Developing in vitro expanded CD45RA+regulatory T cells as an adoptive cell therapy for Crohn's disease

Clinical Grade Manufacturing of Human Alloantigen-Reactive Regulatory T Cells for Use in Transplantation

(2013) A. L. Putnam et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Comparison of Regulatory T Cells in Hemodialysis Patients and Healthy Controls: Implications for Cell Therapy in Transplantation

(2013) B. Afzali et al.   Clinical Journal of the American Society of Nephrology

CD161 expression characterizes a subpopulation of human regulatory T cells that produces IL-17 in a STAT3-dependent manner

(2013) Behdad Afzali et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A rapid diagnostic test for human regulatory T-cell function to enable regulatory T-cell therapy

(2012) J. B. Canavan et al.   BLOOD

Administration of CD4+CD25highCD127- Regulatory T Cells Preserves  -Cell Function in Type 1 Diabetes in Children

(2012) N. Marek-Trzonkowska et al.   DIABETES CARE

Assessment of regulatory T-cell function in forthcoming clinical trials of cell therapy

(2012) James B Canavan et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Safety and Efficacy of Antigen-Specific Regulatory T-Cell Therapy for Patients With Refractory Crohn's Disease

(2012) Pierre Desreumaux et al.   GASTROENTEROLOGY

Differential effects of rapamycin and retinoic acid on expansion, stability and suppressive qualities of human CD4+CD25+FOXP3+ T regulatory cell subpopulations

(2012) C. Scotta et al.   HAEMATOLOGICA

The Transcription Factor T-bet Regulates Intestinal Inflammation Mediated by Interleukin-7 Receptor+ Innate Lymphoid Cells

(2012) Nick Powell et al.   IMMUNITY

Demethylation analysis of the FOXP3 locus shows quantitative defects of regulatory T cells in IPEX-like syndrome

(2012) F. Barzaghi et al.   JOURNAL OF AUTOIMMUNITY

Generation and Large-Scale Expansion of Human Inducible Regulatory T Cells That Suppress Graft-Versus-Host Disease

(2011) K. L. Hippen et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Relative Resistance of Human CD4+ Memory T Cells to Suppression by CD4+CD25+ Regulatory T Cells

(2011) B. Afzali et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Epigenetic quantification of tumor-infiltrating T-lymphocytes

(2011) Jalid Sehouli et al.   Epigenetics

Epigenetic reprogramming of the RORC locus during in vitro expansion is a distinctive feature of human memory but not naïve Treg

(2011) Christian Schmidl et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Interleukin-12 Converts Foxp3+ Regulatory T Cells to Interferon–γ-Producing Foxp3+ T Cells That Inhibit Colitis

(2011) Ting Feng et al.   GASTROENTEROLOGY

Stability of human rapamycin-expanded CD4+CD25+ T regulatory cells

(2011) E. Tresoldi et al.   HAEMATOLOGICA

Retinoic Acid and Rapamycin Differentially Affect and Synergistically Promote the Ex Vivo Expansion of Natural Human T Regulatory Cells

(2011) Tatiana N. Golovina et al.   PLoS One

Increase of regulatory T cells in ileal mucosa of untreated pediatric Crohn's disease patients

(2011) Dag Henrik Reikvam et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Regulatory T Cells Get Their Chance to Shine

(2011) M. Leslie   SCIENCE

Massive ex Vivo Expansion of Human Natural Regulatory T Cells (Tregs) with Minimal Loss of in Vivo Functional Activity

(2011) K. L. Hippen et al.   Science Translational Medicine

Human Regulatory T Cells with Alloantigen Specificity Are More Potent Inhibitors of Alloimmune Skin Graft Damage than Polyclonal Regulatory T Cells

(2011) P. Sagoo et al.   Science Translational Medicine

Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics

(2010) C. G. Brunstein et al.   BLOOD

Enhanced suppressive function of regulatory T cells from patients with immune-mediated diseases following successful ex vivo expansion

(2010) Tinghua Cao et al.   CLINICAL IMMUNOLOGY

Enterohemorrhagic Escherichia coli induce attaching and effacing lesions and hemorrhagic colitis in human and bovine intestinal xenograft models

(2010) L. Golan et al.   Disease Models & Mechanisms

Characterization of Interleukin-17–Producing Regulatory T Cells in Inflamed Intestinal Mucosa From Patients With Inflammatory Bowel Diseases

(2010) Zaruhi Hovhannisyan et al.   GASTROENTEROLOGY

In vivo prevention of transplant arteriosclerosis by ex vivo–expanded human regulatory T cells

(2010) Satish N Nadig et al.   NATURE MEDICINE

Ex Vivo–Expanded Human Regulatory T Cells Prevent the Rejection of Skin Allografts in a Humanized Mouse Model

(2010) Fadi Issa et al.   TRANSPLANTATION

First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127− T regulatory cells

(2009) Piotr Trzonkowski et al.   CLINICAL IMMUNOLOGY

Loss of FOXP3 expression in natural human CD4+CD25+regulatory T cells upon repetitivein vitrostimulation

(2009) Petra Hoffmann et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulatory T Cells Sequentially Migrate from Inflamed Tissues to Draining Lymph Nodes to Suppress the Alloimmune Response

(2009) Nan Zhang et al.   IMMUNITY

Decrease of Foxp3+ Treg Cell Number and Acquisition of Effector Cell Phenotype during Lethal Infection

(2009) Guillaume Oldenhove et al.   IMMUNITY

Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor

(2009) Makoto Miyara et al.   IMMUNITY

Regulatory T cells: how do they suppress immune responses?

(2009) S. Sakaguchi et al.   INTERNATIONAL IMMUNOLOGY

The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation

(2009) Meghan A Koch et al.   NATURE IMMUNOLOGY

Differential Responses of Human Regulatory T Cells (Treg) and Effector T Cells to Rapamycin

(2009) Laura Strauss et al.   PLoS One

Identification of IL-17-producing FOXP3+ regulatory T cells in humans

(2009) K. S. Voo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD4+ Regulatory T Cells Control TH17 Responses in a Stat3-Dependent Manner

(2009) A. Chaudhry et al.   SCIENCE

Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells

(2008) H. J. P. M. Koenen et al.   BLOOD

Expansion of Human Regulatory T-Cells From Patients With Type 1 Diabetes

(2008) A. L. Putnam et al.   DIABETES

DNA methylation controls Foxp3 gene expression

(2008) Julia K. Polansky et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Smad7 Controls Resistance of Colitogenic T Cells to Regulatory T Cell-Mediated Suppression

(2008) Massimo C. Fantini et al.   GASTROENTEROLOGY

Cytotoxic-T-Lymphocyte-Associated Antigen 4 Blockade Abrogates Protection by Regulatory T Cells in a Mouse Model of Microbially Induced Innate Immune-Driven Colitis

(2008) K. Watanabe et al.   INFECTION AND IMMUNITY