Multiple Topoisomerase I (TopoI), Topoisomerase II (TopoII) and Tyrosyl-DNA Phosphodiesterase (TDP) inhibitors in the development of anticancer drugs

The Aza-Analogous Benzo[c]phenanthridine P8-D6 Acts as a Dual Topoisomerase I and II Poison, thus Exhibiting Potent Genotoxic Properties

(2020) Georg Aichinger et al.   MOLECULES

Microwave synthesis of novel halogenated β-enaminonitriles linked 9-bromo-1H-benzo[f]chromene moieties: Induces cell cycle arrest and apoptosis in human cancer cells via dual inhibition of topoisomerase I and II

(2019) Ahmed M. Fouda et al.   BIOORGANIC CHEMISTRY

Design, synthesis, biological evaluation, structure-activity relationship study, and mode of action of 2-phenol-4,6-dichlorophenyl-pyridines

(2018) Aarajana Shrestha et al.   BIOORGANIC CHEMISTRY

Development of 13H-benzo[f]chromeno[4,3-b][1,7]naphthyridines and their salts as potent cytotoxic agents and topoisomerase I/IIα inhibitors

(2018) Sateesh Kumar Arepalli et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate

(2018) Shin-Fu Chen et al.   Nature Communications

Recent developments in topoisomerase targeted cancer chemotherapy

(2018) KirkE. Hevener et al.   Acta Pharmaceutica Sinica B

Determination of in vitro absorption in Caco-2 monolayers of anticancer Ru(II)-based complexes acting as dual human topoisomerase and PARP inhibitors

(2018) Mariana S. de Camargo et al.   BIOMETALS

Discovery, Synthesis, and Evaluation of Oxynitidine Derivatives as Dual Inhibitors of DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1), and Potential Antitumor Agents

(2018) Xiao-Ru Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cinnamomum verum ingredient 2-methoxycinnamaldehyde

(2017) Yi-Heng Liu et al.   EUROPEAN JOURNAL OF CANCER PREVENTION

Novel 2-aryl-4-(4′-hydroxyphenyl)-5H-indeno[1,2-b]pyridines as potent DNA non-intercalative topoisomerase catalytic inhibitors

(2017) Seojeong Park et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Rational design, synthesis, and evaluation of novel 2,4-Chloro- and Hydroxy-Substituted diphenyl Benzofuro[3,2- b ]Pyridines: Non-intercalative catalytic topoisomerase I and II dual inhibitor

(2017) Seojeong Park et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Dihydroxylated 2,6-diphenyl-4-chlorophenylpyridines: Topoisomerase I and IIα dual inhibitors with DNA non-intercalative catalytic activity

(2017) Ganesh Bist et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Type I DNA Topoisomerases

(2017) Giovanni Capranico et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Biological Evaluation of the First Triple Inhibitors of Human Topoisomerase 1, Tyrosyl–DNA Phosphodiesterase 1 (Tdp1), and Tyrosyl–DNA Phosphodiesterase 2 (Tdp2)

(2017) Ping Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Combination therapy in combating cancer

(2017) Reza Bayat Mokhtari et al.   Oncotarget

Synthesis and biological evaluation of new fluorinated and chlorinated indenoisoquinoline topoisomerase I poisons

(2016) Daniel E. Beck et al.   BIOORGANIC & MEDICINAL CHEMISTRY

One-Step Synthetic Access to Isosteric and Potent Anticancer Nitrogen Heterocycles with the Benzo[c]phenanthridine Scaffold

(2016) Tamara N. Steinhauer et al.   CHEMISTRY-A EUROPEAN JOURNAL

A new series of 2-phenol-4-aryl-6-chlorophenyl pyridine derivatives as dual topoisomerase I/II inhibitors: Synthesis, biological evaluation and 3D-QSAR study

(2016) Radha Karki et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of a novel anti-cancer agent targeting both topoisomerase I and II in hepatocellular carcinoma Hep 3B cells in vitro and in vivo: Cinnamomum verum component 2-methoxycinnamaldehyde

(2016) Daw-Shyong Perng et al.   JOURNAL OF DRUG TARGETING

Ruthenium(II) polypyridyl complexes with 1,8-naphthalimide group as DNA binder, photonuclease, and dual inhibitors of topoisomerases I and IIα

(2016) Yanmei Sun et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Counting on natural products for drug design

(2016) Tiago Rodrigues et al.   Nature Chemistry

Inhibition of human topoisomerase I and II and anti-proliferative effects on MCF-7 cells by new titanocene complexes

(2015) Adele Chimento et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Antiproliferative and apoptosis-inducing activities of novel naphthalimide–cyclam conjugates through dual topoisomerase (topo) I/II inhibition

(2015) Shaoying Tan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship study of dihydroxylated 2,6-diphenyl-4-aryl pyridines

(2015) Radha Karki et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship study of 2-phenyl- or hydroxylated 2-phenyl-4-aryl-5 H -indeno[1,2- b ]pyridines

(2015) Tara Man Kadayat et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Tacrine derivatives as dual topoisomerase I and II catalytic inhibitors

(2015) Jana Janočková et al.   BIOORGANIC CHEMISTRY

Pixantrone induces cell death through mitotic perturbations and subsequent aberrant cell divisions

(2015) Neil Beeharry et al.   CANCER BIOLOGY & THERAPY

Design, synthesis and biological evaluation of novel 7-alkylamino substituted benzo[a]phenazin derivatives as dual topoisomerase I/II inhibitors

(2015) Bing-Lei Yao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Modification of 3-arylisoquinolines into 3,4-diarylisoquinolines and assessment of their cytotoxicity and topoisomerase inhibition

(2015) Daulat Bikram Khadka et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of DNA topoisomerases I and II and growth inhibition of HL-60 cells by novel acridine-based compounds

(2015) Jana Janočková et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Phase III Open-Label Randomized Study of Cytarabine in Combination With Amonafide L-Malate or Daunorubicin As Induction Therapy for Patients With Secondary Acute Myeloid Leukemia

(2015) Richard M. Stone et al.   JOURNAL OF CLINICAL ONCOLOGY

Synthesis and Biological Evaluation of Nitrated 7-, 8-, 9-, and 10-Hydroxyindenoisoquinolines as Potential Dual Topoisomerase I (Top1)–Tyrosyl-DNA Phosphodiesterase I (TDP1) Inhibitors

(2015) Trung Xuan Nguyen et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Series of Novel Terpyridine-Skeleton Molecule Derivants Inhibit Tumor Growth and Metastasis by Targeting Topoisomerases

(2015) Han-Byeol Kwon et al.   JOURNAL OF MEDICINAL CHEMISTRY

Scaffold Diversity Inspired by the Natural Product Evodiamine: Discovery of Highly Potent and Multitargeting Antitumor Agents

(2015) Shengzheng Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Strategies for the Optimization of Natural Leads to Anticancer Drugs or Drug Candidates

(2015) Zhiyan Xiao et al.   MEDICINAL RESEARCH REVIEWS

DNA-binding, topoisomerases I and II inhibition and in vitro cytotoxicity of ruthenium(II) polypyridyl complexes: [Ru(dppz)2L]2+ (L=dppz-11-CO2Me and dppz)

(2015) Xiaojun He et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

The structural basis for cancer treatment decisions

(2015) Ruth Nussinov et al.   Oncotarget

Thread Insertion of a Bis(dipyridophenazine) Diruthenium Complex into the DNA Double Helix by the Extrusion of AT Base Pairs and Cross-Linking of DNA Duplexes

(2014) D. Roeland Boer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Core of Human Topoisomerase IIα: Insights into Enzyme–DNA Interactions and Drug Mechanism

(2014) R. Hunter Lindsey et al.   BIOCHEMISTRY

Dual inhibition of topoisomerases I and IIα by ruthenium(ii) complexes containing asymmetric tridentate ligands

(2014) Kejie Du et al.   DALTON TRANSACTIONS

Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2)

(2014) Yves Pommier et al.   DNA REPAIR

Design, synthesis and systematic evaluation of cytotoxic 3-heteroarylisoquinolinamines as topoisomerases inhibitors

(2014) Hue Thi My Van et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Pyrroloquinolinone-based dual topoisomerase I/II inhibitor

(2014) Lisa Dalla Via et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Optimization of the Lactam Side Chain of 7-Azaindenoisoquinoline Topoisomerase I Inhibitors and Mechanism of Action Studies in Cancer Cells

(2014) Evgeny Kiselev et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Biological Evaluation of O-2-Modified Indenoisoquinolines as Dual Topoisomerase I–Tyrosyl-DNA Phosphodiesterase I Inhibitors

(2014) Peng-Cheng Lv et al.   JOURNAL OF MEDICINAL CHEMISTRY

Polypharmacology: Challenges and Opportunities in Drug Discovery

(2014) Andrew Anighoro et al.   JOURNAL OF MEDICINAL CHEMISTRY

TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function

(2014) Fernando Gómez-Herreros et al.   NATURE GENETICS

4β-[4′-(1-(Aryl)ureido)benzamide]podophyllotoxins as DNA topoisomerase I and IIα inhibitors and apoptosis inducing agents

(2013) Ahmed Kamal et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Rational design and synthesis of topoisomerase I and II inhibitors based on oleanolic acid moiety for new anti-cancer drugs

(2013) Ahmed Ashour et al.   BIOORGANIC & MEDICINAL CHEMISTRY

2,4-Diaryl Benzofuro[3,2-b]pyridine Derivatives: Design, Synthesis, and Evaluation of Topoisomerase Inhibitory Activity and Cytotoxicity

(2013) Pritam Thapa et al.   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Advances in Copper Complexes as Anticancer Agents

(2013) Carlo Santini et al.   CHEMICAL REVIEWS

Chiral ruthenium(ii) complexes with phenolic hydroxyl groups as dual poisons of topoisomerases I and IIα

(2013) Pingyu Zhang et al.   DALTON TRANSACTIONS

Discovery, synthesis and biological evaluation of cycloprotoberberine derivatives as potential antitumor agents

(2013) Yang-Biao Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel N-4-piperazinyl-ciprofloxacin-chalcone hybrids: Synthesis, physicochemical properties, anticancer and topoisomerase I and II inhibitory activity

(2013) Mohamed Abdel-Aziz et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Oxo-heterocyclic fused naphthalimides as antitumor agents: Synthesis and biological evaluation

(2013) Shaoying Tan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Type IA topoisomerase inhibition by clamp closure

(2013) Majety Naga Leelaram et al.   FASEB JOURNAL

Gold(III) Complexes of Pyridyl- and Isoquinolylamido Ligands: Structural, Spectroscopic, and Biological Studies of a New Class of Dual Topoisomerase I and II Inhibitors

(2013) Colin R. Wilson et al.   INORGANIC CHEMISTRY

Dual topoisomerase I and II poisoning by chiral Ru(II) complexes containing 2-thiophenylimidazo[4,5-f][1,10]phenanthroline derivatives

(2013) Yu-Chuan Wang et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Novel Antitumor Indolizino[6,7-b]indoles with Multiple Modes of Action: DNA Cross-Linking and Topoisomerase I and II Inhibition

(2013) Ravi Chaniyara et al.   JOURNAL OF MEDICINAL CHEMISTRY

Differential and Common DNA Repair Pathways for Topoisomerase I- and II-Targeted Drugs in a Genetic DT40 Repair Cell Screen Panel

(2013) Y. Maede et al.   MOLECULAR CANCER THERAPEUTICS

Discovery of indeno[1,2- $$c$$ c ]quinoline derivatives as dual topoisomerases I/II inhibitors: Part 3

(2013) Chih-Hua Tseng et al.   MOLECULAR DIVERSITY

Anthracyclines and Heart Failure

(2013) Douglas B. Sawyer   NEW ENGLAND JOURNAL OF MEDICINE

Synthesis and biological evaluation of benzo[a]phenazine derivatives as a dual inhibitor of topoisomerase I and II

(2013) Shi-Tian Zhuo et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis and evaluation of novel ellipticines as potential anti-cancer agents

(2013) Fiona M. Deane et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

TDP2–Dependent Non-Homologous End-Joining Protects against Topoisomerase II–Induced DNA Breaks and Genome Instability in Cells and In Vivo

(2013) Fernando Gómez-Herreros et al.   PLoS Genetics

Drugging Topoisomerases: Lessons and Challenges

(2012) Yves Pommier   ACS Chemical Biology

Tyrosyl-DNA Phosphodiesterase as a Target for Anticancer Therapy

(2012) Thomas Dexheimer et al.   Anti-Cancer Agents in Medicinal Chemistry

New topoisomerases inhibitors: Synthesis of rutaecarpine derivatives and their inhibitory activity against topoisomerases

(2012) Seung Ill Kim et al.   ARCHIVES OF PHARMACAL RESEARCH

Anticancer activity of novel indenopyridine derivatives

(2012) Mostafa M. Ghorab et al.   ARCHIVES OF PHARMACAL RESEARCH

Synthesis of benzo-annulated tryptanthrins and their biological properties

(2012) Jing Lu Liang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

2,4-Diaryl-5,6-dihydro-1,10-phenanthrolines with Furyl or Thienyl Moiety at 4-Position: Synthesis, Topoisomerase I and II Inhibitory Activity, and Cytotoxicity

(2012) Pritam Thapa et al.   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

2,4-Diaryl-5H-chromeno [4,3-b]pyridines: Synthesis, Topoisomerase I and II Inhibitory Activity, and Cytotoxicity

(2012) Pritam Thapa et al.   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Gossypol Interferes with Both Type I and Type II Topoisomerase Activities Without Generating Strand Breaks

(2012) Muge Senarisoy et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

N-Heterocyclic carbene metal complexes in medicinal chemistry

(2012) Luciano Oehninger et al.   DALTON TRANSACTIONS

Design, synthesis, and antitumor evaluation of 2,4,6-triaryl pyridines containing chlorophenyl and phenolic moiety

(2012) Pritam Thapa et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Dihydroxylated 2,4,6-triphenyl pyridines: Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship study

(2012) Radha Karki et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and antiproliferative evaluation of 3-phenylquinolinylchalcone derivatives against non-small cell lung cancers and breast cancers

(2012) Chih-Hua Tseng et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Biochemical Characterization of Human Tyrosyl-DNA Phosphodiesterase 2 (TDP2/TTRAP)

(2012) Rui Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Repairs DNA Damage Induced by Topoisomerases I and II and Base Alkylation in Vertebrate Cells

(2012) Junko Murai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Azaindenoisoquinolines as Topoisomerase I Inhibitors and Potential Anticancer Agents: A Systematic Study of Structure–Activity Relationships

(2012) Evgeny Kiselev et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification, Synthesis, and Biological Evaluation of Metabolites of the Experimental Cancer Treatment Drugs Indotecan (LMP400) and Indimitecan (LMP776) and Investigation of Isomerically Hydroxylated Indenoisoquinoline Analogues as Topoisomerase I Poisons

(2012) Maris A. Cinelli et al.   JOURNAL OF MEDICINAL CHEMISTRY

New Tricks for an Old Natural Product: Discovery of Highly Potent Evodiamine Derivatives as Novel Antitumor Agents by Systemic Structure–Activity Relationship Analysis and Biological Evaluations

(2012) Guoqiang Dong et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Biological Evaluation of the First Dual Tyrosyl-DNA Phosphodiesterase I (Tdp1)–Topoisomerase I (Top1) Inhibitors

(2012) Trung Xuan Nguyen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Biological Evaluation of Indenoisoquinolines That Inhibit Both Tyrosyl-DNA Phosphodiesterase I (Tdp1) and Topoisomerase I (Top1)

(2012) Martin Conda-Sheridan et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Structure of DNA-Bound Human Topoisomerase II Alpha: Conformational Mechanisms for Coordinating Inter-Subunit Interactions with DNA Cleavage

(2012) Timothy J. Wendorff et al.   JOURNAL OF MOLECULAR BIOLOGY

Inhibition of Human Topoisomerases I and II by Simocyclinone D8

(2012) Lisa M. Oppegard et al.   JOURNAL OF NATURAL PRODUCTS

TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1

(2012) Zhihong Zeng et al.   NUCLEIC ACIDS RESEARCH

Evodiamine, a dual catalytic inhibitor of type I and II topoisomerases, exhibits enhanced inhibition against camptothecin resistant cells

(2012) Xiaobei Pan et al.   PHYTOMEDICINE

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(2011) M. Kowalski   ACTA PHYSICA POLONICA B

Topoisomerase I/II inhibition by a novel naphthoquinone containing a modified anthracycline ring system

(2011) Steven Kennedy et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

2,4-Diaryl-5,6-dihydro-1,10-phenanthroline and 2,4-diaryl-5,6-dihydrothieno[2,3-h] quinoline derivatives for topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship study

(2011) Pritam Thapa et al.   BIOORGANIC CHEMISTRY

Novel activity of acriflavine against colorectal cancer tumor cells

(2011) Saadia Hassan et al.   CANCER SCIENCE

Synthesis, DNA-binding and topoisomerase inhibitory activity of ruthenium(II) polypyridyl complexes

(2011) Ke-Jie Du et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of 2,4-diaryl chromenopyridines and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship

(2011) Uttam Thapa et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) inhibitors

(2011) Shar-yin N Huang et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Chiral ruthenium(II) anthraquinone complexes as dual inhibitors of topoisomerases I and II

(2011) Jun-Feng Kou et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

7-Azaindenoisoquinolines as Topoisomerase I Inhibitors and Potential Anticancer Agents

(2011) Evgeny Kiselev et al.   JOURNAL OF MEDICINAL CHEMISTRY

Comprehensive analysis of kinase inhibitor selectivity

(2011) Mindy I Davis et al.   NATURE BIOTECHNOLOGY

Interfacial inhibitors: targeting macromolecular complexes

(2011) Yves Pommier et al.   NATURE REVIEWS DRUG DISCOVERY

Constituents with DNA Topoisomerases I and II Inhibitory Activity and Cytotoxicity from the Roots ofRubia cordifolia

(2011) Su-Yang Jeong et al.   PLANTA MEDICA

Potent DNA-directed alkylating agents: Synthesis and biological activity of phenyl N-mustard–quinoline conjugates having a urea or hydrazinecarboxamide linker

(2010) Rajesh Kakadiya et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of 2-(thienyl-2-yl or -3-yl)-4-furyl-6-aryl pyridine derivatives and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship

(2010) Pritam Thapa et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship study of hydroxylated 2,4-diphenyl-6-aryl pyridines

(2010) Radha Karki et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel thiophene derivatives as PTP1B inhibitors with selectivity and cellular activity

(2010) Deju Ye et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Cytotoxicity and topoisomerase I/II inhibition of glycosylated 2-phenyl-indoles, 2-phenyl-benzo[b]thiophenes and 2-phenyl-benzo[b]furans

(2010) Wei Shi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs

(2010) Yves Pommier et al.   CHEMISTRY & BIOLOGY

Recent Advances in the Development of Dual Topoisomerase I and II Inhibitors as Anticancer Drugs

(2010) S. Salerno et al.   CURRENT MEDICINAL CHEMISTRY

Tacrine Derivatives and Alzheimers Disease

(2010) V. Tumiatti et al.   CURRENT MEDICINAL CHEMISTRY

TDP2/TTRAP Is the Major 5′-Tyrosyl DNA Phosphodiesterase Activity in Vertebrate Cells and Is Critical for Cellular Resistance to Topoisomerase II-induced DNA Damage

(2010) Zhihong Zeng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of ancillary ligands on the topoisomerases II and transcription inhibition activity of polypyridyl ruthenium(II) complexes

(2010) Xing Chen et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Selection of Evodiamine as a Novel Topoisomerase I Inhibitor by Structure-Based Virtual Screening and Hit Optimization of Evodiamine Derivatives as Antitumor Agents

(2010) Guoqiang Dong et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Antiproliferative Evaluation of Certain Indeno[1,2-c]quinoline Derivatives. Part 2

(2010) Chih-Hua Tseng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Copper−Doxorubicin as a Nanoparticle Cargo Retains Efficacy with Minimal Toxicity

(2010) Azadeh Kheirolomoom et al.   MOLECULAR PHARMACEUTICS

Downregulation of GSTπ expression by tryptanthrin contributing to sensitization of doxorubicin-resistant MCF-7 cells through c-jun NH2-terminal kinase-mediated apoptosis

(2009) Sung-Tsai Yu et al.   ANTI-CANCER DRUGS

7-((4-Substituted)piperazin-1-yl) derivatives of ciprofloxacin: Synthesis and in vitro biological evaluation as potential antitumor agents

(2009) Joëlle Azéma et al.   BIOORGANIC & MEDICINAL CHEMISTRY

2-Thienyl-4-furyl-6-aryl pyridine derivatives: Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship study

(2009) Pritam Thapa et al.   BIOORGANIC & MEDICINAL CHEMISTRY

2,6-Dithienyl-4-furyl pyridines: Synthesis, topoisomerase I and II inhibition, cytotoxicity, structure–activity relationship, and docking study

(2009) Arjun Basnet et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Anthracycline- and/or taxane-resistant breast cancer: Results of a literature review to determine the clinical challenges and current treatment trends

(2009) Alvaro Moreno-Aspitia et al.   CLINICAL THERAPEUTICS

Overview of Naphthalimide Analogs as Anticancer Agents

(2009) Min Lv et al.   CURRENT MEDICINAL CHEMISTRY

Synthesis, DNA-binding, photocleavage, cytotoxicity and antioxidant activity of ruthenium (II) polypyridyl complexes

(2009) Yun-Jun Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Anti-proliferative effects of simocyclinone D8 (SD8), a novel catalytic inhibitor of topoisomerase II

(2009) Ahad A. Sadiq et al.   INVESTIGATIONAL NEW DRUGS

A human 5′-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage

(2009) Felipe Cortes Ledesma et al.   NATURE

Synthesis and DNA-binding affinity studies of glycosylated intercalators designed as functional mimics of the anthracycline antibiotics

(2009) Wei Shi et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization

(2009) K. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Convenient Synthesis and Antimicrobial Activity of New 3-Substituted 5-(Benzofuran-2-yl)-pyrazole Derivatives

(2008) Bakr F. Abdel-Wahab et al.   ARCHIV DER PHARMAZIE

Synthesis and biological activity of stable and potent antitumor agents, aniline nitrogen mustards linked to 9-anilinoacridines via a urea linkage

(2008) Naval Kapuriya et al.   BIOORGANIC & MEDICINAL CHEMISTRY

(–)-Epigallocatechin Gallate, A Major Constituent of Green Tea, Poisons Human Type II Topoisomerases

(2008) Omari J. Bandele et al.   CHEMICAL RESEARCH IN TOXICOLOGY

DNA Binding, Photocleavage, and Topoisomerase Inhibition of Functionalized Ruthenium(II)-Polypyridine Complexes

(2008) Feng Gao et al.   CHEMISTRY & BIODIVERSITY

Gemcitabine Plus Paclitaxel Versus Paclitaxel Monotherapy in Patients With Metastatic Breast Cancer and Prior Anthracycline Treatment

(2008) Kathy S. Albain et al.   JOURNAL OF CLINICAL ONCOLOGY

Synthesis, GC selective DNA binding and topoisomerase II inhibition activities of ruthenium(II) polypyridyl complex containing 11-aminopteridino[6,7-f][1,10]phenanthrolin-13(12H)-one

(2008) Feng Gao et al.   JOURNAL OF INORGANIC BIOCHEMISTRY