Cross talk between human regulatory T cells and antigen‐presenting cells: Lessons for clinical applications

Regulatory T Cells and Human Disease

(2020) Shimon Sakaguchi et al.   Annual Review of Immunology

Natural and Induced Tolerogenic Dendritic Cells

(2020) Courtney A. Iberg et al.   JOURNAL OF IMMUNOLOGY

Activation and expansion of human T cells using artificial antigen-presenting cell scaffolds

(2020) David K. Y. Zhang et al.   Nature Protocols

Antigen presentation by dendritic cells and their instruction of CD4+ T helper cell responses

(2020) Kerry L. Hilligan et al.   Cellular & Molecular Immunology

Pharmacological inhibition of RORC2 enhances human Th17‐Treg stability and function

(2020) Dominic A Boardman et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Biting off what can be chewed: Trogocytosis in health, infection and disease

(2020) Akhila Bettadapur et al.   INFECTION AND IMMUNITY

Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials

(2020) Birgit Sawitzki et al.   LANCET

Non-invasive Reporter Gene Imaging of Cell Therapies, including T Cells and Stem Cells

(2020) Candice Ashmore-Harris et al.   MOLECULAR THERAPY

Control of foreign Ag‐specific Ab responses by Treg and Tfr

(2020) James B. Wing et al.   IMMUNOLOGICAL REVIEWS

Safety and feasibility of intradermal injection with tolerogenic dendritic cells pulsed with proinsulin peptide—for type 1 diabetes

(2020) Tatjana Nikolic et al.   Lancet Diabetes & Endocrinology

Regulatory T cells for minimising immune suppression in kidney transplantation: phase I/IIa clinical trial

(2020) Andy Roemhild et al.   BMJ-British Medical Journal

Building a CAR-Treg: Going from the basic to the luxury model

(2020) Isaac Rosado-Sánchez et al.   CELLULAR IMMUNOLOGY

Treg cell therapy: How cell heterogeneity can make the difference

(2020) Giulio Giganti et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Feasibility, long‐term safety, and immune monitoring of regulatory T cell therapy in living donor kidney transplant recipients

(2020) Paul N. Harden et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Regulatory T cells mediate specific suppression by depleting peptide–MHC class II from dendritic cells

(2019) Billur Akkaya et al.   NATURE IMMUNOLOGY

Methods to manufacture regulatory T cells for cell therapy

(2019) Katherine N. MacDonald et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Guidance factors orchestrating regulatory T cell positioning in tissues during development, homeostasis, and response

(2019) Thorsten R. Mempel et al.   IMMUNOLOGICAL REVIEWS

PD-1+ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer

(2019) Takahiro Kamada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune tolerance in multiple sclerosis and neuromyelitis optica with peptide-loaded tolerogenic dendritic cells in a phase 1b trial

(2019) Irati Zubizarreta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiscale engineering of immune cells and lymphoid organs

(2019) Sungwoong Kim et al.   Nature Reviews Materials

Suppressive and Gut Reparative Functions of Human Type 1 T-regulatory Cells

(2019) Laura Cook et al.   GASTROENTEROLOGY

Next-generation regulatory T cell therapy

(2019) Leonardo M. R. Ferreira et al.   NATURE REVIEWS DRUG DISCOVERY

Tailoring the homing capacity of human Tregs for directed migration to sites of Th1-inflammation or intestinal regions

(2018) R. E. Hoeppli et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Cousins at work: How combining medical with optical imaging enhances in vivo cell tracking

(2018) Alessia Volpe et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Spatial distribution and function of T follicular regulatory cells in human lymph nodes

(2018) Ismail Sayin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Chemokine-Mediated Choreography of Thymocyte Development and Selection

(2018) Jessica N. Lancaster et al.   TRENDS IN IMMUNOLOGY

A Phase I Clinical Trial with Ex Vivo Expanded Recipient Regulatory T cells in Living Donor Kidney Transplants

(2018) James M. Mathew et al.   Scientific Reports

A Rapamycin-Based GMP-Compatible Process for the Isolation and Expansion of Regulatory T Cells for Clinical Trials

(2018) Henrieta Fraser et al.   Molecular Therapy-Methods & Clinical Development

The Biology of T Regulatory Type 1 Cells and Their Therapeutic Application in Immune-Mediated Diseases

(2018) Maria Grazia Roncarolo et al.   IMMUNITY

Human retinoic acid–regulated CD161+ regulatory T cells support wound repair in intestinal mucosa

(2018) Giovanni A. M. Povoleri et al.   NATURE IMMUNOLOGY

Dendritic Cells Display Subset and Tissue-Specific Maturation Dynamics over Human Life

(2017) Tomer Granot et al.   IMMUNITY

Class II MHC–independent suppressive adhesion of dendritic cells by regulatory T cells in vivo

(2017) Jiacong Yan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Strong adhesion by regulatory T cells induces dendritic cell cytoskeletal polarization and contact-dependent lethargy

(2017) Jiahuan Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human Blood CD1c+Dendritic Cells Encompass CD5highand CD5lowSubsets That Differ Significantly in Phenotype, Gene Expression, and Functions

(2017) Xiangyun Yin et al.   JOURNAL OF IMMUNOLOGY

Stability and function of regulatory T cells expressing the transcription factor T-bet

(2017) Andrew G. Levine et al.   NATURE

An Atlas of Human Regulatory T Helper-like Cells Reveals Features of Th2-like Tregs that Support a Tumorigenic Environment

(2017) Leena Halim et al.   Cell Reports

Clinical Tolerogenic Dendritic Cells: Exploring Therapeutic Impact on Human Autoimmune Disease

(2017) Brett Eugene Phillips et al.   Frontiers in Immunology

Single CD28 stimulation induces stable and polyclonal expansion of human regulatory T cells

(2017) Xuehui He et al.   Scientific Reports

Autologous tolerogenic dendritic cells for rheumatoid and inflammatory arthritis

(2016) G M Bell et al.   ANNALS OF THE RHEUMATIC DISEASES

Follicular B Lymphomas Generate Regulatory T Cells via the ICOS/ICOSL Pathway and Are Susceptible to Treatment by Anti-ICOS/ICOSL Therapy

(2016) K.-S. Le et al.   CANCER RESEARCH

Broad and Largely Concordant Molecular Changes Characterize Tolerogenic and Immunogenic Dendritic Cell Maturation in Thymus and Periphery

(2016) Laurence Ardouin et al.   IMMUNITY

Induced Regulatory T Cells: Their Development, Stability, and Applications

(2016) Mitsuhiro Kanamori et al.   TRENDS IN IMMUNOLOGY

Successful expansion of functional and stable regulatory T cells for immunotherapy in liver transplantation

(2016) Niloufar Safinia et al.   Oncotarget

Compartment-specific immunity in the human gut: properties and functions of dendritic cells in the colon versus the ileum

(2015) Elizabeth R Mann et al.   GUT

Developing in vitro expanded CD45RA+regulatory T cells as an adoptive cell therapy for Crohn's disease

(2015) James B Canavan et al.   GUT

Homeostatic NF-κB Signaling in Steady-State Migratory Dendritic Cells Regulates Immune Homeostasis and Tolerance

(2015) Myriam Baratin et al.   IMMUNITY

Regulatory T cells produce profibrotic cytokines in the skin of patients with systemic sclerosis

(2015) Katherine G. MacDonald et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Intraperitoneal Administration of Autologous Tolerogenic Dendritic Cells for Refractory Crohn’s Disease: A Phase I Study

(2015) Aranzazu Jauregui-Amezaga et al.   Journal of Crohns & Colitis

CXCR3+ Regulatory T Cells Control TH1 Responses in Crescentic GN

(2015) H.-J. Paust et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Early-life compartmentalization of human T cell differentiation and regulatory function in mucosal and lymphoid tissues

(2015) Joseph J C Thome et al.   NATURE MEDICINE

Citrullinated peptide dendritic cell immunotherapy in HLA risk genotype–positive rheumatoid arthritis patients

(2015) Helen Benham et al.   Science Translational Medicine

Type 1 diabetes immunotherapy using polyclonal regulatory T cells

(2015) Jeffrey A. Bluestone et al.   Science Translational Medicine

The Environment of Regulatory T Cell Biology: Cytokines, Metabolites, and the Microbiome

(2015) Romy E. Hoeppli et al.   Frontiers in Immunology

Regulatory T-Cell Development in the Human Thymus

(2015) Íris Caramalho et al.   Frontiers in Immunology

GITR engagement in combination with CTLA-4 blockade completely abrogates immunosuppression mediated by human liver tumor-derived regulatory T cellsex vivo

(2015) Alexander Pedroza-Gonzalez et al.   OncoImmunology

Ex vivo fucosylation of third-party human regulatory T cells enhances anti-graft-versus-host disease potency in vivo

(2014) S. Parmar et al.   BLOOD

Distinct Chemokine Signaling Regulates Integrin Ligand Specificity to Dictate Tissue-Specific Lymphocyte Homing

(2014) Hao Sun et al.   DEVELOPMENTAL CELL

Control of tissue-localized immune responses by human regulatory T cells

(2014) Anne M. Pesenacker et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Treg Cells Expressing the Coinhibitory Molecule TIGIT Selectively Inhibit Proinflammatory Th1 and Th17 Cell Responses

(2014) Nicole Joller et al.   IMMUNITY

Circulating T follicular regulatory and helper cells have memory-like properties

(2014) Peter T. Sage et al.   JOURNAL OF CLINICAL INVESTIGATION

Memory regulatory T cells reside in human skin

(2014) Robert Sanchez Rodriguez et al.   JOURNAL OF CLINICAL INVESTIGATION

CD28 Costimulation Is Essential for Human T Regulatory Expansion and Function

(2014) T. N. Golovina et al.   JOURNAL OF IMMUNOLOGY

Ex Vivo–Expanded but Not In Vitro–Induced Human Regulatory T Cells Are Candidates for Cell Therapy in Autoimmune Diseases Thanks to Stable Demethylation of the FOXP3 Regulatory T Cell–Specific Demethylated Region

(2014) Maura Rossetti et al.   JOURNAL OF IMMUNOLOGY

Thymocyte apoptosis drives the intrathymic generation of regulatory T cells

(2014) J. E. Konkel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4

(2014) H. S. Kuehn et al.   SCIENCE

The Immunological Synapse

(2014) M. L. Dustin   Cancer Immunology Research

Clinical Grade Manufacturing of Human Alloantigen-Reactive Regulatory T Cells for Use in Transplantation

(2013) A. L. Putnam et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Antibodies Targeting Human OX40 Expand Effector T Cells and Block Inducible and Natural Regulatory T Cell Function

(2013) K. S. Voo et al.   JOURNAL OF IMMUNOLOGY

Langerhans Cells Favor Skin Flora Tolerance through Limited Presentation of Bacterial Antigens and Induction of Regulatory T Cells

(2013) Angelic M.G. van der Aar et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Comparative transcriptional and functional profiling defines conserved programs of intestinal DC differentiation in humans and mice

(2013) Payal B Watchmaker et al.   NATURE IMMUNOLOGY

Homing of Regulatory T Cells to Human Skin Is Important for the Prevention of Alloimmune-Mediated Pathology in an In Vivo Cellular Therapy Model

(2013) Fadi Issa et al.   PLoS One

Targeting CD28, CTLA-4 and PD-L1 Costimulation Differentially Controls Immune Synapses and Function of Human Regulatory and Conventional T-Cells

(2013) Nahzli Dilek et al.   PLoS One

High-Dose Vitamin D3 Supplementation Is a Requisite for Modulation of Skin-Homing Markers on Regulatory T Cells in HIV-Infected Patients

(2012) Ai-Leng Khoo et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

IL-5 promotes induction of antigen-specific CD4+CD25+ T regulatory cells that suppress autoimmunity

(2012) G. T. Tran et al.   BLOOD

Functionally distinct subsets of human FOXP3+ Treg cells that phenotypically mirror effector Th cells

(2012) T. Duhen et al.   BLOOD

Chemokine-mediated tissue recruitment of CXCR3+ CD4+ T cells plays a major role in the pathogenesis of chronic GVHD

(2012) J. E. Croudace et al.   BLOOD

Differential effects of rapamycin and retinoic acid on expansion, stability and suppressive qualities of human CD4+CD25+FOXP3+ T regulatory cell subpopulations

(2012) C. Scotta et al.   HAEMATOLOGICA

Activated tumor-infiltrating CD4+ regulatory T cells restrain antitumor immunity in patients with primary or metastatic liver cancer

(2012) Alexander Pedroza-Gonzalez et al.   HEPATOLOGY

Resident CD141 (BDCA3)+dendritic cells in human skin produce IL-10 and induce regulatory T cells that suppress skin inflammation

(2012) Chung-Ching Chu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Differentiation and function of Foxp3+ effector regulatory T cells

(2012) Erika Cretney et al.   TRENDS IN IMMUNOLOGY

Phase I (Safety) Study of Autologous Tolerogenic Dendritic Cells in Type 1 Diabetic Patients

(2011) N. Giannoukakis et al.   DIABETES CARE

Killing of myeloid APCs via HLA class I, CD2 and CD226 defines a novel mechanism of suppression by human Tr1 cells

(2011) Chiara F. Magnani et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Intestinal Dendritic Cells Specialize to Activate Transforming Growth Factor-β and Induce Foxp3+ Regulatory T Cells via Integrin αvβ8

(2011) John J. Worthington et al.   GASTROENTEROLOGY

Vitamin D3 targets epidermal and dermal dendritic cells for induction of distinct regulatory T cells

(2011) Angelic M.G. van der Aar et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions

(2011) Yeonseok Chung et al.   NATURE MEDICINE

Foxp3+ follicular regulatory T cells control the germinal center response

(2011) Michelle A Linterman et al.   NATURE MEDICINE

Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4

(2011) O. S. Qureshi et al.   SCIENCE

Characterization of Interleukin-17–Producing Regulatory T Cells in Inflamed Intestinal Mucosa From Patients With Inflammatory Bowel Diseases

(2010) Zaruhi Hovhannisyan et al.   GASTROENTEROLOGY

LAG-3 Expression Defines a Subset of CD4+CD25highFoxp3+ Regulatory T Cells That Are Expanded at Tumor Sites

(2010) C. Camisaschi et al.   JOURNAL OF IMMUNOLOGY

Distinct Roles for CCR4 and CXCR3 in the Recruitment and Positioning of Regulatory T Cells in the Inflamed Human Liver

(2010) Y. H. Oo et al.   JOURNAL OF IMMUNOLOGY

Protein Kinase C-  Mediates Negative Feedback on Regulatory T Cell Function

(2010) A. Zanin-Zhorov et al.   SCIENCE

Early defects in human T-cell development severely affect distribution and maturation of thymic stromal cells: possible implications for the pathophysiology of Omenn syndrome

(2009) P. L. Poliani et al.   BLOOD

Regulatory T Cells Sequentially Migrate from Inflamed Tissues to Draining Lymph Nodes to Suppress the Alloimmune Response

(2009) Nan Zhang et al.   IMMUNITY

PD-L1 negatively regulates CD4+CD25+Foxp3+ Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV

(2009) Debora Franceschini et al.   JOURNAL OF CLINICAL INVESTIGATION

Analysis of Adhesion Molecules, Target Cells, and Role of IL-2 in Human FOXP3+ Regulatory T Cell Suppressor Function

(2009) D. Q. Tran et al.   JOURNAL OF IMMUNOLOGY

Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control TH2 responses

(2009) Ye Zheng et al.   NATURE

The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation

(2009) Meghan A Koch et al.   NATURE IMMUNOLOGY

CD4+ Regulatory T Cells Control TH17 Responses in a Stat3-Dependent Manner

(2009) A. Chaudhry et al.   SCIENCE

Umbilical cord blood regulatory T-cell expansion and functional effects of tumor necrosis factor receptor family members OX40 and 4-1BB expressed on artificial antigen-presenting cells

(2008) K. L. Hippen et al.   BLOOD

Two Functional Subsets of FOXP3+ Regulatory T Cells in Human Thymus and Periphery

(2008) Tomoki Ito et al.   IMMUNITY