Role of glucose metabolism in aggressive phenotype of fibroblast-like synoviocytes: Latest evidence and therapeutic approaches in rheumatoid arthritis

Efficacy of Dual Inhibition of Glycolysis and Glutaminolysis for Therapy of Renal Lesions in Tsc2+/− Mice

(2019) Ashley T. Jones et al.   NEOPLASIA

Can Metabolic Pathways Be Therapeutic Targets in Rheumatoid Arthritis?

(2019) Elsa Sanchez-Lopez et al.   Journal of Clinical Medicine

Fibroblast-Like Synoviocytes Glucose Metabolism as a Therapeutic Target in Rheumatoid Arthritis

(2019) Patricia Gnieslaw de Oliveira et al.   Frontiers in Immunology

Epigenetics in rheumatoid arthritis; fibroblast‐like synoviocytes as an emerging paradigm in the pathogenesis of the disease

(2019) Jafar Karami et al.   IMMUNOLOGY AND CELL BIOLOGY

Succinate receptor deficiency attenuates arthritis by reducing dendritic cell traffic and expansion of Th17 cells in the lymph nodes

(2018) André L. Saraiva et al.   FASEB JOURNAL

Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer’s Disease

(2018) P. Hemachandra Reddy et al.   JOURNAL OF ALZHEIMERS DISEASE

ICOS Signaling Controls Induction and Maintenance of Collagen-Induced Arthritis

(2018) Vincent Panneton et al.   JOURNAL OF IMMUNOLOGY

Increased hyperpolarized [1-13 C] lactate production in a model of joint inflammation is not accompanied by tissue acidosis as assessed using hyperpolarized 13 C-labelled bicarbonate

(2018) Alan J. Wright et al.   NMR IN BIOMEDICINE

JAK-STAT blockade alters synovial bioenergetics, mitochondrial function and pro-inflammatory mediators in Rheumatoid arthritis

(2018) Trudy McGarry et al.   Arthritis & Rheumatology

Review: Synovial Cell Metabolism and Chronic Inflammation in Rheumatoid Arthritis

(2018) Jane Falconer et al.   Arthritis & Rheumatology

Hexokinase 2 as a novel selective metabolic target for rheumatoid arthritis

(2018) Marta F Bustamante et al.   ANNALS OF THE RHEUMATIC DISEASES

1H NMR metabolomics identifies underlying inflammatory pathology in osteoarthritis and rheumatoid arthritis synovial joints

(2018) James R. Anderson et al.   JOURNAL OF PROTEOME RESEARCH

Glycogen Metabolism and Rheumatoid Arthritis: The Role of Glycogen Synthase 1 in Regulation of Synovial Inflammation via Blocking AMP-Activated Protein Kinase Activation

(2018) Maohua Shi et al.   Frontiers in Immunology

Inhibition of Glycolysis Reduces Disease Severity in an Autoimmune Model of Rheumatoid Arthritis

(2018) Georges Abboud et al.   Frontiers in Immunology

Altered metabolic pathways regulate synovial inflammation in rheumatoid arthritis

(2018) U. Fearon et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

A reference set of curated biomedical data and metadata from clinical case reports

(2018) J. Harry Caufield et al.   Scientific Data

The impact of cellular metabolism on chromatin dynamics and epigenetics

(2017) Michael A. Reid et al.   NATURE CELL BIOLOGY

Clinical Value of FDG-PET/CT for the Evaluation of Rheumatic Diseases: Rheumatoid Arthritis, Polymyalgia Rheumatica, and Relapsing Polychondritis

(2017) Kazuo Kubota et al.   SEMINARS IN NUCLEAR MEDICINE

Resolution of TLR2-induced inflammation through manipulation of metabolic pathways in Rheumatoid Arthritis

(2017) Trudy McGarry et al.   Scientific Reports

3-bromopyruvate ameliorate autoimmune arthritis by modulating Th17/Treg cell differentiation and suppressing dendritic cell activation

(2017) Takaichi Okano et al.   Scientific Reports

Dysregulated bioenergetics: a key regulator of joint inflammation

(2016) M Biniecka et al.   ANNALS OF THE RHEUMATIC DISEASES

PGK1, a glucose metabolism enzyme, may play an important role in rheumatoid arthritis

(2016) Yan Zhao et al.   INFLAMMATION RESEARCH

GC/TOF-MS-based metabolomic profiling in cultured fibroblast-like synoviocytes from rheumatoid arthritis

(2016) Joong Kyong Ahn et al.   JOINT BONE SPINE

GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis

(2016) Amanda Littlewood-Evans et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targeted Metabolic Profiling of the Tg197 Mouse Model Reveals Itaconic Acid as a Marker of Rheumatoid Arthritis

(2016) Filippos Michopoulos et al.   JOURNAL OF PROTEOME RESEARCH

Interplay between Metabolism and Epigenetics: A Nuclear Adaptation to Environmental Changes

(2016) Jean-Pierre Etchegaray et al.   MOLECULAR CELL

Hypoxia, mitochondrial dysfunction and synovial invasiveness in rheumatoid arthritis

(2016) Ursula Fearon et al.   Nature Reviews Rheumatology

Metabolomics in rheumatic diseases: desperately seeking biomarkers

(2016) Monica Guma et al.   Nature Reviews Rheumatology

Non-metabolic functions of glycolytic enzymes in tumorigenesis

(2016) X Yu et al.   ONCOGENE

Increased aerobic glycolysis is important for the motility of activated VSMC and inhibited by indirubin-3′-monoxime

(2016) Elke H. Heiss et al.   VASCULAR PHARMACOLOGY

Critical Role of Glucose Metabolism in Rheumatoid Arthritis Fibroblast-like Synoviocytes

(2016) Ricard Garcia-Carbonell et al.   Arthritis & Rheumatology

Hypoxia-Inducible Factor (HIF) as a Target for Novel Therapies in Rheumatoid Arthritis

(2016) Susan Hua et al.   Frontiers in Pharmacology

Succinate/NLRP3 Inflammasome Induces Synovial Fibroblast Activation: Therapeutical Effects of Clematichinenoside AR on Arthritis

(2016) Yi Li et al.   Frontiers in Immunology

The role of the synovial fibroblast in rheumatoid arthritis pathogenesis

(2015) Jason D. Turner et al.   CURRENT OPINION IN RHEUMATOLOGY

Hypoxia-inducible factor-1α perpetuates synovial fibroblast interactions with T cells and B cells in rheumatoid arthritis

(2015) Fanlei Hu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Kinome Screen Identifies PFKFB3 and Glucose Metabolism as Important Regulators of the Insulin/Insulin-like Growth Factor (IGF)-1 Signaling Pathway

(2015) Sophie Trefely et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Successes and failures of chemokine-pathway targeting in rheumatoid arthritis

(2015) Zoltán Szekanecz et al.   Nature Reviews Rheumatology

Normalization of CD4 + T cell metabolism reverses lupus

(2015) Yiming Yin et al.   Science Translational Medicine

Fructose 1,6-bisphosphate, a high-energy intermediate of glycolysis, attenuates experimental arthritis by activating anti-inflammatory adenosinergic pathway

(2015) Flávio P. Veras et al.   Scientific Reports

Glucose Metabolism Regulates T Cell Activation, Differentiation, and Functions

(2015) Clovis S. Palmer et al.   Frontiers in Immunology

Metabolomic Elucidation of the Effects of Curcumin on Fibroblast-Like Synoviocytes in Rheumatoid Arthritis

(2015) Joong Kyong Ahn et al.   PLoS One

Hypoxia and STAT3 signalling interactions regulate pro-inflammatory pathways in rheumatoid arthritis

(2014) Wei Gao et al.   ANNALS OF THE RHEUMATIC DISEASES

Sarilumab for the treatment of ankylosing spondylitis: results of a Phase II, randomised, double-blind, placebo-controlled study (ALIGN)

(2014) Joachim Sieper et al.   ANNALS OF THE RHEUMATIC DISEASES

Normalizing glycosphingolipids restores function in CD4+ T cells from lupus patients

(2014) Georgia McDonald et al.   JOURNAL OF CLINICAL INVESTIGATION

Metabolism of stromal and immune cells in health and disease

(2014) Bart Ghesquière et al.   NATURE

Hypoxia and hypoxia-inducible factor-1α provoke toll-like receptor signalling-induced inflammation in rheumatoid arthritis

(2013) Fanlei Hu et al.   ANNALS OF THE RHEUMATIC DISEASES

The Impact of Inflammation on Metabolomic Profiles in Patients With Arthritis

(2013) Stephen P. Young et al.   ARTHRITIS AND RHEUMATISM

Metabolic Pathways in Immune Cell Activation and Quiescence

(2013) Erika L. Pearce et al.   IMMUNITY

Targeting 6-Phosphofructo-2-Kinase (PFKFB3) as a Therapeutic Strategy against Cancer

(2013) B. F. Clem et al.   MOLECULAR CANCER THERAPEUTICS

PI3 Kinase δ Is a Key Regulator of Synoviocyte Function in Rheumatoid Arthritis

(2012) Beatrix Bartok et al.   AMERICAN JOURNAL OF PATHOLOGY

Cellular and molecular mechanisms of mitochondrial function

(2012) Laura D. Osellame et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors

(2012) Nunzio Bottini et al.   Nature Reviews Rheumatology

2010 Update of the international ASAS recommendations for the use of anti-TNF agents in patients with axial spondyloarthritis

(2011) D. van der Heijde et al.   ANNALS OF THE RHEUMATIC DISEASES

Mitochondrial Metabolism Inhibitors for Cancer Therapy

(2011) Emma E. Ramsay et al.   PHARMACEUTICAL RESEARCH

CP690,550 inhibits oncostatin M-induced JAK/STAT signaling pathway in rheumatoid synoviocytes

(2011) Kiyoshi Migita et al.   ARTHRITIS RESEARCH & THERAPY

Synovial tissue hypoxia and inflammation in vivo

(2010) C. T. Ng et al.   ANNALS OF THE RHEUMATIC DISEASES

Synovial fibroblasts self-direct multicellular lining architecture and synthetic function in three-dimensional organ culture

(2010) Hans P. Kiener et al.   ARTHRITIS AND RHEUMATISM

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

Human inflammatory synovial fibroblasts induce enhanced myeloid cell recruitment and angiogenesis through a hypoxia-inducible transcription factor 1α/vascular endothelial growth factor-mediated pathway in immunodeficient mice

(2009) Manuel J. del Rey et al.   ARTHRITIS AND RHEUMATISM

Inflammatory Cytokines and Hypoxia Contribute to 18F-FDG Uptake by Cells Involved in Pannus Formation in Rheumatoid Arthritis

(2009) T. Matsui et al.   JOURNAL OF NUCLEAR MEDICINE

Synovial fibroblasts spread rheumatoid arthritis to unaffected joints

(2009) Stephanie Lefèvre et al.   NATURE MEDICINE

The role of resident synovial cells in destructive arthritis

(2008) Caroline Ospelt et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY