Journal
CANCERS
Volume 11, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/cancers11101469
Keywords
apoptosis; immune regulation; tumor; myeloid cells; lymphoid cells
Categories
Funding
- TUBITAK [118Z363, 118Z997]
- H2020-MSCA-RISE-2017 grant [777995]
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Expression of TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) by immune cells can lead to the induction of apoptosis in tumor cells. However, it becomes increasingly clear that the interaction of TRAIL and its death receptors (DRs) can also directly impact immune cells and influence immune responses. Here, we review what is known about the role of TRAIL/DRs in immune cells and immune responses in general and in the tumor microenvironment in particular.
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