Article
Biology
Antonion Korcari, Anne E. C. Nichols, Mark R. Buckley, Alayna E. Loiselle, Mei Wan
Summary: Aged tendons disrupt homeostasis, increase injury risk, and impair healing capacity. Understanding the mechanisms of homeostatic disruption is crucial for developing therapeutics to maintain tendon health.
Article
Developmental Biology
Yudai Ono, Saundra Schlesinger, Kanako Fukunaga, Shinsei Yambe, Tempei Sato, Takako Sasaki, Chisa Shukunami, Hiroshi Asahara, Masafumi Inui
Summary: Movement of the vertebrate body is supported by the connection of muscle, tendon, and bone. A study using targeted cell ablation in mouse embryos reveals the essential role of Scx-lineage cells in muscle morphogenesis and attachment. The absence of these cells leads to altered muscle bundle shapes and attachment sites, impairments in muscle separation and dislocation of limb girdle muscles. Furthermore, lineage tracing suggests that the muscle patterning defect is primarily due to a reduction in tendon/ligament cells.
Review
Biotechnology & Applied Microbiology
Varun Arvind, Alice H. Huang
Summary: Inflammation plays a dual role in tendon healing, serving as the root cause of chronic tendinopathy while also aiding tissue repair. Recent research focuses on the cells and cytokines involved in reparative inflammation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Cell & Tissue Engineering
Chase A. Pagani, Amanda K. Huber, Charles Hwang, Simone Marini, Karthik Padmanabhan, Nicholas Livingston, Johanna Nunez, Yuxiao Sun, Nicole Edwards, Yu-Hao Cheng, Noelle Visser, Pauline Yu, Nicole Patel, Joseph A. Greenstein, Husain Rasheed, Reagan Nelson, Karen Kessel, Kaetlin Vasquez, Amy L. Strong, Geoffrey E. Hespe, Jane Y. Song, Deneen M. Wellik, Benjamin Levi
Summary: The research discovered a specific lineage of cells as ectopic bone progenitors in the zeugopod, providing a new perspective on fate specification and multipotency acquired after injury.
Article
Immunology
Haiyun Li, Zhanqi Wang, Feng Zhou, Guorui Zhang, Xuan Feng, Yi Xiong, Yingying Wu
Summary: Cutaneous wounds in the elderly heal poorly due to persistent inflammation and insufficient ECM deposition. The NLRP3 inflammasome plays a critical role in age-related inflammatory diseases and impaired wound healing. In this study, the activation of NLRP3 inflammasome was found to be increased in aged mice, causing a delay in wound healing. The application of NLRP3 inhibitor (MCC950) improved wound healing in aged mice by reducing inflammation and cell death.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Engineering, Biomedical
Siqi He, Tanaya Walimbe, Hongyuan Chen, Kewa Gao, Priyadarsini Kumar, Yifan Wei, Dake Hao, Ruiwu Liu, Diana L. Farmer, Kit S. Lam, Jianda Zhou, Alyssa Panitch, Aijun Wang
Summary: In this study, a multi-functional pro-angiogenic molecule was designed and synthesized to enhance the treatment of diabetic ischemic wounds. The modified extracellular matrix scaffolds significantly promoted cell attachment, growth, and survival, leading to improved wound healing and neovascularization in an ischemic environment.
BIOACTIVE MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Zilu Ge, Wei Li, Renliang Zhao, Wei Xiong, Dong Wang, Yunfeng Tang, Qian Fang, Xiangtian Deng, Zhen Zhang, Yaojia Zhou, Xiaoting Chen, Yue Li, Yanrong Lu, Chengshi Wang, Guanglin Wang
Summary: Tendon stem/progenitor cells (TSPCs) therapy using a DNA hydrogel delivery system shows promising results in enhancing tendon injury repair. Encapsulating TSPCs in a DNA hydrogel creates an artificial extracellular matrix (ECM) microenvironment that provides nutrition and protection for the cells. TSPCs-Gel injections promote tendon healing and improve the mechanical properties of injured tendons. RNA-sequencing analysis also suggests potential gene and signaling pathway targets for further treatment strategies.
Article
Dermatology
Xinling Zhang, Huier Wangguan, Yidan Sun, Pengbing Ding, Xin Yang, Zhenmin Zhao
Summary: The study revealed that Z-plasty treatment for chronic non-healing wounds is more effective than direct suturing, reducing the incidence of abnormal wound edge color and promoting better wound healing.
INTERNATIONAL WOUND JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Walker D. Short, Emily Steen, Aditya Kaul, Xinyi Wang, Oluyinka O. Olutoye, Hima V. Vangapandu, Natalie Templeman, Alexander J. Blum, Chad M. Moles, Daria A. Narmoneva, Timothy M. Crombleholme, Manish J. Butte, Paul L. Bollyky, Sundeep G. Keswani, Swathi Balaji
Summary: This study found that overexpression of IL-10 in dermal wounds recruits EPCs, increases vascular structures, and accelerates re-epithelialization.
Article
Orthopedics
Natalie L. L. Leong, Jocelyn Wu, Kathryn E. E. Greskovich, Yang Li, Jie Jiang
Summary: The study tracked the changes of Pdgfr-beta lineage cells at the site of Achilles tendon injury and found that these cells decreased over time. It was also concluded that Pdgfr-beta lineage cells are unlikely to be the cells that differentiate into myofibroblasts and directly contribute to tendon fibrous scar formation. This study provides insight into tendon healing process.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Xue Xu, Yulong Zhang, Pin Ha, Yao Chen, Chenshuang Li, Emily Yen, Yuxing Bai, Renji Chen, Benjamin M. Wu, Andrew Da Lio, Kang Ting, Chia Soo, Zhong Zheng
Summary: Tendons are commonly injured tissues in the musculoskeletal system, and current treatments for enhancing tendon healing have not achieved significant clinical improvements. In this study, a novel FMOD/gHA-hydrogel was developed to deliver FMOD and enhance tendon healing. The hydrogel exhibited desired characteristics, such as microinvasive application and a two-phase release of FMOD. The hydrogel significantly improved tendon healing in a rat model.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Jin Suk Ryu, So Yeon Kim, Mee Kum Kim, Joo Youn Oh
Summary: Recent evidence suggests that epithelial stem/progenitor cells in barrier tissues retain a memory of previous injuries, enabling faster restoration of the barrier after subsequent injuries. The corneal epithelium, the outermost layer of the cornea, also shows signs of inflammatory memory. Mice and ocular Sjogren's syndrome patients both exhibited accelerated corneal wound healing and reduced inflammation after subsequent injuries, indicating the presence of nonspecific inflammatory memory in the cornea.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Jie Lian, Guanqun Ju, Xueyao Cai, Yuchen Cai, Chun Li, Sunxiang Ma, Yi Cao
Summary: Hydrogen sulfide and endothelial progenitor cells have been shown to enhance wound healing, and a novel drug carrier nanofibrous membrane has been developed for effective release of H2S and improved therapeutic effects of EPCs.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Orthopedics
Helen L. Moser, Adam C. Abraham, Kristen Howell, Damien Laudier, Matthias A. Zumstein, Leesa M. Galatz, Alice H. Huang
Summary: This study investigated clinically relevant features of a mouse model of supraspinatus tendon injury to determine outcomes, including pain, function, and structure. Lineage tracing revealed the involvement of two specific cell populations in the healing process after tendon injury and repair. Scar formation after surgery was mainly mediated by a specific cell population, leading to permanently reduced functional and structural properties.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Surgery
Walker D. Short, Meredith Rae, Thomas Lu, Benjamin Padon, Tanuj J. Prajapati, Fayiz Faruk, Oluyinka O. Olutoye II, Ling Yu, Paul Bollyky, Sundeep G. Keswani, Swathi Balaji
Summary: This study investigates the role of endogenous interleukin-10 (IL-10) in postnatal dermal wound healing using a murine model. The results demonstrate that endogenous IL-10 expression does not affect wound healing rate, but leads to increased inflammatory cell infiltration and scar formation.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Biology
Rushita A. Bagchi, Patricia Roche, Nina Aroutiounova, Leon Espira, Bernard Abrenica, Ronen Schweitzer, Michael P. Czubryt
Meeting Abstract
Orthopedics
R. Schweitzer, D. Pal, S. Schlesinger, A. Huang, B. Pryce, J. Brigande
OSTEOARTHRITIS AND CARTILAGE
(2018)
Article
Cell & Tissue Engineering
Xiao Xia Cong, Xi Sheng Rao, Jun Xin Lin, Xiao Ceng Liu, Guang An Zhang, Xiu Kui Gao, Min Yi He, Wei Liang Shen, Wei Fan, Dominique Pioletti, Li Ling Zheng, Huan Huan Liu, Zi Yin, Boon Chuan Low, Ronen Schweitzer, Hongwei Ouyang, Xiao Chen, Yi Ting Zhou
Article
Multidisciplinary Sciences
Joohyun Lim, Elda Munivez, Ming-Ming Jiang, I-Wen Song, Francis Gannon, Douglas R. Keene, Ronen Schweitzer, Brendan H. Lee, Kyu Sang Joeng
SCIENTIFIC REPORTS
(2017)
Article
Developmental Biology
Neta Felsenthal, Sarah Rubin, Tomer Stern, Sharon Krief, Deepanwita Pal, Brian A. Pryce, Ronen Schweitzer, Elazar Zelzer
Article
Biochemistry & Molecular Biology
Dirk Hubmacher, Nandaraj Taye, Zerina Balic, Stetson Thacker, Sheila M. Adams, David E. Birk, Ronen Schweitzer, Suneel S. Apte
Article
Developmental Biology
Ryan R. Roberts, Lauren Bobzin, Camilla S. Teng, Deepanwita Pal, Creighton T. Tuzon, Ronen Schweitzer, Amy E. Merrill
Article
Developmental Biology
Alice H. Huang, Spencer S. Watson, Lingyan Wang, Brendon M. Baker, Haruhiko Akiyama, John V. Brigande, Ronen Schweitzer
Article
Cell & Tissue Engineering
R. Wilder Scott, Martin Arostegui, Ronen Schweitzer, Fabio M. Rossi, T. Michael Underhill
Article
Biology
Guak-Kim Tan, Brian A. Pryce, Anna Stabio, John V. Brigande, ChaoJie Wang, Zheng Xia, Sara F. Tufa, Douglas R. Keene, Ronen Schweitzer
Article
Developmental Biology
Saundra Y. Schlesinger, Seongkyung Seo, Brian A. Pryce, Sara F. Tufa, Douglas R. Keene, Alice H. Huang, Ronen Schweitzer
Summary: This study established a novel murine model of joint contracture by targeting Smad4 deletion in the tendon cell lineage. Smad4(ScxCre) mutants showed joint contracture shortly after birth, with severity increasing with age. Disruption of the BMP pathway in Alk3(ScxCre)/Alk6(null) mutants replicated many features of the joint contracture phenotype, suggesting a role for BMP signaling in tendon elongation and extracellular matrix accumulation.
DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Joohyun Lim, Caressa Lietman, Matthew W. Grol, Alexis Castellon, Brian Dawson, Mary Adeyeye, Jyoti Rai, MaryAnn Weis, Douglas R. Keene, Ronen Schweitzer, Dongsu Park, David R. Eyre, Deborah Krakow, Brendan H. Lee
Summary: This study reveals that defects in Fkbp10 in tendons and ligaments can cause joint dysfunction in osteogenesis imperfecta, involving ectopic chondrogenesis and dysregulated Hedgehog signaling.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell & Tissue Engineering
Guak-Kim Tan, Brian A. Pryce, Anna Stabio, Douglas R. Keene, Sara F. Tufa, Ronen Schweitzer
Summary: This study reveals that in damaged tendons, stem/progenitor cells are recruited directly into the tissue, originating from a Sox9-expressing lineage and their recruitment being dependent on cell autonomous TGF beta signaling. This recruitment differs from previous reports and highlights the critical role of TGF beta signaling in cell recruitment for tendon repair.
Meeting Abstract
Endocrinology & Metabolism
Amel Dudakovic, Emily Camilleri, Deepanwita Pal, Sonia Rozario, Christopher Paradise, Roman Thaler, Meghan McGee-Lawrence, Elizabeth Bradley, Gary Stein, Martin Montecino, Jennifer Westendorf, Ronen Schweitzer, Emi Shimizu, Andre van Wijnen
JOURNAL OF BONE AND MINERAL RESEARCH
(2017)