Altered metabolic pathways regulate synovial inflammation in rheumatoid arthritis

Hypermetabolic macrophages in rheumatoid arthritis and coronary artery disease due to glycogen synthase kinase 3b inactivation

(2018) Markus Zeisbrich et al.   ANNALS OF THE RHEUMATIC DISEASES

Succinate receptor deficiency attenuates arthritis by reducing dendritic cell traffic and expansion of Th17 cells in the lymph nodes

(2018) André L. Saraiva et al.   FASEB JOURNAL

Succinate induces synovial angiogenesis in rheumatoid arthritis through metabolic remodeling and HIF-1α/VEGF axis

(2018) Yi Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Endothelial Cell Metabolism

(2018) Guy Eelen et al.   PHYSIOLOGICAL REVIEWS

Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis

(2018) Fumitaka Mizoguchi et al.   Nature Communications

Glycolytic metabolism is essential for CCR7 oligomerization and dendritic cell migration

(2018) Hannah Guak et al.   Nature Communications

mTOR Senses Environmental Cues to Shape the Fibroblast-like Synoviocyte Response to Inflammation

(2018) Thomas Karonitsch et al.   Cell Reports

Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions

(2018) Ashley V. Menk et al.   Cell Reports

JAK-STAT blockade alters synovial bioenergetics, mitochondrial function and pro-inflammatory mediators in Rheumatoid arthritis

(2018) Trudy McGarry et al.   Arthritis & Rheumatology

Role of SLC7A5 in Metabolic Reprogramming of Human Monocyte/Macrophage Immune Responses

(2018) Bo Ruem Yoon et al.   Frontiers in Immunology

Hexokinase 2 as a novel selective metabolic target for rheumatoid arthritis

(2018) Marta F Bustamante et al.   ANNALS OF THE RHEUMATIC DISEASES

Pathogenetic insights from the treatment of rheumatoid arthritis

(2017) Iain B McInnes et al.   LANCET

Functional analysis of choline transporters in rheumatoid arthritis synovial fibroblasts

(2017) Masayuki Seki et al.   Modern Rheumatology

Immunometabolism in early and late stages of rheumatoid arthritis

(2017) Cornelia M. Weyand et al.   Nature Reviews Rheumatology

Tocilizumab improves the proatherothrombotic profile of rheumatoid arthritis patients modulating endothelial dysfunction, NETosis, and inflammation

(2017) Patricia Ruiz-Limón et al.   Translational Research

Glucose represses dendritic cell-induced T cell responses

(2017) Simon J. Lawless et al.   Nature Communications

Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions

(2017) Mojca Frank-Bertoncelj et al.   Nature Communications

Resolution of TLR2-induced inflammation through manipulation of metabolic pathways in Rheumatoid Arthritis

(2017) Trudy McGarry et al.   Scientific Reports

Glucose-6-Phosphate Isomerase (G6PI) Mediates Hypoxia-Induced Angiogenesis in Rheumatoid Arthritis

(2017) Ying Lu et al.   Scientific Reports

3-bromopyruvate ameliorate autoimmune arthritis by modulating Th17/Treg cell differentiation and suppressing dendritic cell activation

(2017) Takaichi Okano et al.   Scientific Reports

Dysregulated bioenergetics: a key regulator of joint inflammation

(2016) M Biniecka et al.   ANNALS OF THE RHEUMATIC DISEASES

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity

(2016) Roger Geiger et al.   CELL

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

(2016) Vicky Lampropoulou et al.   Cell Metabolism

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

(2016) Almut Brand et al.   Cell Metabolism

Lactate at the crossroads of metabolism, inflammation, and autoimmunity

(2016) Valentina Pucino et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

GC/TOF-MS-based metabolomic profiling in cultured fibroblast-like synoviocytes from rheumatoid arthritis

(2016) Joong Kyong Ahn et al.   JOINT BONE SPINE

GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis

(2016) Amanda Littlewood-Evans et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease

(2016) Tsuyoshi Shirai et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targeted Metabolic Profiling of the Tg197 Mouse Model Reveals Itaconic Acid as a Marker of Rheumatoid Arthritis

(2016) Filippos Michopoulos et al.   JOURNAL OF PROTEOME RESEARCH

Hypoxia, mitochondrial dysfunction and synovial invasiveness in rheumatoid arthritis

(2016) Ursula Fearon et al.   Nature Reviews Rheumatology

Glycolytic regulation of cell rearrangement in angiogenesis

(2016) Bert Cruys et al.   Nature Communications

Critical Role of Glucose Metabolism in Rheumatoid Arthritis Fibroblast-like Synoviocytes

(2016) Ricard Garcia-Carbonell et al.   Arthritis & Rheumatology

Monocytes from patients with rheumatoid arthritis and type 2 diabetes mellitus display an increased production of interleukin (IL)-1β via the nucleotide-binding domain and leucine-rich repeat containing family pyrin 3(NLRP3)-inflammasome activation: a pos

(2015) P. Ruscitti et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Epigenetic pathways in macrophages emerge as novel targets in atherosclerosis

(2015) Annette E. Neele et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A Broken Krebs Cycle in Macrophages

(2015) Luke A.J. O’Neill   IMMUNITY

Targeting of proangiogenic signalling pathways in chronic inflammation

(2015) Sander W. Tas et al.   Nature Reviews Rheumatology

Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions

(2015) Robert Haas et al.   PLOS BIOLOGY

AMPK Activation by A-769662 Controls IL-6 Expression in Inflammatory Arthritis

(2015) Monica Guma et al.   PLoS One

Hypoxia and STAT3 signalling interactions regulate pro-inflammatory pathways in rheumatoid arthritis

(2014) Wei Gao et al.   ANNALS OF THE RHEUMATIC DISEASES

Choline kinase inhibition in rheumatoid arthritis

(2014) M Guma et al.   ANNALS OF THE RHEUMATIC DISEASES

Apoptosis inhibition by Bcl-2 gives way to autophagy in glucocorticoid-treated lymphocytes

(2014) Sarah Swerdlow et al.   Autophagy

Tumor-Secreted Lactic Acid Promotes IL-23/IL-17 Proinflammatory Pathway

(2014) H. Shime et al.   JOURNAL OF IMMUNOLOGY

Hypoxia and Hypoxia-Inducible Factor-1  Modulate Lipopolysaccharide-Induced Dendritic Cell Activation and Function

(2014) J. Jantsch et al.   JOURNAL OF IMMUNOLOGY

TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation

(2014) Bart Everts et al.   NATURE IMMUNOLOGY

Global Metabolite Profiling of Synovial Fluid for the Specific Diagnosis of Rheumatoid Arthritis from Other Inflammatory Arthritis

(2014) Sooah Kim et al.   PLoS One

mTOR- and HIF-1 -mediated aerobic glycolysis as metabolic basis for trained immunity

(2014) S.-C. Cheng et al.   SCIENCE

Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity

(2014) S. Saeed et al.   SCIENCE

Direct Type I IFN but Not MDA5/TLR3 Activation of Dendritic Cells Is Required for Maturation and Metabolic Shift to Glycolysis after Poly IC Stimulation

(2014) Austin Pantel et al.   PLOS BIOLOGY

Ex vivo analysis of pancreatic cancer-infiltrating T lymphocytes reveals that ENO-specific Tregs accumulate in tumor tissue and inhibit Th1/Th17 effector cell functions

(2013) Amedeo Amedei et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells

(2013) Zhen Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Differential regulation of HIF-mediated pathways increases mitochondrial metabolism and ATP production in hypoxic osteoclasts

(2013) Karl J Morten et al.   JOURNAL OF PATHOLOGY

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Notch signalling pathways mediate synovial angiogenesis in response to vascular endothelial growth factor and angiopoietin 2

(2012) Wei Gao et al.   ANNALS OF THE RHEUMATIC DISEASES

Notch-1 mediates hypoxia-induced angiogenesis in rheumatoid arthritis

(2012) Wei Gao et al.   ARTHRITIS AND RHEUMATISM

Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells

(2012) B. Everts et al.   BLOOD

IL-22 induced cell proliferation is regulated by PI3K/Akt/mTOR signaling cascade

(2012) Anupam Mitra et al.   CYTOKINE

Dendritic cells tolerized with adenosine A2AR agonist attenuate acute kidney injury

(2012) Li Li et al.   JOURNAL OF CLINICAL INVESTIGATION

 -Enolase Expressed on the Surfaces of Monocytes and Macrophages Induces Robust Synovial Inflammation in Rheumatoid Arthritis

(2012) S. Bae et al.   JOURNAL OF IMMUNOLOGY

Prostaglandin E2 Induces Oncostatin M Expression in Human Chronic Wound Macrophages through Axl Receptor Tyrosine Kinase Pathway

(2012) K. Ganesh et al.   JOURNAL OF IMMUNOLOGY

PI3 kinase/Akt/HIF-1α pathway is associated with hypoxia-induced epithelial–mesenchymal transition in fibroblast-like synoviocytes of rheumatoid arthritis

(2012) Guo-Qing Li et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Human monocytes and macrophages differ in their mechanisms of adaptation to hypoxia

(2012) Monique Fangradt et al.   ARTHRITIS RESEARCH & THERAPY

Mitochondrial mutagenesis correlates with the local inflammatory environment in arthritis

(2011) Leonard C Harty et al.   ANNALS OF THE RHEUMATIC DISEASES

Autophagy activation by rapamycin reduces severity of experimental osteoarthritis

(2011) Beatriz Caramés et al.   ANNALS OF THE RHEUMATIC DISEASES

Hypoxia induces mitochondrial mutagenesis and dysfunction in inflammatory arthritis

(2011) Monika Biniecka et al.   ARTHRITIS AND RHEUMATISM

Tumor necrosis factor blocking therapy alters joint inflammation and hypoxia

(2011) Aisling Kennedy et al.   ARTHRITIS AND RHEUMATISM

Reduction of in vitro invasion and in vivo cartilage degradation in a SCID mouse model by loss of function of the fibrinolytic system of rheumatoid arthritis synovial fibroblasts

(2011) Simona Serratì et al.   ARTHRITIS AND RHEUMATISM

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Synovial tissue hypoxia and inflammation in vivo

(2010) C. T. Ng et al.   ANNALS OF THE RHEUMATIC DISEASES

Angiogenesis and blood vessel stability in inflammatory arthritis

(2010) Aisling Kennedy et al.   ARTHRITIS AND RHEUMATISM

Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation

(2010) C. M. Krawczyk et al.   BLOOD

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(2010) Teresina Laragione et al.   MOLECULAR MEDICINE

The engine driving the ship: metabolic steering of cell proliferation and death

(2010) Marisa R. Buchakjian et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hypoxia Activates NF-κB–Dependent Gene Expression Through the Canonical Signaling Pathway

(2009) Kathryn M. Oliver et al.   ANTIOXIDANTS & REDOX SIGNALING

l-Type amino acid transporter 1 inhibitors inhibit tumor cell growth

(2009) Koji Oda et al.   CANCER SCIENCE

mTOR: taking cues from the immune microenvironment

(2009) Greg M. Delgoffe et al.   IMMUNOLOGY

Immature Blood Vessels in Rheumatoid Synovium Are Selectively Depleted in Response to Anti-TNF Therapy

(2009) Elena Izquierdo et al.   PLoS One

Hypoxia upregulates angiogenesis and synovial cell migration in rheumatoid arthritis

(2009) Mohammed A Akhavani et al.   ARTHRITIS RESEARCH & THERAPY

Synovial Hypoxia as a Cause of Tendon Rupture in Rheumatoid Arthritis

(2008) Branavan Sivakumar et al.   JOURNAL OF HAND SURGERY-AMERICAN VOLUME

Triggering the succinate receptor GPR91 on dendritic cells enhances immunity

(2008) Tina Rubic et al.   NATURE IMMUNOLOGY