The multifaceted role of TRAIL signaling in cancer and immunity

Convergence of pathway analysis and pattern recognition predicts sensitization to latest generation TRAIL therapeutics by IAP antagonism

(2020) Vesna Vetma et al.   CELL DEATH AND DIFFERENTIATION

Redundant and receptor-specific activities of TRADD, RIPK1 and FADD in death receptor signaling

(2019) Simone Füllsack et al.   Cell Death & Disease

Cytomegalovirus evades TRAIL-mediated innate lymphoid cell 1 defenses

(2019) Gaelle Picarda et al.   JOURNAL OF VIROLOGY

TRAIL suppresses gut inflammation and inhibits colitogeic T-cell activation in experimental colitis via an apoptosis-independent pathway

(2019) I. T. Chyuan et al.   Mucosal Immunology

The Role of TRAIL/DRs in the Modulation of Immune Cells and Responses

(2019) Duygu Sag et al.   Cancers

Non‐apoptotic TRAIL function modulates NK cell activity during viral infection

(2019) Ludmila Cardoso Alves et al.   EMBO REPORTS

TRAIL mediates and sustains constitutive NF-κB activation in LGL leukemia

(2018) Jun Yang et al.   BLOOD

TRAIL-Mediated Suppression of T Cell Receptor Signaling Inhibits T Cell Activation and Inflammation in Experimental Autoimmune Encephalomyelitis

(2018) I-Tsu Chyuan et al.   Frontiers in Immunology

The TRAIL-Induced Cancer Secretome Promotes a Tumor-Supportive Immune Microenvironment via CCR2

(2017) Torsten Hartwig et al.   MOLECULAR CELL

Caspase-8 Acts in a Non-enzymatic Role as a Scaffold for Assembly of a Pro-inflammatory “FADDosome” Complex upon TRAIL Stimulation

(2017) Conor M. Henry et al.   MOLECULAR CELL

TRAIL facilitates cytokine expression and macrophage migration during hypoxia/reoxygenation via ER stress-dependent NF-κB pathway

(2017) Yinan Jiang et al.   MOLECULAR IMMUNOLOGY

The immunology of atherosclerosis

(2017) Anton Gisterå et al.   Nature Reviews Nephrology

Virus Infection and Death Receptor-Mediated Apoptosis

(2017) Xingchen Zhou et al.   Viruses-Basel

Dual role of DR5 in death and survival signaling leads to TRAIL resistance in cancer cells

(2017) Yelyzaveta Shlyakhtina et al.   Cell Death & Disease

Cancer preventive effect of recombinant TRAIL by ablation of oncogenic inflammation in colitis-associated cancer rather than anticancer effect

(2017) Joo-Young Kim et al.   Oncotarget

Pro-survival effects by NF-κB, Akt and ERK(1/2) and anti-apoptosis actions by Six1 disrupt apoptotic functions of TRAIL-Dr4/5 pathway in ovarian cancer

(2016) Juan Yang et al.   BIOMEDICINE & PHARMACOTHERAPY

Identification of Mitoxantrone as a TRAIL-sensitizing agent for Glioblastoma Multiforme

(2016) Filiz Senbabaoglu et al.   CANCER BIOLOGY & THERAPY

TRAIL receptor gene editing unveils TRAIL-R1 as a master player of apoptosis induced by TRAIL and ER stress

(2016) Florent Dufour et al.   Oncotarget

An Evolution-Guided Analysis Reveals a Multi-Signaling Regulation of Fas by Tyrosine Phosphorylation and its Implication in Human Cancers

(2016) Krittalak Chakrabandhu et al.   PLOS BIOLOGY

Oncolytic measles virus induces tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated cytotoxicity by human myeloid and plasmacytoid dendritic cells

(2016) Carole Achard et al.   OncoImmunology

Natural Killer Cells and Liver Transplantation: Orchestrators of Rejection or Tolerance?

(2015) C. Harmon et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Cancer Cell-Autonomous TRAIL-R Signaling Promotes KRAS-Driven Cancer Progression, Invasion, and Metastasis

(2015) Silvia von Karstedt et al.   CANCER CELL

TNF-related apoptosis-inducing ligand (TRAIL) regulates midline-1, thymic stromal lymphopoietin, inflammation, and remodeling in experimental eosinophilic esophagitis

(2015) Adam M. Collison et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

RIP1 Cleavage in the Kinase Domain Regulates TRAIL-Induced NF-κB Activation and Lymphoma Survival

(2015) Laiqun Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY

Tumor necrosis factor–related apoptosis-inducing ligand induces the expression of proinflammatory cytokines in macrophages and re-educates tumor-associated macrophages to an antitumor phenotype

(2015) Jing Gao et al.   MOLECULAR BIOLOGY OF THE CELL

A set of NF-κB–regulated microRNAs induces acquired TRAIL resistance in Lung cancer

(2015) Young-Jun Jeon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRAIL-R2 promotes skeletal metastasis in a breast cancer xenograft mouse model

(2015) Hendrik Fritsche et al.   Oncotarget

Trailing TRAIL Resistance: Novel Targets for TRAIL Sensitization in Cancer Cells

(2015) Rachana Trivedi et al.   Frontiers in Oncology

TRAIL+ NK Cells Control CD4+ T Cell Responses during Chronic Viral Infection to Limit Autoimmunity

(2014) Iona S. Schuster et al.   IMMUNITY

Dominant Negative Effects of Tumor Necrosis Factor (TNF)-related Apoptosis-inducing Ligand (TRAIL) Receptor 4 on TRAIL Receptor 1 Signaling by Formation of Heteromeric Complexes

(2014) Simon Neumann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ER stress regulates myeloid-derived suppressor cell fate through TRAIL-R–mediated apoptosis

(2014) Thomas Condamine et al.   JOURNAL OF CLINICAL INVESTIGATION

CD40 Ligand Protects from TRAIL-Induced Apoptosis in Follicular Lymphomas through NF- B Activation and Up-Regulation of c-FLIP and Bcl-xL

(2014) M. Travert et al.   JOURNAL OF IMMUNOLOGY

TRAIL Deficiency Does Not Rescue Impaired CD8+ T Cell Memory Generated in the Absence of CD4+ T Cell Help

(2014) J. A. Sacks et al.   JOURNAL OF IMMUNOLOGY

CD8 T Cells Utilize TRAIL to Control Influenza Virus Infection

(2014) E. L. Brincks et al.   JOURNAL OF IMMUNOLOGY

TRAIL–Receptor Costimulation Inhibits Proximal TCR Signaling and Suppresses Human T Cell Activation and Proliferation

(2014) Corinna Lehnert et al.   JOURNAL OF IMMUNOLOGY

Tumor necrosis factor-related apoptosis-inducing ligand mediates the resolution of allergic airway inflammation induced by chronic allergen inhalation

(2014) L Faustino et al.   Mucosal Immunology

TRAIL/DR5 Signaling Promotes Macrophage Foam Cell Formation by Modulating Scavenger Receptor Expression

(2014) Fang Fang Liu et al.   PLoS One

Trail Resistance Induces Epithelial-Mesenchymal Transition and Enhances Invasiveness by Suppressing PTEN via miR-221 in Breast Cancer

(2014) Haiji Wang et al.   PLoS One

TRAIL Induces Neutrophil Apoptosis and Dampens Sepsis-Induced Organ Injury in Murine Colon Ascendens Stent Peritonitis

(2014) Katharina Beyer et al.   PLoS One

Intranasal Administration of Recombinant TRAIL Down-Regulates CXCL-1/KC in an Ovalbumin-Induced Airway Inflammation Murine Model

(2014) Veronica Tisato et al.   PLoS One

Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand on NK Cells Protects From Hepatic Ischemia-Reperfusion Injury

(2014) René Fahrner et al.   TRANSPLANTATION

Plasminogen activator urokinase expression reveals TRAIL responsiveness and supports fractional survival of cancer cells

(2014) V Pavet et al.   Cell Death & Disease

Inhibition of the TRAIL Death Receptor by CMV Reveals Its Importance in NK Cell-Mediated Antiviral Defense

(2014) Shilpi Verma et al.   PLoS Pathogens

Death receptors as targets in cancer

(2013) O Micheau et al.   BRITISH JOURNAL OF PHARMACOLOGY

Functional roles of tumor necrosis factor-related apoptosis-inducing ligand-DR5 interaction in B16F10 cells by activating the nuclear factor-κB pathway to induce metastatic potential

(2013) Kei Takahashi et al.   CANCER SCIENCE

Non-canonical kinase signaling by the death ligand TRAIL in cancer cells: discord in the death receptor family

(2013) K Azijli et al.   CELL DEATH AND DIFFERENTIATION

TRAIL-induced miR-146a expression suppresses CXCR4-mediated human breast cancer migration

(2013) Dongsheng Wang et al.   FEBS Journal

Down regulation of TRAIL and FasL on NK cells by Cyclosporin A in renal transplantation patients

(2013) Yun Zhang et al.   IMMUNOLOGY LETTERS

Cells surviving fractional killing by TRAIL exhibit transient but sustainable resistance and inflammatory phenotypes

(2013) Deborah A. Flusberg et al.   MOLECULAR BIOLOGY OF THE CELL

The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity

(2013) Adam Collison et al.   NATURE MEDICINE

Apoptosome Structure, Assembly, and Procaspase Activation

(2013) Shujun Yuan et al.   STRUCTURE

Death Receptor-Ligand Systems in Cancer, Cell Death, and Inflammation

(2013) H. Walczak   Cold Spring Harbor Perspectives in Biology

A molecular view on signal transduction by the apoptosome

(2012) Thomas F. Reubold et al.   CELLULAR SIGNALLING

Bortezomib and TRAIL: A perfect match for apoptotic elimination of tumour cells?

(2012) L.H.A.M. de Wilt et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Molecular Targets of TRAIL-Sensitizing Agents in Colorectal Cancer

(2012) Carmine Stolfi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Absence of death receptor translocation into lipid rafts in acquired TRAIL-resistant NSCLC cells

(2012) WEN OUYANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Kinome profiling of non-canonical TRAIL signaling reveals RIP1-Src-STAT3-dependent invasion in resistant non-small cell lung cancer cells

(2012) K. Azijli et al.   JOURNAL OF CELL SCIENCE

Imiquimod clears tumors in mice independent of adaptive immunity by converting pDCs into tumor-killing effector cells

(2012) Barbara Drobits et al.   JOURNAL OF CLINICAL INVESTIGATION

TNF-related apoptosis-inducing ligand (TRAIL) exerts therapeutic efficacy for the treatment of pneumococcal pneumonia in mice

(2012) Kathrin Steinwede et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Up-regulation of a death receptor renders antiviral T cells susceptible to NK cell–mediated deletion

(2012) Dimitra Peppa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TRAIL+ Human Plasmacytoid Dendritic Cells Kill Tumor Cells In Vitro: Mechanisms of Imiquimod- and IFN- -Mediated Antitumor Reactivity

(2012) M. L. Kalb et al.   JOURNAL OF IMMUNOLOGY

CD8+ T Cells Use TRAIL To Restrict West Nile Virus Pathogenesis by Controlling Infection in Neurons

(2012) B. Shrestha et al.   JOURNAL OF VIROLOGY

A Death Effector Domain Chain DISC Model Reveals a Crucial Role for Caspase-8 Chain Assembly in Mediating Apoptotic Cell Death

(2012) Laura S. Dickens et al.   MOLECULAR CELL

TRAF-6 Dependent Signaling Pathway Is Essential for TNF-Related Apoptosis-Inducing Ligand (TRAIL) Induces Osteoclast Differentiation

(2012) Men-Luh Yen et al.   PLoS One

TNF receptor family signaling in the development and functions of medullary thymic epithelial cells

(2012) Taishin Akiyama et al.   Frontiers in Immunology

NK cells sense tumors, course of disease and treatments

(2012) Giulia Fregni et al.   OncoImmunology

TRAIL attenuates the development of atherosclerosis in apolipoprotein E deficient mice

(2011) Victoria Watt et al.   ATHEROSCLEROSIS

Synergy between TLR3 and IL-18 promotes IFN-γ dependent TRAIL expression in human liver NK cells

(2011) Zhengkun Tu et al.   CELLULAR IMMUNOLOGY

TNF-related apoptosis-inducing ligand (TRAIL) protects against diabetes and atherosclerosis in Apoe −/− mice

(2011) B. A. Di Bartolo et al.   DIABETOLOGIA

TRAIL/DR5 Plays a Critical Role in NK Cell-Mediated Negative Regulation of Dendritic Cell Cross-Priming of T Cells

(2011) M. Iyori et al.   JOURNAL OF IMMUNOLOGY

The Role of Natural Killer Cells in Human Solid Organ and Tissue Transplantation

(2011) Jean Villard   Journal of Innate Immunity

TRAIL-Induced Keratinocyte Differentiation Requires Caspase Activation and p63 Expression

(2011) Nan-Lin Wu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

TNF-related apoptosis-inducing ligand (TRAIL) regulates inflammatory neutrophil apoptosis and enhances resolution of inflammation

(2011) Emmet E. McGrath et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Natural killer cells act as rheostats modulating antiviral T cells

(2011) Stephen N. Waggoner et al.   NATURE

Identification of a novel pro-apoptotic role of NF-κB in the regulation of TRAIL- and CD95-mediated apoptosis of glioblastoma cells

(2011) C Jennewein et al.   ONCOGENE

TRAIL-R4 Promotes Tumor Growth and Resistance to Apoptosis in Cervical Carcinoma HeLa Cells through AKT

(2011) Najoua Lalaoui et al.   PLoS One

The role of tumor necrosis factor receptor superfamily members in mammalian brain development, function and homeostasis

(2011) Jason P. Twohig et al.   REVIEWS IN THE NEUROSCIENCES

Cancer-related inflammation: Common themes and therapeutic opportunities

(2011) Frances R. Balkwill et al.   SEMINARS IN CANCER BIOLOGY

Extreme lymphoproliferative disease and fatal autoimmune thrombocytopenia in FasL and TRAIL double-deficient mice

(2010) L. M. Sedger et al.   BLOOD

TRAIL Promotes VSMC Proliferation and Neointima Formation in a FGF-2–, Sp1 Phosphorylation–, and NFκB-Dependent Manner

(2010) Jeffrey Chan et al.   CIRCULATION RESEARCH

Interferon-α–Induced TRAIL on Natural Killer Cells Is Associated With Control of Hepatitis C Virus Infection

(2010) Kerstin A. Stegmann et al.   GASTROENTEROLOGY

Oncogenic K-Ras Turns Death Receptors Into Metastasis-Promoting Receptors in Human and Mouse Colorectal Cancer Cells

(2010) Frederik J.H. Hoogwater et al.   GASTROENTEROLOGY

Alternative cell death mechanisms in development and beyond

(2010) J. Yuan et al.   GENES & DEVELOPMENT

Lipopolysaccharide-induced expression of TRAIL promotes dendritic cell differentiation

(2010) Young S. Cho et al.   IMMUNOLOGY

Phase 1b Study of Dulanermin (recombinant human Apo2L/TRAIL) in Combination With Paclitaxel, Carboplatin, and Bevacizumab in Patients With Advanced Non-Squamous Non–Small-Cell Lung Cancer

(2010) Jean-Charles Soria et al.   JOURNAL OF CLINICAL ONCOLOGY

Phase I Dose-Escalation Study of Recombinant Human Apo2L/TRAIL, a Dual Proapoptotic Receptor Agonist, in Patients With Advanced Cancer

(2010) Roy S. Herbst et al.   JOURNAL OF CLINICAL ONCOLOGY

Lipid Raft Assembly and Lck Recruitment in TRAIL Costimulation Mediates NF- B Activation and T Cell Proliferation

(2010) S.-C. Huang et al.   JOURNAL OF IMMUNOLOGY

Dual Effects of TRAIL in Suppression of Autoimmunity: The Inhibition of Th1 Cells and the Promotion of Regulatory T Cells

(2010) T. Ikeda et al.   JOURNAL OF IMMUNOLOGY

TRAIL signaling is mediated by DR4 in pancreatic tumor cells despite the expression of functional DR5

(2010) Johannes Lemke et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induces chemotactic migration of monocytes via a death receptor 4-mediated RhoGTPase pathway

(2010) Wei Wei et al.   MOLECULAR IMMUNOLOGY

The inhibition of Bid expression by Akt leads to resistance to TRAIL-induced apoptosis in ovarian cancer cells

(2010) N Goncharenko-Khaider et al.   ONCOGENE

Activation of the Akt Survival Pathway Contributes to TRAIL Resistance in Cancer Cells

(2010) Jing Xu et al.   PLoS One

Phase I and pharmacokinetic study of lexatumumab (HGS-ETR2) given every 2 weeks in patients with advanced solid tumors

(2009) H. A. Wakelee et al.   ANNALS OF ONCOLOGY

Plasmacytoid dendritic cells express TRAIL and induce CD4+ T-cell apoptosis in HIV-1 viremic patients

(2009) G. Stary et al.   BLOOD

NK cell-mediated killing of target cells triggers robust antigen-specific T cell-mediated and humoral responses

(2009) P. Krebs et al.   BLOOD

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

TRAIL receptor mediates inflammatory cytokine release in an NF-κB-dependent manner

(2009) Wanhu Tang et al.   CELL RESEARCH

TRAIL, DR4 and DR5 are upregulated in kidneys from patients with lupus nephritis and exert proliferative and proinflammatory effects

(2009) Vinh Nguyen et al.   CLINICAL IMMUNOLOGY

Natural Killer Cells Are Polarized Toward Cytotoxicity in Chronic Hepatitis C in an Interferon-Alfa–Dependent Manner

(2009) Golo Ahlenstiel et al.   GASTROENTEROLOGY

DR5-mediated DISC controls caspase-8 cleavage and initiation of apoptosis in human glioblastomas

(2009) Anita C. Bellail et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Prognostic significance of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor expression in patients with breast cancer

(2009) Tom M. Ganten et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis

(2009) Sabrina L. Spencer et al.   NATURE

Cyclophosphamide Chemotherapy Sensitizes Tumor Cells to TRAIL-Dependent CD8 T Cell-Mediated Immune Attack Resulting in Suppression of Tumor Growth

(2009) Robbert G. van der Most et al.   PLoS One

Rapid and significant induction of TRAIL-mediated type II cells in apoptosis of primary salivary epithelial cells in primary Sjögren’s syndrome

(2008) Hideki Nakamura et al.   APOPTOSIS

TRAIL induces proliferation of human glioma cells by c-FLIPL-mediated activation of ERK1/2

(2008) U. Vilimanovich et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A Phase 1 Study of Mapatumumab (Fully Human Monoclonal Antibody to TRAIL-R1) in Patients with Advanced Solid Malignancies

(2008) S. J. Hotte et al.   CLINICAL CANCER RESEARCH

Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Inhibits Experimental Autoimmune Thyroiditis by the Expansion of CD4+CD25+Regulatory T Cells

(2008) Su He Wang et al.   ENDOCRINOLOGY

JNK inhibition sensitises hepatocellular carcinoma cells but not normal hepatocytes to the TNF-related apoptosis-inducing ligand

(2008) S R Mucha et al.   GUT

No requirement for TRAIL in intrathymic negative selection

(2008) Erika Cretney et al.   INTERNATIONAL IMMUNOLOGY

TRAIL Stimulates Proliferation of Vascular Smooth Muscle Cells via Activation of NF-κB and Induction of Insulin-like Growth Factor-1 Receptor

(2008) Mary M. Kavurma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRAIL-R deficiency in mice enhances lymph node metastasis without affecting primary tumor development

(2008) Anne Grosse-Wilde et al.   JOURNAL OF CLINICAL INVESTIGATION

TRAIL-R deficiency in mice promotes susceptibility to chronic inflammation and tumorigenesis

(2008) Niklas Finnberg et al.   JOURNAL OF CLINICAL INVESTIGATION

Cell cycle regulation by FasL and Apo2L/TRAIL in human T-cell blasts. Implications for autoimmune lymphoproliferative syndromes

(2008) Alberto Bosque et al.   JOURNAL OF LEUKOCYTE BIOLOGY

TRAIL-induced survival and proliferation of SCLC cells is mediated by ERK and dependent on TRAIL-R2/DR5 expression in the absence of caspase-8

(2008) Larisa L. Belyanskaya et al.   LUNG CANCER

TNF-related apoptosis-inducing ligand (TRAIL) induces osteoclast differentiation from monocyte/macrophage lineage precursor cells

(2008) Men-Luh Yen et al.   MOLECULAR IMMUNOLOGY