53BP1 and USP28 mediate p53-dependent cell cycle arrest in response to centrosome loss and prolonged mitosis

Chromosome missegregation during anaphase triggers p53 cell cycle arrest through histone H3.3 Ser31 phosphorylation

(2016) Edward H. Hinchcliffe et al.   NATURE CELL BIOLOGY

Promotion and Suppression of Centriole Duplication Are Catalytically Coupled through PLK4 to Ensure Centriole Homeostasis

(2016) Minhee Kim et al.   Cell Reports

p53 protects against genome instability following centriole duplication failure

(2015) Bramwell G. Lambrus et al.   JOURNAL OF CELL BIOLOGY

Binding of STIL to Plk4 activates kinase activity to promote centriole assembly

(2015) Tyler C. Moyer et al.   JOURNAL OF CELL BIOLOGY

Chromothripsis from DNA damage in micronuclei

(2015) Cheng-Zhong Zhang et al.   NATURE

Reversible centriole depletion with an inhibitor of Polo-like kinase 4

(2015) Y. L. Wong et al.   SCIENCE

Cellular responses to a prolonged delay in mitosis are determined by a DNA damage response controlled by Bcl-2 family proteins

(2015) D. J. Colin et al.   Open Biology

Cytokinesis Failure Triggers Hippo Tumor Suppressor Pathway Activation

(2014) Neil J. Ganem et al.   CELL

USP28 Is Recruited to Sites of DNA Damage by the Tandem BRCT Domains of 53BP1 but Plays a Minor Role in Double-Strand Break Metabolism

(2014) P. A. Knobel et al.   MOLECULAR AND CELLULAR BIOLOGY

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Acentriolar mitosis activates a p53-dependent apoptosis pathway in the mouse embryo

(2014) H. Bazzi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitosis Inhibits DNA Double-Strand Break Repair to Guard Against Telomere Fusions

(2014) A. Orthwein et al.   SCIENCE

Stabilization of Cartwheel-less Centrioles for Duplication Requires CEP295-Mediated Centriole-to-Centrosome Conversion

(2014) Denisse Izquierdo et al.   Cell Reports

Mitosis and apoptosis: how is the balance set?

(2013) Caroline H Topham et al.   CURRENT OPINION IN CELL BIOLOGY

Double-strand break repair: 53BP1 comes into focus

(2013) Stephanie Panier et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

The Spindle Assembly Checkpoint

(2012) Pablo Lara-Gonzalez et al.   CURRENT BIOLOGY

Centrosomes, chromosome instability (CIN) and aneuploidy

(2012) Benjamin D Vitre et al.   CURRENT OPINION IN CELL BIOLOGY

Aneuploidy causes proteotoxic stress in yeast

(2012) A. B. Oromendia et al.   GENES & DEVELOPMENT

DNA breaks and chromosome pulverization from errors in mitosis

(2012) Karen Crasta et al.   NATURE

A telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrest

(2012) Makoto T Hayashi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction

(2011) James D. Orth et al.   MOLECULAR BIOLOGY OF THE CELL

Chromosome Segregation Errors as a Cause of DNA Damage and Structural Chromosome Aberrations

(2011) A. Janssen et al.   SCIENCE

Prolonged Prometaphase Blocks Daughter Cell Proliferation Despite Normal Completion of Mitosis

(2010) Yumi Uetake et al.   CURRENT BIOLOGY

Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling

(2010) John Maciejowski et al.   JOURNAL OF CELL BIOLOGY

Polo Kinase and Separase Regulate the Mitotic Licensing of Centriole Duplication in Human Cells

(2009) Meng-Fu Bryan Tsou et al.   DEVELOPMENTAL CELL

Mitotic catastrophe cell death induced by heat shock protein 90 inhibitor in BRCA1-deficient breast cancer cell lines

(2008) M. Zajac et al.   MOLECULAR CANCER THERAPEUTICS