Kinome Screen Identifies PFKFB3 and Glucose Metabolism as Important Regulators of the Insulin/Insulin-like Growth Factor (IGF)-1 Signaling Pathway

Glycolytic Reprogramming in Myofibroblast Differentiation and Lung Fibrosis

(2015) Na Xie et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The RabGAP TBC1D1 Plays a Central Role in Exercise-Regulated Glucose Metabolism in Skeletal Muscle

(2015) Jacqueline Stöckli et al.   DIABETES

Selective Insulin Resistance in Adipocytes

(2015) Shi-Xiong Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A comparative analysis of inhibitors of the glycolysis pathway in breast and ovarian cancer cell line models

(2015) Chrysi Xintaropoulou et al.   Oncotarget

Endothelial PFKFB3 Plays a Critical Role in Angiogenesis

(2014) Yiming Xu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inflammation and insulin/IGF-1 resistance as the possible link between obesity and neurodegeneration

(2014) Lindsay J. Spielman et al.   JOURNAL OF NEUROIMMUNOLOGY

A clearer pathway view

(2014) Sarah Seton-Rogers   NATURE REVIEWS DRUG DISCOVERY

Cultured 3T3L1 adipocytes dispose of excess medium glucose as lactate under abundant oxygen availability

(2014) David Sabater et al.   Scientific Reports

Src tyrosine kinase signaling antagonizes nuclear localization of FOXO and inhibits its transcription factor activity

(2014) Margret H. Bülow et al.   Scientific Reports

Blocking Lactate Export by Inhibiting the Myc Target MCT1 Disables Glycolysis and Glutathione Synthesis

(2013) J. R. Doherty et al.   CANCER RESEARCH

Role of PFKFB3-Driven Glycolysis in Vessel Sprouting

(2013) Katrien De Bock et al.   CELL

Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2

(2013) Sean J. Humphrey et al.   Cell Metabolism

Partial and Transient Reduction of Glycolysis by PFKFB3 Blockade Reduces Pathological Angiogenesis

(2013) Sandra Schoors et al.   Cell Metabolism

Overexpression of a key regulator of lipid homeostasis, Scap, promotes respiration in prostate cancer cells

(2013) Anika Vinayak Prabhu et al.   FEBS LETTERS

Lactate Engages Receptor Tyrosine Kinases Axl, Tie2, and Vascular Endothelial Growth Factor Receptor 2 to Activate Phosphoinositide 3-Kinase/Akt and Promote Angiogenesis

(2013) Guo-Xiang Ruan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased Concentrations of Fructose 2,6-Bisphosphate Contribute to the Warburg Effect in Phosphatase and Tensin Homolog (PTEN)-deficient Cells

(2013) Lucía Cordero-Espinoza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting 6-Phosphofructo-2-Kinase (PFKFB3) as a Therapeutic Strategy against Cancer

(2013) B. F. Clem et al.   MOLECULAR CANCER THERAPEUTICS

Exercise, GLUT4, and Skeletal Muscle Glucose Uptake

(2013) Erik A. Richter et al.   PHYSIOLOGICAL REVIEWS

Targeting cellular metabolism to improve cancer therapeutics

(2013) Y Zhao et al.   Cell Death & Disease

Autoregulation of kinase dephosphorylation by ATP binding in AGC protein kinases

(2012) Tung O. Chan et al.   CELL CYCLE

The Sedoheptulose Kinase CARKL Directs Macrophage Polarization through Control of Glucose Metabolism

(2012) Arvand Haschemi et al.   Cell Metabolism

Metabolic Signatures of Human Adipose Tissue Hypoxia in Obesity

(2012) L. Hodson et al.   DIABETES

Targeted Overexpression of Inducible 6-Phosphofructo-2-kinase in Adipose Tissue Increases Fat Deposition but Protects against Diet-induced Insulin Resistance and Inflammatory Responses

(2012) Yuqing Huo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GLUT4 exocytosis

(2012) Jacqueline Stöckli et al.   JOURNAL OF CELL SCIENCE

Small molecule inhibition of 6-phosphofructo-2-kinase suppresses t cell activation

(2012) Sucheta Telang et al.   Journal of Translational Medicine

Lactate Activates HIF-1 in Oxidative but Not in Warburg-Phenotype Human Tumor Cells

(2012) Christophe J. De Saedeleer et al.   PLoS One

An ATP-Site On-Off Switch That Restricts Phosphatase Accessibility of Akt

(2012) K. Lin et al.   Science Signaling

TBC1D13 is a RAB35 Specific GAP that Plays an Important Role in GLUT4 Trafficking in Adipocytes

(2012) Jonathan R. Davey et al.   TRAFFIC

Akt signalling in health and disease

(2011) Ingeborg Hers et al.   CELLULAR SIGNALLING

Loss of AS160 Akt Substrate Causes Glut4 Protein to Accumulate in Compartments That Are Primed for Fusion in Basal Adipocytes

(2011) Paul Duffield Brewer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amplification and Demultiplexing in Insulin-regulated Akt Protein Kinase Pathway in Adipocytes

(2011) Shi-Xiong Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure-Based Development of Small Molecule PFKFB3 Inhibitors: A Framework for Potential Cancer Therapeutic Agents Targeting the Warburg Effect

(2011) Minsuh Seo et al.   PLoS One

Isoform-specific regulation of Akt by PDGF-induced reactive oxygen species

(2011) R. Wani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Deacetylase SIRT1 Promotes Membrane Localization and Activation of Akt and PDK1 During Tumorigenesis and Cardiac Hypertrophy

(2011) N. R. Sundaresan et al.   Science Signaling

Akt inhibitors reduce glucose uptake independently of their effects on Akt

(2010) Shi-Xiong Tan et al.   BIOCHEMICAL JOURNAL

Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation

(2010) C. M. Krawczyk et al.   BLOOD

An Autocrine Lactate Loop Mediates Insulin-Dependent Inhibition of Lipolysis through GPR81

(2010) Kashan Ahmed et al.   Cell Metabolism

G Protein-Coupled Receptor Kinase 2 Plays a Relevant Role in Insulin Resistance and Obesity

(2010) L. Garcia-Guerra et al.   DIABETES

Protein kinase C isoforms: Mediators of reactive lipid metabolites in the development of insulin resistance

(2010) Sophie Turban et al.   FEBS LETTERS

The CNK1 scaffold binds cytohesins and promotes insulin pathway signaling

(2010) J. Lim et al.   GENES & DEVELOPMENT

Demonstration of a visual cell-based assay for screening glucose transporter 4 translocation modulators in real time

(2010) Maleppillil Vavachan Vijayakumar et al.   JOURNAL OF BIOSCIENCES

Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes

(2010) Robert B. Hamanaka et al.   TRENDS IN BIOCHEMICAL SCIENCES

Lipid and insulin infusion-induced skeletal muscle insulin resistance is likely due to metabolic feedback and not changes in IRS-1, Akt, or AS160 phosphorylation

(2009) Andrew J. Hoy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Regulation of glucose metabolism by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases in cancer

(2009) Abdullah Yalcin et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Disruption of Inducible 6-Phosphofructo-2-kinase Ameliorates Diet-induced Adiposity but Exacerbates Systemic Insulin Resistance and Adipose Tissue Inflammatory Response

(2009) Yuqing Huo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nucleoside diphosphate kinase (NDPK, NM23, AWD): recent regulatory advances in endocytosis, metastasis, psoriasis, insulin release, fetal erythroid lineage and heart failure; translational medicine exemplified

(2009) Anil Mehta et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Aurora-A down-regulates IkappaBα via Akt activation and interacts with insulin-like growth factor-1 induced phosphatidylinositol 3-kinase pathway for cancer cell survival

(2009) Jin-e Yao et al.   Molecular Cancer

c-Src Regulates Akt Signaling in Response to Ghrelin via β-Arrestin Signaling-Independent and -Dependent Mechanisms

(2009) Maria Lodeiro et al.   PLoS One

The atypical kinase Cdk5 is activated by insulin, regulates the association between GLUT4 and E-Syt1, and modulates glucose transport in 3T3-L1 adipocytes

(2009) V. Lalioti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The E3 Ligase TRAF6 Regulates Akt Ubiquitination and Activation

(2009) W.-L. Yang et al.   SCIENCE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Role of GPR81 in lactate-mediated reduction of adipose lipolysis

(2008) Tian-Quan Cai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Development of a novel GLUT4 translocation assay for identifying potential novel therapeutic targets for insulin sensitization

(2008) Franklin Liu et al.   BIOCHEMICAL JOURNAL

IRS1-Independent Defects Define Major Nodes of Insulin Resistance

(2008) Kyle L. Hoehn et al.   Cell Metabolism

Dual role for myosin II in GLUT4-mediated glucose uptake in 3T3-L1 adipocytes

(2008) F FULCHER et al.   EXPERIMENTAL CELL RESEARCH

CDK5-dependent Phosphorylation of the Rho Family GTPase TC10α Regulates Insulin-stimulated GLUT4 Translocation

(2008) Shuichi Okada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

(2008) Pierre Sonveaux et al.   JOURNAL OF CLINICAL INVESTIGATION

Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival

(2008) Nancie J. MacIver et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth

(2008) B. Clem et al.   MOLECULAR CANCER THERAPEUTICS

Regulation of Glucose Transporter 4 Translocation by the Rab Guanosine Triphosphatase-Activating Protein AS160/TBC1D4: Role of Phosphorylation and Membrane Association

(2008) Jacqueline Stöckli et al.   MOLECULAR ENDOCRINOLOGY

Is Akt the “Warburg kinase”?—Akt-energy metabolism interactions and oncogenesis

(2008) R. Brooks Robey et al.   SEMINARS IN CANCER BIOLOGY