Effects of Ketone Bodies on Brain Metabolism and Function in Neurodegenerative Diseases

Metabolic compartmentalization between astroglia and neurons in physiological and pathophysiological conditions of the neurovascular unit

(2020) Shinichi Takahashi   NEUROPATHOLOGY

Confusion in the nomenclature of ketogenic diets blurs evidence

(2020) Pierpaolo Trimboli et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

β-hydroxybutyrate and its metabolic effects on age-associated pathology

(2020) Young-Min Han et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

A Placebo-Controlled, Parallel-Group, Randomized Clinical Trial of AC-1204 in Mild-to-Moderate Alzheimer’s Disease

(2020) Samuel T. Henderson et al.   JOURNAL OF ALZHEIMERS DISEASE

Neurodegenerative Diseases – Is Metabolic Deficiency the Root Cause?

(2020) Vignayanandam Ravindernath Muddapu et al.   Frontiers in Neuroscience

Ketone Body, 3-Hydroxybutyrate: Minor Metabolite - Major Medical Manifestations

(2020) Niels Møller   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Medium-Chain Triglycerides (8:0 and 10:0) Increase Mini-Mental State Examination (MMSE) Score in Frail Elderly Adults in a Randomized Controlled Trial

(2020) Sakiko Abe et al.   JOURNAL OF NUTRITION

Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

(2020) Stephen C. Cunnane et al.   NATURE REVIEWS DRUG DISCOVERY

Effect of ketogenic diet versus regular diet on voice quality of patients with Parkinson’s disease

(2020) Handan Koyuncu et al.   ACTA NEUROLOGICA BELGICA

Role of Ketogenic Diets in Neurodegenerative Diseases (Alzheimer’s Disease and Parkinson’s Disease)

(2019) Dariusz Włodarek   Nutrients

Links Between Metabolic and Structural Changes in the Brain of Cognitively Normal Older Adults: A 4-Year Longitudinal Follow-Up

(2019) Christian-Alexandre Castellano et al.   Frontiers in Aging Neuroscience

Synaptic energy metabolism and neuronal excitability, in sickness and health

(2019) Alfonso Oyarzabal et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Preliminary Report on the Feasibility and Efficacy of the Modified Atkins Diet for Treatment of Mild Cognitive Impairment and Early Alzheimer’s Disease

(2019) Jason Brandt et al.   JOURNAL OF ALZHEIMERS DISEASE

A ketogenic drink improves brain energy and some measures of cognition in mild cognitive impairment

(2019) Mélanie Fortier et al.   Alzheimers & Dementia

The energetic brain ‐ A review from students to students

(2019) M.P. Bordone et al.   JOURNAL OF NEUROCHEMISTRY

Ketogenic Diet in Alzheimer’s Disease

(2019) Marta Rusek et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Modified Ketogenic Diet Is Associated With Improved Cerebrospinal Fluid Biomarker Profile, Cerebral Perfusion, And Cerebral Ketone Body Uptake In Older Adults At-Risk For Alzheimer’s Disease: A Pilot Study

(2019) Bryan J. Neth et al.   NEUROBIOLOGY OF AGING

Risk of dementia and cognitive dysfunction in individuals with diabetes or elevated blood glucose

(2019) I K Wium-Andersen et al.   Epidemiology and Psychiatric Sciences

Modified Mediterranean-ketogenic diet modulates gut microbiome and short-chain fatty acids in association with Alzheimer's disease markers in subjects with mild cognitive impairment

(2019) Ravinder Nagpal et al.   EBioMedicine

Medium-chain triglycerides improved cognition and lipid metabolomics in mild to moderate Alzheimer's disease patients with APOE4−/−: A double-blind, randomized, placebo-controlled crossover trial

(2019) Qing Xu et al.   CLINICAL NUTRITION

Antidiabetic medication and risk of dementia in patients with type 2 diabetes: a nested case–control study

(2019) Ida Kim Wium-Andersen et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Ketone bodies, stress response, and redox homeostasis

(2019) Pedro Rojas-Morales et al.   Redox Biology

Effects of β-hydroxybutyrate on cognition in patients with type 2 diabetes

(2019) Nicole Jacqueline Jensen et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

BHBA treatment improves cognitive function by targeting pleiotropic mechanisms in transgenic mouse model of Alzheimer's disease

(2019) Yancheng Wu et al.   FASEB JOURNAL

Safety and tolerability of sustained exogenous ketosis using ketone monoester drinks for 28 days in healthy adults

(2019) Adrian Soto-Mota et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Energy metabolism in ALS: an underappreciated opportunity?

(2018) Tijs Vandoorne et al.   ACTA NEUROPATHOLOGICA

A cross-sectional comparison of brain glucose and ketone metabolism in cognitively healthy older adults, mild cognitive impairment and early Alzheimer's disease

(2018) E. Croteau et al.   EXPERIMENTAL GERONTOLOGY

Changes in regional cerebral blood flow associated with a 45 day course of the ketogenic agent, caprylidene, in patients with mild to moderate Alzheimer's disease: Results of a randomized, double-blinded, pilot study

(2018) Nare Torosyan et al.   EXPERIMENTAL GERONTOLOGY

Ketogenic Medium Chain Triglycerides Increase Brain Energy Metabolism in Alzheimer’s Disease

(2018) Etienne Croteau et al.   JOURNAL OF ALZHEIMERS DISEASE

Astrocytic glycogen metabolism in the healthy and diseased brain

(2018) Lasse K. Bak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of action for the medium-chain triglyceride ketogenic diet in neurological and metabolic disorders

(2018) Katrin Augustin et al.   LANCET NEUROLOGY

Neuroketotherapeutics: A modern review of a century-old therapy

(2018) Scott J. Koppel et al.   NEUROCHEMISTRY INTERNATIONAL

Regional cerebral effects of ketone body infusion with 3-hydroxybutyrate in humans: Reduced glucose uptake, unchanged oxygen consumption and increased blood flow by positron emission tomography. A randomized, controlled trial

(2018) Mads Svart et al.   PLoS One

The High Costs of Low-Grade Inflammation: Persistent Fatigue as a Consequence of Reduced Cellular-Energy Availability and Non-adaptive Energy Expenditure

(2018) Tamara E. Lacourt et al.   Frontiers in Behavioral Neuroscience

Lower Brain 18F-Fluorodeoxyglucose Uptake But Normal 11C-Acetoacetate Metabolism in Mild Alzheimer's Disease Dementia

(2018) Christian-Alexandre Castellano et al.   JOURNAL OF ALZHEIMERS DISEASE

Improvement of Main Cognitive Functions in Patients with Alzheimer’s Disease after Treatment with Coconut Oil Enriched Mediterranean Diet: A Pilot Study

(2018) José Enrique de la Rubia Ortí et al.   JOURNAL OF ALZHEIMERS DISEASE

Low-fat versus ketogenic diet in Parkinson's disease: A pilot randomized controlled trial

(2018) Matthew C.L. Phillips et al.   MOVEMENT DISORDERS

Effects of a medium-chain triglyceride-based ketogenic formula on cognitive function in patients with mild-to-moderate Alzheimer’s disease

(2018) Miho Ota et al.   NEUROSCIENCE LETTERS

The vicious circle of hypometabolism in neurodegenerative diseases: Ways and mechanisms of metabolic correction

(2017) Yuri Zilberter et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Ketone-Based Metabolic Therapy: Is Increased NAD+ a Primary Mechanism?

(2017) Marwa Elamin et al.   Frontiers in Molecular Neuroscience

On the Metabolism of Exogenous Ketones in Humans

(2017) Brianna J. Stubbs et al.   Frontiers in Physiology

Blood-Brain Glucose Transfer in Alzheimer’s disease: Effect of GLP-1 Analog Treatment

(2017) Michael Gejl et al.   Scientific Reports

Can ketones compensate for deteriorating brain glucose uptake during aging? Implications for the risk and treatment of Alzheimer's disease

(2016) Stephen C. Cunnane et al.   Annals of the New York Academy of Sciences

Current status of PET imaging in Huntington’s disease

(2016) Gennaro Pagano et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Medium-chain fatty acids inhibit mitochondrial metabolism in astrocytes promoting astrocyte–neuron lactate and ketone body shuttle systems

(2016) Jonathan Thevenet et al.   FASEB JOURNAL

Inverse relationship between brain glucose and ketone metabolism in adults during short-term moderate dietary ketosis: A dual tracer quantitative positron emission tomography study

(2016) Alexandre Courchesne-Loyer et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

β-Hydroxybutyrate in the Brain: One Molecule, Multiple Mechanisms

(2016) Lavanya B. Achanta et al.   NEUROCHEMICAL RESEARCH

Brain Insulin Resistance at the Crossroads of Metabolic and Cognitive Disorders in Humans

(2016) Stephanie Kullmann et al.   PHYSIOLOGICAL REVIEWS

Effect of a ketogenic meal on cognitive function in elderly adults: potential for cognitive enhancement

(2016) Miho Ota et al.   PSYCHOPHARMACOLOGY

Can Ketones Help Rescue Brain Fuel Supply in Later Life? Implications for Cognitive Health during Aging and the Treatment of Alzheimer’s Disease

(2016) Stephen C. Cunnane et al.   Frontiers in Molecular Neuroscience

Brain and behavioral perturbations in rats following Western diet access

(2015) Sara L. Hargrave et al.   APPETITE

A new way to produce hyperketonemia: Use of ketone ester in a case of Alzheimer's disease

(2015) Mary T. Newport et al.   Alzheimers & Dementia

Systemic, Cerebral and Skeletal Muscle Ketone Body and Energy Metabolism During Acute Hyper-D-β-Hydroxybutyratemia in Post-Absorptive Healthy Males

(2015) Kristian H. Mikkelsen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Anti-inflammatory effects of BHBA in both in vivo and in vitro Parkinson’s disease models are mediated by GPR109A-dependent mechanisms

(2015) Shou-Peng Fu et al.   Journal of Neuroinflammation

The Antidiabetic Drug Metformin Stimulates Glycolytic Lactate Production in Cultured Primary Rat Astrocytes

(2015) Adrian Westhaus et al.   NEUROCHEMICAL RESEARCH

Degeneration of spinal motor neurons by chronic AMPA-induced excitotoxicity in vivo and protection by energy substrates

(2015) Citlalli Netzahualcoyotzi et al.   Acta Neuropathologica Communications

Role of Energy Metabolic Deficits and Oxidative Stress in Excitotoxic Spinal Motor Neuron Degeneration in Vivo

(2014) Luz Diana Santa-Cruz et al.   ASN Neuro

Acute exercise increases brain region-specific expression of MCT1, MCT2, MCT4, GLUT1, and COX IV proteins

(2014) Masaki Takimoto et al.   JOURNAL OF APPLIED PHYSIOLOGY

Phenotypic Spectrum of Glucose Transporter Type 1 Deficiency Syndrome (Glut1 DS)

(2013) Toni S. Pearson et al.   Current Neurology and Neuroscience Reports

Dietary Therapies for Epilepsy

(2013) EricH Kossoff et al.   Biomedical Journal

Synaptic Energy Use and Supply

(2012) Julia J. Harris et al.   NEURON

Caprylic Triglyceride as a Novel Therapeutic Approach to Effectively Improve the Performance and Attenuate the Symptoms Due to the Motor Neuron Loss in ALS Disease

(2012) Wei Zhao et al.   PLoS One

A ketogenic diet delays weight loss and does not impair working memory or motor function in the R6/2 1J mouse model of Huntington's disease

(2011) David N. Ruskin et al.   PHYSIOLOGY & BEHAVIOR

D-β-Hydroxybutyrate Is Protective in Mouse Models of Huntington's Disease

(2011) Soyeon Lim et al.   PLoS One

Cerebral blood flow and metabolic rate of oxygen, glucose, lactate, pyruvate, ketone bodies and amino acids

(2010) Ulla Lying-Tunell et al.   ACTA NEUROLOGICA SCANDINAVICA

Insulin Resistance and Alzheimer-like Reductions in Regional Cerebral Glucose Metabolism for Cognitively Normal Adults With Prediabetes or Early Type 2 Diabetes

(2010) Laura D. Baker et al.   ARCHIVES OF NEUROLOGY

A Ketone Ester Diet Increases Brain Malonyl-CoA and Uncoupling Proteins 4 and 5 while Decreasing Food Intake in the Normal Wistar Rat

(2010) Yoshihiro Kashiwaya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroprotective and Anti-inflammatory Activities of Ketogenic Diet on MPTP-induced Neurotoxicity

(2010) Xinxin Yang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Dietary ketosis enhances memory in mild cognitive impairment

(2010) Robert Krikorian et al.   NEUROBIOLOGY OF AGING

Brain fuel metabolism, aging, and Alzheimer’s disease

(2010) Stephen Cunnane et al.   NUTRITION

Ketogenic diet protects dopaminergic neurons against 6-OHDA neurotoxicity via up-regulating glutathione in a rat model of Parkinson's disease

(2009) Baohua Cheng et al.   BRAIN RESEARCH

Medium-Chain Fatty Acids Improve Cognitive Function in Intensively Treated Type 1 Diabetic Patients and Support In Vitro Synaptic Transmission During Acute Hypoglycemia

(2009) K. A. Page et al.   DIABETES

Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer's disease: a randomized, double-blind, placebo-controlled, multicenter trial

(2009) Samuel T Henderson et al.   Nutrition & Metabolism

Distribution of the monocarboxylate transporter MCT2 in human cerebral cortex: An immunohistochemical study

(2008) Oriana Chiry et al.   BRAIN RESEARCH

Antioxidant capacity contributes to protection of ketone bodies against oxidative damage induced during hypoglycemic conditions

(2008) María L. Haces et al.   EXPERIMENTAL NEUROLOGY

Ketone bodies as a therapeutic for Alzheimer’s disease

(2008) Samuel T. Henderson   Neurotherapeutics

Measurement of β-hydroxybutyrate in acute hyperketonemia in human brain

(2003) J. W. Pan et al.   JOURNAL OF NEUROCHEMISTRY