Energy substrate metabolism and mitochondrial oxidative stress in cardiac ischemia/reperfusion injury

Effect of hyperglycaemia and diabetes on acute myocardial ischaemia‐reperfusion injury and cardioprotection by ischaemic conditioning protocols

(2020) Claudia Penna et al.   BRITISH JOURNAL OF PHARMACOLOGY

Translational issues for mitoprotective agents as adjunct to reperfusion therapy in patients with ST‐segment elevation myocardial infarction

(2020) Hans Erik Bøtker et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Updating insights into rosiglitazone and cardiovascular risk through shared data: individual patient and summary level meta-analyses

(2020) Joshua D Wallach et al.   BMJ-British Medical Journal

Experimental oxygen concentration influences rates of mitochondrial hydrogen peroxide release from cardiac and skeletal muscle preparations

(2020) Lance C. Li Puma et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Empagliflozin Protects Cardiac Mitochondrial Fatty Acid Metabolism in a Mouse Model of Diet-Induced Lipid Overload

(2020) Marina Makrecka-Kuka et al.   CARDIOVASCULAR DRUGS AND THERAPY

Hyperglycemia Acutely Increases Cytosolic Reactive Oxygen Species via O -linked GlcNAcylation and CaMKII Activation in Mouse Ventricular Myocytes

(2020) Shan Lu et al.   CIRCULATION RESEARCH

Cardiac metabolism as a driver and therapeutic target of myocardial infarction

(2020) Coert J. Zuurbier et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Mild depolarization of the inner mitochondrial membrane is a crucial component of an anti-aging program

(2020) Mikhail Y. Vyssokikh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acute dapagliflozin administration exerts cardioprotective effects in rats with cardiac ischemia/reperfusion injury

(2020) Sarayut Lahnwong et al.   Cardiovascular Diabetology

Quantitative analyses of the umami characteristics of disodium succinate in aqueous solution

(2020) Jie Ma et al.   FOOD CHEMISTRY

Long-chain free fatty acids inhibit ischaemic preconditioning of the isolated rat heart

(2020) Amanda Lochner et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Na+ controls hypoxic signalling by the mitochondrial respiratory chain

(2020) Pablo Hernansanz-Agustín et al.   NATURE

Inhibition of Fatty Acid Oxidation Promotes Macrophage Control of Mycobacterium tuberculosis

(2020) Pallavi Chandra et al.   mBio

Cardioprotective effect of succinate dehydrogenase inhibition in rat hearts and human myocardium with and without diabetes mellitus

(2020) Nichlas Riise Jespersen et al.   Scientific Reports

Novel approach to quantify mitochondrial content and intrinsic bioenergetic efficiency across organs

(2020) Kelsey L. McLaughlin et al.   Scientific Reports

Acid enhancement of ROS generation by complex-I reverse electron transport is balanced by acid inhibition of complex-II: Relevance for tissue reperfusion injury

(2020) Alexander S. Milliken et al.   Redox Biology

ROS systems are a new integrated network for sensing homeostasis and alarming stresses in organelle metabolic processes

(2020) Yu Sun et al.   Redox Biology

Discovery of new therapeutic redox targets for cardioprotection against ischemia/reperfusion injury and heart failure

(2020) Andreas Daiber et al.   FREE RADICAL BIOLOGY AND MEDICINE

Delayed ischemic contracture onset by Empagliflozin associates with NHE-1 inhibition and is dependent on insulin in isolated mouse hearts

(2019) Laween Uthman et al.   CARDIOVASCULAR RESEARCH

Control and Regulation of Substrate Selection in Cytoplasmic and Mitochondrial Catabolic Networks. A Systems Biology Analysis

(2019) Sonia Cortassa et al.   Frontiers in Physiology

Exenatide Protects Against Cardiac Dysfunction by Attenuating Oxidative Stress in the Diabetic Mouse Heart

(2019) Wei Ding et al.   Frontiers in Endocrinology

Protective effects of dimethyl itaconate in mice acute cardiotoxicity induced by doxorubicin

(2019) Qing Shan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mitochondrial fatty acid oxidation and the electron transport chain comprise a multifunctional mitochondrial protein complex

(2019) Yudong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dietary fats and mortality among patients with type 2 diabetes: analysis in two population based cohort studies

(2019) Jingjing Jiao et al.   BMJ-British Medical Journal

The cardioprotective effects of carvedilol on ischemia and reperfusion injury by AMPK signaling pathway

(2019) Haiyan Hu et al.   BIOMEDICINE & PHARMACOTHERAPY

A Mitochondrial Approach to Cardiovascular Risk and Disease

(2019) Caroline D. Veloso et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

The Immunomodulatory Potential of the Metabolite Itaconate

(2019) Alexander Hooftman et al.   TRENDS IN IMMUNOLOGY

Succinate in ischemia: Where does it come from?

(2019) Christos Chinopoulos   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Ischemia/Reperfusion Injury Revisited: An Overview of the Latest Pharmacological Strategies

(2019) Ricardo O. S. Soares et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cardiovascular effects of glucagon-like peptide 1 receptor agonists: from mechanistic studies in humans to clinical outcomes

(2019) Valerie D Heuvelman et al.   CARDIOVASCULAR RESEARCH

Targeting Succinate Metabolism in Ischemia/Reperfusion Injury

(2019) Duvaraka Kula-Alwar et al.   CIRCULATION

Itaconate modulates tricarboxylic acid and redox metabolism to mitigate reperfusion injury

(2019) Thekla Cordes et al.   Molecular Metabolism

Mitochondria "THE" target of myocardial conditioning

(2018) Kerstin Boengler et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Determination of mitochondrial metabolic phenotype through investigation of the intrinsic inhibition of succinate dehydrogenase

(2018) Alexander Panov et al.   ANALYTICAL BIOCHEMISTRY

For when bacterial infections persist: Toll-like receptor-inducible direct antimicrobial pathways in macrophages

(2018) Claudia J. Stocks et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Loss of the Mitochondrial Fatty Acid β-Oxidation Protein Medium-Chain Acyl-Coenzyme A Dehydrogenase Disrupts Oxidative Phosphorylation Protein Complex Stability and Function

(2018) Sze Chern Lim et al.   Scientific Reports

Selective Inhibition of Succinate Dehydrogenase in Reperfused Myocardium with Intracoronary Malonate Reduces Infarct Size

(2018) Laura Valls-Lacalle et al.   Scientific Reports

Accumulation of Succinate in Cardiac Ischemia Primarily Occurs via Canonical Krebs Cycle Activity

(2018) Jimmy Zhang et al.   Cell Reports

Metabolomic Profiling in Acute ST‐Segment–Elevation Myocardial Infarction Identifies Succinate as an Early Marker of Human Ischemia–Reperfusion Injury

(2018) Matthias Kohlhauer et al.   Journal of the American Heart Association

GLP-1 Receptor Agonists and Cardiovascular Disease in Patients with Type 2 Diabetes

(2018) María Isabel del Olmo-Garcia et al.   Journal of Diabetes Research

Mitochondrial dysfunction in pathophysiology of heart failure

(2018) Bo Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial energetics is impaired in very long-chain acyl-CoA dehydrogenase deficiency and can be rescued by treatment with mitochondria-targeted electron scavengers

(2018) Bianca Seminotti et al.   HUMAN MOLECULAR GENETICS

Liraglutide and Glycaemic Outcomes in the LEADER Trial

(2018) Bernard Zinman et al.   Diabetes Therapy

Production of superoxide and hydrogen peroxide from specific mitochondrial sites under different bioenergetic conditions

(2017) Hoi-Shan Wong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of succinate and ROS in reperfusion injury – A critical appraisal

(2017) Tatyana N. Andrienko et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Empagliflozin Limits Myocardial Infarction in Vivo and Cell Death in Vitro: Role of STAT3, Mitochondria, and Redox Aspects

(2017) Ioanna Andreadou et al.   Frontiers in Physiology

Sodium-myoinositol cotransporter-1, SMIT1, mediates the production of reactive oxygen species induced by hyperglycemia in the heart

(2017) Anne Van Steenbergen et al.   Scientific Reports

Plasma acylcarnitine concentrations reflect the acylcarnitine profile in cardiac tissues

(2017) Marina Makrecka-Kuka et al.   Scientific Reports

Long-chain acylcarnitines determine ischaemia/reperfusion-induced damage in heart mitochondria

(2016) E. Liepinsh et al.   BIOCHEMICAL JOURNAL

Succinate metabolism: a new therapeutic target for myocardial reperfusion injury

(2016) Victoria R. Pell et al.   CARDIOVASCULAR RESEARCH

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

(2016) Evanna L. Mills et al.   CELL

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

(2016) Vicky Lampropoulou et al.   Cell Metabolism

Moving Forwards by Blocking Back-Flow

(2016) Victoria R. Pell et al.   CIRCULATION RESEARCH

Mitochondrial Metabolism in Aging Heart

(2016) Edward J. Lesnefsky et al.   CIRCULATION RESEARCH

Effects of Liraglutide on Reperfusion Injury in Patients With ST-Segment–Elevation Myocardial InfarctionCLINICAL PERSPECTIVE

(2016) Wei Ren Chen et al.   Circulation-Cardiovascular Imaging

Empagliflozin decreases myocardial cytoplasmic Na+ through inhibition of the cardiac Na+/H+ exchanger in rats and rabbits

(2016) Antonius Baartscheer et al.   DIABETOLOGIA

Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling

(2016) Martin D. Brand   FREE RADICAL BIOLOGY AND MEDICINE

Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels

(2016) Thekla Cordes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reducing mitochondrial bound hexokinase II mediates transition from non-injurious into injurious ischemia/reperfusion of the intact heart

(2016) Rianne Nederlof et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

The protective effect of trimetazidine on myocardial ischemia/reperfusion injury through activating AMPK and ERK signaling pathway

(2016) Zhenling Liu et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Interplay between oxidant species and energy metabolism

(2016) Celia Quijano et al.   Redox Biology

Real-Time Fluorescence Measurements of ROS and [Ca2+] in Ischemic / Reperfused Rat Hearts: Detectable Increases Occur only after Mitochondrial Pore Opening and Are Attenuated by Ischemic Preconditioning

(2016) Tatyana Andrienko et al.   PLoS One

The role of sirtuins in cardiac disease

(2015) Shouji Matsushima et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Itaconic Acid: The Surprising Role of an Industrial Compound as a Mammalian Antimicrobial Metabolite

(2015) Thekla Cordes et al.   Annual Review of Nutrition

Inhibition of L-carnitine biosynthesis and transport by methyl-γ-butyrobetaine decreases fatty acid oxidation and protects against myocardial infarction

(2015) E Liepinsh et al.   BRITISH JOURNAL OF PHARMACOLOGY

Succinate dehydrogenase inhibition with malonate during reperfusion reduces infarct size by preventing mitochondrial permeability transition

(2015) Laura Valls-Lacalle et al.   CARDIOVASCULAR RESEARCH

Metabolomic profiling of the heart during acute ischemic preconditioning reveals a role for SIRT1 in rapid cardioprotective metabolic adaptation

(2015) Sergiy M. Nadtochiy et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Characterization of the cardiac succinylome and its role in ischemia–reperfusion injury

(2015) Jennifer A. Boylston et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cardioprotection Resulting from Glucagon-Like Peptide-1 Administration Involves Shifting Metabolic Substrate Utilization to Increase Energy Efficiency in the Rat Heart

(2015) Karpagam Aravindhan et al.   PLoS One

Mitochondrial inefficiencies and anoxic ATP hydrolysis capacities in diabetic rat heart

(2014) Toan Pham et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

HIF-1 reduces ischaemia–reperfusion injury in the heart by targeting the mitochondrial permeability transition pore

(2014) Sang-Ging Ong et al.   CARDIOVASCULAR RESEARCH

Long-chain acylcarnitine content determines the pattern of energy metabolism in cardiac mitochondria

(2014) Marina Makrecka et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

Cardioprotective Mechanism of Diazoxide Involves the Inhibition of Succinate Dehydrogenase

(2013) Melissa M. Anastacio et al.   ANNALS OF THORACIC SURGERY

Cardioprotective Effects of Exenatide in Patients With ST-Segment–Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

(2013) Jong Shin Woo et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Targeting hexokinase II to mitochondria to modulate energy metabolism and reduce ischaemia-reperfusion injury in heart

(2013) Rianne Nederlof et al.   BRITISH JOURNAL OF PHARMACOLOGY

SIRT5 Regulates the Mitochondrial Lysine Succinylome and Metabolic Networks

(2013) Matthew J. Rardin et al.   Cell Metabolism

Differential Translocation of the Fatty Acid Transporter, FAT/CD36, and the Glucose Transporter, GLUT4, Coordinates Changes in Cardiac Substrate Metabolism During Ischemia and Reperfusion

(2013) Lisa C. Heather et al.   Circulation-Heart Failure

In the eye of the storm: mitochondrial damage during heart and brain ischaemia

(2013) Vilmante Borutaite et al.   FEBS Journal

Inhibition of protein kinase C βII isoform rescues glucose toxicity-induced cardiomyocyte contractile dysfunction: Role of mitochondria

(2013) Zikuan Wang et al.   LIFE SCIENCES

The heart is better protected against myocardial infarction in the fed state compared to the fasted state

(2013) Edgars Liepinsh et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Activated peroxisomal fatty acid metabolism improves cardiac recovery in ischemia-reperfusion

(2013) Edgars Liepinsh et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production

(2013) A. Michelucci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extent of Mitochondrial Hexokinase II Dissociation During Ischemia Correlates With Mitochondrial Cytochrome c Release, Reactive Oxygen Species Production, and Infarct Size on Reperfusion

(2013) Philippe Pasdois et al.   Journal of the American Heart Association

Mechanism of superoxide and hydrogen peroxide generation by human electron-transfer flavoprotein and pathological variants

(2012) João V. Rodrigues et al.   FREE RADICAL BIOLOGY AND MEDICINE

The role of oxidized cytochromecin regulating mitochondrial reactive oxygen species production and its perturbation in ischaemia

(2011) Philippe Pasdois et al.   BIOCHEMICAL JOURNAL

Targeting fatty acid and carbohydrate oxidation — A novel therapeutic intervention in the ischemic and failing heart

(2011) Jagdip S. Jaswal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

NADPH oxidase activation by hyperglycaemia in cardiomyocytes is independent of glucose metabolism but requires SGLT1

(2011) Magali Balteau et al.   CARDIOVASCULAR RESEARCH

Disruption of Hexokinase II–Mitochondrial Binding Blocks Ischemic Preconditioning and Causes Rapid Cardiac Necrosis

(2011) Kirsten M.A. Smeele et al.   CIRCULATION RESEARCH

Itaconic Acid Is a Mammalian Metabolite Induced during Macrophage Activation

(2011) Cheryl L. Strelko et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Non-targeted metabolite profiling in activated macrophage secretion

(2011) Masahiro Sugimoto et al.   Metabolomics

The Role of Mitochondria in Reactive Oxygen Species Metabolism and Signaling

(2010) Anatoly A. Starkov   Annals of the New York Academy of Sciences

Mitochondrial fatty acid oxidation and oxidative stress: Lack of reverse electron transfer-associated production of reactive oxygen species

(2010) Peter Schönfeld et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

(2010) Matthew D. Hirschey et al.   NATURE

Acyl-CoA synthesis, lipid metabolism and lipotoxicity

(2009) Lei O. Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Mitochondrial KATP opening confers protection against lethal myocardial injury and ischaemia-induced arrhythmias in the rat heart via PI3K/Akt-dependent and -independent mechanismsThis article is one of a selection of papers published in a special issue on Advances in Cardiovascular Research.

(2009) Jana Matejíková et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Tissue-, substrate-, and site-specific characteristics of mitochondrial reactive oxygen species generation

(2009) Erich B. Tahara et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ischemic preconditioning affects hexokinase activity and HKII in different subcellular compartments throughout cardiac ischemia-reperfusion

(2009) Ebru Gürel et al.   JOURNAL OF APPLIED PHYSIOLOGY

Electron Transport Chain-dependent and -independent Mechanisms of Mitochondrial H2O2Emission during Long-chain Fatty Acid Oxidation

(2009) Erin L. Seifert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxygen Sensitivity of Mitochondrial Reactive Oxygen Species Generation Depends on Metabolic Conditions

(2009) David L. Hoffman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial oxygen tension within the heart

(2009) Egbert G. Mik et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Stress hyperglycaemia

(2009) Kathleen M Dungan et al.   LANCET

Different effects of palmitoyl-l-carnitine and palmitoyl-CoA on mitochondrial function in rat ventricular myocytes

(2008) Hiromutsu Tominaga et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

High rates of superoxide production in skeletal-muscle mitochondria respiring on both complex I- and complex II-linked substrates

(2008) Florian L. Muller et al.   BIOCHEMICAL JOURNAL

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Perioperative hyperinsulinaemic normoglycaemic clamp causes hypolipidaemia after coronary artery surgery † †This article is accompanied by Editorial I.

(2008) C.J. Zuurbier et al.   BRITISH JOURNAL OF ANAESTHESIA

Glucose-Insulin Therapy, Plasma Substrate Levels and Cardiac Recovery After Cardiac Ischemic Events

(2008) C. J. Zuurbier et al.   CARDIOVASCULAR DRUGS AND THERAPY

AMP-Activated Protein Kinase Conducts the Ischemic Stress Response Orchestra

(2008) Lawrence H. Young   CIRCULATION

Fatty acids as modulators of the cellular production of reactive oxygen species

(2008) Peter Schönfeld et al.   FREE RADICAL BIOLOGY AND MEDICINE

Methylmalonate inhibits succinate-supported oxygen consumption by interfering with mitochondrial succinate uptake

(2008) S. R. Mirandola et al.   JOURNAL OF INHERITED METABOLIC DISEASE