IGF2 Ameliorates Amyloidosis, Increases Cholinergic Marker Expression and Raises BMP9 and Neurotrophin Levels in the Hippocampus of the APPswePS1dE9 Alzheimer’s Disease Model Mice

Rapid β-Amyloid Deposition and Cognitive Impairment After Cholinergic Denervation in APP/PS1 Mice

(2013) Juan Jose Ramos-Rodriguez et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Reduced Adult Hippocampal Neurogenesis and Working Memory Deficits in the Dgcr8-Deficient Mouse Model of 22q11.2 Deletion-Associated Schizophrenia Can Be Rescued by IGF2

(2013) Y. Ouchi et al.   JOURNAL OF NEUROSCIENCE

Early BDNF Treatment Ameliorates Cell Loss in the Entorhinal Cortex of APP Transgenic Mice

(2013) A. H. Nagahara et al.   JOURNAL OF NEUROSCIENCE

Cholinergic degeneration is associated with increased plaque deposition and cognitive impairment in APPswe/PS1dE9 mice

(2012) Bettina Laursen et al.   BEHAVIOURAL BRAIN RESEARCH

Differential cell proliferation in the cortex of the appsweps1de9 alzheimer's disease mouse model

(2012) Willem Kamphuis et al.   GLIA

Specificity and Structure of a High Affinity Activin Receptor-like Kinase 1 (ALK1) Signaling Complex

(2012) Sharon A. Townson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin-Like Growth Factor-I and Insulin-Like Growth Factor Binding Protein-3 in Alzheimer's Disease

(2012) Emmanuelle Duron et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Gene Expression Profiling of Neural Stem Cells and Their Neuronal Progeny Reveals IGF2 as a Regulator of Adult Hippocampal Neurogenesis

(2012) O. Bracko et al.   JOURNAL OF NEUROSCIENCE

Mechanisms Underlying the Rapid Peroxisome Proliferator-Activated Receptor- -Mediated Amyloid Clearance and Reversal of Cognitive Deficits in a Murine Model of Alzheimer's Disease

(2012) S. Mandrekar-Colucci et al.   JOURNAL OF NEUROSCIENCE

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

(2012) Iryna Benilova et al.   NATURE NEUROSCIENCE

The many faces of insulin-like peptide signalling in the brain

(2012) Ana M. Fernandez et al.   NATURE REVIEWS NEUROSCIENCE

Early brain amyloidosis in APP/PS1 mice with serum insulin-like growth factor-I deficiency

(2012) R. Poirier et al.   NEUROSCIENCE LETTERS

GFAP Isoforms in Adult Mouse Brain with a Focus on Neurogenic Astrocytes and Reactive Astrogliosis in Mouse Models of Alzheimer Disease

(2012) Willem Kamphuis et al.   PLoS One

Memory enhancement: consolidation, reconsolidation and insulin-like growth factor 2

(2012) Cristina M. Alberini et al.   TRENDS IN NEUROSCIENCES

Loss of Muscarinic M1 Receptor Exacerbates Alzheimer's Disease–Like Pathology and Cognitive Decline

(2011) Rodrigo Medeiros et al.   AMERICAN JOURNAL OF PATHOLOGY

Atrophy of the Cholinergic Basal Forebrain Over the Adult Age Range and in Early Stages of Alzheimer's Disease

(2011) Michel Grothe et al.   BIOLOGICAL PSYCHIATRY

A hippocampal insulin-growth factor 2 pathway regulates the extinction of fear memories

(2011) Roberto Carlos Agis-Balboa et al.   EMBO JOURNAL

A critical role for IGF-II in memory consolidation and enhancement

(2011) Dillon Y. Chen et al.   NATURE

Cholinergic axon length reduced by 300 meters in the brain of an Alzheimer mouse model

(2011) Gitte Nykjær Nikolajsen et al.   NEUROBIOLOGY OF AGING

7,8-Dihydroxyflavone, a Small-Molecule TrkB Agonist, Reverses Memory Deficits and BACE1 Elevation in a Mouse Model of Alzheimer's Disease

(2011) Latha Devi et al.   NEUROPSYCHOPHARMACOLOGY

BMP9 Protects Septal Neurons from Axotomy-Evoked Loss of Cholinergic Phenotype

(2011) Ignacio Lopez-Coviella et al.   PLoS One

FGF2 gene transfer restores hippocampal functions in mouse models of Alzheimer's disease and has therapeutic implications for neurocognitive disorders

(2011) T. Kiyota et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Controlled Generation of Functional Basal Forebrain Cholinergic Neurons from Human Embryonic Stem Cells

(2011) Christopher J. Bissonnette et al.   STEM CELLS

The cholinergic system in aging and neuronal degeneration

(2010) Reinhard Schliebs et al.   BEHAVIOURAL BRAIN RESEARCH

Complex environment experience rescues impaired neurogenesis, enhances synaptic plasticity, and attenuates neuropathology in familial Alzheimer’s disease-linked APPswe/PS1ΔE9 mice

(2010) Yuan-Shih Hu et al.   FASEB JOURNAL

Memory Impairment in Transgenic Alzheimer Mice Requires Cellular Prion Protein

(2010) D. A. Gimbel et al.   JOURNAL OF NEUROSCIENCE

BMP9 (Bone Morphogenetic Protein 9) Induces NGF as an Autocrine/Paracrine Cholinergic Trophic Factor in Developing Basal Forebrain Neurons

(2010) A. C. Schnitzler et al.   JOURNAL OF NEUROSCIENCE

Increased BMP6 Levels in the Brains of Alzheimer's Disease Patients and APP Transgenic Mice Are Accompanied by Impaired Neurogenesis

(2010) L. Crews et al.   JOURNAL OF NEUROSCIENCE

Impaired neurogenesis is an early event in the etiology of familial Alzheimer's disease in transgenic mice

(2010) Michael Demars et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Functional cholinergic damage develops with amyloid accumulation in young adult APPswe/PS1dE9 transgenic mice

(2010) Eva Machová et al.   NEUROBIOLOGY OF DISEASE

Visuo-spatial learning and memory deficits on the Barnes maze in the 16-month-old APPswe/PS1dE9 mouse model of Alzheimer's disease

(2009) Timothy P. O’Leary et al.   BEHAVIOURAL BRAIN RESEARCH

Noggin and BMP4 co-modulate adult hippocampal neurogenesis in the APPswe/PS1ΔE9 transgenic mouse model of Alzheimer’s disease

(2009) Jun Tang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibitors of Class 1 Histone Deacetylases Reverse Contextual Memory Deficits in a Mouse Model of Alzheimer's Disease

(2009) Mark Kilgore et al.   NEUROPSYCHOPHARMACOLOGY

Prenatal choline supplementation in rats increases the expression of IGF2 and its receptor IGF2R and enhances IGF2-induced acetylcholine release in hippocampus and frontal cortex

(2008) Isabella Napoli et al.   BRAIN RESEARCH

Age-related declines in exploratory behavior and markers of hippocampal plasticity are attenuated by prenatal choline supplementation in rats

(2008) Melissa J. Glenn et al.   BRAIN RESEARCH

Impaired muscarinic regulation of excitatory synaptic transmission in the APPswe/PS1dE9 mouse model of Alzheimer's disease

(2008) Yasuaki Goto et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cholinergic system during the progression of Alzheimer’s disease: therapeutic implications

(2008) Elliott J Mufson et al.   Expert Review of Neurotherapeutics

Decreased hippocampal cell proliferation correlates with increased expression of BMP4 in the APPswe/PS1ΔE9 mouse model of Alzheimer's disease

(2008) Dabing Li et al.   HIPPOCAMPUS

Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer’s disease

(2008) Melanie Meyer-Luehmann et al.   NATURE

Animal models of Alzheimer's disease and frontotemporal dementia

(2008) Jürgen Götz et al.   NATURE REVIEWS NEUROSCIENCE

Prenatal choline supplementation attenuates neuropathological response to status epilepticus in the adult rat hippocampus

(2008) Sarah J.E. Wong-Goodrich et al.   NEUROBIOLOGY OF DISEASE

Differential regulation of neurogenesis in two neurogenic regions of APPswe/PS1dE9 transgenic mice

(2008) Tetsuhiro Niidome et al.   NEUROREPORT