Drug-repositioning screening identified piperlongumine as a direct STAT3 inhibitor with potent activity against breast cancer

A STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction

(2016) Marco Demaria et al.   Aging-US

A Renewable Tissue Resource of Phenotypically Stable, Biologically and Ethnically Diverse, Patient-Derived Human Breast Cancer Xenograft Models

(2013) X. Zhang et al.   CANCER RESEARCH

Insights into p53 transcriptional function via genome-wide chromatin occupancy and gene expression analysis

(2012) F Nikulenkov et al.   CELL DEATH AND DIFFERENTIATION

Mechanisms of Unphosphorylated STAT3 Transcription Factor Binding to DNA

(2012) Olga A. Timofeeva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signal transducer and activator of transcription 3 promotes angiogenesis and drives malignant progression in glioma

(2012) Tiffany A. Doucette et al.   NEURO-ONCOLOGY

SomaticSTAT3Mutations in Large Granular Lymphocytic Leukemia

(2012) Hanna L.M. Koskela et al.   NEW ENGLAND JOURNAL OF MEDICINE

Selective Small Molecule Stat3 Inhibitor Reduces Breast Cancer Tumor-Initiating Cells and Improves Recurrence Free Survival in a Human-Xenograft Model

(2012) Bhuvanesh Dave et al.   PLoS One

Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs

(2012) D. J. Adams et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stat3: linking inflammation to epithelial cancer - more than a "gut" feeling?

(2012) Andrew Jarnicki et al.   Cell Division

Nuclear Ago2/HSP60 Contributes to Broad Spectrum of hATSCs Function via Oct4 Regulation

(2011) Jin Hwa Jang et al.   ANTIOXIDANTS & REDOX SIGNALING

Osteoblast/osteocyte-specific inactivation of Stat3 decreases load-driven bone formation and accumulates reactive oxygen species

(2011) Hongkang Zhou et al.   BONE

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Roles of STAT3 and ZEB1 Proteins in E-cadherin Down-regulation and Human Colorectal Cancer Epithelial-Mesenchymal Transition

(2011) Hua Xiong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumors

(2011) Lauren L.C. Marotta et al.   JOURNAL OF CLINICAL INVESTIGATION

Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas

(2011) Camilla Pilati et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A murine model of inducible, cardiac-specific deletion of STAT3: Its use to determine the role of STAT3 in the upregulation of cardioprotective proteins by ischemic preconditioning

(2011) Roberto Bolli et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

JAK1 Activates STAT3 Activity in Non-Small-Cell Lung Cancer Cells and IL-6 Neutralizing Antibodies Can Suppress JAK1-STAT3 Signaling

(2011) L. Song et al.   MOLECULAR CANCER THERAPEUTICS

STAT3 SIGNALING: Anticancer Strategies and Challenges

(2011) P. A. Johnston et al.   MOLECULAR INTERVENTIONS

Selective killing of cancer cells by a small molecule targeting the stress response to ROS

(2011) Lakshmi Raj et al.   NATURE

Necdin, a Negative Growth Regulator, Is a Novel STAT3 Target Gene Down-Regulated in Human Cancer

(2011) Rachel Haviland et al.   PLoS One

Tyrosine Phosphorylation Profiling Reveals the Signaling Network Characteristics of Basal Breast Cancer Cells

(2010) F. Hochgrafe et al.   CANCER RESEARCH

High IGF-IR Activity in Triple-Negative Breast Cancer Cell Lines and Tumorgrafts Correlates with Sensitivity to Anti-IGF-IR Therapy

(2010) B. C. Litzenburger et al.   CLINICAL CANCER RESEARCH

STAT3 modulates the DNA damage response pathway

(2010) Seán P. Barry et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Disruption of Astrocyte STAT3 Signaling Decreases Mitochondrial Function and Increases Oxidative Stress In Vitro

(2010) Theodore A. Sarafian et al.   PLoS One

STAT3 deletion sensitizes cells to oxidative stress

(2009) Seán P. Barry et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The JAK2 Inhibitor AZD1480 Potently Blocks Stat3 Signaling and Oncogenesis in Solid Tumors

(2009) Michael Hedvat et al.   CANCER CELL

Regulation of Mn-Superoxide Dismutase Activity and Neuroprotection by STAT3 in Mice after Cerebral Ischemia

(2009) J. E. Jung et al.   JOURNAL OF NEUROSCIENCE

Chemical Probes that Competitively and Selectively Inhibit Stat3 Activation

(2009) Xuejun Xu et al.   PLoS One

Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features

(2009) C. J. Creighton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Roles of unphosphorylated STATs in signaling

(2008) Jinbo Yang et al.   CELL RESEARCH