TRPM2 in ischemic stroke: Structure, molecular mechanisms, and drug intervention

Curcumin diminishes cisplatin-induced apoptosis and mitochondrial oxidative stress through inhibition of TRPM2 channel signaling pathway in mouse optic nerve

(2020) Dilek Özkaya et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Modulation of the excitability of stellate neurons in the ventral cochlear nucleus of mice by TRPM2 channels

(2020) Ramazan Bal et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Resveratrol attenuates hypoxia-induced neuronal cell death, inflammation and mitochondrial oxidative stress by modulation of TRPM2 channel

(2020) Yener Akyuva et al.   Scientific Reports

Transient Receptor Potential Melastatin 2 (TRPM2) Inhibition by Antioxidant, N-Acetyl-l-Cysteine, Reduces Global Cerebral Ischemia-Induced Neuronal Death

(2020) Dae Ki Hong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Selenium prevents interferon-gamma induced activation of TRPM2 channel and inhibits inflammation, mitochondrial oxidative stress, and apoptosis in microglia

(2020) Yener Akyuva et al.   METABOLIC BRAIN DISEASE

Pharmacology of JNJ-28583113: A novel TRPM2 antagonist

(2019) Lawrence Fourgeaud et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Neuroprotective Effects of AG490 in Neonatal Hypoxic-Ischemic Brain Injury

(2019) Feiya Li et al.   MOLECULAR NEUROBIOLOGY

Reversal of Global Ischemia-Induced Cognitive Dysfunction by Delayed Inhibition of TRPM2 Ion Channels

(2019) Robert M. Dietz et al.   Translational Stroke Research

TRPM2 channel regulates cytokines production in astrocytes and aggravates brain disorder during lipopolysaccharide-induced endotoxin sepsis

(2019) Tao Zhu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Albumin evokes Ca2+-induced cell oxidative stress and apoptosis through TRPM2 channel in renal collecting duct cells reduced by curcumin

(2019) Mustafa Nazıroğlu et al.   Scientific Reports

A structural overview of the ion channels of the TRPM family

(2019) Yihe Huang et al.   CELL CALCIUM

Salidroside-Mitigated Inflammatory Injury of Hepatocytes with Non-Alcoholic Fatty Liver Disease via Inhibition TRPM2 Ion Channel Activation

(2019) Qi Feng et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Blood-Brain Barrier Dysfunction in Ischemic Stroke: Targeting Tight Junctions and Transporters for Vascular Protection

(2018) Wazir Abdullahi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Design, synthesis and biological activities of 2,3-dihydroquinazolin-4(1 H )-one derivatives as TRPM2 inhibitors

(2018) Han Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

8-Br-cADPR, a TRPM2 ion channel antagonist, inhibits renal ischemia-reperfusion injury

(2018) Ersen Eraslan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A critical role of the transient receptor potential melastatin 2 channel in a positive feedback mechanism for reactive oxygen species-induced delayed cell death

(2018) Xin Li et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Protective Effects of Duloxetine against Cerebral Ischemia-Reperfusion Injury via Transient Receptor Potential Melastatin 2 Inhibition

(2018) Takahiro Toda et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

CXCL1 and CXCL2 Regulate NLRP3 Inflammasome Activation via G-Protein–Coupled Receptor CXCR2

(2017) Monoranjan Boro et al.   JOURNAL OF IMMUNOLOGY

Scalaradial Is a Potent Inhibitor of Transient Receptor Potential Melastatin 2 (TRPM2) Ion Channels

(2017) John G. Starkus et al.   JOURNAL OF NATURAL PRODUCTS

Tyrphostin AG-related compounds attenuate H 2 O 2 -induced TRPM2-dependent and -independent cellular responses

(2017) Shinichiro Yamamoto et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

ACA, an inhibitor phospholipases A2 and transient receptor potential melastatin-2 channels, attenuates okadaic acid induced neurodegeneration in rats

(2017) Murat Cakir et al.   LIFE SCIENCES

NADPH oxidase in brain injury and neurodegenerative disorders

(2017) Merry W. Ma et al.   Molecular Neurodegeneration

2′-Deoxyadenosine 5′-diphosphoribose is an endogenous TRPM2 superagonist

(2017) Ralf Fliegert et al.   Nature Chemical Biology

Pathogenic mechanisms following ischemic stroke

(2017) Seyed Esmaeil Khoshnam et al.   NEUROLOGICAL SCIENCES

Alteration in Intracellular Zn2+ Homeostasis as a Result of TRPM2 Channel Activation Contributes to ROS-Induced Hippocampal Neuronal Death

(2017) Xin Li et al.   Frontiers in Molecular Neuroscience

Extended therapeutic window of a novel peptide inhibitor of TRPM2 channels following focal cerebral ischemia

(2016) Takeru Shimizu et al.   EXPERIMENTAL NEUROLOGY

Ovariectomy-Induced Mitochondrial Oxidative Stress, Apoptosis, and Calcium Ion Influx Through TRPA1, TRPM2, and TRPV1 Are Prevented by 17β-Estradiol, Tamoxifen, and Raloxifene in the Hippocampus and Dorsal Root Ganglion of Rats

(2016) Yener Yazğan et al.   MOLECULAR NEUROBIOLOGY

Duloxetine Reduces Oxidative Stress, Apoptosis, and Ca2+ Entry Through Modulation of TRPM2 and TRPV1 Channels in the Hippocampus and Dorsal Root Ganglion of Rats

(2016) Arif Demirdaş et al.   MOLECULAR NEUROBIOLOGY

TRPM2 Promotes Neurotoxin MPP+/MPTP-Induced Cell Death

(2016) Yuyang Sun et al.   MOLECULAR NEUROBIOLOGY

Modulation of Diabetes-Induced Oxidative Stress, Apoptosis, and Ca2+ Entry Through TRPM2 and TRPV1 Channels in Dorsal Root Ganglion and Hippocampus of Diabetic Rats by Melatonin and Selenium

(2016) Mehmet Cemal Kahya et al.   MOLECULAR NEUROBIOLOGY

Curcumin inhibits activation of TRPM2 channels in rat hepatocytes

(2016) E. Kheradpezhouh et al.   Redox Biology

The neuroprotective action of dexmedetomidine on apoptosis, calcium entry and oxidative stress in cerebral ischemia-induced rats: Contribution of TRPM2 and TRPV1 channels

(2016) Hatice Akpınar et al.   Scientific Reports

Designer small molecules to target calcium signalling

(2015) Joanna M. Swarbrick et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Hypericum perforatum Attenuates Spinal Cord Injury-Induced Oxidative Stress and Apoptosis in the Dorsal Root Ganglion of Rats: Involvement of TRPM2 and TRPV1 Channels

(2015) Ümit Sinan Özdemir et al.   MOLECULAR NEUROBIOLOGY

Molecular Docking and Structure-Based Drug Design Strategies

(2015) Leonardo Ferreira et al.   MOLECULES

TRPM2 contributes to LPS/IFNγ-induced production of nitric oxide via the p38/JNK pathway in microglia

(2014) Takahito Miyake et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TNF- -mediated caspase-8 activation induces ROS production and TRPM2 activation in adult ventricular myocytes

(2014) S. Roberge et al.   CARDIOVASCULAR RESEARCH

TRPM2 mediates ischemic kidney injury and oxidant stress through RAC1

(2014) Guofeng Gao et al.   JOURNAL OF CLINICAL INVESTIGATION

Transient Receptor Potential Melastatin Subfamily Member 2 Cation Channel Regulates Detrimental Immune Cell Invasion in Ischemic Stroke

(2014) Mathias Gelderblom et al.   STROKE

TRPM2 channel deficiency prevents delayed cytosolic Zn2+ accumulation and CA1 pyramidal neuronal death after transient global ischemia

(2014) M Ye et al.   Cell Death & Disease

The key role of transient receptor potential melastatin-2 channels in amyloid-β-induced neurovascular dysfunction

(2014) L. Park et al.   Nature Communications

Astrocytic laminin regulates pericyte differentiation and maintains blood brain barrier integrity

(2014) Yao Yao et al.   Nature Communications

Cooperative Interaction of trp Melastatin Channel Transient Receptor Potential (TRPM2) With Its Splice Variant TRPM2 Short Variant Is Essential for Endothelial Cell Apoptosis

(2013) Claudie M. Hecquet et al.   CIRCULATION RESEARCH

Temporal Trends in Patient Characteristics and Treatment With Intravenous Thrombolysis Among Acute Ischemic Stroke Patients at Get With the Guidelines–Stroke Hospitals

(2013) Lee H. Schwamm et al.  

Androgen and PARP-1 Regulation of TRPM2 Channels after Ischemic Injury

(2013) Takeru Shimizu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Structure–Activity Relationship of Adenosine 5′-diphosphoribose at the Transient Receptor Potential Melastatin 2 (TRPM2) Channel: Rational Design of Antagonists

(2013) Christelle Moreau et al.   JOURNAL OF MEDICINAL CHEMISTRY

Sexually Dimorphic Response of TRPM2 Inhibition Following Cardiac Arrest-Induced Global Cerebral Ischemia in Mice

(2013) S. Nakayama et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Modulation of NMDAR Subunit Expression by TRPM2 Channels Regulates Neuronal Vulnerability to Ischemic Cell Death

(2013) I. Alim et al.   JOURNAL OF NEUROSCIENCE

Flufenamic acid as an ion channel modulator

(2013) Romain Guinamard et al.   PHARMACOLOGY & THERAPEUTICS

Effect of non-steroidal anti-inflammatory drugs and new fenamate analogues on TRPC4 and TRPC5 channels

(2012) Hongni Jiang et al.   BIOCHEMICAL PHARMACOLOGY

Attenuation of axonal injury and oxidative stress by edaravone protects against cognitive impairments after traumatic brain injury

(2012) Manabu Ohta et al.   BRAIN RESEARCH

Pharmacological comparison of novel synthetic fenamate analogues with econazole and 2-APB on the inhibition of TRPM2 channels

(2012) Gui-Lan Chen et al.   BRITISH JOURNAL OF PHARMACOLOGY

TRPM2 Contributes to Inflammatory and Neuropathic Pain through the Aggravation of Pronociceptive Inflammatory Responses in Mice

(2012) K. Haraguchi et al.   JOURNAL OF NEUROSCIENCE

TRPM2 channel activation following in vitro ischemia contributes to male hippocampal cell death

(2012) S. Verma et al.   NEUROSCIENCE LETTERS

Melatonin modulates apoptosis and TRPM2 channels in transfected cells activated by oxidative stress

(2012) Ömer Çelik et al.   PHYSIOLOGY & BEHAVIOR

Redox signal-mediated sensitization of transient receptor potential melastatin 2 (TRPM2) to temperature affects macrophage functions

(2012) M. Kashio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Computational Electrophysiology: The Molecular Dynamics of Ion Channel Permeation and Selectivity in Atomistic Detail

(2011) Carsten Kutzner et al.   BIOPHYSICAL JOURNAL

Dendritic cell maturation and chemotaxis is regulated by TRPM2-mediated lysosomal Ca2+ release

(2011) Adriana Sumoza-Toledo et al.   FASEB JOURNAL

Sex Differences in Neuroprotection Provided by Inhibition of TRPM2 Channels following Experimental Stroke

(2011) Jia Jia et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Expression and functional properties of TRPM2 channels in dopaminergic neurons of the substantia nigra of the rat

(2011) Kenny K. H. Chung et al.   JOURNAL OF NEUROPHYSIOLOGY

The Neurophysiology and Pathology of Brain Zinc

(2011) S. L. Sensi et al.   JOURNAL OF NEUROSCIENCE

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

Zinc: new clues to diverse roles in brain ischemia

(2011) C. William Shuttleworth et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Oxidative Stress in Ischemic Brain Damage: Mechanisms of Cell Death and Potential Molecular Targets for Neuroprotection

(2010) Hai Chen et al.   ANTIOXIDANTS & REDOX SIGNALING

Calcium, ischemia and excitotoxicity

(2010) Kinga Szydlowska et al.   CELL CALCIUM

Poly(ADP-ribose)glycohydrolase is an upstream regulator of Ca2+ fluxes in oxidative cell death

(2010) C. Blenn et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Depletion of GSH in glial cells induces neurotoxicity: relevance to aging and degenerative neurological diseases

(2010) Moonhee Lee et al.   FASEB JOURNAL

Astrocyte targeted overexpression of Hsp72 or SOD2 reduces neuronal vulnerability to forebrain ischemia

(2010) Lijun Xu et al.   GLIA

Gender and Stroke Symptoms

(2010) Claudia C. Beal   JOURNAL OF NEUROSCIENCE NURSING

Differential expression of TRPM2 and TRPV4 channels and their potential role in oxidative stress-induced cell death in organotypic hippocampal culture

(2010) Ji-Zhong Bai et al.   NEUROTOXICOLOGY

The complexity of neurobiological processes in acute ischemic stroke

(2009) R. Brouns et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Involvement of ROS in BBB dysfunction

(2009) Pamela B. L. Pun et al.   FREE RADICAL RESEARCH

Intracellular Zn2+ Accumulation Contributes to Synaptic Failure, Mitochondrial Depolarization, and Cell Death in an Acute Slice Oxygen-Glucose Deprivation Model of Ischemia

(2009) Y. V. Medvedeva et al.   JOURNAL OF NEUROSCIENCE

Ca2+-dependent induction of TRPM2 currents in hippocampal neurons

(2009) Michelle E. Olah et al.   JOURNAL OF PHYSIOLOGY-LONDON

Pericyte contraction induced by oxidative-nitrative stress impairs capillary reflow despite successful opening of an occluded cerebral artery

(2009) Muge Yemisci et al.   NATURE MEDICINE

Intracellular calcium activates TRPM2 and its alternative spliced isoforms

(2009) J. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sex Differences in Caspase Activation After Stroke

(2009) Fudong Liu et al.   STROKE

Inhibition of the transient receptor potential cation channel TRPM2 by 2-aminoethoxydiphenyl borate (2-APB)

(2008) K Togashi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Synergistic regulation of endogenous TRPM2 channels by adenine dinucleotides in primary human neutrophils

(2008) Ingo Lange et al.   CELL CALCIUM

Zinc and 4-Hydroxy-2-Nonenal Mediate Lysosomal Membrane Permeabilization Induced by H2O2 in Cultured Hippocampal Neurons

(2008) J. J. Hwang et al.   JOURNAL OF NEUROSCIENCE

Pathways to ischemic neuronal cell death: are sex differences relevant?

(2008) Jesse T Lang et al.   Journal of Translational Medicine

TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration

(2008) Shinichiro Yamamoto et al.   NATURE MEDICINE

Blood-brain barrier tight junction permeability and ischemic stroke

(2008) Karin E. Sandoval et al.   NEUROBIOLOGY OF DISEASE

Mechanisms of ischemic brain damage

(2008) Kristian P. Doyle et al.   NEUROPHARMACOLOGY

Pericyte Signaling in the Neurovascular Unit

(2008) M. Fisher   STROKE

Beyond NMDA and AMPA glutamate receptors: emerging mechanisms for ionic imbalance and cell death in stroke

(2008) Elaine Besancon et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Inhibition of TRPM2 cation channels by N-(p-amylcinnamoyl)anthranilic acid

(2006) Robert Kraft et al.   BRITISH JOURNAL OF PHARMACOLOGY