Ketone Body, 3-Hydroxybutyrate: Minor Metabolite - Major Medical Manifestations

Ketogenic diets in medical oncology: a systematic review with focus on clinical outcomes

(2020) Rainer J. Klement et al.   MEDICAL ONCOLOGY

Diet modulates brain network stability, a biomarker for brain aging, in young adults

(2020) Lilianne R. Mujica-Parodi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cardiovascular Effects of Treatment with the Ketone Body 3-Hydroxybutyrate in Chronic Heart Failure Patients

(2019) Roni Nielsen et al.   CIRCULATION

Ketone ester supplementation blunts overreaching symptoms during endurance training overload

(2019) Chiel Poffé et al.   JOURNAL OF PHYSIOLOGY-LONDON

Satiating Effect of a Ketogenic Diet and Its Impact on Muscle Improvement and Oxidation State in Multiple Sclerosis Patients

(2019) María Benlloch et al.   Nutrients

Long-Term Effects of a Novel Continuous Remote Care Intervention Including Nutritional Ketosis for the Management of Type 2 Diabetes: A 2-Year Non-randomized Clinical Trial

(2019) Shaminie J. Athinarayanan et al.   Frontiers in Endocrinology

Ketone Administration for Seizure Disorders: History and Rationale for Ketone Esters and Metabolic Alternatives

(2019) Angela M. Poff et al.   Frontiers in Neuroscience

Multi-dimensional roles of ketone bodies in cancer biology: Opportunities for cancer therapy

(2019) Siqi Feng et al.   PHARMACOLOGICAL RESEARCH

OUP accepted manuscript

(2018)   AMERICAN JOURNAL OF CLINICAL NUTRITION

β-Hydroxybutyrate protects from alcohol-induced liver injury via a Hcar2-cAMP dependent pathway

(2018) Yonglin Chen et al.   JOURNAL OF HEPATOLOGY

Enantioselective and simultaneous determination of lactate and 3-hydroxybutyrate in human plasma and urine using a narrow-bore online two-dimensional high-performance liquid chromatography system

(2018) Chin-Ling Hsieh et al.   JOURNAL OF SEPARATION SCIENCE

Neuroketotherapeutics: A modern review of a century-old therapy

(2018) Scott J. Koppel et al.   NEUROCHEMISTRY INTERNATIONAL

Do ketone bodies mediate the anti-seizure effects of the ketogenic diet?

(2018) Timothy A. Simeone et al.   NEUROPHARMACOLOGY

Regional cerebral effects of ketone body infusion with 3-hydroxybutyrate in humans: Reduced glucose uptake, unchanged oxygen consumption and increased blood flow by positron emission tomography. A randomized, controlled trial

(2018) Mads Svart et al.   PLoS One

Targeting Histone Deacetylases with Natural and Synthetic Agents: An Emerging Anticancer Strategy

(2018) Amit Singh et al.   Nutrients

Ketone Body Infusion Increases Circulating Erythropoietin and Bone Marrow Glucose Uptake

(2018) Katrine M. Lauritsen et al.   DIABETES CARE

Substrate metabolism, hormone and cytokine levels and adipose tissue signalling in individuals with type 1 diabetes after insulin withdrawal and subsequent insulin therapy to model the initiating steps of ketoacidosis

(2018) Thomas S. Voss et al.   DIABETOLOGIA

Two-Week Exclusive Supplementation of Modified Ketogenic Nutrition Drink Reserves Lean Body Mass and Improves Blood Lipid Profile in Obese Adults: A Randomized Clinical Trial

(2018) Hae-Ryeon Choi et al.   Nutrients

Ketone bodies mimic the life span extending properties of caloric restriction

(2017) Richard L. Veech et al.   IUBMB LIFE

Hydroxy-Carboxylic Acid Receptor Actions in Metabolism

(2017) Stefan Offermanns   TRENDS IN ENDOCRINOLOGY AND METABOLISM

β-Hydroxybutyrate Deactivates Neutrophil NLRP3 Inflammasome to Relieve Gout Flares

(2017) Emily L. Goldberg et al.   Cell Reports

Ketone Body Infusion With 3‐Hydroxybutyrate Reduces Myocardial Glucose Uptake and Increases Blood Flow in Humans: A Positron Emission Tomography Study

(2017) Lars C. Gormsen et al.   Journal of the American Heart Association

Nutritional Ketosis Alters Fuel Preference and Thereby Endurance Performance in Athletes

(2016) Pete J. Cox et al.   Cell Metabolism

Failing Heart and Starving Brain

(2016) Heinrich Taegtmeyer   CIRCULATION

Combined Insulin Deficiency and Endotoxin Exposure Stimulate Lipid Mobilization and Alter Adipose Tissue Signaling in an Experimental Model of Ketoacidosis in Subjects With Type 1 Diabetes: A Randomized Controlled Crossover Trial

(2016) Mads Svart et al.   DIABETES

CV Protection in the EMPA-REG OUTCOME Trial: A “Thrifty Substrate” Hypothesis

(2016) Ele Ferrannini et al.   DIABETES CARE

Effects of insulin-induced hypoglycaemia on lipolysis rate, lipid oxidation and adipose tissue signalling in human volunteers: a randomised clinical study

(2016) Thomas S. Voss et al.   DIABETOLOGIA

Anti-inflammatory effects of the hydroxycarboxylic acid receptor 2

(2016) Emily C. Graff et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Effect of a ketogenic meal on cognitive function in elderly adults: potential for cognitive enhancement

(2016) Miho Ota et al.   PSYCHOPHARMACOLOGY

Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate

(2016) Sama F Sleiman et al.   eLife

D-beta-hydroxybutyrate extends lifespan in C. elegans

(2016) Clare Edwards et al.   Aging-US

Estimated Life Expectancy in a Scottish Cohort With Type 1 Diabetes, 2008-2010

(2015) Shona J. Livingstone et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Systemic, Cerebral and Skeletal Muscle Ketone Body and Energy Metabolism During Acute Hyper-D-β-Hydroxybutyratemia in Post-Absorptive Healthy Males

(2015) Kristian H. Mikkelsen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease

(2015) Yun-Hee Youm et al.   NATURE MEDICINE

Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes

(2015) Bernard Zinman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ketogenesis prevents diet-induced fatty liver injury and hyperglycemia

(2014) David G. Cotter et al.   JOURNAL OF CLINICAL INVESTIGATION

Dissecting adipose tissue lipolysis: molecular regulation and implications for metabolic disease

(2014) Thomas Svava Nielsen et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

The β-hydroxybutyrate receptor HCA2 activates a neuroprotective subset of macrophages

(2014) Mahbubur Rahman et al.   Nature Communications

Ketone body metabolism and cardiovascular disease

(2013) David G. Cotter et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Ketosis Proportionately Spares Glucose Utilization in Brain

(2013) Yifan Zhang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Why cachexia kills: examining the causality of poor outcomes in wasting conditions

(2013) Kamyar Kalantar-Zadeh et al.   Journal of Cachexia Sarcopenia and Muscle

Suppression of Oxidative Stress by  -Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

(2012) T. Shimazu et al.   SCIENCE

Treatment with beta-hydroxybutyrate and melatonin is associated with improved survival in a porcine model of hemorrhagic shock

(2011) Kristine E. Mulier et al.   RESUSCITATION

Lipid-induced insulin resistance: unravelling the mechanism

(2010) Varman T Samuel et al.   LANCET

Small-Volume d-β-Hydroxybutyrate Solution Infusion Increases Survivability of Lethal Hemorrhagic Shock in Rats

(2010) Amanda H. Klein et al.   SHOCK

The Randle cycle revisited: a new head for an old hat

(2009) Louis Hue et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Regulation of myocardial ketone body metabolism by the gut microbiota during nutrient deprivation

(2009) P. A. Crawford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial

(2008) Elizabeth G Neal et al.   LANCET NEUROLOGY