Antagonism of the Stat3-Stat3 Protein Dimer with Salicylic Acid Based Small Molecules

A Novel Small Molecule, LLL12, Inhibits STAT3 Phosphorylation and Activities and Exhibits Potent Growth-Suppressive Activity in Human Cancer Cells

(2015) Li Lin et al.   NEOPLASIA

Inhibiting aberrant Stat3 function with molecular therapeutics

(2010) Sina Haftchenary et al.   ANTI-CANCER DRUGS

Design, synthesis, and in vitro characterization of novel hybrid peptidomimetic inhibitors of STAT3 protein

(2010) Vijay M. Shahani et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Signal transducer and activator of transcription 3 inhibitors: a patent review

(2010) Brent DG Page et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

A Cell-permeable Stat3 SH2 Domain Mimetic Inhibits Stat3 Activation and Induces Antitumor Cell Effectsin Vitro

(2010) Wei Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Purine-Scaffold Small-Molecule Inhibitors of Stat3 Activation by QSAR Studies

(2010) Vijay M. Shahani et al.   ACS Medicinal Chemistry Letters

Structure-Based Design of Conformationally Constrained, Cell-Permeable STAT3 Inhibitors

(2010) Jianyong Chen et al.   ACS Medicinal Chemistry Letters

Molecular disruption of oncogenic signal transducer and activator of transcription 3 (STAT3) protein

(2009) Steven Fletcher et al.   Biochemistry and Cell Biology

Disruption of Transcriptionally Active Stat3 Dimers with Non-phosphorylated, Salicylic Acid-Based Small Molecules: Potent in vitro and Tumor Cell Activities

(2009) Steven Fletcher et al.   CHEMBIOCHEM

The transcriptional network for mesenchymal transformation of brain tumours

(2009) Maria Stella Carro et al.   NATURE

Stat3 Promotes Metastatic Progression of Prostate Cancer

(2008) Junaid Abdulghani et al.   AMERICAN JOURNAL OF PATHOLOGY

Targeting Protein-Protein Interactions: Suppression of Stat3 Dimerization with Rationally Designed Small-Molecule, Nonpeptidic SH2 Domain Binders

(2008) Patrick T. Gunning et al.   CHEMBIOCHEM

Molecular Approaches towards the Inhibition of the Signal Transducer and Activator of Transcription 3 (Stat3) Protein

(2008) Steven Fletcher et al.   ChemMedChem

Paradigm shifts in the cell biology of STAT signaling

(2008) Pravin B. Sehgal   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Mild, efficient and rapid O-debenzylation of ortho-substituted phenols with trifluoroacetic acid

(2008) Steven Fletcher et al.   TETRAHEDRON LETTERS