The food plant Silybum marianum (L.) Gaertn.: Phytochemistry, Ethnopharmacology and clinical evidence
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Title
The food plant Silybum marianum (L.) Gaertn.: Phytochemistry, Ethnopharmacology and clinical evidence
Authors
Keywords
S. marianum, Silymarin, Milk thistle, Ethnopharmacology, Clinical
Journal
JOURNAL OF ETHNOPHARMACOLOGY
Volume 265, Issue -, Pages 113303
Publisher
Elsevier BV
Online
2020-09-02
DOI
10.1016/j.jep.2020.113303
References
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Note: Only part of the references are listed.- Relative Bioavailability of Silybin A and Silybin B From 2 Multiconstituent Dietary Supplement Formulations Containing Milk Thistle Extract: A Single-dose Study
- (2018) Wen-Yi Li et al. CLINICAL THERAPEUTICS
- Milk thistle (Silybum marianum ): A concise overview on its chemistry, pharmacological, and nutraceutical uses in liver diseases
- (2018) Ludovico Abenavoli et al. PHYTOTHERAPY RESEARCH
- New amides from seeds of Silybum marianum with potential antioxidant and antidiabetic activities
- (2017) Ning-bo Qin et al. FITOTERAPIA
- The silymarin composition… and why does it matter???
- (2017) Christopher Steven Chambers et al. FOOD RESEARCH INTERNATIONAL
- Assessment of silibinin as a potential antifungal agent and investigation of its mechanism of action
- (2017) Dae Gyu Yun et al. IUBMB LIFE
- Pikuni-Blackfeet traditional medicine: Neuroprotective activities of medicinal plants used to treat Parkinson’s disease-related symptoms
- (2017) Aurélie de Rus Jacquet et al. JOURNAL OF ETHNOPHARMACOLOGY
- Protective role of silymarin and D-penicillamine against lead-induced liver toxicity and oxidative stress
- (2017) Seyedeh Missagh Jalali et al. TOXICOLOGY AND INDUSTRIAL HEALTH
- Protective effects of combined β-caryophyllene and silymarin against ketoprofen-induced hepatotoxicity in rats
- (2016) Mohamed Elsayed Kelany et al. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
- Flavonolignan 2,3-dehydroderivatives: Preparation, antiradical and cytoprotective activity
- (2016) Michaela Pyszková et al. FREE RADICAL BIOLOGY AND MEDICINE
- Phenolic profile and in vitro antioxidant power of different milk thistle [Silybum marianum (L.) Gaertn.] cultivars
- (2016) Luigi Lucini et al. INDUSTRIAL CROPS AND PRODUCTS
- Silibinin triggers yeast apoptosis related to mitochondrial Ca2+ influx in Candida albicans
- (2016) Dae Gyu Yun et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Herbal remedies use by breast cancer patients in the West Bank of Palestine
- (2016) Nidal Amin Jaradat et al. JOURNAL OF ETHNOPHARMACOLOGY
- Ethnobotanical study on the medicinal plants in the Mainarde Mountains (central-southern Apennine, Italy)
- (2016) P. Fortini et al. JOURNAL OF ETHNOPHARMACOLOGY
- Investigation of traditional medicinal floral knowledge of Sarban Hills, Abbottabad, KP, Pakistan
- (2016) Farhana Ijaz et al. JOURNAL OF ETHNOPHARMACOLOGY
- Ethnobotanical investigation on medicinal plants in the Vesuvio National Park (Campania, Southern Italy)
- (2016) Bruno Menale et al. JOURNAL OF ETHNOPHARMACOLOGY
- Recent advances in the analysis of flavonolignans of Silybum marianum
- (2016) Dezső Csupor et al. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
- Antioxidant, anti-collagenase and anti-elastase activities ofPhyllanthus emblica,Manilkara zapotaand silymarin: anin vitrocomparative study for anti-aging applications
- (2016) Sirinya Pientaweeratch et al. PHARMACEUTICAL BIOLOGY
- Intraperitoneal administration of silymarin protects end organs from multivisceral ischemia/reperfusion injury in a rat model
- (2016) Aydemir Koçarslan et al. Revista Brasileira de Cirurgia Cardiovascular
- Potential therapeutic effects of silymarin and silymarin-loaded solid lipidnanoparticles on experimental kidney damage in BALB/c mice: biochemical and histopathological evaluation
- (2016) Mustafa CENGİZ et al. TURKISH JOURNAL OF BIOLOGY
- Intraperitoneal administration of silymarin protects end organs from multivisceral ischemia/reperfusion injury in a rat model
- (2016) Aydemir Koçarslan et al. BRAZILIAN JOURNAL OF CARDIOVASCULAR SURGERY
- Inflammation, Metabolic Dysregulation, and Pulmonary Function among Obese Urban Adolescents with Asthma
- (2015) Deepa Rastogi et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Silymarin and hepatocellular carcinoma
- (2015) Jeanetta K. Mastron et al. ANTI-CANCER DRUGS
- Berberis aristata combined with Silybum marianum on lipid profile in patients not tolerating statins at high doses
- (2015) Giuseppe Derosa et al. ATHEROSCLEROSIS
- Cancer Therapy with Phytochemicals: Present and Future Perspectives
- (2015) Muobarak J. Tuorkey BIOMEDICAL AND ENVIRONMENTAL SCIENCES
- Chemical and productive properties of two Sardinian milk thistle (Silybum marianum (L.) Gaertn.) populations as sources of nutrients and antioxidants
- (2015) Leonardo Sulas et al. GENETIC RESOURCES AND CROP EVOLUTION
- Silymarin and dimercaptosuccinic acid ameliorate lead-induced nephrotoxicity and genotoxicity in rats
- (2015) Y Alcaraz-Contreras et al. HUMAN & EXPERIMENTAL TOXICOLOGY
- Silymarin has antioxidant potential and changes the activity of Na+/K+-ATPase and monoamine oxidase in vitro
- (2015) Dayanne Rakelly de Oliveira et al. INDUSTRIAL CROPS AND PRODUCTS
- Silymarin induces cyclin D1 proteasomal degradation via its phosphorylation of threonine-286 in human colorectal cancer cells
- (2015) Hyun Ji Eo et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Significance of Antioxidant Potential of Plants and its Relevance to Therapeutic Applications
- (2015) Deepak M. Kasote et al. International Journal of Biological Sciences
- High-performance thin-layer chromatography linked with (bio)assays and mass spectrometry – A suited method for discovery and quantification of bioactive components? Exemplarily shown for turmeric and milk thistle extracts
- (2015) Mahmoud N. Taha et al. JOURNAL OF CHROMATOGRAPHY A
- Ethnomedicinal plants of Sarigöl district (Manisa), Turkey
- (2015) Seyid Ahmet Sargin et al. JOURNAL OF ETHNOPHARMACOLOGY
- Uses of plants, animal and mineral substances in Mediterranean ethno-veterinary practices for the care of small ruminants
- (2015) G. Piluzza et al. JOURNAL OF ETHNOPHARMACOLOGY
- Effects of Silybum marianum (L.) Gaertn. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: A randomized, triple-blind, placebo-controlled clinical trial
- (2015) Soraiya Ebrahimpour koujan et al. PHYTOMEDICINE
- Berberis aristata/Silybum marianum fixed combination (Berberol®) effects on lipid profile in dyslipidemic patients intolerant to statins at high dosages: A randomized, placebo-controlled, clinical trial
- (2015) Giuseppe Derosa et al. PHYTOMEDICINE
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- (2015) Foroud Shahbazi et al. PHYTOTHERAPY RESEARCH
- In VitroAntimicrobial and Modulatory Activity of the Natural Products Silymarin and Silibinin
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- Local knowledge of medicinal plants and wild food plants among Tatars and Romanians in Dobruja (South-East Romania)
- (2014) Andrea Pieroni et al. GENETIC RESOURCES AND CROP EVOLUTION
- Protective effect of silymarin against cisplatin-induced ototoxicity
- (2014) Sung Il Cho et al. INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
- Simplified Procedure of Silymarin Extraction from Silybum marianum L. Gaertner
- (2014) D. Wianowska et al. JOURNAL OF CHROMATOGRAPHIC SCIENCE
- The use of plants in the traditional management of diabetes in Nigeria: Pharmacological and toxicological considerations
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- Flavonolignans from Aspergillus iizukae, a Fungal Endophyte of Milk Thistle (Silybum marianum)
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- Plant-Derived Anti-Inflammatory Compounds: Hopes and Disappointments regarding the Translation of Preclinical Knowledge into Clinical Progress
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- Chemistry of silybin
- (2014) D. Biedermann et al. NATURAL PRODUCT REPORTS
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- (2013) David Sadava et al. CANCER LETTERS
- A Phase I Dose-Finding Study of Silybin Phosphatidylcholine (Milk Thistle) in Patients With Advanced Hepatocellular Carcinoma
- (2013) Abby B. Siegel et al. INTEGRATIVE CANCER THERAPIES
- Immunomodulatory effects of silymarin in patients with β-thalassemia major
- (2013) Marjan Gharagozloo et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- New Insight into the Biosynthesis of Flavanolignans in the White-Flowered Variant of Silybum marianum
- (2013) S. Nyiredy et al. JOURNAL OF CHROMATOGRAPHIC SCIENCE
- An ethnobotanical study of medicinal plants used by the local people of Alaşehir (Manisa) in Turkey
- (2013) Seyid Ahmet Sargın et al. JOURNAL OF ETHNOPHARMACOLOGY
- Ethnopharmacological study of medicinal plants used in the treatment of CNS disorders in Sinai Peninsula, Egypt
- (2013) T.A.F. Eissa et al. JOURNAL OF ETHNOPHARMACOLOGY
- Mediterranean non-cultivated vegetables as dietary sources of compounds with antioxidant and biological activity
- (2013) Patricia Morales et al. LWT-FOOD SCIENCE AND TECHNOLOGY
- Silibinin pretreatment attenuates biochemical and behavioral changes induced by intrastriatal MPP+ injection in rats
- (2013) Milind Geed et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- Anti-herpes virus activity of silibinin, the primary active component of Silybum marianum
- (2013) Anthony P. Cardile et al. Journal of Herbal Medicine
- Effect of silymarin on sodium fluoride-induced toxicity and oxidative stress in rat cardiac tissues
- (2012) Seyed M. Nabavi et al. ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
- THE SAFETY AND EFFICACY OF A SILYMARIN AND SELENIUM COMBINATION IN MEN AFTER RADICAL PROSTATECTOMY - A SIX MONTH PLACEBO-CONTROLLED DOUBLE-BLIND CLINICAL TRIAL
- (2012) Ales Vidlar et al. BIOMEDICAL PAPERS-OLOMOUC
- A randomized double-blind, placebo-controlled study of therapeutic effects of silymarin in β-thalassemia major patients receiving desferrioxamine
- (2012) Behjat Moayedi et al. EUROPEAN JOURNAL OF HAEMATOLOGY
- Failure of Intravenous Silibinin Monotherapy to Prevent Hepatitis C Genotype 2A Liver Graft Reinfection
- (2012) Alessio Aghemo et al. Hepatitis Monthly
- Hepatoprotective and antiviral functions of silymarin components in hepatitis C virus infection
- (2012) Stephen J. Polyak et al. HEPATOLOGY
- Silibinin, a natural flavonoid, modulates the early expression of chemoprevention biomarkers in a preclinical model of colon carcinogenesis
- (2012) HENRIETTE KAUNTZ et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Ethnobotanical survey of herbal remedies traditionally used in Kohghiluyeh va Boyer Ahmad province of Iran
- (2012) Mahmoud Mosaddegh et al. JOURNAL OF ETHNOPHARMACOLOGY
- 178 INTRAVENOUS SILIBININ-THERAPY IN PATIENTS WITH CHRONIC HEPATITIS C IN THE TRANSPLANT SETTING
- (2012) S. Beinhardt et al. JOURNAL OF HEPATOLOGY
- Hepatoprotective and anti-inflammatory effects of silibinin on experimental preeclampsia induced by l-NAME in rats
- (2012) Camila Oliveira de Souza et al. LIFE SCIENCES
- Protection by silibinin against experimental ischemic stroke: Up-regulated pAkt, pmTOR, HIF-1α and Bcl-2, down-regulated Bax, NF-κB expression
- (2012) Chaohui Wang et al. NEUROSCIENCE LETTERS
- Silymarin improves the behavioural, biochemical and histoarchitecture alterations in focal ischemic rats: A comparative evaluation with piracetam and protocatachuic acid
- (2012) Milind M. Muley et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- Absorption and metabolism of milk thistle flavanolignans in humans
- (2012) Luca Calani et al. PHYTOMEDICINE
- Silymarin regulates the cytochrome P450 3A2 and glutathione peroxides in the liver of streptozotocin-induced diabetic rats
- (2012) H. Malekinejad et al. PHYTOMEDICINE
- Intravenous silibinin as ‘rescue treatment’ for on-treatment non-responders to pegylated interferon/ribavirin combination therapy
- (2011) Karoline Rutter et al. ANTIVIRAL THERAPY
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- (2011) Anestis Karkanis et al. INDUSTRIAL CROPS AND PRODUCTS
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- (2011) Rıdvan Polat et al. JOURNAL OF ETHNOPHARMACOLOGY
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- (2011) M. Biermer et al. JOURNAL OF VIRAL HEPATITIS
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- (2010) José A. González et al. JOURNAL OF ETHNOPHARMACOLOGY
- Successful prevention of hepatitis C virus (HCV) liver graft reinfection by silibinin mono-therapy
- (2010) U.P. Neumann et al. JOURNAL OF HEPATOLOGY
- Silibinin: A novel inhibitor of Aβ aggregation
- (2010) Fei Yin et al. NEUROCHEMISTRY INTERNATIONAL
- Neuroprotective effect of silymarin in 6-hydroxydopamine hemi-parkinsonian rat: Involvement of estrogen receptors and oxidative stress
- (2010) Tourandokht Baluchnejadmojarad et al. NEUROSCIENCE LETTERS
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- 12-O-Tetradecanoyl phorbol-13-acetate (TPA)-induced growth arrest is increased by silibinin by the down-regulation of cyclin B1 and cdc2 and the up-regulation of p21 expression in MDA-MB231 human breast cancer cells
- (2010) Sangmin Kim et al. PHYTOMEDICINE
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- (2010) Yu-Chang Hou et al. PHYTOMEDICINE
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- (2010) Hassan Malekinejad et al. PHYTOTHERAPY RESEARCH
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- (2010) Thomas W. Flaig et al. PROSTATE
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- (2010) Ghazal Vessal et al. RENAL FAILURE
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- (2009) Ping Lu et al. BEHAVIOURAL BRAIN RESEARCH
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- (2009) P Lu et al. BRITISH JOURNAL OF PHARMACOLOGY
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- (2009) Elena J. Ladas et al. CANCER
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- (2009) E. Shaker et al. FOOD AND CHEMICAL TOXICOLOGY
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- (2009) Omar M.E. Abdel Salam et al. FUNDAMENTAL & CLINICAL PHARMACOLOGY
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- (2009) Hong Liu et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
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- (2009) Roy L. Hawke et al. JOURNAL OF CLINICAL PHARMACOLOGY
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- (2009) Arlene Sy-Cordero et al. PLANTA MEDICA
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- (2007) H. Ligeret et al. JOURNAL OF ETHNOPHARMACOLOGY
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