The inflammatory response to silver and titanium dioxide nanoparticles in the central nervous system

Effects of silver nanoparticles on the interactions of neuron- and glia-like cells: Toxicity, uptake mechanisms, and lysosomal tracking

(2017) I-Lun Hsiao et al.   ENVIRONMENTAL TOXICOLOGY

Recent advances in use of silver nanoparticles as antimalarial agents

(2017) Mahendra Rai et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Toxicity of inhaled particulate matter on the central nervous system: neuroinflammation, neuropsychological effects and neurodegenerative disease

(2017) Yan Wang et al.   JOURNAL OF APPLIED TOXICOLOGY

Ultra-small silver nanoparticles induced ROS activated Toll-pathway against Staphylococcus aureus disease in silkworm model

(2017) Pala Rajasekharreddy et al.   Materials Science & Engineering C-Materials for Biological Applications

Inflammation-induced brain endothelial activation leads to uptake of electrostatically stabilized iron oxide nanoparticles via sulfated glycosaminoglycans

(2017) Dominique Berndt et al.   Nanomedicine-Nanotechnology Biology and Medicine

Effect of TiO2Nanoparticles on Inflammasome-Mediated Airway Inflammation and Responsiveness

(2017) Byeong-Gon Kim et al.   Allergy Asthma & Immunology Research

Silver nanoparticles reduce brain inflammation and related neurotoxicity through induction of H2S-synthesizing enzymes

(2017) Daniel A. Gonzalez-Carter et al.   Scientific Reports

Inhibition of lanthanide nanocrystal-induced inflammasome activation in macrophages by a surface coating peptide through abrogation of ROS production and TRPM2-mediated Ca2+ influx

(2016) Han Yao et al.   BIOMATERIALS

The effect of titanium dioxide nanoparticles on neuroinflammation response in rat brain

(2016) Intissar Grissa et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Microglial cells (BV-2) internalize titanium dioxide (TiO2) nanoparticles: toxicity and cellular responses

(2016) Naima Rihane et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Influence of silver and titanium dioxide nanoparticles on in vitro blood-brain barrier permeability

(2016) I-Chieh Chen et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Titanium dioxide nanoparticles exacerbate DSS-induced colitis: role of the NLRP3 inflammasome

(2016) Pedro A Ruiz et al.   GUT

Silver nanoparticles induce pro-inflammatory gene expression and inflammasome activation in human monocytes

(2016) A. Murphy et al.   JOURNAL OF APPLIED TOXICOLOGY

Microglial migration and interactions with dendrimer nanoparticles are altered in the presence of neuroinflammation

(2016) Fan Zhang et al.   Journal of Neuroinflammation

Acute systemic exposure to silver-based nanoparticles induces hepatotoxicity and NLRP3-dependent inflammation

(2016) Khalil B. Ramadi et al.   Nanotoxicology

Organ burden and pulmonary toxicity of nano-sized copper (II) oxide particles after short-term inhalation exposure

(2016) Ilse Gosens et al.   Nanotoxicology

Silver nanoparticles induced neurotoxicity through oxidative stress in rat cerebral astrocytes is distinct from the effects of silver ions

(2016) Cheng Sun et al.   NEUROTOXICOLOGY

Silver Nanoparticle-Induced Autophagic-Lysosomal Disruption and NLRP3-Inflammasome Activation in HepG2 Cells Is Size-Dependent

(2016) Anurag R. Mishra et al.   TOXICOLOGICAL SCIENCES

Transcriptomic gene-network analysis of exposure to silver nanoparticle reveals potentially neurodegenerative progression in mouse brain neural cells

(2016) Ho-Chen Lin et al.   TOXICOLOGY IN VITRO

Toxicity of Nano-Titanium Dioxide (TiO2-NP) Through Various Routes of Exposure: a Review

(2015) Muhammad Shakeel et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Green synthesis of nanoparticles and its potential application

(2015) Imtiyaz Hussain et al.   BIOTECHNOLOGY LETTERS

Silver nanoparticles affect on gene expression of inflammatory and neurodegenerative responses in mouse brain neural cells

(2015) Chin-Lin Huang et al.   ENVIRONMENTAL RESEARCH

Subacute toxicity of titanium dioxide (TiO2) nanoparticles in male rats: emotional behavior and pathophysiological examination

(2015) Naima Rihane Ben Younes et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Determination of LC50 and sub-chronic neurotoxicity of diesel exhaust nanoparticles

(2015) M. Durga et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Silver and titanium dioxide nanoparticles alter oxidative/inflammatory response and renin–angiotensin system in brain

(2015) Agata Krawczyńska et al.   FOOD AND CHEMICAL TOXICOLOGY

Silver Nanoparticles Induce Degradation of the Endoplasmic Reticulum Stress Sensor Activating Transcription Factor-6 Leading to Activation of the NLRP-3 Inflammasome

(2015) Jean-Christophe Simard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Negligible particle-specific toxicity mechanism of silver nanoparticles: The role of Ag+ ion release in the cytosol

(2015) Valeria De Matteis et al.   Nanomedicine-Nanotechnology Biology and Medicine

MPA-capped CdTe quantum dots exposure causes neurotoxic effects in nematode Caenorhabditis elegans by affecting the transporters and receptors of glutamate, serotonin and dopamine at the genetic level, or by increasing ROS, or both

(2015) Tianshu Wu et al.   Nanoscale

Mitochondrial dysfunction and loss of glutamate uptake in primary astrocytes exposed to titanium dioxide nanoparticles

(2015) Christina L. Wilson et al.   Nanoscale

Synaptopathy connects inflammation and neurodegeneration in multiple sclerosis

(2015) Georgia Mandolesi et al.   Nature Reviews Neurology

Internalization of titanium dioxide nanoparticles by glial cells is given at short times and is mainly mediated by actin reorganization-dependent endocytosis

(2015) Elizabeth Huerta-García et al.   NEUROTOXICOLOGY

Titanium dioxide nanoparticles induce strong oxidative stress and mitochondrial damage in glial cells

(2014) Elizabeth Huerta-García et al.   FREE RADICAL BIOLOGY AND MEDICINE

Toxicity of Silver Nanoparticles to Human Dermal Fibroblasts on MicroRNA Level

(2014) Yan Huang et al.   Journal of Biomedical Nanotechnology

Oxidative Stress-Induced Signaling Pathways Implicated in the Pathogenesis of Parkinson’s Disease

(2014) Georgia S. Gaki et al.   NEUROMOLECULAR MEDICINE

TiO2 Nanoparticles Induced Hippocampal Neuroinflammation in Mice

(2014) Yuguan Ze et al.   PLoS One

Integrated testing strategies for safety assessments

(2014) Thomas Hartung   ALTEX-Alternatives to Animal Experimentation

Nanosilver: application and novel aspects of toxicology

(2013) Jan K. Schluesener et al.   ARCHIVES OF TOXICOLOGY

Differential nanotoxicological and neuroinflammatory liabilities of non-viral vectors for RNA interference in the central nervous system

(2013) Bruno M.D.C. Godinho et al.   BIOMATERIALS

Cytotoxicity of titanium dioxide nanoparticles in rat neuroglia cells

(2013) Yanfei Liu et al.   BRAIN INJURY

Assessing nanoparticle toxicity in cell-based assays: influence of cell culture parameters and optimized models for bridging the in vitro–in vivo gap

(2013) Freya Joris et al.   CHEMICAL SOCIETY REVIEWS

Alzheimer´s Disease and Oxidative Stress: A Review

(2013) Miroslav Pohanka   CURRENT MEDICINAL CHEMISTRY

Comparative study on effects of two different types of titanium dioxide nanoparticles on human neuronal cells

(2013) Vanessa Valdiglesias et al.   FOOD AND CHEMICAL TOXICOLOGY

Neurotoxicity and gene-expressed profile in brain-injured mice caused by exposure to titanium dioxide nanoparticles

(2013) Yuguan Ze et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

The Exonuclease Trex1 Restrains Macrophage Proinflammatory Activation

(2013) S. Pereira-Lopes et al.   JOURNAL OF IMMUNOLOGY

Implementation of alternative test strategies for the safety assessment of engineered nanomaterials

(2013) A. E. Nel   JOURNAL OF INTERNAL MEDICINE

Influence of Nanoparticle Shape, Size, and Surface Functionalization on Cellular Uptake

(2013) Ningning Ma et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Nanostructured TiO2 surfaces promote polarized activation of microglia, but not astrocytes, toward a proinflammatory profile

(2013) Silvia De Astis et al.   Nanoscale

Development, maintenance and disruption of the blood-brain barrier

(2013) Birgit Obermeier et al.   NATURE MEDICINE

Health effects of exposure to nano-TiO2: a meta-analysis of experimental studies

(2013) Xuhong Chang et al.   Nanoscale Research Letters

Distribution, Elimination, and Toxicity of Silver Nanoparticles and Silver Ions in Rats after 28-Day Oral Exposure

(2012) Meike van der Zande et al.   ACS Nano

Inflammasomes and Their Roles in Health and Disease

(2012) Mohamed Lamkanfi et al.   Annual Review of Cell and Developmental Biology

TLR-induced NF-κB activation regulates NLRP3 expression in murine macrophages

(2012) Yu Qiao et al.   FEBS LETTERS

Time-dependent biodistribution and excretion of silver nanoparticles in male Wistar rats

(2012) K. Dziendzikowska et al.   JOURNAL OF APPLIED TOXICOLOGY

Silver nanoparticle-induced oxidative stress, genotoxicity and apoptosis in cultured cells and animal tissues

(2012) Soohee Kim et al.   JOURNAL OF APPLIED TOXICOLOGY

Handling of Iron Oxide and Silver Nanoparticles by Astrocytes

(2012) Michaela C. Hohnholt et al.   NEUROCHEMICAL RESEARCH

Neuroinflammation: A Common Pathway in CNS Diseases as Mediated at the Blood-Brain Barrier

(2012) Michelle A. Erickson et al.   NEUROIMMUNOMODULATION

Alterations in physical state of silver nanoparticles exposed to synthetic human stomach fluid

(2012) Kim R. Rogers et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Titanium dioxide nanoparticles inhibit proliferation and induce morphological changes and apoptosis in glial cells

(2012) Sandra Gissela Márquez-Ramírez et al.   TOXICOLOGY

Four types of inorganic nanoparticles stimulate the inflammatory reaction in brain microglia and damage neurons in vitro

(2012) Yang Xue et al.   TOXICOLOGY LETTERS

In vitro evidence of dysregulation of blood–brain barrier function after acute and repeated/long-term exposure to TiO2 nanoparticles

(2011) Emilie Brun et al.   BIOMATERIALS

Macropinocytosis: an endocytic pathway for internalising large gulps

(2011) Jet Phey Lim et al.   IMMUNOLOGY AND CELL BIOLOGY

The neurotoxic potential of engineered nanomaterials

(2011) William K. Boyes et al.   NEUROTOXICOLOGY

The effect of agglomeration state of silver and titanium dioxide nanoparticles on cellular response of HepG2, A549 and THP-1 cells

(2011) Anna Lankoff et al.   TOXICOLOGY LETTERS

Cellular Uptake, Cytotoxicity, and Innate Immune Response of Silica−Titania Hollow Nanoparticles Based on Size and Surface Functionality

(2010) Wan-Kyu Oh et al.   ACS Nano

Neurotoxicological effects and the impairment of spatial recognition memory in mice caused by exposure to TiO2 nanoparticles

(2010) Renping Hu et al.   BIOMATERIALS

A review of the in vivo and in vitro toxicity of silver and gold particulates: Particle attributes and biological mechanisms responsible for the observed toxicity

(2010) Helinor J. Johnston et al.   CRITICAL REVIEWS IN TOXICOLOGY

The Caenorhabiditis elegans model as a reliable tool in neurotoxicology

(2010) Daiana Avila et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Activation of the inflammasome by amorphous silica and TiO2nanoparticles in murine dendritic cells

(2010) Meike Winter et al.   Nanotoxicology

Microglial alterations in human Alzheimer's disease following Aβ42 immunization

(2010) E. Zotova et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Silver Nanoparticle Induced Blood-Brain Barrier Inflammation and Increased Permeability in Primary Rat Brain Microvessel Endothelial Cells

(2010) William J. Trickler et al.   TOXICOLOGICAL SCIENCES

ROS-mediated genotoxicity induced by titanium dioxide nanoparticles in human epidermal cells

(2010) Ritesh K. Shukla et al.   TOXICOLOGY IN VITRO

Environmental and Human Health Risks of Aerosolized Silver Nanoparticles

(2010) Marina E. Quadros et al.   JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION

Mechanisms of Endocytosis

(2009) Gary J. Doherty et al.   Annual Review of Biochemistry

Oxidative stress in the brain of mice caused by translocated nanoparticulate TiO2 delivered to the abdominal cavity

(2009) Linglan Ma et al.   BIOMATERIALS

Nanosized titanium dioxide enhanced inflammatory responses in the septic brain of mouse

(2009) J.A. Shin et al.   NEUROSCIENCE

Toxicity and penetration of TiO2 nanoparticles in hairless mice and porcine skin after subchronic dermal exposure

(2009) Jianhong Wu et al.   TOXICOLOGY LETTERS

The IKK-related kinases: from innate immunity to oncogenesis

(2008) Jean-François Clément et al.   CELL RESEARCH

Diesel exhaust particles induce oxidative stress, proinflammatory signaling, and P-glycoprotein up-regulation at the blood-brain barrier

(2008) Anika M. S. Hartz et al.   FASEB JOURNAL

Homocysteine and inflammation as main determinants of oxidative stress in the elderly

(2008) Emilie Ventura et al.   FREE RADICAL BIOLOGY AND MEDICINE

Time-dependent translocation and potential impairment on central nervous system by intranasally instilled TiO2 nanoparticles

(2008) Jiangxue Wang et al.   TOXICOLOGY

Potential neurological lesion after nasal instillation of TiO2 nanoparticles in the anatase and rutile crystal phases

(2008) J WANG et al.   TOXICOLOGY LETTERS

From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE