Hyaluronan synthase 2–mediated hyaluronan production mediates Notch1 activation and liver fibrosis

HALO-109–301: a Phase III trial of PEGPH20 (with gemcitabine and nab-paclitaxel) in hyaluronic acid-high stage IV pancreatic cancer

(2018) Gary J Doherty et al.   Future Oncology

TMEM2: A missing link in hyaluronan catabolism identified?

(2018) Yu Yamaguchi et al.   MATRIX BIOLOGY

Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis

(2018) Changyu Zhu et al.   Science Translational Medicine

MicroRNA 181b-3p and its target importin α5 regulate toll-like receptor 4 signaling in Kupffer cells and liver injury in mice in response to ethanol

(2017) Paramananda Saikia et al.   HEPATOLOGY

Mechanisms of hepatic stellate cell activation

(2017) Takuma Tsuchida et al.   Nature Reviews Gastroenterology & Hepatology

Targeting TGF-β Mediated SMAD Signaling for the Prevention of Fibrosis

(2017) Kelly L. Walton et al.   Frontiers in Pharmacology

Carcinoma Cell Hyaluronan as a "Portable" Cancerized Prometastatic Microenvironment

(2016) E. A. Turley et al.   CANCER RESEARCH

Hyaluronic acid as a non-invasive biomarker of liver fibrosis

(2016) Manuela G. Neuman et al.   CLINICAL BIOCHEMISTRY

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

The Tetraspanin TSPAN33 Controls TLR-Triggered Macrophage Activation through Modulation of NOTCH Signaling

(2016) Almudena Ruiz-García et al.   JOURNAL OF IMMUNOLOGY

Hyaluronan and TLR4 promote surfactant-protein-C-positive alveolar progenitor cell renewal and prevent severe pulmonary fibrosis in mice

(2016) Jiurong Liang et al.   NATURE MEDICINE

Notch in fibrosis and as a target of anti-fibrotic therapy

(2016) Biao Hu et al.   PHARMACOLOGICAL RESEARCH

Oncogenic role of the Notch pathway in primary liver cancer

(2016) JIE LU et al.   Oncology Letters

Novel drug targets for idiopathic pulmonary fibrosis

(2016) Giacomo Sgalla et al.   Expert Review of Respiratory Medicine

Soluble Notch ligand and receptor peptides act antagonistically during angiogenesis

(2015) Ralph Klose et al.   CARDIOVASCULAR RESEARCH

4-Methylumbelliferone Treatment and Hyaluronan Inhibition as a Therapeutic Strategy in Inflammation, Autoimmunity, and Cancer

(2015) Nadine Nagy et al.   Frontiers in Immunology

Metabolic Activation of Intrahepatic CD8+ T Cells and NKT Cells Causes Nonalcoholic Steatohepatitis and Liver Cancer via Cross-Talk with Hepatocytes

(2014) Monika Julia Wolf et al.   CANCER CELL

Osteopontin-CD44 Signaling in the Glioma Perivascular Niche Enhances Cancer Stem Cell Phenotypes and Promotes Aggressive Tumor Growth

(2014) Alexander Pietras et al.   Cell Stem Cell

Notch signaling regulates col1α1 and col1α2 expression in airway fibroblasts

(2014) Mei Hu et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Emerging roles of Notch signaling in liver disease

(2014) Fabian Geisler et al.   HEPATOLOGY

Sonic hedgehog signaling directly targets Hyaluronic Acid Synthase 2, an essential regulator of phalangeal joint patterning

(2013) Jiang Liu et al.   DEVELOPMENTAL BIOLOGY

Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology

(2013) Ingmar Mederacke et al.   Nature Communications

Cross-Talk Between the Toll-Like Receptor 4 and Notch1 Pathways Augments the Inflammatory Response in the Interstitial Cells of Stenotic Human Aortic Valves

(2012) Q. Zeng et al.   CIRCULATION

Identification of Function for CD44 Intracytoplasmic Domain (CD44-ICD)

(2012) Karl E. Miletti-González et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Notch Signal Suppresses Toll-like Receptor-triggered Inflammatory Responses in Macrophages by Inhibiting Extracellular Signal-regulated Kinase 1/2-mediated Nuclear Factor κB Activation

(2011) Qinghua Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Severe lung fibrosis requires an invasive fibroblast phenotype regulated by hyaluronan and CD44

(2011) Yuejuan Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hyaluronan as an Immune Regulator in Human Diseases

(2011) Dianhua Jiang et al.   PHYSIOLOGICAL REVIEWS

Conditional inactivation of Has2 reveals a crucial role for hyaluronan in skeletal growth, patterning, chondrocyte maturation and joint formation in the developing limb

(2009) K. Matsumoto et al.   DEVELOPMENT

Interaction of CD44 and hyaluronan is the dominant mechanism for neutrophil sequestration in inflamed liver sinusoids

(2008) Braedon McDonald et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Notch signaling is activated by TLR stimulation and regulates macrophage functions

(2007) Tanapat Palaga et al.   EUROPEAN JOURNAL OF IMMUNOLOGY