Article
Chemistry, Medicinal
Hui Zhong, Mingxuan Zhao, Chunyu Wu, Jiayao Zhang, Li Chen, Jianbo Sun
Summary: A series of oxoisoaporphine derivatives with topoisomerase I inhibition and cytotoxic activities were investigated. Compound 14 exhibited the most potent cytotoxic activity against cancer cell lines and low toxicity to normal cells. Mechanistic studies revealed that 14 could interfere with DNA and inhibit the activity of topoisomerase I, leading to cell cycle arrest and apoptosis. Additionally, 14 showed chemo-reversal ability on multidrug-resistant breast cancer cells.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Soumi Chakraborty, Arpan Das, Swadhin K. Mandal
Summary: A new Mn(i) catalyst with a redox-active ligand is reported for the efficient hydrosilylation of esters to alcohols, with mechanistic investigations showing a strong cooperation between the ligand and metal in initiating the reaction through a ligand-based single electron transfer (SET) process activating the Si-H bond.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Milyausha F. Galimova, Temurbek A. Begaliev, Ekaterina M. Zueva, Svetlana A. Kondrashova, Shamil K. Latypov, Alexey B. Dobrynin, Ilya E. Kolesnikov, Rustem R. Musin, Elvira Musina, Andrey A. Karasik
Summary: This study focuses on the synthesis, structural, and photophysical characterization of platinum dihalogenide complexes with different 10-(aryl)phenoxarsine ligands. The structures of the complexes were determined using various techniques, with the cis/trans isomerism in solution studied using NMR spectroscopy. In the solid state, platinum diiodide trans complexes exhibited intense orange-red emission under UV irradiation, which was attributed to a metal halide-centered triplet state. The UV/vis absorption and emission properties were rationalized through density functional theory (DFT) and time-dependent DFT calculations.
INORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Caio Cesar Candido, Henrique Vieira Reis Silva, Bruno Zavan, Marisa Ionta, Marilia Imaculada Frazao Barbosa, Antonio Carlos Doriguetto
Summary: In this study, novel ruthenium(II) complexes with metronidazole as a ligand were synthesized and characterized. The results showed that complexes (1) and (3) exhibited inhibitory effects on the proliferation of MCF-7 cells and induced apoptosis.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Alvar Serrano-Pindado, Michael Aondona Iorhemba, Diana Diaz-Garcia, Miguel Diaz-Sanchez, Irene Mena-Palomo, Santiago Gomez-Ruiz, Sanjiv Prashar
Summary: This study aimed to prepare and structurally characterize titanocene functionalized mesoporous silica nanoparticles and evaluate their cytotoxic activity against cancer cells. The titanocene-functionalized mesoporous silica nanoparticles showed promising antitumoral activity against breast cancer cells.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Article
Chemistry, Multidisciplinary
Sushma Singh, Mokshada Varma, Bhupendra Shravage, Prasad Kulkarni, Avinash Kumbhar
Summary: By incorporating the photosensitizer Ru(II) polypyridyl complexes into the cis-PtCl2 moiety, the anticancer properties of the complexes were improved, leading to increased cytotoxicity against MCF-7 cells and potential candidacy for Photodynamic Therapy.
JOURNAL OF CHEMICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ye Zhong, Xing Tian, Xinyue Jiang, Wen Dang, Maosheng Cheng, Ning Li, Yang Liu
Summary: A series of novel ziyuglycoside II derivatives were synthesized, with compound Z-15 showing the most potent antiproliferative effect on K562, MCF-7, and MV411 cell lines. Z-15 did not exhibit cytotoxicity on MCF-10A cells and could inhibit cell proliferation more robustly than ziyuglycoside II and 5-fluorouracil. It also significantly inhibited MCF-7 cell migration and induced mitochondrial-mediated apoptosis and autophagy in a dose-dependent manner.
BIOORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Carolina Rivera, Hector A. Bacilio-Beltran, Ana M. Puebla-Perez, Irma I. Rangel-Salas, Jose G. Alvarado-Rodriguez, Roberto Flores-Moreno, Gilberto Velazquez-Juarez, A. Aaron Peregrina-Lucano, Elvia Becerra-Martinez, Jaime Valdez-Ruvalcaba, Jose E. Rubio, Sara A. Cortes-Llamas
Summary: The synthesis of cis and trans isomers of platinum complexes with a symmetric N-heterocyclic carbene ligand has been reported. These complexes were obtained from a masked N-heterocyclic carbene precursor. Their cytotoxicity, oxidative nature, and antibacterial behavior were investigated, and the cis-[Pt((NHC)-N-Me)(2)Cl-2] complex exhibited the highest cytotoxic effect in the HeLa cervical cancer cell line.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Dimakatso Mokoena, Blassan P. George, Heidi Abrahamse
Summary: Breast cancer, a common and treatment-resistant cancer, can be effectively treated using photodynamic therapy with the aid of gold nanoparticles. This study demonstrates the successful adsorption of a photosensitizer onto gold nanoparticles and its application in inducing apoptosis in MCF-7 breast cancer cells in vitro.
Article
Chemistry, Inorganic & Nuclear
Balaji Babu, John Mack, Tebello Nyokong
Summary: A new Sn(IV) tetraarylchlorin with thien-2-yl substituents (SnC) has been synthesized and characterized, showing high Phi(Delta) value and promising photodynamic activity against MCF-7 breast cancer cells. These results suggest that Sn(IV) tetraarylchlorins like SnC are suitable candidates for further photodynamic therapy studies.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Olaya Gomez-Paz, Rosa Carballo, Ana B. Lago, Inmaculada Prieto, Ezequiel M. Vazquez-Lopez
Summary: Three coordination compounds were synthesized and characterized from the reaction of copper(ii) bromide with the flexible bis-tetrazole organosulfur ligand, 1,2-bis(1-methyl-1H-tetrazole-5-ylthio)ethane (bmtte). Different reaction conditions led to the formation of polymeric 2 & INFIN;Cu2Br4(bmtte) (1), trinuclear [Cu3Br4(bmtte)(2)] (2), and tetranuclear [Cu2Br2(bmtte)](2) (3) compounds with different structures. The thermal stability, aqueous behavior, and reactivity of the compounds were investigated, and a new polymeric compound (8Cu4I4)-Cu-2(bmtte)(2) (4) was prepared through solid-state reaction and microwave irradiation. The redox behavior of the compounds was analyzed by cyclic voltammetry.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Elena Cuellar, Alberto Diez-Varga, Tomas Torroba, Pablo Domingo-Legarda, Jose Aleman, Silvia Cabrera, Jose M. Martin-Alvarez, Daniel Miguel, Fernando Villafane
Summary: In this study, a series of new 1,2-azolylamidino complexes were synthesized and characterized using NMR, IR spectroscopy, and X-ray diffraction. Photophysical and electrochemical studies showed that these complexes exhibit good phosphorescence and reversible oxidation properties. Furthermore, the complexes were successfully used as catalysts in the photooxidation of different thioethers, with one of the complexes showing superior catalytic performance compared to a standard ruthenium complex.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Jaekwan Kim, Dominic T. Egger, Connor W. Frye, Evan P. Beaumier, Ian A. Tonks
Summary: This article reports the Ti-catalyzed oxidative alkyne carboamination reaction between alkenes and azo compounds, which can yield either alpha,beta-unsaturated imines or cyclopropyl imines through a common azatitanacyclo-hexene intermediate. A model azatitanacyclohexene complex (3) was synthesized through the ring-opening of a cyclopropyl imine with Cp2Ti(BTMSA) (BTMSA = bis-(trimethylsilyl)acetylene). Complex 3 readily undergoes ring contraction to an azatitanacyclopentene (4), analogous to the proposed mechanism for forming alpha,beta-unsaturated imines in the catalytic reaction. The liberation of cyclopropyl imine or alpha,beta-unsaturated imine through the oxidation of 3 or 4 with azobenzene further confirms the role of these metallacycles in the Ti-catalyzed carboamination reaction.
Article
Chemistry, Multidisciplinary
Balaji Babu, John Mack, Tebello Nyokong
Summary: Two readily synthesized Sn(IV) porphyrins with and without a cationic triphenylphosphonium moiety (TPP+) were prepared in this study. The Sn(IV) porphyrin with a TPP+ moiety exhibited favorable photodynamic activity against MCF-7 cells and showed higher cellular uptake compared to the one without TPP+. Further investigation suggested that this structural modification strategy deserves further exploration.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Plant Sciences
Lei Yu, Shuang Han, Lang Lang, Hui Song, CaiYun Zhang, Lin Dong, ShaoHua Jia, Ying Zhang, Di Xiao, Jun Liu, Ying Xu, XiaoPo Zhang
Summary: Oxocrebanine, an active aporphine alkaloid in Stephania hainanensis, exhibited strong anti-breast cancer activity by inhibiting Topo I and II alpha, leading to DNA damage and mitotic arrest in MCF-7 cells. It acted as a catalytic inhibitor and DNA intercalator, also inducing autophagy and disrupting tubulin polymerization. Oxocrebanine showed potential as a dual Topo inhibitor for effective breast cancer treatment.
Article
Biochemistry & Molecular Biology
Raffaele Longo, Marialuigia Raimondo, Luigi Vertuccio, Maria Camilla Ciardulli, Marco Sirignano, Annaluisa Mariconda, Giovanna Della Porta, Liberata Guadagno
Summary: Electrospun systems have shown potential in topical treatments, particularly in delivering different therapies such as anti-inflammatory and antitumoral substances. This study focused on producing polycaprolactone electrospun membranes loaded with antitumoral substances and comparing their performance with membranes loaded with a highly active but low affinity complex. The findings highlighted the importance of the matrix-filler affinity in designing effective drug delivery devices. Additionally, the study showed that synthetic derivatives of the antitumoral substance were more active than the commercial dacarbazine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Materials Science, Multidisciplinary
Elisa Calabrese, Liberata Guadagno, Marialuigia Raimondo, Andrea Sorrentino, Simona Russo, Pasquale Longo, Annaluisa Mariconda
Summary: This study reports the synthesis and characterization of PEGMA-based copolymers incorporating different percentages of HEMA-UPy and evaluates their thermal properties and healing efficiency. The results show that increasing the amount of HEMA-UPy moiety leads to slight changes in glass transition temperature and significant changes in crystallization and melting temperatures. Dynamic mechanical analysis demonstrates the ability of the copolymer to recover its original storage modulus values.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2023)
Review
Infectious Diseases
Domenico Iacopetta, Jessica Ceramella, Alessia Catalano, Assunta D'Amato, Graziantonio Lauria, Carmela Saturnino, Inmaculada Andreu, Pasquale Longo, Maria Stefania Sinicropi
Summary: Dental caries is a significant global oral health issue caused by biofilms. Streptococcus mutans is the main cariogenic pathogen responsible for dental caries, forming biofilms through quorum sensing. Diarylureas, including BPU and DMTU, have shown promising antimicrobial activity against S. mutans in studies. Considering the limited antimicrobial options for caries prevention and treatment, further research on these compounds and other diarylureas may lead to the development of effective agents with low cytotoxicity.
Article
Biochemistry & Molecular Biology
Maria Camilla Ciardulli, Annaluisa Mariconda, Marco Sirignano, Erwin Pavel Lamparelli, Raffaele Longo, Pasqualina Scala, Raffaella D'Auria, Antonietta Santoro, Liberata Guadagno, Giovanna Della Porta, Pasquale Longo
Summary: In the study, synthesized and purified silver(I) and gold(I) complexes showed higher cell viability inhibition on human malignant melanoma cells from lymph node metastatic site (MeWo) compared to Cisplatin. Among the complexes, AuM1 demonstrated the strongest inhibitory effect and exhibited better selectivity on non-cancerous cell lines after 48 hours of treatment.
Review
Chemistry, Multidisciplinary
Domenico Iacopetta, Jessica Ceramella, Alessia Catalano, Elisabetta Scali, Domenica Scumaci, Michele Pellegrino, Stefano Aquaro, Carmela Saturnino, Maria Stefania Sinicropi
Summary: The cytochrome P450 (CYP) enzyme family plays a major role in the metabolism of xenobiotics. Polymorphic and inducible enzymes in this family can alter or enhance drug metabolism and toxicity. Drug-drug interactions can occur due to the inhibition or induction of CYP enzymes. The review aims to summarize significant examples of commonly used drugs and highlight the activity and toxicity of their metabolites.
APPLIED SCIENCES-BASEL
(2023)
Article
Infectious Diseases
Jessica Ceramella, Rubina Troiano, Domenico Iacopetta, Annaluisa Mariconda, Michele Pellegrino, Alessia Catalano, Carmela Saturnino, Stefano Aquaro, Maria Stefania Sinicropi, Pasquale Longo
Summary: Ruthenium N-heterocyclic carbene (Ru-NHC) complexes were designed, synthesized, and evaluated for their biological activities. The complexes displayed significant anticancer activity against triple-negative human breast cancer cell lines MDA-MB-231. They also showed potent antibacterial activity against Gram-positive bacteria Staphylococcus aureus and strong antioxidant ability.
Review
Infectious Diseases
Alessia Catalano, Annaluisa Mariconda, Maria Stefania Sinicropi, Jessica Ceramella, Domenico Iacopetta, Carmela Saturnino, Pasquale Longo
Summary: In this review, recent studies on ruthenium N-heterocyclic carbene (NHC) complexes are summarized, with a focus on their antimicrobial and antiproliferative activities. The results indicate that ruthenium NHC complexes have strong activity against Gram-positive bacteria but limited activity against Gram-negative bacteria and fungal strains. In terms of antiproliferative activity, these complexes demonstrated higher cytotoxicity than standard anticancer drugs.
Article
Chemistry, Medicinal
Jessica Ceramella, Domenico Iacopetta, Anna Caruso, Annaluisa Mariconda, Anthi Petrou, Athina Geronikaki, Camillo Rosano, Carmela Saturnino, Alessia Catalano, Pasquale Longo, Maria Stefania Sinicropi
Summary: Carbazoles have been extensively studied for their various biological properties, including their potential as antibacterial, antimalarial, antioxidant, antidiabetic, neuroprotective, and anticancer agents. This study focused on the anticancer activity of a series of carbazole derivatives against breast cancer cell lines. Compounds 3 and 4 showed the highest activity against the triple negative MDA-MB-231 cell line without affecting normal cells. Further investigations revealed that these compounds selectively inhibited human topoisomerase I and disrupted the actin system, leading to apoptosis. Therefore, compounds 3 and 4 hold promise for the development of multi-targeted therapy for triple negative breast cancer.
Article
Chemistry, Inorganic & Nuclear
Assunta D'Amato, Annaluisa Mariconda, Pasquale Longo
Summary: The synthesis of a new complex, HGII(Ph-Mes), with phenyl backbone substituents and mesityl N-substituents, is reported. This complex exhibits higher thermal stability and activity in ring-closing and ring-opening metathesis of olefins, making it suitable for materials applications.
Article
Chemistry, Medicinal
Domenico Iacopetta, Chiara Costabile, Marina La Chimia, Annaluisa Mariconda, Jessica Ceramella, Domenica Scumaci, Alessia Catalano, Camillo Rosano, Giovanni Cuda, Maria Stefania Sinicropi, Pasquale Longo
Summary: N-Heterocyclic carbene metal complexes have versatile functionalization properties and are of interest for potential medicinal chemistry applications. Among them, silver and gold complexes show promising anticancer properties, affecting the growth of breast cancer cells significantly.
ACS MEDICINAL CHEMISTRY LETTERS
(2023)
Article
Chemistry, Medicinal
Maria Stefania Sinicropi, Jessica Ceramella, Patrice Vanelle, Domenico Iacopetta, Camillo Rosano, Omar Khoumeri, Shawkat Abdelmohsen, Wafaa Abdelhady, Hussein El-Kashef
Summary: Cancer is a complex disease and developing new compounds for cancer treatments is urgently needed. In recent years, the design and synthesis of innovative hybrid molecules have gained interest, with promising results in inhibiting cancer cells. The tested hybrid compounds containing trimethoxybenzene, thiazolidinedione and thiazole showed good efficacy against breast cancer cells, with compound 7e being the most effective. Docking simulations indicated that these compounds may target human Topoisomerases I and II, and enzymatic assays confirmed their inhibitory activity. Compound 7e was found to induce apoptosis in MCF-7 cells. These findings support further research in designing and synthesizing analogues for anticancer purposes.
Review
Chemistry, Inorganic & Nuclear
Domenico Iacopetta, Jessica Ceramella, Alessia Catalano, Annaluisa Mariconda, Federica Giuzio, Carmela Saturnino, Pasquale Longo, Maria Stefania Sinicropi
Summary: Complexes of Schiff bases with metals are versatile compounds with a wide range of applications, including catalysis, polymers, dyes, and various biological activities, such as antimicrobial, anticancer, antioxidant, antimalarial, analgesic, antiviral, antipyretic, and antidiabetic actions. In this review, the focus is on the antimicrobial activity of Schiff bases, especially the most recent studies in this field. Moreover, some interesting catalytic applications of metal complexes with Schiff bases are also discussed.
