Folate-mediated one-carbon metabolism: a targeting strategy in cancer therapy

Metabolic Profiling Reveals a Dependency of Human Metastatic Breast Cancer on Mitochondrial Serine and One-Carbon Unit Metabolism

(2020) Albert M. Li et al.   MOLECULAR CANCER RESEARCH

Serine-dependent redox homeostasis regulates glioblastoma cell survival

(2020) Anna L. Engel et al.   BRITISH JOURNAL OF CANCER

Serine Catabolism Feeds NADH when Respiration Is Impaired

(2020) Lifeng Yang et al.   Cell Metabolism

SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia

(2020) Juan C. García-Cañaveras et al.   LEUKEMIA

Identification of three new compounds that directly target human serine hydroxymethyltransferase SHMT2

(2020) Yanfang Han et al.   Chemical Biology & Drug Design

Mthfd2 Modulates Mitochondrial Function and DNA Repair to Maintain the Pluripotency of Mouse Stem Cells

(2020) Liang Yue et al.   Stem Cell Reports

Cytosolic ME1 integrated with mitochondrial IDH2 supports tumor growth and metastasis

(2020) Chang Shao et al.   Redox Biology

Cisplatin inhibits SIRT3-deacetylation MTHFD2 to disturb cellular redox balance in colorectal cancer cell

(2020) Xingyou Wan et al.   Cell Death & Disease

Elucidating cancer metabolic plasticity by coupling gene regulation with metabolic pathways

(2019) Dongya Jia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Navigating metabolic pathways to enhance antitumour immunity and immunotherapy

(2019) Xiaoyun Li et al.   Nature Reviews Clinical Oncology

DHFR Inhibitors: Reading the Past for Discovering Novel Anticancer Agents

(2019) Maria Raimondi et al.   MOLECULES

Structural basis of inhibition of the human serine hydroxymethyltransferase SHMT 2 by antifolate drugs

(2019) Emma Scaletti et al.   FEBS LETTERS

Novel pyrrolo[3,2-d]pyrimidine compounds target mitochondrial and cytosolic one-carbon metabolism with broad-spectrum antitumor efficacy

(2019) Aamod S. Dekhne et al.   MOLECULAR CANCER THERAPEUTICS

MTHFD2 links RNA methylation to metabolic reprogramming in renal cell carcinoma

(2019) Nathanael H. Green et al.   ONCOGENE

Association of transcriptional levels of folate-mediated one-carbon metabolism-related genes in cancer cell lines with drug treatment response

(2019) Dong-Joon Min et al.   Cancer Genetics

Shmt2: A Stat3 Signaling New Player in Prostate Cancer Energy Metabolism

(2019) Marrocco et al.   Cells

Down‐regulation of MTHFD2 inhibits NSCLC progression by suppressing cycle‐related genes

(2019) Chang Yu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Discovery of a Potent, Selective, and Orally Available MTHFD2 Inhibitor (DS18561882) with in Vivo Antitumor Activity

(2019) Junya Kawai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dysregulation of de novo nucleotide biosynthetic pathway enzymes in cancer and targeting opportunities

(2019) Alyncia D. Robinson et al.   CANCER LETTERS

MTHFD1L-Mediated Redox Homeostasis Promotes Tumor Progression in Tongue Squamous Cell Carcinoma

(2019) Hao Li et al.   Frontiers in Oncology

HBXIP-elevated methyltransferase METTL3 promotes the progression of breast cancer via inhibiting tumor suppressor let-7g

(2018) Xiaoli Cai et al.   CANCER LETTERS

SOX7 Target Genes and Their Contribution to Its Tumor Suppressive Function

(2018) Yumeng Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

EWS-FLI1 reprograms the metabolism of Ewing sarcoma cells via positive regulation of glutamine import and serine-glycine biosynthesis

(2018) Nirmalya Sen et al.   MOLECULAR CARCINOGENESIS

Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs

(2018) Denise R. Minton et al.   MOLECULAR CELL

mTORC1 Promotes Metabolic Reprogramming by the Suppression of GSK3-Dependent Foxk1 Phosphorylation

(2018) Long He et al.   MOLECULAR CELL

ROS signalling in the biology of cancer

(2018) Jennifer N. Moloney et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells

(2018) Juliane Hitzel et al.   Nature Communications

The PERK Arm of the Unfolded Protein Response Regulates Mitochondrial Morphology during Acute Endoplasmic Reticulum Stress

(2018) Justine Lebeau et al.   Cell Reports

Pathway analysis of genetic variants in folate-mediated one-carbon metabolism-related genes and survival in a prospectively followed cohort of colorectal cancer patients

(2018) Jennifer Ose et al.   Cancer Medicine

Nuclear Folate Metabolism

(2018) Martha S. Field et al.   Annual Review of Nutrition

OUP accepted manuscript

(2018)   JNCI-Journal of the National Cancer Institute

Mitochondrial translation requires folate-dependent tRNA methylation

(2018) Raphael J. Morscher et al.   NATURE

Bacterial folate biosynthesis and colorectal cancer risk: more than just a gut feeling

(2018) Dieuwertje E. Kok et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2

(2018) Tatsunori Nishimura et al.   ONCOGENE

Deacetylation of serine hydroxymethyl-transferase 2 by SIRT3 promotes colorectal carcinogenesis

(2018) Zhen Wei et al.   Nature Communications

Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma

(2017) Gregory S. Ducker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overexpression of mitochondrial serine hydroxyl-methyltransferase 2 is associated with poor prognosis and promotes cell proliferation and invasion in gliomas

(2017) Ming Wu et al.   OncoTargets and Therapy

The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD

(2017) Chengzhang Fu et al.   Nature Communications

Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor

(2016) Robert Gustafsson et al.   CANCER RESEARCH

The importance of mitochondrial folate enzymes in human colorectal cancer

(2016) Masaaki Miyo et al.   ONCOLOGY REPORTS

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

(2016) I. Ben-Sahra et al.   SCIENCE

Oxidative stress inhibits distant metastasis by human melanoma cells

(2015) Elena Piskounova et al.   NATURE

Targeting tumor-initiating cells: Eliminating anabolic cancer stem cells with inhibitors of protein synthesis or by mimicking caloric restriction

(2015) Rebecca Lamb et al.   Oncotarget

A pyrazolopyran derivative preferentially inhibits the activity of human cytosolic serine hydroxymethyltransferase and induces cell death in lung cancer cells

(2015) Marina Marani et al.   Oncotarget

The folate-coupled enzyme MTHFD2 is a nuclear protein and promotes cell proliferation

(2015) Nina Gustafsson Sheppard et al.   Scientific Reports

Comparative Oncogenomics Identifies PSMB4 and SHMT2 as Potential Cancer Driver Genes

(2014) G. Y. Lee et al.   CANCER RESEARCH

Quantitative flux analysis reveals folate-dependent NADPH production

(2014) Jing Fan et al.   NATURE

Increased MTHFD2 expression is associated with poor prognosis in breast cancer

(2014) Feng Liu et al.   TUMOR BIOLOGY

SHMT1 knockdown induces apoptosis in lung cancer cells by causing uracil misincorporation

(2014) A Paone et al.   Cell Death & Disease

Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer

(2014) Roland Nilsson et al.   Nature Communications

Serine Catabolism Regulates Mitochondrial Redox Control during Hypoxia

(2014) J. Ye et al.   Cancer Discovery

Human mitochondrial DNA: roles of inherited and somatic mutations

(2012) Eric A. Schon et al.   NATURE REVIEWS GENETICS

Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation

(2012) M. Jain et al.   SCIENCE

Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria

(2011) D. D. Anderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Compartmentalization of Mammalian Folate-Mediated One-Carbon Metabolism

(2010) Anne S. Tibbetts et al.   Annual Review of Nutrition