Article
Biochemistry & Molecular Biology
Jiarui Zhang, Yoshihiro Nishida, Hiroshi Koike, Lisheng Zhuo, Kan Ito, Kunihiro Ikuta, Tomohisa Sakai, Shiro Imagama
Summary: This study aimed to investigate the effects of ipriflavone on the development and progression of osteoarthritis (OA) by reducing KIAA1199 activity. The results showed that ipriflavone could suppress OA onset and progression by targeting KIAA1199 activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Laura C. Bahlmann, Alexander E. G. Baker, Chang Xue, Sophie Liu, Moritz Meier-Merziger, Danielle Karakas, Luke Zhu, Ileana Co, Spencer Zhao, Allysia Chin, Alison McGuigan, John Kuruvilla, Rob C. Laister, Molly S. Shoichet
Summary: Studies have shown that macrophages migrate to a greater depth in cryogels with greater porosity and pore size, primarily through a matrix metalloproteinase-mediated mechanism. The migration of macrophages in cryogels is influenced by cell polarization, with polarized macrophages using a combination of amoeboid and mesenchymal migration. These findings pave the way for further research on macrophage invasion in a biomimetic tumor microenvironment.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Oncology
Evgenia Karousou, Arianna Parnigoni, Paola Moretto, Alberto Passi, Manuela Viola, Davide Vigetti
Summary: The extracellular matrix has a complex structure and the glycans within are difficult to study, but they have various effects on cells, especially the glycosaminoglycan hyaluronan. Changes in hyaluronan concentration or dimension can affect tissue stiffness and cellular response through membrane receptors. Hyaluronan plays a role in cancer progression and can be affected by growth factors and cell metabolism.
Review
Cell Biology
Celine Evrard, Catherine Lambert de Rouvroit, Yves Poumay
Summary: In the skin, the extracellular matrix (ECM) plays a crucial role in forming and maintaining the epidermal barrier. Hyaluronan (HA) is a key ECM molecule in the epidermis, involved in formation, organization, and stabilization of the ECM. However, the exact functions of HA in keratinocyte proliferation and differentiation are still controversial.
Review
Biochemistry & Molecular Biology
Eva Nagyova, Lucie Nemcova, Antonella Camaioni
Summary: The extracellular matrix plays a crucial role in the development of ovarian follicles, and its formation and function are regulated by proteolytic cleavage and hormonal stimulation. Specifically, the proteasome inhibitor MG132 affects the cytoskeletal structure, organization of cumulus ECM, steroidogenesis, and nuclear maturation in gonadotropin-stimulated oocyte-cumulus complexes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Marina Marozzi, Arianna Parnigoni, Aide Negri, Manuela Viola, Davide Vigetti, Alberto Passi, Evgenia Karousou, Federica Rizzi
Summary: Cancer is a complex pathology characterized by uncontrolled cell proliferation and decreased apoptosis, often in an inflammatory environment. Changes in the extracellular matrix (ECM) and signaling pathways play crucial roles in tumor growth and metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Nansy Albtoush, Kimberly A. Queisser, Ash Zawerton, Mark E. Lauer, Ellen J. Beswick, Aaron C. Petrey
Summary: Changes in the extracellular matrix are crucial in the inflammatory response, and TSG6 plays a significant role in modifying the matrix by transferring HC proteins to HA. This modification leads to the formation of HC:HA complexes, which have implications in both protective and pathological responses. In IBD, the expression of TSG6 is elevated, and HC deposition is increased, indicating its involvement in intestinal inflammation. TSG6's enzymatic activity contributes to the stability of the HA ECM during inflammation, and HC:HA complexes can attenuate the inflammatory response.
Review
Medicine, General & Internal
Rafaela-Maria Kavasi, Monica Neagu, Carolina Constantin, Adriana Munteanu, Mihaela Surcel, Aristidis Tsatsakis, George N. Tzanakakis, Dragana Nikitovic
Summary: This article discusses the structural and functional modulations of the keratinocyte carcinoma microenvironment, focusing on the extracellular matrix (ECM) and its role in the pathogenesis of skin cancer.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Carolyn G. Chen, Aastha Kapoor, Christopher Xie, Alison Moss, Rajanikanth Vadigepalli, Sylvie Ricard-Blum, Renato V. Iozzo
Summary: The accumulation of pro-angiogenic and pro-tumorigenic hyaluronan in the tumor stroma contributes to tumorigenesis and metastatic potential. The primary enzyme promoting hyaluronan build-up in breast cancer is HAS2. This study found that endorepellin, a fragment of perlecan, targets endothelial HAS2 and hyaluronan through autophagy, leading to the suppression of breast cancer growth and angiogenesis.
Article
Biochemistry & Molecular Biology
Dimitris Kokoretsis, Evangelia-Konstantina Maniaki, Konstantina Kyriakopoulou, Christos Koutsakis, Zoi Piperigkou, Nikos K. Karamanos
Summary: This article highlights the vital functions of hyaluronan (HA) in cancer cell initiation, progression, and immune response, as well as its paracrine interactions with stromal cells. Furthermore, it discusses the important role of HA in the formation of pre-metastatic niche, which may contribute to the improvement of current theranostic approaches for cancer management.
Article
Oncology
Emma L. Reeves, Jin Li, Konstantinos Zormpas-Petridis, Jessica K. R. Boult, James Sullivan, Craig Cummings, Barbara Blouw, David Kang, Ralph Sinkus, Jeffrey C. Bamber, Yann Jamin, Simon P. Robinson
Summary: Hyaluronan is a key component in breast cancer and its accumulation is associated with poor prognosis. PEGPH20 can degrade HA and enhance drug delivery. Multiparametric MRI was used to evaluate the response of breast tumor models to PEGPH20.
MOLECULAR ONCOLOGY
(2023)
Article
Materials Science, Biomaterials
Lun Liang, Run Cui, Sheng Zhong, Zhenning Wang, Zhenqiang He, Hao Duan, Xiaoyu Guo, Jie Lu, Hongrong Hu, Chang Li, Chengwei Yu, Yanjiao Yu, Chengcheng Guo, Yonggao Mou
Summary: Biomimetic hydrogels offer an exceptional window for the construction of tumor organoids, ensuring the accuracy of research and clinical data.
BIOMATERIALS SCIENCE
(2022)
Article
Neurosciences
Jana Dubisova, Jana Svobodova Burianova, Lucie Svobodova, Pavol Makovicky, Noelia Martinez-Varea, Anda Cimpean, James W. Fawcett, Jessica C. F. Kwok, Sarka Kubinova
Summary: Memory retention was enhanced by attenuating perineuronal net formation using 4-MU treatment in mice, but the effect was not sustained.
BRAIN RESEARCH BULLETIN
(2022)
Review
Oncology
Daiana L. Vitale, Antonella Icardi, Paolo Rosales, Fiorella M. Spinelli, Ina Sevic, Laura D. Alaniz
Summary: 4-Methylumbelliferone (4-MU), a natural product with antitumoral properties, inhibits tumor growth and progression by specifically inhibiting hyaluronan synthesis. It also impacts tumor cell functions, cancer stem cells, and the tumor microenvironment. However, more scientific evidence is needed to support its use in cancer therapy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Genetics & Heredity
Wendena S. Parkes, Farners Amargant, Luhan T. Zhou, Cecilia E. Villanueva, Francesca E. Duncan, Michele T. Pritchard
Summary: The extracellular matrix (ECM) of the ovarian stroma, consisting of collagen and hyaluronan (HA), varies in content, molecular weight, and gene transcripts among different mammalian species. These differences have implications for the composition, organization, and regulation of the ovarian ECM in large mammalian species, including humans.
Article
Microbiology
Ky Van Hoang, Carolyn G. Chen, Jacob Koopman, Jasmine Moshiri, Haley E. Adcox, John S. Gunn
FRONTIERS IN MICROBIOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Aastha Kapoor, Amlan Barai, Bhushan Thakur, Alakesh Das, Sejal R. Patwardhan, Melissa Monteiro, Snehal Gaikwad, Amirali B. Bukhari, Pankaj Mogha, Abhijit Majumder, Abhijit De, Pritha Ray, Shamik Sen
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Panagiotis Bouris, Dimitra Manou, Anastasia Sopaki-Valalaki, Anthi Kolokotroni, Aristidis Moustakas, Aastha Kapoor, Renato V. Iozzo, Nikos K. Karamanos, Achilleas D. Theocharis
Article
Multidisciplinary Sciences
Sandeep Kumar, Aastha Kapoor, Sejal Desai, Mandar M. Inamdar, Shamik Sen
SCIENTIFIC REPORTS
(2016)
Review
Oncology
Maria A. Gubbiotti, Simone Buraschi, Aastha Kapoor, Renato Iozzo
SEMINARS IN CANCER BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Thomas Neill, Carolyn G. Chen, Simone Buraschi, Renato V. Iozzo
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Aastha Kapoor, Carolyn G. Chen, Renato V. Iozzo
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Review
Cell Biology
Thomas Neill, Simone Buraschi, Aastha Kapoor, Renato V. Iozzo
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
(2020)
Review
Biochemistry & Molecular Biology
Carolyn G. Chen, Renato V. Iozzo
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Review
Biochemistry & Molecular Biology
Carolyn G. Chen, Renato Iozzo
Summary: The extracellular matrix (ECM) plays a critical role in maintaining tissue homeostasis and has a significant impact on cancer initiation and progression. The emerging field of matrix biology focuses on the role of proteoglycans in regulating autophagy, a cellular process that has complex and context-dependent functions in cancer.