Review
Biochemistry & Molecular Biology
Makoto Nakashima, Kaoru Uchimaru
Summary: CD30, a member of the tumor necrosis factor receptor superfamily, plays important roles in the survival and proliferation of peripheral T-cell lymphoma (PTCL) and adult T-cell leukemia/lymphoma (ATL). Its overexpression is observed in various lymphomas, including PTCL, ATL, Hodgkin lymphoma (HL), anaplastic large cell lymphoma (ALCL), and a portion of diffuse large B-cell lymphoma (DLBCL). CD30 expression is often associated with HTLV-1 infection, and recent studies have shed light on the molecular mechanisms underlying the relationship between CD30 expression and HTLV-1 infection or ATL progression. The successful use of anti-CD30 antibody-drug conjugate (ADC) therapy in treating HL, ALCL, and PTCL further highlights the significance of CD30 in these lymphomas.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Roberta Piovesana, Adam J. Reid, Ada Maria Tata
Summary: The communication between neurons and glial cells has been well-documented in various stages of development and disease. Neurotransmitters, especially acetylcholine, play a significant role in regulating the development and physiology of glial cells. This review focuses on the contribution of neurotransmitter receptors, particularly the M2 muscarinic receptor and the alpha 7 nicotinic receptor, in influencing the phenotype and functioning of Schwann cells. Understanding these interactions can help identify potential therapeutic targets for pathological conditions involving glial cells.
Review
Immunology
Mei Tang, Fuya Jia, Fang Nan, Fengqiong Zuo, Zhu Yuan, Dunfang Zhang
Summary: This review summarizes the functions of cytokines in the generation of Treg cells and concludes that four members of the gamma c family cytokines, transforming growth factor beta, and three members of the TNF superfamily cytokines play vital roles in regulating tTreg cell generation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Plant Sciences
Do-Geun Kim, Hyeon-Joong Kim, Sun-Hye Choi, Sung Min Nam, Hyoung-Chun Kim, Hyewhon Rhim, Ik-Hyun Cho, Man Hee Rhee, Seung-Yeol Nah
Summary: Gintonin, a ginseng-derived exogenous G-protein-coupled LPA receptor ligand, has been shown to influence the migration and morphology of adult mouse brain neurons in vivo. The effects of gintonin on hNPCs were also observed in vitro, with changes in morphology and migration. These findings suggest that gintonin may have potential therapeutic effects on neurological diseases by affecting the morphology and migration of brain neurons.
JOURNAL OF GINSENG RESEARCH
(2021)
Review
Neurosciences
Alfredo Llorca, Ruben Deogracias
Summary: This review describes the diversity of interneurons that make up local circuits in the neocortex and summarizes the mechanisms underlying their development and assembly into functional networks.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Blaine Connor, Guillermo Moya-Alvarado, Naoya Yamashita, Rejji Kuruvilla
Summary: In neurons, transcytosis, an atypical transport mechanism, is essential for delivering TrkA neurotrophin receptors to axons, influencing neuronal connectivity and function. Disruption of PTP1B-dependent transcytosis in TrkAR685A mice leads to decreased axonal TrkA levels, loss of sympathetic neurons, and reduced inner-vation of targets. This axon targeting mechanism is crucial during development and also affects the nociceptive neurons in dorsal root ganglia.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Biochemistry & Molecular Biology
Jae-Yeon Kim, Mercedes F. Paredes
Summary: The prolonged developmental timeline of GABAergic interneurons in larger, gyrencephalic animals extends into the early postnatal period, contributing to increased cognitive complexity and flexibility. This delayed integration of interneurons also offers an opportunity for environmental influences to shape neural circuit formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Physiology
Ankan Gupta, Kevin R. Rarick, Ramani Ramchandran
Summary: This review discusses the state of knowledge on embryonic brain vascular patterning in zebrafish and mouse model systems, focusing on the origins and distinguishing features of brain endothelial cells. The interplay between brain endothelial cells and neural stem cells, mechanisms of Wnt signaling in brain vascular patterning, and emerging areas in vertebrates' cerebrovascular structures are explored.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
John K. Cusick, Jessa Alcaide, Yihui Shi
Summary: This review highlights the functions of RELT and its two paralogs, RELL1 and RELL2, and their associations with cancer and other human diseases. RELTfms play a role in processes related to cell death or survival and may promote an immunosuppressive environment for tumors. The roles of individual RELTfms in different cancers vary, serving as both risk factors and protective factors. Additionally, RELTfms are involved in various processes related to human health, such as microbial pathogenesis, inflammation, behavior, reproduction, and development.
Article
Biochemistry & Molecular Biology
Ramona Pap, Edina Pandur, Gergely Janosa, Katalin Sipos, Tamas Nagy, Attila Agocs, Jozsef Deli
Summary: The xanthophyll carotenoid lutein has been shown to have protective effects in light-induced oxidative stress and may also play a neuroprotective role. Glutamate, a major neurotransmitter, can cause oxidative stress and neurotoxicity. This study demonstrates that glutamate affects oxidative stress, inflammation, iron metabolism, and lipid peroxidation in neuroblastoma cells, while lutein attenuates these effects. These findings suggest that lutein could be a beneficial treatment in neurodegenerative disorders.
Review
Cell Biology
Theoharis C. Theoharides, Duraisamy Kempuraj
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19, and approximately 45% of patients experience long-term fatigue and neurovascular inflammation. The spike protein of SARS-CoV-2 can disrupt the blood-brain barrier, damage neurons, and activate brain mast cells and microglia, resulting in the release of neuroinflammatory molecules. Recent evidence suggests that the flavanol eriodictyol, along with oleuropein and sulforaphane, may be effective in treating COVID-19 and its long-term consequences.
Article
Oncology
Jennifer Jess, Bonnie Yates, Alina Dulau-Florea, Kevin Parker, Jon Inglefield, Dan Lichtenstein, Fiorella Schischlik, Martin Ongkeko, Yanyu Wang, Shilpa Shahani, Ann Cullinane, Hannah Smith, Eli Kane, Lauren Little, Dong Chen, Terry J. Fry, Haneen Shalabi, Hao-Wei Wang, Ansuman Satpathy, Jay Lozier, Nirali N. Shah
Summary: This report characterizes the hematologic toxicities of CD22 CAR T-cells and their relationship with cytokine release syndrome (CRS) and neurotoxicity. Despite the presence of coagulopathy, endothelial activation, and cytopenias, the neurotoxicity observed was relatively mild. The differential expression of CD22 and CD19 in the central nervous system may explain the divergent neurotoxicity profiles.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Cell Biology
Lauren H. Fairley, Amandine Grimm, Anne Eckert
Summary: Intercellular mitochondria transfer is a novel form of cell signalling that plays an important role in brain disorders and is considered a potential therapeutic strategy.
Article
Neurosciences
Xuan Du, Rosana Penalva, Karis Little, Adrien Kissenpfennig, Mei Chen, Heping Xu
Summary: The LysMCre-Socs3(fl/fl)Cx3cr1(gfp/gfp) DKO mice showed primary microglial dysfunction and age-related retinal microgliopathy, characterized by increased microglial activation and degeneration of retinal neurons and RPE. The microglia from DKO mice exhibited higher phagocytic activity and pro-inflammatory cytokine production compared to microglia from Socs3(fl/fl) mice, leading to reduced cone photoreceptor survival.
MOLECULAR NEURODEGENERATION
(2021)
Article
Cell Biology
Maud Wurmser, Mridula Muppavarapu, Christine Mary Tait, Christophe Laumonnerie, Luz Maria Gonzalez-Castrillon, Sara Ivy Wilson
Summary: The correct organization and connectivity of neurons rely on the complex development from neural stem cell domains, with a significant role played by Robo2, particularly during embryonic stages in influencing axon guidance and cell body migration of dI1 neurons.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Orthopedics
Fraser L. Collins, Michael D. Stone, Jane Turton, Laura R. McCabe, Eddie C. Y. Wang, Anwen S. Williams
BMC MUSCULOSKELETAL DISORDERS
(2019)
Article
Biology
Luis Nobre, Katie Nightingale, Benjamin J. Ravenhill, Robin Antrobus, Lior Soday, Jenna Nichols, James A. Davies, Sepehr Seirafian, Eddie C. Y. Wang, Andrew J. Davison, Gavin W. G. Wilkinson, Richard J. Stanton, Edward L. Huttlin, Michael P. Weekes
Article
Biotechnology & Applied Microbiology
Hana Elasifer, Eddie C. Y. Wang, Virginie Prod'homme, James Davies, Simone Forbes, Richard J. Stanton, Mihil Patel, Ceri A. Fielding, Dawn Roberts, James A. Traherne, Nicole Gruber, Joachim J. Bugert, Rebecca J. Aicheler, Gavin W. G. Wilkinson
JOURNAL OF GENERAL VIROLOGY
(2020)
Article
Immunology
Betty Lau, Karen Kerr, Quan Gu, Katie Nightingale, Robin Antrobus, Nicolas M. Suarez, Richard J. Stanton, Eddie C. Y. Wang, Michael P. Weekes, Andrew J. Davison
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2020)
Article
Cell Biology
Raya Ahmed, Kelly L. Miners, Julio Lahoz-Beneytez, Rhiannon E. Jones, Laureline Roger, Christina Baboonian, Yan Zhang, Eddie C. Y. Wang, Marc K. Hellerstein, Joseph M. McCune, Duncan M. Baird, David A. Price, Derek C. Macallan, Becca Asquith, Kristin Ladell
Article
Medicine, Research & Experimental
Virginia-Maria Vlahava, Isa Murrell, Lihui Zhuang, Rebecca J. Aicheler, Eleanor Lim, Kelly L. Miners, Kristin Ladell, Nicolas M. Suarez, David A. Price, Andrew J. Davison, Gavin W. G. Wilkinson, Mark R. Wills, Michael P. Weekes, Eddie C. Y. Wang, Richard J. Stanton
Summary: Research has shown that the addition of anti-HCMV antibodies can activate NK cells through ADCC, overcoming viral immune evasins; screening of HCMV proteins identified viral antigens responsible for ADCC activation, including immune evasins; and cloned antibodies targeting a single antigen were found to be effective in mediating ADCC against HCMV-infected cells, even at low concentrations.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Multidisciplinary Sciences
Katie Nightingale, Martin Potts, Leah M. Hunter, Ceri A. Fielding, Cassie M. Zerbe, Alice Fletcher-Etherington, Luis Nobre, Eddie C. Y. Wang, Blair L. Strang, Jack W. Houghton, Robin Antrobus, Nicolas M. Suarez, Jenna Nichols, Andrew J. Davison, Richard J. Stanton, Michael P. Weekes
Summary: In this study, we identified a previously unknown mechanism by which a viral protein degrades the host protein SLFN11, and showed that SLFN11 has inhibitory effects on HCMV infection. This research provides an important resource for studying antiviral immunity and viral immune evasion.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Arthur Wickenhagen, Elena Sugrue, Spyros Lytras, Srikeerthana Kuchi, Marko Noerenberg, Matthew L. Turnbull, Colin Loney, Vanessa Herder, Jay Allan, Innes Jarmson, Natalia Cameron-Ruiz, Margus Varjak, Rute M. Pinto, Jeffrey Y. Lee, Louisa Iselin, Natasha Palmalux, Douglas G. Stewart, Simon Swingler, Edward J. D. Greenwood, Thomas W. M. Crozier, Quan Gu, Emma L. Davies, Sara Clohisey, Bo Wang, Fabio Trindade Maranhao Costa, Monique Freire Santana, Luiz Carlos de Lima Ferreira, Lee Murphy, Angie Fawkes, Alison Meynert, Graeme Grimes, Joao Luiz Da Silva Filho, Matthias Marti, Joseph Hughes, Richard J. Stanton, Eddie C. Y. Wang, Antonia Ho, Ilan Davis, Ruth F. Jarrett, Alfredo Castello, David L. Robertson, Malcolm G. Semple, Peter J. M. Openshaw, Massimo Palmarini, Paul J. Lehner, J. Kenneth Baillie, Suzannah J. Rihn, Sam J. Wilson
Summary: Inherited genetic factors can influence the severity of COVID-19, with intracellular antiviral defenses, particularly OAS1 through ribonuclease L, playing a significant role in inhibiting SARS-CoV-2. The expression of prenylated OAS1 may be associated with protection from severe COVID-19 in hospitalized patients.
Article
Biotechnology & Applied Microbiology
Evelina Statkute, Eddie C. Y. Wang, Richard J. Stanton
Summary: This study adapts the AdZ vector system for high-throughput cloning of CRISPR/Cas9 editing sequences. By optimizing the vectors and modifying the Cas9 and sgRNA sequences, efficient gene knockout and editing can be achieved.
HUMAN GENE THERAPY
(2022)
Article
Biology
Ceri Alan Fielding, Pragati Sabberwal, James C. Williamson, Edward J. D. Greenwood, Thomas W. M. Crozier, Wioleta Zelek, Jeffrey Seow, Carl Graham, Isabella Huettner, Jonathan D. Edgeworth, David A. Price, Paul B. Morgan, Kristin Ladell, Matthias Eberl, Ian R. Humphreys, Blair Merrick, Katie Doores, Sam J. Wilson, Paul J. Lehner, Eddie C. Y. Wang, Richard J. Stanton
Summary: The outcome of infection depends on the ability of viruses to manipulate the infected cells and the immune response. Understanding this process is crucial for understanding disease progression and immunity. SARS-CoV-2 can antagonize innate immunity and decrease NK cell activation through modulation of protein synthesis. Antibody-dependent NK cell activation plays a significant role in disease, and vaccine-induced ADNKA is different from natural infection-induced ADNKA.
Article
Biochemistry & Molecular Biology
Shunqun Luo, Nurcin Liman, Can Li, Assiatu Crossman, Eddie C. Y. Wang, Francoise Meylan, Jung-Hyun Park
Summary: In this study, the researchers identified the cytokine receptor DR3 to be specifically expressed on thymic NKT17 cells and mostly absent on other thymic iNKT subsets. The binding of DR3 promoted the activation of thymic NKT17 cells and provided costimulatory effects upon agonistic alpha-GalCer stimulation. These findings provide new insights for deciphering the role and function of murine NKT17 cells and for understanding the development and activation mechanisms of iNKT cells in general.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Medicine, Research & Experimental
Huw J. Morgan, Elise Rees, Simone Lanfredini, Kate A. Powell, Jasmine Gore, Alex Gibbs, Charlotte Lovatt, Gemma E. Davies, Carlotta Olivero, Boris Y. Shorning, Giusy Tornillo, Alex Tonks, Richard Darley, Eddie C. Y. Wang, Girish K. Patel
Summary: This study found that CD200 protein in basal cell carcinoma may lead to the near absence of NK cells in the tumor microenvironment through ectodomain shedding. CD200 suppresses MAPK signaling in NK cells, blocking indirect and direct cell killing. Blocking CD200 inhibition can restore NK cell killing ability.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Letter
Medicine, Research & Experimental
Eddie C. Y. Wang, Ceri A. Fielding, Richard J. Stanton
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Immunology
Nidhi Malhotra, Juan Manuel Leyva-Castillo, Unmesh Jadhav, Olga Barreiro, Christy Kam, Nicholas K. O'Neill, Francoise Meylan, Pierre Chambon, Ulrich H. von Andrian, Richard M. Siegel, Eddie C. Wang, Ramesh Shivdasani, Raif S. Geha
SCIENCE IMMUNOLOGY
(2018)
Article
Immunology
Lies Boelen, Bisrat Debebe, Marcos Silveira, Arafa Salam, Julia MaKinde, Chrissy H. Roberts, Eddie C. Y. Wang, John Frater, Jill Gilmour, Katie Twigger, Kristin Ladell, Kelly L. Miners, Jyothi Jayaraman, James A. Traherne, David A. Price, Ying Qi, Maureen P. Martin, Derek C. Macallan, Chloe L. Thio, Jacquie Astemborski, Gregory Kirk, Sharyne M. Donfield, Susan Buchbinder, Salim Khakoo, James J. Goedert, John Trowsdale, Mary Carrington, Simon Kollnberger, Becca Asquith
SCIENCE IMMUNOLOGY
(2018)