Article
Multidisciplinary Sciences
Egle Kvedaraite, Laura Hertwig, Indranil Sinha, Andrea Ponzetta, Ida Hed Myrberg, Magda Lourda, Majda Dzidic, Mira Akber, Jonas Klingstrom, Elin Folkesson, Jagadeeswara Rao Muvva, Puran Chen, Sara Gredmark-Russ, Susanna Brighenti, Anna Norrby-Teglund, Lars Eriksson, Olav Rooyackers, Soo Aleman, Kristoffer Stralin, Hans-Gustaf Ljunggren, Florent Ginhoux, Niklas K. Bjorkstrom, Jan-Inge Henter, Mattias Svensson
Summary: This study found that COVID-19 patients experience a redistribution of monocyte subsets towards intermediate monocytes and a general decrease in circulating dendritic cells. Severe disease is associated with the appearance of monocytic myeloid-derived suppressor cell-like cells and a higher frequency of pre-DC2. The phenotypic alterations in mononuclear phagocytes are cell-lineage-specific and linked to the response against SARS-CoV-2 or COVID-19 severity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Andrew D. Hoffmann, Sam E. Weinberg, Suchitra Swaminathan, Shuvam Chaudhuri, Hannah Faisal Almubarak, Matthew J. Schipma, Chengsheng Mao, Xinkun Wang, Lamiaa El-Shennawy, Nurmaa K. Dashzeveg, Juncheng Wei, Paul J. Mehl, Laura J. Shihadah, Ching Man Wai, Carolina Ostiguin, Yuzhi Jia, Paolo Amico, Neale R. Wang, Yuan Luo, Alexis R. Demonbreun, Michael G. Ison, Huiping Liu, Deyu Fang
Summary: After more than two years of the COVID-19 pandemic, the long-term impact of SARS-CoV-2 on the immune response remains largely unknown. This study conducted single-cell analyses on 100 patients, including those who have recovered from severe COVID-19, revealing altered frequencies and molecular signatures of monocytes and Treg cells associated with COVID-19 severity. The findings suggest sustained alterations in short-lived monocytes and restoration of long-lived Tregs over time.
CLINICAL IMMUNOLOGY
(2023)
Article
Immunology
Yuyue Zhang, Jie Zhang, Yun Shi, Min Shen, Hui Lv, Shu Chen, Yingjie Feng, Heng Chen, Xinyu Xu, Tao Yang, Kuanfeng Xu
Summary: In this study, differences in maturation status and immune phenotypes were observed in Helios(+) and Helios(-) Treg subsets in individuals with type 1 diabetes (T1D). The association between these Treg subsets and monocyte subsets was found to be disrupted in T1D patients, indicating potential implications for understanding the mechanisms of T1D.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Immunology
Annika Frede, Simon Milling
Summary: The fetal immune system shows higher tolerance to foreign antigens compared to the adult immune system, and neonates rely on maternal antibodies for protection. The establishment of tolerance during early life may have long-term implications for immune homeostasis and predisposition to autoimmune diseases, but the mechanisms underlying the switch from perinatal tolerogenic immune responses to adult-like effector immune responses are not well understood.
Article
Immunology
Camille Chauvin, Daniel Alvarez-Simon, Katarina Radulovic, Olivier Boulard, William Laine, Myriam Delacre, Nadine Waldschmitt, Elodie Segura, Jerome Kluza, Mathias Chamaillard, Lionel F. F. Poulin
Summary: The recruitment of pathogenic macrophages in Crohn's Disease (CD) patients with NOD2 risk alleles is believed to be caused by the recruitment of monocytes from the intestine. However, this study suggests that NOD2 may instead inhibit the differentiation of monocytes into macrophages from the bloodstream.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Koichi Murakami, Haruka Sasaki, Akira Nishiyama, Daisuke Kurotaki, Wataru Kawase, Tatsuma Ban, Jun Nakabayashi, Satoko Kanzaki, Yoichi Sekita, Hideaki Nakajima, Keiko Ozato, Tohru Kimura, Tomohiko Tamura
Summary: IRF8 transcription factor regulates lineage choice in the myeloid cell system in a dose-dependent manner through epigenetic regulation of distinct sets of enhancers in cooperation with other transcription factors.
Article
Oncology
Hongsheng Wang, Jie Wan, Huangao Zhou, Jianing Xu, Yunpeng Lu, Xiaoyun Ji, Yizheng Yao, Hou Chao, Jun Zhang, Xiaochun Zhang, Shun Yao, Yinqiu Wu
Summary: This review discusses the impact of the GBM microenvironment on T-cell subsets and strategies to overcome immunosuppression.
Article
Immunology
Pengju Yang, Mei Luan, Weizhe Li, Mengtian Niu, Qiannan He, Yixin Zhao, Jianan Chen, Binyue Mao, Kuanhou Mou, Pan Li
Summary: This study utilized single cell RNA sequencing to investigate the mechanisms of peripheral immune responses in vitiligo patients, identifying differences in transcriptome profiles of various immune cell populations. The findings provide new insights into the pathogenesis of vitiligo and may aid in the identification of potential therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Weiwei Sun, Lili Dai, Yuqing Cao, Pengtao Pan, Lijuan Zhi, Xinke Wang, Xinzhong Yuan, Zi Gao, Sheng Guo, Guoyan Liu, Junlei Yin, Liangliang Xie, Liping Wang, Yanling Wang, Wensheng Li, Hong Li, Yunjie Jia
Summary: Tumor microparticles (T-MPs) are potential candidates for tumor vaccines, but the mechanism of how they stimulate anti-tumor immune response is not fully understood. This study demonstrates that T-MPs induce macrophages to release CCL2, attracting monocytes to the vaccine injection site and enhancing antigen endocytosis. The monocytes then differentiate into moDCs, presenting tumor antigens to T lymphocytes and promoting a strong anti-tumor immune response. Furthermore, T-MPs activate cGAS-STING signaling, upregulate IRF4 expression in monocytes, and confer the ability to treat tumors. This research provides insights into the development of novel vaccination strategies and the clinical application of T-MPs in oncotherapy.
CANCER NANOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Silvia Galvan-Pena, Juliette Leon, Kaitavjeet Chowdhary, Daniel A. Michelson, Brinda Vijaykumar, Liang Yang, Angela Magnuson, Zachary Manickas-Hill, Alicja Piechocka-Trocha, Daniel P. Worrall, Kathryn E. Hall, Musie Ghebremichael, Bruce D. Walker, Jonathan Z. Li, Xu G. Yu, Diane Mathis, Christophe Benoist
Summary: Severe COVID-19 is characterized by an uncontrolled inflammatory response, potentially linked to dysregulation in T regulatory cells (Treg) which may suppress antiviral T cell responses and have a direct proinflammatory role.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Javad Rasouli, Giacomo Casella, Larissa L. W. Ishikawa, Rodolfo Thome, Alexandra Boehm, Adam Ertel, Carolina R. Melo-Silva, Elisabeth R. Mari, Patrizia Porazzi, Weifeng Zhang, Dan Xiao, Luis J. Sigal, Paolo Fortina, Guang-Xian Zhang, Abdolmohamad Rostami, Bogoljub Ciric
Summary: The study reveals that IFN-beta therapy reduces GM-CSF production by Th cells indirectly through its effects on monocytes, and increases IL-10 expression in monocytes to suppress IL-1 beta secretion, thereby disrupting a proinflammatory loop involving several molecules derived from Th cells and monocytes.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Sudhir Gupta, Anshu Agrawal
Summary: In this study, the authors reviewed the biology of dendritic cells (DCs) in inborn errors of immunity (IEI) and discussed the role of DCs in clinical and immunological manifestations. They focused on severe immunodeficiency diseases, antibody deficiencies, combined immunodeficiency with associated and syndromic features, disorders of synapse formation, and disorders of immune regulation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Allergy
Andrzej Eljaszewicz, Fiorella Ruchti, Urszula Radzikowska, Anna Globinska, Tadech Boonpiyathad, Anna Gschwend, Hideaki Morita, Arthur Helbling, Stefania Arasi, Helga Kahlert, Nadine Berek, Andreas Nandy, Mubeccel Akdis, Christoph Willers, Marcin Moniuszko, Cezmi A. Akdis, Milena Sokolowska
Summary: This study found that AIT treatment can induce changes in the composition and heterogeneity of circulating innate immune cells, bringing them to the level observed in healthy individuals. Monitoring of ILCs, monocytes, and DCs during AIT may serve as a novel biomarker strategy.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Qiaomei Zheng, Ping Wu, Yanjing Zhao, Jinhua Wang, Shaozhan Chen, Lihong Chen
Summary: This study found that there is an increased number of dendritic cells (DCs) in the peritoneal cavity of endometriosis patients, with a decreased proportion of mature DCs and an increased proportion of immature DCs. Similar results were observed in a mouse model of endometriosis. These findings are important for further understanding the pathogenesis of endometriosis and providing new insights into medical treatment.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Article
Immunology
Mostafa G. G. Aly, Eman H. H. Ibrahim, Hristos Karakizlis, Rolf Weimer, Gerhard Opelz, Christian Morath, Martin Zeier, Naruemol Ekpoom, Volker Daniel
Summary: In this study, the relationship between regulatory cells and immunosuppressive drugs in transplant recipients was investigated. The results showed a negative correlation between CD4+CD25+CD127-Foxp3+ Tregs and CD19+IL-10+ Bregs in early transplant recipients, with Tregs being affected by steroid dose and tacrolimus levels, while Bregs seemed less affected by potent immunosuppression. It was also found that CD4+CD25+CD127-Foxp3+ Tregs were lower in patients treated with certain antibodies compared to end-stage kidney disease patients. Early transplant recipients exhibited different patterns of Tregs and Bregs within the first 3 months post-transplant, indicating a complex relationship between these regulatory cells and immunosuppression.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Hematology
Omid Shah, John S. Tamaresis, Laura Jean Kenyon, Liwen Xu, Pingping Zheng, Puja Gupta, Krish Rangarajan, Stephanie Lee, Stephen Spellman, Sarah Nikiforow, James Zehnder, Everett H. Meyer
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2020)
Article
Hematology
Pingping Zheng, John Tamaresis, Govindarajan Thangavelu, Liwen Xu, Xiaoqing You, Bruce R. Blazar, Robert S. Negrin, James L. Zehnder, Bettina P. Iliopoulou, Everett H. Meyer
Article
Behavioral Sciences
Tyler R. Prestwood, Roshanak Asgariroozbehani, Sally Wu, Sri Mahavir Agarwal, Ryan W. Logan, Jacob S. Ballon, Margaret K. Hahn, Zachary Freyberg
Summary: Schizophrenia is characterized by inflammation and metabolic disturbances, with inflammation playing a key role in the disease. While antipsychotic drugs have revolutionized management of psychosis, they also lead to metabolic disturbances.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Immunology
Ligal Aizik, Yael Dror, David Taussig, Adi Barzel, Yaron Carmi, Yariv Wine
Summary: The study found that B cells in the tumor microenvironment exhibit high clonal polarization and mutation rates, suggesting a local antigen-driven B-cell response. Importantly, these B cells are highly mutated but not class switched, indicating that class-switch recombination may be inhibited in the TME. Tracing the distribution of these B cell clones across compartments indicates their migration to and from the TME, suggesting that antibody repertoire signatures can be used as indicators for identifying tumor-reactive B cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Nathan E. Reticker-Flynn, Weiruo Zhang, Julia A. Belk, Pamela A. Basto, Nichole K. Escalante, Genay O. W. Pilarowski, Alborz Bejnood, Maria M. Martins, Justin A. Kenkel, Ian L. Linde, Sreya Bagchi, Robert Yuan, Serena Chang, Matthew H. Spitzer, Yaron Carmi, Jiahan Cheng, Lorna L. Tolentino, Okmi Choi, Nancy Wu, Christina S. Kong, Andrew J. Gentles, John B. Sunwoo, Ansuman T. Satpathy, Sylvia K. Plevritis, Edgar G. Engleman
Summary: Lymph node metastasis plays an active role in shaping distant metastasis in solid malignancies, and this mechanism involves the evasion of immune cells, colonization in lymph nodes, and subsequent colonization in other tissues. This mechanism is conserved in human cancers and murine cancer models.
Editorial Material
Immunology
Gideon Gross, Yaron Carmi, Hinrich Abken
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Manu Prasad, Jonathan Zorea, Sankar Jagadeeshan, Avital B. Shnerb, Sooraj Mathukkada, Jebrane Bouaoud, Lucas Michon, Ofra Novoplansky, Mai Badarni, Limor Cohen, Ksenia M. Yegodayev, Sapir Tzadok, Barak Rotblat, Libor Brezina, Andreas Mock, Andy Karabajakian, Jerome Fayette, Idan Cohen, Tomer Cooks, Irit Allon, Orr Dimitstein, Benzion Joshua, Dexin Kong, Elena Voronov, Maurizio Scaltriti, Yaron Carmi, Cristina Conde-Lopez, Jochen Hess, Ina Kurth, Luc G. T. Morris, Pierre Saintigny, Moshe Elkabets
Summary: In head and neck cancer, treatment with MEK1/2 inhibitor delays tumor progression and enhances antitumor immunity of CD8(+) T cells. Sensitizing tumors to immunotherapy during MEK1/2 inhibition can eliminate tumors and induce immune memory. Prolonged treatment with MEK1/2 inhibitor may lead to immunosuppressive tumor microenvironment due to epithelial to mesenchymal transition.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Biotechnology & Applied Microbiology
Alessio D. Nahmad, Cicera R. Lazzarotto, Natalie Zelikson, Talia Kustin, Mary Tenuta, Deli Huang, Inbal Reuveni, Daniel Nataf, Yuval Raviv, Miriam Horovitz-Fried, Iris Dotan, Yaron Carmi, Rina Rosin-Arbesfeld, David Nemazee, James E. Voss, Adi Stern, Shengdar Q. Tsai, Adi Barzel
Summary: In vivo engineering of B cells to secrete anti-HIV antibodies is a safe, potent, and scalable method that can be used for the treatment of infectious and noncommunicable diseases.
NATURE BIOTECHNOLOGY
(2022)
Article
Biology
Amit Gutwillig, Nadine Santana-Magal, Leen Farhat-Younis, Diana Rasoulouniriana, Asaf Madi, Chen Luxenburg, Jonathan Cohen, Krishnanand Padmanabhan, Noam Shomron, Guy Shapira, Annette Gleiberman, Roma Parikh, Carmit Levy, Meora Feinmesser, Dov Hershkovitz, Valentina Zemser-Werner, Oran Zlotnik, Sanne Kroon, Wolf-Dietrich Hardt, Reno Debets, Nathan Edward Reticker-Flynn, Peleg Rider, Yaron Carmi
Summary: Despite the successes of cancer immunotherapies, many patients experience partial response and relapse due to treatment resistance. This study reveals a previously unknown resistance mechanism where tumor cells form unique cell-in-cell structures to evade immunotherapy. Inhibiting specific factors involved in this process improves therapeutic efficacy.
Article
Oncology
Ian L. Linde, Tyler R. Prestwood, Jingtao Qiu, Genay Pilarowski, Miles H. Linde, Xiangyue Zhang, Lei Shen, Nathan E. Reticker-Flynn, David Kung-Chun Chiu, Lauren Y. Sheu, Simon Van Deursen, Lorna L. Tolentino, Wen-Chao Song, Edgar G. Engleman
Summary: Although neutrophils are often used by cancers to promote immunosuppression, tumor growth, and metastasis, this study shows that neutrophils can be harnessed to induce eradication of tumors and reduce metastatic seeding. The combination of tumor necrosis factor, CD40 agonist, and tumor-binding antibody activates human neutrophils in vitro, leading to their lysis of human tumor cells. Mechanistically, this therapy mobilizes neutrophils to infiltrate tumors and activate complement, resulting in the production of leukotriene B4 and subsequent oxidative damage and T cell-independent clearance of multiple tumor types. These findings highlight the potential of using neutrophils as anti-tumor immune mediators.
Meeting Abstract
Biotechnology & Applied Microbiology
Y. Carmi
HUMAN GENE THERAPY
(2022)
Article
Oncology
Shelley E. Ackerman, Cecelia I. Pearson, Joshua D. Gregorio, Joseph C. Gonzalez, Justin A. Kenkel, Felix J. Hartmann, Angela Luo, Po Y. Ho, Heidi LeBlanc, Lisa K. Blum, Samuel C. Kimmey, Andrew Luo, Murray L. Nguyen, Jason C. Paik, Lauren Y. Sheu, Benjamin Ackerman, Arthur Lee, Hai Li, Jennifer Melrose, Richard P. Laura, Vishnu C. Ramani, Karla A. Henning, David Y. Jackson, Brian S. Safina, Grant Yonehiro, Bruce H. Devens, Yaron Carmi, Steven J. Chapin, Sean C. Bendall, Marcin Kowanetz, David Dornan, Edgar G. Engleman, Michael N. Alonso
Summary: Alonso and colleagues have developed immune-stimulating antibody conjugates that can specifically deliver TLR7/8 agonists to tumors, inducing durable antitumor immunity.
Article
Oncology
Robert Yuan, Nupur Bhattacharya, Justin A. Kenkel, Jeanne Shen, Michael A. DiMaio, Sreya Bagchi, Tyler R. Prestwood, Aida Habtezion, Edgar G. Engleman
FRONTIERS IN ONCOLOGY
(2020)