期刊
EUROPEAN JOURNAL OF IMMUNOLOGY
卷 51, 期 1, 页码 27-38出版社
WILEY
DOI: 10.1002/eji.202048746
关键词
regulatory T cells; antigen‐ presenting cells; immune tolerance; homing; suppression
类别
资金
- Canadian Institutes for Health Research [FDN-154304]
- BC Children's Hospital Research Institute
- Canadian Institutes for Health Research
- Sangamo Therapeutics
- Takeda
- Bristol Myers Squibb
- Pfizer
- CRISPR Therapeutics
Regulatory T cells (Tregs) play a crucial role in maintaining self-tolerance and immune homeostasis. The interaction between Tregs and antigen-presenting cells (APCs) is essential for optimizing Treg-based therapeutic approaches in treating autoimmune diseases.
Regulatory T cells (Tregs) have a critical role in maintaining self-tolerance and immune homeostasis. There is much interest in using Tregs as a cell therapy to re-establish tolerance in conditions such as inflammatory bowel disease and type 1 diabetes, with many ongoing clinical studies testing the safety and efficacy of this approach. Manufacturing of Tregs for therapy typically involves ex vivo expansion to obtain sufficient cell numbers for infusion and comes with the risk of altering the activity of key biological processes. However, this process also offers an opportunity to tailor Treg function to maximize in vivo activity. In this review, we focus on the roles of antigen-presenting cells (APCs) in the generation and function of Tregs in humans. In addition to stimulating the development of Tregs, APCs activate Tregs and provide signals that induce specialized functional and homing marker expression. Cross talk between Tregs and APCs is a critical, often under-appreciated, aspect of Treg biology, with APCs mediating the key properties of infectious tolerance and bystander suppression. Understanding the biology of human Treg-APC interactions will reveal new ways to optimize Treg-based therapeutic approaches.
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