Synaptic energy metabolism and neuronal excitability, in sickness and health

Glucose and lactate as metabolic constraints on presynaptic transmission at an excitatory synapse

(2018) Sarah J. Lucas et al.   JOURNAL OF PHYSIOLOGY-LONDON

CrossTalk opposing view: lack of evidence supporting an astrocyte-to-neuron lactate shuttle coupling neuronal activity to glucose utilisation in the brain

(2018) Lasse K. Bak et al.   JOURNAL OF PHYSIOLOGY-LONDON

CrossTalk proposal: an important astrocyte-to-neuron lactate shuttle couples neuronal activity to glucose utilisation in the brain

(2018) L. F. Barros et al.   JOURNAL OF PHYSIOLOGY-LONDON

Contemporary scope of inborn errors of metabolism involving epilepsy or seizures

(2018) Birutė Tumienė et al.   METABOLIC BRAIN DISEASE

A pilot study of add-on oral triheptanoin treatment for children with medically refractory epilepsy

(2018) Sophie Calvert et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Spectrum of movement disorders and neurotransmitter abnormalities in paediatric POLG disease

(2018) A. Papandreou et al.   JOURNAL OF INHERITED METABOLIC DISEASE

The clinical spectrum and natural history of early-onset diseases due to DNA polymerase gamma mutations

(2017) Omar Hikmat et al.   GENETICS IN MEDICINE

Inborn Errors of Metabolism and Epilepsy: Current Understanding, Diagnosis, and Treatment Approaches

(2017) Suvasini Sharma et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ketogenic diet in pyruvate dehydrogenase complex deficiency: short- and long-term outcomes

(2017) Kalliopi Sofou et al.   JOURNAL OF INHERITED METABOLIC DISEASE

GLUT4 Mobilization Supports Energetic Demands of Active Synapses

(2017) Ghazaleh Ashrafi et al.   NEURON

Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism

(2017) Philip Hasel et al.   Nature Communications

Clinical Aspects of Glucose Transporter Type 1 Deficiency

(2017) Jian Hao et al.   JAMA Neurology

In Vivo Evidence for a Lactate Gradient from Astrocytes to Neurons

(2016) Philipp Mächler et al.   Cell Metabolism

Epilepsy due to mutations in the mitochondrial polymerase gamma(POLG)gene: A clinical and molecular genetic review

(2016) Maria-Eleni Anagnostou et al.   EPILEPSIA

Tridecanoin is anticonvulsant, antioxidant, and improves mitochondrial function

(2016) Kah Ni Tan et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Phenotypic and Neuropathological Characterization of Fetal Pyruvate Dehydrogenase Deficiency

(2016) Nathalie Pirot et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Novel Roles for the Insulin-Regulated Glucose Transporter-4 in Hippocampally Dependent Memory

(2016) Jiah Pearson-Leary et al.   JOURNAL OF NEUROSCIENCE

Regulation of neuron–astrocyte metabolic coupling across the sleep–wake cycle

(2016) J.-M. Petit et al.   NEUROSCIENCE

Epilepsy Characteristics and Clinical Outcome in Patients With Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes (MELAS)

(2016) Ha Neul Lee et al.   PEDIATRIC NEUROLOGY

Use of dietary therapies amongst patients with GLUT1 deficiency syndrome

(2016) Hannah R. Kass et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Recommendations for the Management of Strokelike Episodes in Patients With Mitochondrial Encephalomyopathy, Lactic Acidosis, and Strokelike Episodes

(2016) Mary Kay Koenig et al.   JAMA Neurology

Pathophysiology of mitochondrial disease causing epilepsy and status epilepticus

(2015) Shamima Rahman   EPILEPSY & BEHAVIOR

Pyruvate dehydrogenase complex deficiency and its relationship with epilepsy frequency – An overview

(2015) Suman Bhandary et al.   EPILEPSY RESEARCH

Triheptanoin dramatically reduces paroxysmal motor disorder in patients with GLUT1 deficiency

(2015) Fanny Mochel et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

MELAS syndrome: Clinical manifestations, pathogenesis, and treatment options

(2015) Ayman W. El-Hattab et al.   MOLECULAR GENETICS AND METABOLISM

A Cellular Perspective on Brain Energy Metabolism and Functional Imaging

(2015) Pierre J. Magistretti et al.   NEURON

Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism

(2015) Iben Lundgaard et al.   Nature Communications

Activity-Driven Local ATP Synthesis Is Required for Synaptic Function

(2014) Vidhya Rangaraju et al.   CELL

The ratio of acetate-to-glucose oxidation in astrocytes from a single13C NMR spectrum of cerebral cortex

(2014) Isaac Marin-Valencia et al.   JOURNAL OF NEUROCHEMISTRY

Decreased carbon shunting from glucose toward oxidative metabolism in diet-induced ketotic rat brain

(2014) Yifan Zhang et al.   JOURNAL OF NEUROCHEMISTRY

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Metabolic costs and evolutionary implications of human brain development

(2014) C. W. Kuzawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cerebral Creatine Deficiencies: A Group of Treatable Intellectual Developmental Disorders

(2014) Clara van Karnebeek et al.   SEMINARS IN NEUROLOGY

A Thermolabile Aldolase A Mutant Causes Fever-Induced Recurrent Rhabdomyolysis without Hemolytic Anemia

(2014) Asmaa Mamoune et al.   PLoS Genetics

Triheptanoin for Glucose Transporter Type I Deficiency (G1D)

(2014) Juan M. Pascual et al.   JAMA Neurology

Variant non ketotic hyperglycinemia is caused by mutations in LIAS, BOLA3 and the novel gene GLRX5

(2013) Peter R. Baker et al.   BRAIN

Phenotypic Spectrum of Glucose Transporter Type 1 Deficiency Syndrome (Glut1 DS)

(2013) Toni S. Pearson et al.   Current Neurology and Neuroscience Reports

Targeting deficiencies in mitochondrial respiratory complex I and functional uncoupling exerts anti-seizure effects in a genetic model of temporal lobe epilepsy and in a model of acute temporal lobe seizures

(2013) Kristina A. Simeone et al.   EXPERIMENTAL NEUROLOGY

Mitochondrial involvement and oxidative stress in temporal lobe epilepsy

(2013) Shane Rowley et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial Calcium Uptake Capacity Modulates Neocortical Excitability

(2013) Basavaraju G Sanganahalli et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Modeling of Brain Metabolism and Pyruvate Compartmentation Using 13C NMR in Vivo: Caution Required

(2013) F Mark Jeffrey et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Glutamatergic Function in the Resting Awake Human Brain is Supported by Uniformly High Oxidative Energy

(2013) Fahmeed Hyder et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Glycolysis and Oxidative Phosphorylation in Neurons and Astrocytes during Network Activity in Hippocampal Slices

(2013) Anton I Ivanov et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Increased brain uptake and oxidation of acetate in heavy drinkers

(2013) Lihong Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Mutations inSDHDlead to autosomal recessive encephalomyopathy and isolated mitochondrial complex II deficiency

(2013) Christopher Benjamin Jackson et al.   JOURNAL OF MEDICAL GENETICS

Movement disorders in GLUT1 deficiency syndrome respond to the modified Atkins diet

(2013) Wilhelmina G. Leen et al.   MOVEMENT DISORDERS

HIBCH mutations can cause Leigh-like disease with combined deficiency of multiple mitochondrial respiratory chain enzymes and pyruvate dehydrogenase

(2013) Sacha Ferdinandusse et al.   Orphanet Journal of Rare Diseases

Clinical and Molecular Features of POLG-Related Mitochondrial Disease

(2013) J. D. Stumpf et al.   Cold Spring Harbor Perspectives in Biology

Mitochondrial disease and epilepsy

(2012) SHAMIMA RAHMAN   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Mitochondrial diseases and epilepsy

(2012) Laurence A. Bindoff et al.   EPILEPSIA

Glucose transporter type I deficiency syndrome: Epilepsy phenotypes and outcomes

(2012) Amanda W. Pong et al.   EPILEPSIA

Clinical review of genetic epileptic encephalopathies

(2012) Grace J. Noh et al.   European Journal of Medical Genetics

Heptanoate as a Neural Fuel: Energetic and Neurotransmitter Precursors in Normal and Glucose Transporter I-Deficient (G1D) Brain

(2012) Isaac Marin-Valencia et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Recessive germlineSDHAandSDHBmutations causing leukodystrophy and isolated mitochondrial complex II deficiency

(2012) Charlotte L Alston et al.   JOURNAL OF MEDICAL GENETICS

The Energetics of CNS White Matter

(2012) J. J. Harris et al.   JOURNAL OF NEUROSCIENCE

The spectrum of pyruvate dehydrogenase complex deficiency: Clinical, biochemical and genetic features in 371 patients

(2012) Kavi P. Patel et al.   MOLECULAR GENETICS AND METABOLISM

Glut1 deficiency (G1D): Epilepsy and metabolic dysfunction in a mouse model of the most common human phenotype

(2012) Isaac Marin-Valencia et al.   NEUROBIOLOGY OF DISEASE

Synaptic Energy Use and Supply

(2012) Julia J. Harris et al.   NEURON

A Mitochondrial Pyruvate Carrier Required for Pyruvate Uptake in Yeast, Drosophila, and Humans

(2012) D. K. Bricker et al.   SCIENCE

Lipoic Acid Synthetase Deficiency Causes Neonatal-Onset Epilepsy, Defective Mitochondrial Energy Metabolism, and Glycine Elevation

(2011) Johannes A. Mayr et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation

(2011) Akinobu Suzuki et al.   CELL

Brain Lactate Metabolism: The Discoveries and the Controversies

(2011) Gerald A Dienel   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Single KATP Channel Opening in Response to Action Potential Firing in Mouse Dentate Granule Neurons

(2011) G. R. Tanner et al.   JOURNAL OF NEUROSCIENCE

Increased oxygen consumption in human visual cortex: response to visual stimulation

(2010) M. S. Vafaee et al.   ACTA NEUROLOGICA SCANDINAVICA

MELAS and l-arginine therapy: pathophysiology of stroke-like episodes

(2010) Yasutoshi Koga et al.   Annals of the New York Academy of Sciences

Mitochondrial DNA mutations affect calcium handling in differentiated neurons

(2010) Andrew J. Trevelyan et al.   BRAIN

Gamma oscillations in the hippocampus require high complex I gene expression and strong functional performance of mitochondria

(2010) Oliver Kann et al.   BRAIN

Epileptic phenotypes in children with respiratory chain disorders

(2010) Sandra El Sabbagh et al.   EPILEPSIA

Phosphorylation status of pyruvate dehydrogenase distinguishes metabolic phenotypes of cultured rat brain astrocytes and neurons

(2010) Nader D. Halim et al.   GLIA

Metabolic Autocrine Regulation of Neurons Involves Cooperation among Pannexin Hemichannels, Adenosine Receptors, and KATP Channels

(2010) M. Kawamura et al.   JOURNAL OF NEUROSCIENCE

Metabolic Control of Vesicular Glutamate Transport and Release

(2010) Narinobu Juge et al.   NEURON

Triosephosphate isomerase deficiency: New insights into an enigmatic disease

(2009) Ferenc Orosz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Pyruvate dehydrogenase complex deficiency: four neurological phenotypes with differing pathogenesis

(2009) CHRISTINE BARNERIAS et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Pyruvate dehydrogenase E2 deficiency: A potentially treatable cause of episodic dystonia

(2009) Catherine A. McWilliam et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Mitochondrial involvement in temporal lobe epilepsy

(2009) Alexei P. Kudin et al.   EXPERIMENTAL NEUROLOGY

Pyruvate dehydrogenase phosphatase 1 (PDP1) null mutation produces a lethal infantile phenotype

(2009) J. M. Cameron et al.   HUMAN GENETICS

The Energy Use Associated with Neural Computation in the Cerebellum

(2009) Clare Howarth et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

In vivo proton MRS to quantify anesthetic effects of pentobarbital on cerebral metabolism and brain activity in rat

(2009) Fei Du et al.   MAGNETIC RESONANCE IN MEDICINE

Neuronal glucose transporter isoform 3 deficient mice demonstrate features of autism spectrum disorders

(2009) Y Zhao et al.   MOLECULAR PSYCHIATRY

The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C–Cdh1

(2009) Angel Herrero-Mendez et al.   NATURE CELL BIOLOGY

Mitochondrial respiratory chain defects: Underlying etiology in various epileptic conditions

(2008) Young Mock Lee et al.   EPILEPSIA

Structural Signatures and Membrane Helix 4 in GLUT1

(2008) Juan M. Pascual et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcium-dependent production of reactive oxygen species is involved in neuronal damage induced during glycolysis inhibition in cultured hippocampal neurons

(2008) Karla Hernández-Fonseca et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Epilepsy and Respiratory Chain Defects in Children with Mitochondrial Encephalopathies

(2008) D. Khurana et al.   NEUROPEDIATRICS

Astroglial Metabolic Networks Sustain Hippocampal Synaptic Transmission

(2008) N. Rouach et al.   SCIENCE

Serial Diffusion Imaging in a Case of Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes

(2008) Charalampos Tzoulis et al.   STROKE