Reducing mitochondrial bound hexokinase II mediates transition from non-injurious into injurious ischemia/reperfusion of the intact heart

Succinate metabolism: a new therapeutic target for myocardial reperfusion injury

(2016) Victoria R. Pell et al.   CARDIOVASCULAR RESEARCH

Metabolomic profiling of the heart during acute ischemic preconditioning reveals a role for SIRT1 in rapid cardioprotective metabolic adaptation

(2015) Sergiy M. Nadtochiy et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

HIF-1 reduces ischaemia–reperfusion injury in the heart by targeting the mitochondrial permeability transition pore

(2014) Sang-Ging Ong et al.   CARDIOVASCULAR RESEARCH

Targeting hexokinase II to mitochondria to modulate energy metabolism and reduce ischaemia-reperfusion injury in heart

(2013) Rianne Nederlof et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hexokinase II and Reperfusion Injury

(2013) Philippe Pasdois et al.   CIRCULATION RESEARCH

Pathophysiological Consequences of TAT-HKII Peptide Administration Are Independent of Impaired Vascular Function and Ensuing Ischemia

(2013) Rianne Nederlof et al.   CIRCULATION RESEARCH

Regulation of cellular metabolism: programming and maintaining metabolic homeostasis

(2013) David F. Wilson   JOURNAL OF APPLIED PHYSIOLOGY

Hexokinase–mitochondrial interactions regulate glucose metabolism differentially in adult and neonatal cardiac myocytes

(2013) Guillaume Calmettes et al.   JOURNAL OF GENERAL PHYSIOLOGY

Dimers of mitochondrial ATP synthase form the permeability transition pore

(2013) V. Giorgio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extent of Mitochondrial Hexokinase II Dissociation During Ischemia Correlates With Mitochondrial Cytochrome c Release, Reactive Oxygen Species Production, and Infarct Size on Reperfusion

(2013) Philippe Pasdois et al.   Journal of the American Heart Association

Hexokinase II knockdown results in exaggerated cardiac hypertrophy via increased ROS production

(2012) Rongxue Wu et al.   EMBO Molecular Medicine

Helium-induced cardioprotection of healthy and hypertensive rat myocardium in vivo

(2012) Gezina T.M.L. Oei et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The role of oxidized cytochromecin regulating mitochondrial reactive oxygen species production and its perturbation in ischaemia

(2011) Philippe Pasdois et al.   BIOCHEMICAL JOURNAL

Disruption of Hexokinase II–Mitochondrial Binding Blocks Ischemic Preconditioning and Causes Rapid Cardiac Necrosis

(2011) Kirsten M.A. Smeele et al.   CIRCULATION RESEARCH

Programmed Necrosis, Not Apoptosis, in the Heart

(2011) Gloria Kung et al.   CIRCULATION RESEARCH

Biophysical properties and functional consequences of reactive oxygen species (ROS)-induced ROS release in intact myocardium

(2011) Nora Biary et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mitochondria: isolation, structure and function

(2011) Martin Picard et al.   JOURNAL OF PHYSIOLOGY-LONDON

The effect of standard chow and reduced hexokinase II on growth, cardiac and skeletal muscle hexokinase and low-flow cardiac ischaemia–reperfusion injury

(2011) Kirsten M Smeele et al.   LABORATORY ANIMALS

A pore way to die: the role of mitochondria in reperfusion injury and cardioprotection

(2010) Andrew P. Halestrap   BIOCHEMICAL SOCIETY TRANSACTIONS

Reduction in Hexokinase II Levels Results in Decreased Cardiac Function and Altered Remodeling After Ischemia/Reperfusion Injury

(2010) Rongxue Wu et al.   CIRCULATION RESEARCH

Ischemic preconditioning affects hexokinase activity and HKII in different subcellular compartments throughout cardiac ischemia-reperfusion

(2009) Ebru Gürel et al.   JOURNAL OF APPLIED PHYSIOLOGY

Cardioprotection by metabolic shut-down and gradual wake-up

(2009) Lindsay S. Burwell et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mitochondrial oxygen tension within the heart

(2009) Egbert G. Mik et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Reactive oxygen species generation is modulated by mitochondrial kinases: Correlation with mitochondrial antioxidant peroxidases in rat tissues

(2008) Ana Paula S.A. Santiago et al.   BIOCHIMIE

Hexokinase II Detachment from Mitochondria Triggers Apoptosis through the Permeability Transition Pore Independent of Voltage-Dependent Anion Channels

(2008) Federica Chiara et al.   PLoS One