Lentivirus-Mediated Expression of Human Secreted Amyloid Precursor Protein-Alpha Promotes Long-Term Induction of Neuroprotective Genes and Pathways in a Mouse Model of Alzheimer’s Disease

A role for CIM6P/IGF2 receptor in memory consolidation and enhancement

(2020) Xiao-Wen Yu et al.   eLife

Klotho overexpression improves amyloid‐β clearance and cognition in the APP/PS1 mouse model of Alzheimer's disease

(2020) Yue Zhao et al.   AGING CELL

Effects of Betaine on LPS-Stimulated Activation of Microglial M1/M2 Phenotypes by Suppressing TLR4/NF-κB Pathways in N9 Cells

(2019) Hui Shi et al.   MOLECULES

Secreted amyloid-β precursor protein functions as a GABABR1a ligand to modulate synaptic transmission

(2019) Heather C. Rice et al.   SCIENCE

Alterations in cholesterol metabolism as a risk factor for developing Alzheimer's disease: Potential novel targets for treatment

(2019) Raúl Loera-Valencia et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Comparative Gene-Expression Analysis of Alzheimer’s Disease Progression with Aging in Transgenic Mouse Model

(2019) Noman Abid et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structural and molecular aspects of betaine-GABA transporter 1 (BGT1) and its relation to brain function

(2019) Stefanie Kickinger et al.   NEUROPHARMACOLOGY

Brain Injury–Mediated Neuroinflammatory Response and Alzheimer’s Disease

(2019) Duraisamy Kempuraj et al.   NEUROSCIENTIST

Tau pathology reduction with SM07883, a novel, potent, and selective oral DYRK1A inhibitor: A potential therapeutic for Alzheimer's disease

(2019) Benoît Melchior et al.   AGING CELL

The interleukin-4/PPARγ signaling axis promotes oligodendrocyte differentiation and remyelination after brain injury

(2019) Qingxiu Zhang et al.   PLOS BIOLOGY

Evaluation of reference genes for gene expression studies in mouse and N2a cell ischemic stroke models using quantitative real-time PCR

(2018) Yingbo Kang et al.   BMC NEUROSCIENCE

The role of some ADAM-proteins and activation of the insulin growth factor-related pathway in colorectal cancer

(2018) Katarzyna Walkiewicz et al.   Central European Journal of Immunology

The GABAergic System as a Therapeutic Target for Alzheimer's Disease

(2018) B Calvo-Flores Guzmán et al.   JOURNAL OF NEUROCHEMISTRY

Lentivirus-mediated expression of human secreted amyloid precursor protein-alpha prevents development of memory and plasticity deficits in a mouse model of Alzheimer's disease

(2018) Valerie T. Y. Tan et al.   Molecular Brain

Traumatic brain injury and the risk of dementia diagnosis: A nationwide cohort study

(2018) Anna Nordström et al.   PLOS MEDICINE

Impaired Lipoprotein Receptor-Mediated Peripheral Binding of Plasma Amyloid-β is an Early Biomarker for Mild Cognitive Impairment Preceding Alzheimer's Disease

(2018) Abhay P. Sagare et al.   JOURNAL OF ALZHEIMERS DISEASE

Levels of ADAM10 are reduced in Alzheimer’s disease CSF

(2018) Aitana Sogorb-Esteve et al.   Journal of Neuroinflammation

Knockdown of a disintegrin A metalloprotease 12 (ADAM12) during adipogenesis reduces cell numbers, delays differentiation, and increases lipid accumulation in 3T3-L1 cells

(2018) Chantal A. Coles et al.   MOLECULAR BIOLOGY OF THE CELL

DYRK1A and cognition: A lifelong relationship

(2018) Maria L. Arbones et al.   PHARMACOLOGY & THERAPEUTICS

The role of decorin in cardiovascular diseases: more than just a decoration

(2018) Thu Thi Vu et al.   FREE RADICAL RESEARCH

Actions of Brain-Derived Neurotrophin Factor in the Neurogenesis and Neuronal Function, and Its Involvement in the Pathophysiology of Brain Diseases

(2018) Tadahiro Numakawa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Changes in Expression Profiles Revealed by Transcriptomic Analysis in Peripheral Blood Mononuclear Cells of Alzheimer’s Disease Patients

(2018) Giovana Silva Leandro et al.   JOURNAL OF ALZHEIMERS DISEASE

Circulating Plasma microRNAs are Altered with Amyloidosis in a Mouse Model of Alzheimer’s Disease

(2018) Margaret M. Ryan et al.   JOURNAL OF ALZHEIMERS DISEASE

Distinct cytokine profiles in human brains resilient to Alzheimer's pathology

(2018) Isabel Barroeta-Espar et al.   NEUROBIOLOGY OF DISEASE

ArrayExpress update – from bulk to single-cell expression data

(2018) Awais Athar et al.   NUCLEIC ACIDS RESEARCH

A novel mechanism of synaptic and cognitive impairments mediated via microRNA-30b in Alzheimer's disease

(2018) Yunping Song et al.   EBioMedicine

A genome-wide association study for extremely high intelligence

(2017) D Zabaneh et al.   MOLECULAR PSYCHIATRY

Not just amyloid: physiological functions of the amyloid precursor protein family

(2017) Ulrike C. Müller et al.   NATURE REVIEWS NEUROSCIENCE

Betaine in the Brain: Characterization of Betaine Uptake, its Influence on Other Osmolytes and its Potential Role in Neuroprotection from Osmotic Stress

(2017) Leena S. Knight et al.   NEUROCHEMICAL RESEARCH

Amyloid Beta Peptides Block New Synapse Assembly by Nogo Receptor-Mediated Inhibition of T-Type Calcium Channels

(2017) Yanjun Zhao et al.   NEURON

Linking deregulation of non-coding RNA to the core pathophysiology of Alzheimer’s disease: An integrative review

(2017) Mark J. Millan   PROGRESS IN NEUROBIOLOGY

Does Decorin Protect Neuronal Tissue via Its Antioxidant and Antiinflammatory Activity from Traumatic Brain Injury? An Experimental Study

(2017) Rafet Özay et al.   World Neurosurgery

Therapeutic Potential of Secreted Amyloid Precursor Protein APPsα

(2017) Bruce G. Mockett et al.   Frontiers in Molecular Neuroscience

Regulation of Alpha-Secretase ADAM10 In vitro and In vivo: Genetic, Epigenetic, and Protein-Based Mechanisms

(2017) Kristina Endres et al.   Frontiers in Molecular Neuroscience

NF-κB as a Key Mediator of Brain Inflammation in Alzheimer’s Disease

(2017) Chul Ju Hwang et al.   CNS & Neurological Disorders-Drug Targets

Profiling the human hippocampal proteome at all pathologic stages of Alzheimer's disease

(2016) David C. Hondius et al.   Alzheimers & Dementia

GABA B receptors in the hippocampal dentate gyrus are involved in spatial learning and memory impairment in a rat model of vascular dementia

(2016) Guangxie Li et al.   BRAIN RESEARCH BULLETIN

Restoring Soluble Amyloid Precursor Protein α Functions as a Potential Treatment for Alzheimer's Disease

(2016) Ahsan Habib et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Regulatory mechanisms of microRNA expression

(2016) Lyudmila F. Gulyaeva et al.   Journal of Translational Medicine

Betaine reverses the memory impairments in a chronic cerebral hypoperfusion rat model

(2016) Chunjie Nie et al.   NEUROSCIENCE LETTERS

Inflammatory neuroprotection following traumatic brain injury

(2016) M. V. Russo et al.   SCIENCE

Viral gene transfer of APPsα rescues synaptic failure in an Alzheimer’s disease mouse model

(2015) Romain Fol et al.   ACTA NEUROPATHOLOGICA

The canonical Notch pathway effector RBP-J regulates neuronal plasticity and expression of GABA transporters in hippocampal networks

(2015) Shuxi Liu et al.   HIPPOCAMPUS

Determining the role of IL-4 induced neuroinflammation in microglial activity and amyloid-β using BV2 microglial cells and APP/PS1 transgenic mice

(2015) Clare H Latta et al.   Journal of Neuroinflammation

Neuroinflammatory Signals in Alzheimer Disease and APP/PS1 Transgenic Mice

(2015) Irene López-González et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Gene expression parallels synaptic excitability and plasticity changes in Alzheimer’s disease

(2015) Carlos A. Saura et al.   Frontiers in Cellular Neuroscience

The Construction of Common and Specific Significance Subnetworks of Alzheimer’s Disease from Multiple Brain Regions

(2015) Wei Kong et al.   Biomed Research International

MicroRNA Profiling of CSF Reveals Potential Biomarkers to Detect Alzheimer`s Disease

(2015) Johannes Denk et al.   PLoS One

miR-1, miR-10b, miR-155, and miR-191 are novel regulators of BDNF

(2014) Kärt Varendi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Effects ofl-Carnitine, Erythritol and Betaine on Pro-inflammatory Markers in Primary Human Corneal Epithelial Cells Exposed to Hyperosmotic Stress

(2014) Xia Hua et al.   CURRENT EYE RESEARCH

Brain-Derived Neurotrophic Factor in Alzheimer’s Disease: Risk, Mechanisms, and Therapy

(2014) Jing-Hui Song et al.   MOLECULAR NEUROBIOLOGY

T-type channel-mediated neurotransmitter release

(2014) Emilio Carbone et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Epigenetic Regulations of Immediate Early Genes Expression Involved in Memory Formation by the Amyloid Precursor Protein of Alzheimer Disease

(2014) Aurélie Hendrickx et al.   PLoS One

IGF2 Ameliorates Amyloidosis, Increases Cholinergic Marker Expression and Raises BMP9 and Neurotrophin Levels in the Hippocampus of the APPswePS1dE9 Alzheimer’s Disease Model Mice

(2014) Tiffany J. Mellott et al.   PLoS One

Micro spies from the brain to the periphery: new clues from studies on microRNAs in neuropsychiatric disorders

(2014) Elisabetta Maffioletti et al.   Frontiers in Cellular Neuroscience

Time-dependent changes in gene expression induced by secreted amyloid precursor protein-alpha in the rat hippocampus

(2013) Margaret M Ryan et al.   BMC GENOMICS

Alteration of the microRNA network during the progression of Alzheimer's disease

(2013) Pierre Lau et al.   EMBO Molecular Medicine

Cognitive Reserve: Implications for Assessment and Intervention

(2013) Yaakov Stern   FOLIA PHONIATRICA ET LOGOPAEDICA

The neuroprotective activity of the amyloid precursor protein against traumatic brain injury is mediated via the heparin binding site in residues 96-110

(2013) Frances Corrigan et al.   JOURNAL OF NEUROCHEMISTRY

NPY modulates miR-30a-5p and BDNF in opposite direction in an in vitro model of Alzheimer disease: a possible role in neuroprotection?

(2013) Nicoletta Croce et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Amyloid-β oligomers induce tau-independent disruption of BDNF axonal transport via calcineurin activation in cultured hippocampal neurons

(2013) Elisa M. Ramser et al.   MOLECULAR BIOLOGY OF THE CELL

Age-related downregulation of the CaV3.1 T-type calcium channel as a mediator of amyloid beta production

(2013) Rachel A. Rice et al.   NEUROBIOLOGY OF AGING

The Impact of Bdnf Gene Deficiency to the Memory Impairment and Brain Pathology of APPswe/PS1dE9 Mouse Model of Alzheimer’s Disease

(2013) Tomi Rantamäki et al.   PLoS One

An Update of Animal Models of Alzheimer Disease with a Reevaluation of Plaque Depositions

(2013) Jung-Eun Lee et al.   Experimental Neurobiology

Decorin

(2012) Thomas Neill et al.   AMERICAN JOURNAL OF PATHOLOGY

The effect of ageing on neurogenesis and oxidative stress in the APPswe/PS1deltaE9 mouse model of Alzheimer's disease

(2012) Alison Hamilton et al.   BRAIN RESEARCH

What comes first: translational repression or mRNA degradation? The deepening mystery of microRNA function

(2012) Wenqian Hu et al.   CELL RESEARCH

Essential Roles of Heparin-Binding Epidermal Growth Factor-Like Growth Factor in the Brain

(2012) Atsushi Oyagi et al.   CNS Neuroscience & Therapeutics

IL-4 in the Brain: A Cytokine To Remember

(2012) Sachin P. Gadani et al.   JOURNAL OF IMMUNOLOGY

sAPPα rescues deficits in amyloid precursor protein knockout mice following focal traumatic brain injury

(2012) Frances Corrigan et al.   JOURNAL OF NEUROCHEMISTRY

Betaine attenuates Alzheimer-like pathological changes and memory deficits induced by homocysteine

(2012) Gao-Shang Chai et al.   JOURNAL OF NEUROCHEMISTRY

MicroRNAs in Alzheimer's disease

(2012) Charlotte Delay et al.   NEUROBIOLOGY OF DISEASE

Etazolate, an α-secretase activator, reduces neuroinflammation and offers persistent neuroprotection following traumatic brain injury in mice

(2012) Eleni Siopi et al.   NEUROPHARMACOLOGY

General Principals of miRNA Biogenesis and Regulation in the Brain

(2012) Dónal O'Carroll et al.   NEUROPSYCHOPHARMACOLOGY

Heparin-binding EGF-like growth factor is required for synaptic plasticity and memory formation

(2011) Atsushi Oyagi et al.   BRAIN RESEARCH

MicroRNA networks surrounding APP and amyloid-β metabolism — Implications for Alzheimer's disease

(2011) Nicole Schonrock et al.   EXPERIMENTAL NEUROLOGY

CNS expression of anti-inflammatory cytokine interleukin-4 attenuates Alzheimer’s disease-like pathogenesis in APP+PS1 bigenic mice

(2010) Tomomi Kiyota et al.   FASEB JOURNAL

Oligomeric Amyloid-β Inhibits the Proteolytic Conversion of Brain-derived Neurotrophic Factor (BDNF), AMPA Receptor Trafficking, and Classical Conditioning

(2010) Zhaoqing Zheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The widespread regulation of microRNA biogenesis, function and decay

(2010) Jacek Krol et al.   NATURE REVIEWS GENETICS

Neuronal MicroRNA Deregulation in Response to Alzheimer's Disease Amyloid-β

(2010) Nicole Schonrock et al.   PLoS One

Inflammation in transgenic mouse models of neurodegenerative disorders

(2009) Claudia Schwab et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

A set of differentially expressed miRNAs, including miR-30a-5p, act as post-transcriptional inhibitors of BDNF in prefrontal cortex

(2008) Nikolaos Mellios et al.   HUMAN MOLECULAR GENETICS

Cellular roles of ADAM12 in health and disease

(2008) Marie Kveiborg et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols

Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data set

(2008) Winnie S. Liang et al.   PHYSIOLOGICAL GENOMICS