al.   EXPERIMENTAL CELL RESEARCH

Immunological functions of hyaluronan and its receptors in the lymphatics

(2009) David G. Jackson   IMMUNOLOGICAL REVIEWS

Dominant Role of Antigen Dose in CD4+Foxp3+ Regulatory T Cell Induction and Expansion

(2009) M. S. Turner et al.   JOURNAL OF IMMUNOLOGY

Intact extracellular matrix and the maintenance of immune tolerance: high molecular weight hyaluronan promotes persistence of induced CD4+CD25+ regulatory T cells

(2009) Paul L. Bollyky et al.   JOURNAL OF LEUKOCYTE BIOLOGY

T-cell activation through immunological synapses and kinapses

(2008) Michael L. Dustin   IMMUNOLOGICAL REVIEWS

Characterizing the glycome of the mammalian immune system

(2008) Stuart M Haslam et al.   IMMUNOLOGY AND CELL BIOLOGY

Pericellular Hyaluronan Coat Visualized in Live Cells With a Fluorescent Probe Is Scaffolded by Plasma Membrane Protrusions

(2008) Kirsi Rilla et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY