Bringing tendon biology to heel: Leveraging mechanisms of tendon development, healing, and regeneration to advance therapeutic strategies
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Title
Bringing tendon biology to heel: Leveraging mechanisms of tendon development, healing, and regeneration to advance therapeutic strategies
Authors
Keywords
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Journal
DEVELOPMENTAL DYNAMICS
Volume -, Issue -, Pages -
Publisher
Wiley
Online
2020-11-10
DOI
10.1002/dvdy.269
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Note: Only part of the references are listed.- A systematic review of inflammatory cells and markers in human tendinopathy
- (2020) George Jomaa et al. BMC MUSCULOSKELETAL DISORDERS
- Spectrum of Tendon Pathologies: Triggers, Trails and End-State
- (2020) Sara Steinmann et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Widespread diversity in the transcriptomes of functionally divergent limb tendons
- (2020) Nathaniel P Disser et al. JOURNAL OF PHYSIOLOGY-LONDON
- Induced pluripotent stem cell-derived tenocyte-like cells promote the regeneration of injured tendons in mice
- (2020) Shingo Komura et al. Scientific Reports
- Temporal tendinosis: A cause of chronic orofacial pain
- (2020) Hart B. Bressler et al. Current Pain and Headache Reports
- The mevalonate pathway is a critical regulator of tendon cell specification
- (2020) Jessica W. Chen et al. DEVELOPMENT
- Connexin 43 Is Necessary for Murine Tendon Enthesis Formation and Response to Loading
- (2020) Hua Shen et al. JOURNAL OF BONE AND MINERAL RESEARCH
- The role of the macrophage in tendinopathy and tendon healing
- (2020) Joo Y. Sunwoo et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Tendon Cell Regeneration Is Mediated by Attachment Site-Resident Progenitors and BMP Signaling
- (2020) Xubo Niu et al. CURRENT BIOLOGY
- Single-cell Transcriptomic Analyses Identifies Extensive Heterogeneity in the Cellular Composition of Mouse Achilles Tendons
- (2020) Andrea J De Micheli et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Multi-omic single cell analysis resolves novel stromal cell populations in healthy and diseased human tendon
- (2020) Adrian R. Kendal et al. Scientific Reports
- Regenerating the field of cardiovascular cell therapy
- (2019) Kenneth R. Chien et al. NATURE BIOTECHNOLOGY
- Medicinal signalling cells: they work, so use them
- (2019) Arnold I. Caplan NATURE
- The increasing incidence of surgically treated quadriceps tendon ruptures
- (2019) Aleksi Reito et al. KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
- Biomaterials to Mimic and Heal Connective Tissues
- (2019) Benjamin R. Freedman et al. ADVANCED MATERIALS
- Tendinosis develops from age‐ and oxygen tension‐dependent modulation of Rac1 activity
- (2019) Rowena McBeath et al. AGING CELL
- Scleraxis lineage cells contribute to organized bridging tissue during tendon healing and identify a subpopulation of resident tendon cells
- (2019) Katherine T. Best et al. FASEB JOURNAL
- Scleraxis genes are required for normal musculoskeletal development and for rib growth and mineralization in zebrafish
- (2019) Erika Kague et al. FASEB JOURNAL
- The role of macrophages in the resolution of inflammation
- (2019) Satoshi Watanabe et al. JOURNAL OF CLINICAL INVESTIGATION
- Cell non-autonomous functions of S100a4 drive fibrotic tendon healing
- (2019) Jessica E Ackerman et al. eLife
- Mesenchymal Stem Cells Empowering Tendon Regenerative Therapies
- (2019) Raquel Costa-Almeida et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Current Progress in Tendon and Ligament Tissue Engineering
- (2019) Wei Lee Lim et al. Tissue Engineering and Regenerative Medicine
- Multiplicity of Mesenchymal Stromal Cells: Finding the Right Route to Therapy
- (2019) Alison Wilson et al. Frontiers in Immunology
- Mesenchymal Stromal Cell Therapeutic Delivery: Translational Challenges to Clinical Application
- (2019) Henry Caplan et al. Frontiers in Immunology
- Requirement for scleraxis in the recruitment of mesenchymal progenitors during embryonic tendon elongation
- (2019) Alice H. Huang et al. DEVELOPMENT
- Niche stiffness underlies the ageing of central nervous system progenitor cells
- (2019) Michael Segel et al. NATURE
- HMGB1 mediates the development of tendinopathy due to mechanical overloading
- (2019) Guangyi Zhao et al. PLoS One
- A distinct transition from cell growth to physiological homeostasis in the tendon
- (2019) Mor Grinstein et al. eLife
- A Revised Perspective of Skeletal Stem Cell Biology
- (2019) Thomas H. Ambrosi et al. Frontiers in Cell and Developmental Biology
- A Tppp3+Pdgfra+ tendon stem cell population contributes to regeneration and reveals a shared role for PDGF signalling in regeneration and fibrosis
- (2019) Tyler Harvey et al. NATURE CELL BIOLOGY
- Unravelling cellular relationships during development and regeneration using genetic lineage tracing
- (2019) Chloé S. Baron et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Enhancing survival, engraftment, and osteogenic potential of mesenchymal stem cells
- (2019) Daniel Garcia-Sanchez et al. World Journal of Stem Cells
- New function of zebrafish regulatory T cells in organ regeneration
- (2019) Kazu Kikuchi CURRENT OPINION IN IMMUNOLOGY
- Rescue plan for Achilles: Therapeutics steering the fate and functions of stem cells in tendon wound healing
- (2018) Magdalena Schneider et al. ADVANCED DRUG DELIVERY REVIEWS
- Engineering Stem and Stromal Cell Therapies for Musculoskeletal Tissue Repair
- (2018) Claudia Loebel et al. Cell Stem Cell
- Transcription factor scleraxis vitally contributes to progenitor lineage direction in wound healing of adult tendon in mice
- (2018) Tomoya Sakabe et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Integrating soft and hard tissues via interface tissue engineering
- (2018) Sahishnu Patel et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Effect of connective tissue growth factor delivered via porous sutures on the proliferative stage of intrasynovial tendon repair
- (2018) Stephen W. Linderman et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Role of the immune system in regeneration and its dynamic interplay with adult stem cells
- (2018) Prasad Abnave et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Understanding tendons: lessons from transgenic mouse models
- (2018) Manuel Delgado Caceres et al. STEM CELLS AND DEVELOPMENT
- Tenogenic Differentiation of Human Embryonic Stem Cells
- (2018) Tina P. Dale et al. TISSUE ENGINEERING PART A
- A robust method for RNA extraction and purification from a single adult mouse tendon
- (2018) Mor Grinstein et al. PeerJ
- The local microenvironment limits the regenerative potential of the mouse neonatal heart
- (2018) Mario Notari et al. Science Advances
- Roadmap of molecular, compositional, and functional markers during embryonic tendon development
- (2018) Phong K. Nguyen et al. CONNECTIVE TISSUE RESEARCH
- Genetic lineage tracing of targeted cell populations during enthesis healing
- (2018) Helen L. Moser et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Single-cell analysis uncovers convergence of cell identities during axolotl limb regeneration
- (2018) Tobias Gerber et al. SCIENCE
- In tendons, differing physiological requirements lead to functionally distinct nanostructures
- (2018) Andrew S. Quigley et al. Scientific Reports
- Transcriptomic landscape of the blastema niche in regenerating adult axolotl limbs at single-cell resolution
- (2018) Nicholas D. Leigh et al. Nature Communications
- Mechanical force regulates tendon extracellular matrix organization and tenocyte morphogenesis through TGFbeta signaling
- (2018) Arul Subramanian et al. eLife
- Surgical Treatment Versus Conservative Management for Acute Achilles Tendon Rupture: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
- (2017) Senlin Deng et al. Journal of Foot & Ankle Surgery
- Alarmins: Feel the Stress
- (2017) Peleg Rider et al. JOURNAL OF IMMUNOLOGY
- Inflammatory mechanisms in tendinopathy – towards translation
- (2017) Neal L. Millar et al. Nature Reviews Rheumatology
- Review: Emerging concepts in the pathogenesis of tendinopathy
- (2017) Benjamin J.F. Dean et al. SURGEON-JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND IRELAND
- Tenomodulin is essential for prevention of adipocyte accumulation and fibrovascular scar formation during early tendon healing
- (2017) Dasheng Lin et al. Cell Death & Disease
- Effect of single intralesional treatment of surgically induced equine superficial digital flexor tendon core lesions with adipose-derived mesenchymal stromal cells: a controlled experimental trial
- (2017) Florian Geburek et al. Stem Cell Research & Therapy
- Osteocalcin expressing cells from tendon sheaths in mice contribute to tendon repair by activating Hedgehog signaling
- (2017) Yi Wang et al. eLife
- Surgical repair of symptomatic chronic achilles tendon rupture using synthetic graft augmentation
- (2017) Ahmed Shoaib et al. Foot and Ankle Surgery
- Tenomodulin is Required for Tendon Endurance Running and Collagen I Fibril Adaptation to Mechanical Load
- (2017) Sarah Dex et al. EBioMedicine
- Current concepts on tenogenic differentiation and clinical applications
- (2017) Yang Liu et al. Journal of Orthopaedic Translation
- Novel Model of Tendon Regeneration Reveals Distinct Cell Mechanisms Underlying Regenerative and Fibrotic Tendon Healing
- (2017) Kristen Howell et al. Scientific Reports
- Inflammation and the continuum model: time to acknowledge the molecular era of tendinopathy
- (2016) Neal L Millar et al. BRITISH JOURNAL OF SPORTS MEDICINE
- Live Imaging of Axolotl Digit Regeneration Reveals Spatiotemporal Choreography of Diverse Connective Tissue Progenitor Pools
- (2016) Joshua D. Currie et al. DEVELOPMENTAL CELL
- PRP Treatment Efficacy for Tendinopathy: A Review of Basic Science Studies
- (2016) Yiqin Zhou et al. Biomed Research International
- Single-cell analysis reveals a nestin+ tendon stem/progenitor cell population with strong tenogenic potentiality
- (2016) Z. Yin et al. Science Advances
- IL-17A mediates inflammatory and tissue remodelling events in early human tendinopathy
- (2016) Neal L. Millar et al. Scientific Reports
- Progress in cell-based therapies for tendon repair
- (2015) Diana Gaspar et al. ADVANCED DRUG DELIVERY REVIEWS
- Biologics for tendon repair
- (2015) Denitsa Docheva et al. ADVANCED DRUG DELIVERY REVIEWS
- Are inflammatory cells increased in painful human tendinopathy? A systematic review
- (2015) Benjamin John Floyd Dean et al. BRITISH JOURNAL OF SPORTS MEDICINE
- A pathway to bone: signaling molecules and transcription factors involved in chondrocyte development and maturation
- (2015) E. Kozhemyakina et al. DEVELOPMENT
- Tendon development and musculoskeletal assembly: emerging roles for the extracellular matrix
- (2015) A. Subramanian et al. DEVELOPMENT
- Musculoskeletal integration at the wrist underlies the modular development of limb tendons
- (2015) A. H. Huang et al. DEVELOPMENT
- Gdf5 progenitors give rise to fibrocartilage cells that mineralize via hedgehog signaling to form the zonal enthesis
- (2015) Nathaniel A. Dyment et al. DEVELOPMENTAL BIOLOGY
- Harnessing endogenous stem/progenitor cells for tendon regeneration
- (2015) Chang H. Lee et al. JOURNAL OF CLINICAL INVESTIGATION
- Mechanisms of tendon injury and repair
- (2015) Stavros Thomopoulos et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms
- (2015) Tamás Rőszer MEDIATORS OF INFLAMMATION
- Tendon injury: from biology to tendon repair
- (2015) Geoffroy Nourissat et al. Nature Reviews Rheumatology
- Inflammation activation and resolution in human tendon disease
- (2015) Stephanie G. Dakin et al. Science Translational Medicine
- MicroRNA29a regulates IL-33-mediated tissue remodelling in tendon disease
- (2015) Neal L. Millar et al. Nature Communications
- Regeneration of Full-Thickness Rotator Cuff Tendon Tear After Ultrasound-Guided Injection With Umbilical Cord Blood-Derived Mesenchymal Stem Cells in a Rabbit Model
- (2015) Gi-Young Park et al. Stem Cells Translational Medicine
- A structure-based extracellular matrix expansion mechanism of fibrous tissue growth
- (2015) Nicholas S Kalson et al. eLife
- Recurrent turnover of senescent cells during regeneration of a complex structure
- (2015) Maximina H Yun et al. eLife
- Tendon development and diseases
- (2015) Ludovic Gaut et al. Wiley Interdisciplinary Reviews-Developmental Biology
- Tendon Vasculature in Health and Disease
- (2015) Herbert Tempfer et al. Frontiers in Physiology
- Stereological Quantification of Immune-Competent Cells in Baseline Biopsy Specimens From Achilles Tendons
- (2014) Maja Skov Kragsnaes et al. AMERICAN JOURNAL OF SPORTS MEDICINE
- “Mesenchymal” Stem Cells
- (2014) Paolo Bianco Annual Review of Cell and Developmental Biology
- Generation of Functional Human Pancreatic β Cells In Vitro
- (2014) Felicia W. Pagliuca et al. CELL
- Tendon Derived Stem Cells Promote Platelet-Rich Plasma Healing in Collagenase-Induced Rat Achilles Tendinopathy
- (2014) Lei Chen et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- The development of zebrafish tendon and ligament progenitors
- (2014) J. W. Chen et al. DEVELOPMENT
- Enthesis fibrocartilage cells originate from a population of Hedgehog-responsive cells modulated by the loading environment
- (2014) A. G. Schwartz et al. DEVELOPMENT
- Specific pattern of cell cycle during limb fetal myogenesis
- (2014) Joana Esteves de Lima et al. DEVELOPMENTAL BIOLOGY
- Extracellular matrix considerations for scar-free repair and regeneration: Insights from regenerative diversity among vertebrates
- (2014) James Godwin et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Biologic augmentation of rotator cuff repair with mesenchymal stem cells during arthroscopy improves healing and prevents further tears: a case-controlled study
- (2014) Philippe Hernigou et al. INTERNATIONAL ORTHOPAEDICS
- The early inflammatory response after flexor tendon healing: A gene expression and histological analysis
- (2014) Cionne N. Manning et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- The Role of Muscle Loading on Bone (Re)modeling at the Developing Enthesis
- (2014) Alexander M. Tatara et al. PLoS One
- Lineage Tracing of Resident Tendon Progenitor Cells during Growth and Natural Healing
- (2014) Nathaniel A. Dyment et al. PLoS One
- The human myotendinous junction: An ultrastructural and 3D analysis study
- (2014) A. B. Knudsen et al. SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
- Tendon overload results in alterations in cell shape and increased markers of inflammation and matrix degradation
- (2014) C. T. Thorpe et al. SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
- Plasticity of epithelial stem cells in tissue regeneration
- (2014) C. Blanpain et al. SCIENCE
- Epicondylitis
- (2014) Jared Brummel et al. SPORTS MEDICINE AND ARTHROSCOPY REVIEW
- Fetal and adult fibroblasts display intrinsic differences in tendon tissue engineering and regeneration
- (2014) Qiao-Mei Tang et al. Scientific Reports
- An epidemiological study of rotator cuff pathology using The Health Improvement Network database
- (2014) J. J. E. White et al. Bone & Joint Journal
- The role of animal models in tendon research
- (2014) M. W. Hast et al. Bone & Joint Research
- Functional Attachment of Soft Tissues to Bone: Development, Healing, and Tissue Engineering
- (2013) Helen H. Lu et al. Annual Review of Biomedical Engineering
- Tendon-bone attachment unit is formed modularly by a distinct pool of Scx - and Sox9 -positive progenitors
- (2013) Einat Blitz et al. DEVELOPMENT
- Scx+/Sox9+ progenitors contribute to the establishment of the junction between cartilage and tendon/ligament
- (2013) Y. Sugimoto et al. DEVELOPMENT
- Transcription factor EGR1 directs tendon differentiation and promotes tendon repair
- (2013) Marie-Justine Guerquin et al. JOURNAL OF CLINICAL INVESTIGATION
- Macrophage depletion reduces cell proliferation and extracellular matrix accumulation but increases the ultimate tensile strength of injured Achilles tendons
- (2013) Mélissa de la Durantaye et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Alarmins in tendinopathy: unravelling new mechanisms in a common disease
- (2013) N. L. Millar et al. RHEUMATOLOGY
- Increased mast cell numbers in a calcaneal tendon overuse model
- (2013) J. Pingel et al. SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
- Human iPSC-Derived Neural Crest Stem Cells Promote Tendon Repair in a Rat Patellar Tendon Window Defect Model
- (2013) Wei Xu et al. TISSUE ENGINEERING PART A
- The zebrafish as a model for complex tissue regeneration
- (2013) Matthew Gemberling et al. TRENDS IN GENETICS
- Rotator Cuff Regeneration Using a Bioabsorbable Material With Bone Marrow–Derived Mesenchymal Stem Cells in a Rabbit Model
- (2012) Shin Yokoya et al. AMERICAN JOURNAL OF SPORTS MEDICINE
- Controlled treadmill exercise eliminates chondroid deposits and restores tensile properties in a new murine tendinopathy model
- (2012) Rebecca Bell et al. JOURNAL OF BIOMECHANICS
- Macrophage Sub-Populations and the Lipoxin A4 Receptor Implicate Active Inflammation during Equine Tendon Repair
- (2012) Stephanie Georgina Dakin et al. PLoS One
- Aging Contributes to Inflammation in Upper Extremity Tendons and Declines in Forelimb Agility in a Rat Model of Upper Extremity Overuse
- (2012) David M. Kietrys et al. PLoS One
- Force and scleraxis synergistically promote the commitment of human ES cells derived MSCs to tenocytes
- (2012) Xiao Chen et al. Scientific Reports
- Regulation of gene expression in human tendinopathy
- (2011) Scott A Jelinsky et al. BMC MUSCULOSKELETAL DISORDERS
- Substance P accelerates hypercellularity and angiogenesis in tendon tissue and enhances paratendinitis in response to Achilles tendon overuse in a tendinopathy model
- (2011) G. Andersson et al. BRITISH JOURNAL OF SPORTS MEDICINE
- Conversion of Mechanical Force into TGF-β-Mediated Biochemical Signals
- (2011) Toru Maeda et al. CURRENT BIOLOGY
- Tracking adult stem cells
- (2011) Hugo J Snippert et al. EMBO REPORTS
- Tenogenic differentiation of stem cells for tendon repair-what is the current evidence?
- (2011) P. P. Y. Lui et al. Journal of Tissue Engineering and Regenerative Medicine
- Tendon Is Covered by a Basement Membrane Epithelium That Is Required for Cell Retention and the Prevention of Adhesion Formation
- (2011) Susan H. Taylor et al. PLoS One
- Conversion of Human Bone Marrow-Derived Mesenchymal Stem Cells into Tendon Progenitor Cells by Ectopic Expression of Scleraxis
- (2011) Paolo Alberton et al. STEM CELLS AND DEVELOPMENT
- Spatial and Temporal Expression of Molecular Markers and Cell Signals During Normal Development of the Mouse Patellar Tendon
- (2011) Chia-Feng Liu et al. TISSUE ENGINEERING PART A
- Inflammation is Present in Early Human Tendinopathy
- (2010) Neal L. Millar et al. AMERICAN JOURNAL OF SPORTS MEDICINE
- Characterization of differential properties of rabbit tendon stem cells and tenocytes
- (2010) Jianying Zhang et al. BMC MUSCULOSKELETAL DISORDERS
- EGR1 and EGR2 Involvement in Vertebrate Tendon Differentiation
- (2010) Véronique Lejard et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Atypical Homeodomain Transcription Factor Mohawk Controls Tendon Morphogenesis
- (2010) W. Liu et al. MOLECULAR AND CELLULAR BIOLOGY
- The Mohawk homeobox gene is a critical regulator of tendon differentiation
- (2010) Y. Ito et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- What are the validated animal models for tendinopathy?
- (2010) P. P. Y. Lui et al. SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
- Repair of Full-Thickness Tendon Injury Using Connective Tissue Progenitors Efficiently Derived from Human Embryonic Stem Cells and Fetal Tissues
- (2010) Shahar Cohen et al. TISSUE ENGINEERING PART A
- Recruitment and maintenance of tendon progenitors by TGF signaling are essential for tendon formation
- (2009) B. A. Pryce et al. DEVELOPMENT
- Tendon-selective genes identified from rat and human musculoskeletal tissues
- (2009) Scott A. Jelinsky et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Cells keep a memory of their tissue origin during axolotl limb regeneration
- (2009) Martin Kragl et al. NATURE
- Relationship between Neural Crest Cells and Cranial Mesoderm during Head Muscle Development
- (2009) Julien Grenier et al. PLoS One
- Entheses: tendon and ligament attachment sites
- (2009) M. Benjamin et al. SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
- Stepwise Differentiation of Human Embryonic Stem Cells Promotes Tendon Regeneration by Secreting Fetal Tendon Matrix and Differentiation Factors
- (2009) Xiao Chen et al. STEM CELLS
- Is tendon pathology a continuum? A pathology model to explain the clinical presentation of load-induced tendinopathy
- (2008) J L Cook et al. BRITISH JOURNAL OF SPORTS MEDICINE
- Synovial mesenchymal stem cells accelerate early remodeling of tendon-bone healing
- (2008) Young-Jin Ju et al. CELL AND TISSUE RESEARCH
- The Basic Science of Tendinopathy
- (2008) Yinghua Xu et al. CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
- Genome-wide expression analysis of intra- and extraarticular connective tissue
- (2008) Richard V. Pearse et al. JOURNAL OF ORTHOPAEDIC RESEARCH
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